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SURGICAL SCRUB & HAND SANITIZER Contains bioflavanoids anoids cally as part of a clinically on proven formulation


SURGICAL SCRUB A rapid acting biocidal antiseptic solution for pre-operative hand scrubbing and routine skin cleaning to reduce the risk of any cross infection. Vetroxx Surgical Scrub is

• Clinically proven • Antimicrobial • Hypoallergenic • Dermatologically tested • Contains bioflavanoids • Non toxic Vetroxx Surgical Scrub is completely safe and non toxic for both veterinary staff and patients1. It causes minimal irritancy to the skin2 and the mild formulation is suitable for repeated use for all skin types. Vetroxx Surgical Scrub is tested to BSEN1276, BSEN13704 and BSEN1275 standards under dirty conditions. Rigorous pre-operative skin disinfection is essential to good surgical procedure in the veterinary practice.

Available in 5 litre & 500ml

Instructions for use For applying pre-operatively to disinfect skin surface at surgical site:

• Thoroughly clip and clean the area • Apply undiluted to patient’s intact dry skin • Rub into the skin and allow to dry • Maximal effect within minutes

Pre-operative surgical hand disinfection routine:

• Wash hands and apply 5ml of undiluted scrub, wash for 1 minute

• Clean fingernails and scrub thoroughly for 1 minute • Apply a further 5ml, wash and scrub for 3 minutes • Rinse thoroughly and dry

Vetroxx Surgical Scrub is an antimicrobial preparation for pre-operative surgical hand disinfection, routine antiseptic hand washing and pre-operative skin antisepsis for patients undergoing surgery.


HAND SANITIZER For maintaining pathogen free hands and good hygiene for veterinary personnel throughout the working day. Vetroxx Hand Sanitizer is

• Clinically proven • Antimicrobial • Alcohol free • Hypoallergenic • Dermatologically tested • Contains bioflavanoids • Non toxic Vetroxx Hand Sanitizer is completely safe, alcohol free and kind to hands1. It is hypoallergenic, dermatologically tested and causes minimal irritancy to the skin2. The mild, alcohol free formulation is suitable for repeated use for all skin types throughout the working day, maintaining pathogen free hands without causing dryness or irritation. Vetroxx Hand Sanitizer is tested to BSEN1276, BSEN13704 and BSEN1275 standards under dirty conditions. Hand disinfection: • Thorough and regular hand disinfection is essential for infection control in the veterinary practice

• Hands should be disinfected before and after handling patients • Use of a hand sanitizer alleviates the need for constant washing and drying Instructions for use • Apply to clean hands and allow to dry naturally, repeat as often as required

Vetroxx Hand Sanitizer’s alcohol free mild formulation makes it suitable for sensitive skin.

Available in 500ml & 50ml


What is Vetroxx? • Vetroxx active is based on a novel approach to antisepsis

• The active is based on the patented Citroxx technology So what is Citroxx comprised of? • Citroxx is a patented combination of small and large

bioflavanoid molecules in combination with carefully selected fruit acids at certain ratios. The end product results in proven antimicrobial activity, via the bioflavanoid molecules enhancing/potentiating the activity of the fruit acids

• Bioflavanoids are derived from the natural defence

mechanisms of citrus fruit, particularly in Vetroxx’s case Bitter Oranges (Citrus Aurantium)

• Fruit acids are produced from natural sources and are

widely accepted as preservatives and antimicrobials in a wide range of industries

Bioflavanoid enhanced fruit acids and their mode of action against microbes • Enzyme inhibition • Break surface-exposed adhesions • Work on cell wall polypeptides • Work on membrane bound enzymes • Complexing with extra cellular and soluble proteins • Disrupt microbial membranes • Inactivate microbial adhesions, enzymes, cell envelope transport proteins

Fruit acid activity is enhanced by the addition of selected bioflavanoids • Activity enhanced by bioflavanoids from the Bitter Orange

• Naringin and Neohesperidin especially enhance the activity

Properties of bioflavanoids • Polyphenolic compounds • Produced naturally by plants • Pigmentation • Antioxidative • Antimicrobial • Skin conditioning properties

Ancillary roles of fruit acids in Citroxx • Removal of ions (for example insoluble metal ions such as calcium, magnesium etc. present in hard water)

• Necessary control of pH - to control hydrogen ion activity

• Maintenance of the shelf life • Provision of a fully solubilised liquid matrix with well defined physical properties

The Vetroxx active ingredient Citroxx has excellent antimicrobial effectiveness and has been tested under dirty conditions. Also, it is approved for use for disinfectant purposes by the Department of Health (UK) which indicates its potency. Citroxx active has also been used to decontaminate fresh produce in leading high street supermarkets which demonstrates its safety.


