Page 1

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Programme Overview Level 1, Zeus Hall

Thursday May 20, 2010 8:00-18:30 19:30

Registrations

Official Opening Ceremony – Welcome Reception 5th International Hydrocephalus Workshop & 24th Annual Hellenic Congress of Neurosurgery

Friday May 21, 2010 7:45-8:00

Welcome and Announcements Harold L. Rekate, President of the 5th International Hydrocephalus Workshop Konstantinos Kouzelis, Vice President of the 5th International Hydrocephalus Workshop and President of the Hellenic Neurosurgical Society

Session I

Definition and classification

8:00-8:30

The definition and classification of hydrocephalus: A consensus statement from the Hydrocephalus Classification Study Group Harold L. Rekate MD

8:30-9:00

Treatment of hydrocephalus based on the new classification Spyros Sgouros MD FRCS(SN)

9:00-9:30

Clinical research in hydrocephalus Where are we now and where are we going? John Kestle MD

9:30-10:00

International study of infant hydrocephalus Shunts vs. ETV Shlomi Constantini MD MSc

10:00-10:30

Coffee with exhibitors

Session II

Pediatric hydrocephalus

Moderators Carsten Wikkelso, President ISHCSF Petra Klinge, President-Elect ISHCSF

Moderators Shlomi Constantini, Thomas Brinker


Programme Overview

10:30-12:00

Oral presentations

12:00-13:00

Poster discussions

13:00-14:00

Lunch and poster viewing

Session III

Special session: The importance of Dr. Anthony Marmarou

Moderators Harold L. Rekate, President of the 5th International Hydrocephalus Workshop Konstantinos Kouzelis, Vice-President of the 5th International Hydrocephalus Workshop and President of the Hellenic Neurosurgical Society

14:00-14:30

Modeling of CSF dynamics and cerebral blood flow Marek Czosnyka PhD

14:30-15:00

The practice guidelines for the diagnosis and management of NPH History and perspectives Petra Klinge MD PhD

15:00-15:15

The NPH program at Medical College of Virginia: Patient Selection Gunes Aygok MD PhD

15:15-15:30

The NPH program at Medical College of Virginia: Surgical management Harold F. Young MD

15:30-16:00

Break with exhibitors

Session IV Engineering aspects Moderators Michael Pollay, Panagiotis Selviaridis 16:00-17:10 Oral presentations 17:10-18:10

Poster presentations

20:00

Cretan night (optional – please consult the Workshop Secretariat)

17


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Saturday May 22, 2010 Session V

The basic science of hydrocephalus

08:00 – 10:00

Oral presentations

10:00-10:30

Break with exhibitors

Session VI

Physiology and neuroimaging

10:30-11:00

Overview of the dual CSF outflow system Michael Pollay MD PhD

11:00-11:30

Cranial pulsatility: Physiologically important or just a passing wave Mark Luciano MD PhD

11:30-12:00

Disproportionately enlarged subarachnoid-space hydrocephalus Matsasune Ishikawa MD PhD

12:00-12:30

Neuro-imaging of hydrocephalus What’s missing from the picture? Norman Relkin MD PhD

12:30-13:30

Lunch and poster viewing

Moderators John Kestle, Vasilios Varsos

Moderators Jogi Pattisapu, Spyros Sgouros

Level 0, Minos Hall Session VII

Clinical studies

13:30-14:00

Ethical considerations in hydrocephalus research in children and adults Michael Williams MD

14:00-14:30

Alzheimer disease, systemic hypertension and congenital factors What are their roles in normal pressure hydrocephalus? Neil Graff-Radford MD

