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85 costly, but all of them are based on the fundamental concepts first worked out by Yalow and Berson (4). And there is one other legacy. Despite the obstacles she faced, Rosalyn Yalow never complained or made excuses. Barriers were made to be broken. She just worked harder and did better, as if to say, “Bring it on” (12). The sign on her office wall read, “Whatever women do they must do twice as well as men to be thought half as good. Luckily, this is not difficult” (2).

References: 1. Yalow RS (1977) Radioimmunoassay: A probe for fine structure of biologic systems. Nobel Lecture; available from: http:// www.nobelprize.org/nobel_prizes/medicine/laureates/1977/ yalow-lecture.pdf 2. Straus E (1998) Rosalyn Yalow, Nobel laureate: Her life and work in medicine. Plenum Trade, New York. 3. Odelberg W (1978) Rosalyn Yalow - Biography, In: The Nobel Prizes 1977. Nobel Foundation, Stockholm; available from: http://www.nobelprize.org/nobel_prizes/medicine/ laureates/1977/yalow-bio.html 4. Bonolis, L (2014) Rosalyn Yalow research profile. Lindau Nobel Laureate Meetings; available from: http://www.mediatheque. lindau-nobel.org/research-profile/laureate-yalow

5. Chemical Heritage Foundation (August 13, 2015) Rosalyn Yalow and Solomon A. Berson; available from: https://www. chemheritage.org/historical-profile/rosalyn-yalow-andsolomon-a-berson 6. Yalow RS and Berson SA (1951) The use of K42-tagged erythrocytes in blood volume determinations. Science 114(2949): 14-15. 7. Berson SA and Yalow RS (1952) The use of K42 or P32 labeled erythrocytes and I131 tagged human serum albumen in simultaneous blood volume determinations. J Clin Invest 31(6): 572-580. 8. Berson SA, Yalow RS, Sorrentino J, and Roswit B (1952) The determination of thyroidal and renal plasma I131 clearance rates as a routine diagnostic test of thyroid dysfunction. J Clin Invest 31(2): 141-158. 9. Berson SA, Yalow RS, Bauman A, Rothschild MS, and Newerly K (1956) Insulin-I131 metabolism in human subjects: Demonstration of insulin binding globulin in the circulation of insulin treated subjects. J Clin Invest 35(2): 170-190. 10. Yalow RS and Berson SA (1959) Assay of plasma insulin in human subjects by immunological methods. Nature 184(4699): 1648-1649. 11. Yalow RS and Berson SA (1960) Immunoassay of endogenous plasma insulin in man. J Clin Invest 39(7): 1157-1175. 12. Benjamin Yalow and Elanna Yalow, personal communications.

Reprinted from The Pharmacologist • September 2017

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2018 Special Compilation Issue of The Pharmacologist  

ASPET is pleased to present the second in a series of special editions of our quarterly news magazine, The Pharmacologist. This special com...

2018 Special Compilation Issue of The Pharmacologist  

ASPET is pleased to present the second in a series of special editions of our quarterly news magazine, The Pharmacologist. This special com...