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Cardiology DAOM Cohort 6 Summer 2012

Break Through in Clinical Cardiology • Introduction • Key Point: 50% of Americans who have fatal heart attacks have normal Blood Pressure and Cholesterol. We must question the effectiveness of these early markers. • This poster explores an exciting, noninvasive, easy to use, and economical method of assessing patients’ cardiovascular physiologic status that is backed by more than 25 years of advanced research in Medical Physics. • A 2007 Clinical Medicine article points the way to better clinical treatment of CVD, stating: “Arterial stiffness measured by pulse wave velocity (PWV) is an accepted, strong, independent predictor of Cardiovascular events and mortality.” • Known in 1993: Blood pressure alone provides no information of the wave itself. “The fallacy that there is a single ‘systolic’ and a single ‘diastolic’ blood pressure that is the same in all arteries and can be measured in the brachial or radial artery is quite wrong, but few appreciate this fallacy or implications.”1

AIM OF STUDY Design a more effective method of assessing early risk factors for Cardiovascular Health

DPA The shape of the pulse wave is determined, in part, by the elasticity of the blood vessels. The DPA can analyze the shape of the curve to get early information about arterial compliance and developing arterial vascular disease. The DPA uses a fingertip probe sensor-light from the LEDs is transmitted through the tissue at the sensor site. The photodiode detects the changes in the amount of light absorbed by the hemoglobin which forms the PTG.

TEMPLATE DESIGN © 2008

www.PosterPresentations.com

Raman Basha www.BashaHealth.com UNDERSTANDING PULSE WAVE ANALYSIS

METHODS Digital Pulse Analysis (DPA)

The pulse wave is a physiological phenomenon, observable and measureable in the arterial system during blood circulation. During one heart systole a certain blood volume is expelled. The propagates through the arteries due to the reciprocal transformation between the kinetic energy of a segment of the expelled blood volume and the potential energy of a stretched segment of the resilient vascular wall. We can observe the changes in pressure, blood flow, velocity and profile through the whole pulse wave. It can be used for classification of arterial elasticity. 2 Heart Health Seminar, The Galleria ,Houston, Texas Aug 2010

WHY TEST FOR ARTERIAL STIFFNESS? ‘Aging and disease states associated with an increase in cardiovascular events alter the physical characteristic of blood vessel walls and impair the pulsatile function of the arteries. An accumulating body of evidence indicates that impaired pulsatile function of arteries provides important prognostic and therapeutic information beyond that provided by traditional blood pressure measurements.”3

The shape of the pulse wave is determined, in part, by the elasticity of the blood vessels. The DPA can analyze the shape of the curve to get early information about arterial compliance and developing arterial vascular disease. The DPA uses a fingertip probe sensorlight from the LEDs is transmitted through the tissue at the sensor site. The photo-diode detects the changes in the amount of light absorbed by the hemoglobin which forms the PTG.

SUMMARY “Accumulating evidence suggests that the abnormalities in the pulsatile characteristics of arteries occur early in the disease processes associated with increased cardiovascular risk, and can be favorably modified by therapeutic interventions.”5 “We now know that the health of the endothelium and the blood vessels directly affects overall cardiovascular health. Cardiovascular health kills 500,000 Americans every year in the form of heart attack and stroke. About 16 million more Americans suffer pain and disabilities caused by cardiovascular disease. Today, over 60,800,000 Americans (a quarter of thee US Population) have one or more conditions that put them at risk for heart attack and stroke.”6 “The economic costs of these vessel diseases are staggering. In 2001, the economic costs of all cardiovascular diseases was approximately $ 298 billion, including health expenditures and lost productivity.”7

“The ability to detect and monitor sub-clinical damage, representing the cumulative and integrative influence of risk factors in impairing arterial wall integrity, holds potential to further refine cardiovascular risk stratification and enable early intervention to prevent or attenuate disease progression.4

Arterial stiffness occurs at varying rates in different people. In a large scale study involving 3,075 health older people, those who had the highest pulse wave velocity were three times more likely to die of cardiovascular disease than those who had the lowest pulse wave velocity. (National Institute of Health/National Institute on Aging/US Department of Health and Human Services.) It is becoming more apparent that changes in the aging circulatory system, even those without outward systems, precede and predict a higher risk of developing cardiovascular diseases.

APG Waveform-(Accelerated plethysmogram) The second derivative of PTG-an excellent method to evaluate the biological age of the arteries. The reflection wave from the periphery increases with age because of arterial stiffness and early return of wave reflection as a consequence of increased pulse velocity.