The Vetroxx active (Citroxx) has been widely tested and proven against a wide range of microbes including: Bacteria Alternaria sp. Campylobacter jejuni Chaetomium golbosum Dipiodia natalensis Escherichia coli F. sp. tuberosa Fusarium sambucinum Geotrichum candidium Klebsiella pneumonia Lactobacillus pentoaceticus Legionella pneumophila (NCTC 11192) Listeria monocytogenes MRSA (clinical strain) Mycobacterium fortutium (NCTC 8573 for indication of tuberculocidal activity) Penicillium digitatum Penicillium funiculosum Penicillium italicum Penicillium roqueforti Penicillium sp. Phomopsis ortl Proteus vulgaris

Pseudomonas aeruginosa (ATCC 15442) Pullularia pullulans Salmonella chloreraesuis Salmonella typhimurium (DT004) Scerotinia laxa Staphylococcus aureus (NCTC 6571) Staphylococcus pyogenes Staphylococcus sp. Sterptococcus faecalis Trichophyton iterdigitale Viruses Hepatitis A + P H5N1 (Avian Influenza A) Human Rhinovirus Influenza A Human Immunodeficiency Virus (HIV) Urbani SARS African swine fever Foot & mouth disease Gumboro virus Herpes virus

Yeast and Fungi Aspergillus flavus Aspergillus niger Aspergillus terreus Botrytis cinerea Candida albicans Candida glabrata Chaetonium globosum Cladosporium Collectotricum sp. Fusarium sp. Mucor sp. Penicillium sp. Pullularia pullulans Pythium sp. Trichophyton interdigitale Trichophyton mentagrophytes Protozoa Histomonas meleagradis Giardia lamblia Entamoeaba histolytica Blastocystis hominis

Comparison table of Vetroxx active against other commonly used actives Active Agent

Bactercide

T.B.

Sporicidal

Virucidal

Fungicide

Applications

Advantages

Disadvantages

Biodegradable Fast acting Non toxic Organic

None known

Citroxx

Yes

Yes

Yes

Yes

Yes

Skin/hand Air Surfaces Instruments

Alcohol

Yes

Yes

No

Yes

Yes

Skin/hand

Fast acting Dries fast

Irritation Highly flammable Evaporates easily

Phenols

Yes

Yes

No

Yes

Yes

Surfaces Instruments

Low concentrate required

Toxic Long application time Produces odour

Oxidising agents

Yes

Yes

Yes

Yes

Yes

Water Instruments Mucous membranes

Biodegradable Fast acting

Unstable Short shelf life Corrosive

Halogens

Yes

Yes

Yes

Yes

Yes

Hands Instruments

Fast acting

High concentration Allergic reactions Irritations

Aldehydes

Yes

Yes

Yes

Yes

Yes

Surfaces Instruments

Biodegradable Low concentrate

Toxic Binds to proteins Produces odour

Surfaces Instruments

Fast acting Low concentrate Biodegradable High cleaning power Well tolerated

Low spectrum of effectiveness

Quaternary ammonia compounds

Partly

Yes

No

Partly

Partly

In conclusion the Vetroxx active Citroxx is clinically proven for a wide range of applications without any side effects.


Trial comparing active in Vetroxx Surgical Scrub vs. chlorhexidine formulations Time taken for a 6-Log reduction in cell numbers following exposure to active in Vetroxx Surgical Scrub or 4% v/v chlorhexidine. STRAIN

STRAIN INFORMATION

VETROXX SURGICAL SCRUB*

4% CHLORHEXIDINE

S. aureus BH1CC

Hospital-Acquired (HA) MRSA

2 minutes

2 minutes

S. aureus USA300-Lac

Community-Acquired (CA) MRSA

2 minutes

2 minutes

S. aureus NCTC8325-4

Laboratory strain

2 minutes

2 minutes

S. aureus 10/68

Bovine isolate

2 minutes

2 minutes

E. coli 0157

Food pathogen

3 minutes

4 minutes

*1% Citroxx.

Conclusion • Vetroxx Surgical Scrub is as effective as a chlorhexidine based scrub • Vetroxx Surgical Scrub is effective against MRSA • The active in Vetroxx Surgical Scrub is a proven potent antimicrobial substance A clinically proven formulation of bioflavanoids combined with dermatological benefits for the patient and the vet makes Vetroxx Surgical Scrub the best choice of product for your practice. “My colleagues and I at Athy Veterinary Hospital have used Vetroxx for a variety of surgical procedures including orthopaedic surgery. We found it highly effective and experienced no problems with the product. Our staff commented on how effective and gentle it was even on sensitive skin and hands. I would highly recommend the product to other practices.” Andrew Doona MVB Cert(SAS), MRCVS, Partner, Athy Veterinary Hospital.

“All of the work we have done to date in my laboratory with the active ingredient of Vetroxx Surgical Scrub indicates that it has fantastic antimicrobial activity against a range of pathogenic bacteria.”

Vetroxx Surgical Scrub and Vetroxx Hand Sanitizer are approved by DEFRA and the Irish Department of Agriculture, Food and Marine. Independently Tested in Certified Laboratories under dirty conditions. Tested to BSEN1276, BSEN13704 and BSEN1275 standards. References: 1a. Evaluation of the Health Aspects of Hesperidin, Naringin, and Citrus Bioflavanoid Extracts as Food Ingredients. 1b. Acute Dermal Toxicity Study in Rats Limit Test. 1c. Acute Oral Toxicity Up and Down Procedure in Rats. 2a. Dermal Sensitization Study in Guinea Pigs (Buehler Method). 2b. Report on the determination of Acute Dermal Irritancy By Skin Patch Testing - 24hr patch test. Further information is available from: Bimeda UK. Unit 2, Bryn Cefni Industrial Park, Llangefni, Anglesey LL77 7XA • T: 0800 526 769 Bimeda Ireland. Broomhill Road, Tallaght, Dublin 24, Ireland • T: 00353 1451 5011

www.bimeda.com

APRIL 2012 / 5K

Dr James P. O’Gara, Senior Lecturer and Conway Fellow, Head of Graduate Studies, School of Biomolecular and Biomedical Science, UCD.


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