REFERENCE . Biomed Papers 147 (2) 181-184 (2003) Avid Korpas, Jan Halek, Ludmila Chulpova, Institute of Medical BioPhysics, Faculty of Medicine, Palacky University, Olomuc 3-5. Clinical Science (2002) 102, page 52, Gary E. McVeigh, Paul Hamilton and David Morgan, Department of Therapeutics and Pharmacology, Whitla Medical Building, Queen’s University Belfast, 97 Lisburn Road, Belfast, Northern Ireland, UK 6. The CardioVascular Cure (2002), page xvii, John Cooke, MD, PHD, and Judith Zimmer 7. The CardioVascular Cure (2002), page xvii, John Cooke, MD, PHD, and Judith Zimmer


DAOM Cohort 6 Summer 2012

CAPSTONE PROPOSAL

Cardiology

Raman Basha www.BashaHealth.com

•The Role of Digital Pulse Analysis (DPA) in Evaluating Cardio Vascular Function before and after regulated intake of L-Arginine Complex

POSTER TEMPLATE BY:

www.PosterPresentations.com


The aim of this study

•Design a more effective method of assessing early risk factors for Cardiovascular Health

POSTER TEMPLATE BY:

www.PosterPresentations.com


Digital Pulse Analysis (DPA)

•The shape of the pulse wave is determined, in part, by the elasticity of the blood vessels. The DPA can analyze the shape of the curve to get early information about arterial compliance and developing arterial vascular disease. The DPA uses a fingertip probe sensor-light from the LEDs is transmitted through the tissue at the sensor site. The photo-diode detects the changes in the amount of light absorbed by the hemoglobin which forms the PTG. POSTER TEMPLATE BY:

www.PosterPresentations.com


Digital Pulse Analysis (DPA)

•The shape of the pulse wave is determined, in part, by the elasticity of the blood vessels. The DPA can analyze the shape of the curve to get early information about arterial compliance and developing arterial vascular disease. The DPA uses a fingertip probe sensor-light from the LEDs is transmitted through the tissue at the sensor site. The photo-diode detects the changes in the amount of light absorbed by the hemoglobin which forms the PTG. POSTER TEMPLATE BY:

www.PosterPresentations.com


Digital Pulse Analysis (DPA)

Heart Health Seminar, The Galleria ,Houston, Texas Aug 2010 POSTER TEMPLATE BY:

www.PosterPresentations.com


PULSE WAVE ANALYSIS

•The pulse wave is a physiological phenomenon, observable and measureable in the arterial system during blood circulation. During one heart systole a certain blood volume is expelled. The propagates through the arteries due to the reciprocal transformation between the kinetic energy of a segment of the expelled blood volume and the potential energy of a stretched segment of the resilient vascular wall. We can observe the changes in pressure, blood flow, velocity and profile through the whole pulse wave. It can be used for classification of arterial elasticity.

POSTER TEMPLATE BY:

www.PosterPresentations.com


APG Wave form

•APG Wave form Accelerated plethysmogram The second derivative of PTG-an excellent method to evaluate the biological age of the arteries. The reflection wave from the periphery increases with age because of arterial stiffness and early return of wave reflection as a consequence of increased pulse velocity.

POSTER TEMPLATE BY:

www.PosterPresentations.com


APG Waveform

Accumulating evidence suggests that the abnormalities in the pulsatile characteristics of arteries occur early in the disease processes associated with increased cardiovascular risk, and can be favorably modified by therapeutic interventions.�5 “We now know that the health of the endothelium and the blood vessels directly affects overall cardiovascular health.

POSTER TEMPLATE BY:

www.PosterPresentations.com


L-Arginine Complex

POSTER TEMPLATE BY:

www.PosterPresentations.com


We Need a good heart

•Cardiovascular health kills 500,000 Americans every year in the form of heart attack and stroke. About 16 million more Americans suffer pain and disabilities caused by cardiovascular disease. •Today, over 60,800,000 Americans (a quarter of thee US Population) have one or more conditions that put them at risk for heart attack and stroke

POSTER TEMPLATE BY:

www.PosterPresentations.com


West Meets East

•The economic costs of these vessel diseases are staggering. In 2001, the economic costs of all cardiovascular diseases was approximately $ 298 billion, including health expenditures and lost productivity

POSTER TEMPLATE BY:

www.PosterPresentations.com


Cardiology Presentation By Dr. Raman Basha