14:30-15:00

Adjustable valves in the treatment of INPH Carsten Wikkelso MD PhD

Moderators Michael Kiefer, Alexander Andreou


Programme Overview

15:00-15:30

Lessons learned and questions raised during 20 years of ETV Andre Grotenhuis MD

15:30-16:00

Break with exhibitors

Session VIII

Moderators Martin Schuhmann, George Stratzalis

16:00-18:00

Oral presentations

20:30

Gala dinner

Neuroendoscopy

Sunday May 23, 2010 Session IX

NPH and diagnosis

Moderators Michael Pollay, Marek Czosnyka

09:00 – 10:30 Oral presentations 10:30 – 10:50

Break with exhibitors

Session X

Moderators Mark Luciano, Konstantinos Polyzoidis

10:50-13:00

Oral presentations

13:00-13:30

Summary of the accomplishments of the meeting Harold L. Rekate, Kostantinos Kouzelis, Michael Pollay

NPH and shunts


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Final Programme Level 1, Zeus Hall

Thursday May 20, 2010 8:00-18:30 19:30

Registrations

Official Opening Ceremony – Welcome Reception 5th International Hydrocephalus Workshop & 24th Annual Hellenic Congress of Neurosurgery

Friday May 21, 2010 7:45-8:00

Welcome and Announcements Harold L. Rekate, President of the 5th International Hydrocephalus Workshop Konstantinos Kouzelis, Vice President of the 5th International Hydrocephalus Workshop and President of the Hellenic Neurosurgical Society

Session I

Definition and classification

8:00-8:30

The definition and classification of hydrocephalus: A consensus statement from the Hydrocephalus Classification Study Group Harold L. Rekate MD

8:30-9:00

Treatment of hydrocephalus based on the new classification Spyros Sgouros MD FRCS(SN)

9:00-9:30

Clinical research in hydrocephalus Where are we now and where are we going? John Kestle MD

9:30-10:00

International study of infant hydrocephalus Shunts vs. ETV Shlomi Constantini MD MSc

10:00-10:30

Coffee with exhibitors

Session II

Pediatric hydrocephalus

Moderators Carsten Wikkelso, President ISHCSF Petra Klinge, President-Elect ISHCSF

Moderators Shlomi Constantini, Thomas Brinker


Final Programme

10:30-12:00

Oral presentations

o01. Quality and safety of home ICP monitoring compared to in-hospital monitoring Andresen M., Juhler M., Munch T. Clinic of Neurosurgery, Copenhagen University Hospital, Denmark O02. PATHOPHYSIOLOGY OF BRAIN STEM LESIONS DUE TO OVERDRAINAGE Antes S., Eymann R., Schmitt M., Kiefer M. Saarland University, Medical School, Department of Neurosurgery, Homburg-Saar, Germany O03. INAPPROPRIATELY LOW-PRESSURE (NEGATIVE-PRESSURE) HYDROCEPHALUS: EXPERIENCE WITH 20 PATIENTS Hamilton Μ., MDCM, FRCSC Department of Clinical Neurosciences, Division of Neurosurgery, University of Calgary, Canada o04. Adults treated for infantile hydrocephalus – a very long term follow-up study Persson E.K. MD PhD, Lindquist B. PhD, Fernell E. MD PhD, Uvebrant P. MD PhD Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden o05. Medication overuse as a cause of chronic headache in shunted hydrocephalus patients Juhler M., Willer L., Jensen R.H. Department of Neurosurgery, Rigshospitalet, Denmark The Headache Research Centre, Glostrup Hospital, Denmark O06. TREATMENT OF PREMATURE CHILDREN WITH POSTHEMORRHAGIC HYDROCEPHALUS BY TEMPORARY METHODS OF ICP NORMALISATION Zinenko D., Vladimirov M., Hafizov F. Moscow Pediatric and Children Surgery Research Institute, Russia O07. SHUNT SURGERY CAN BE AVOIDED IN MOST PATIENTS WITH BENIGN INTRACRANIAL CYSTS Högfeldt M.1, Tisell M.1, Hellström P.2, Edsbagge M.2, Wikkelsö C.2 (1) Department of Neurosurgery, Sahlgrenska University Hospital Gothenburg, Sweden (2) Department of Neurology, Sahlgrenska University Hospital Gothenburg, Sweden O08. Asymptomatic Treatment Failure in Pediatric Hydrocephalus - Features of an under-diagnosed (?) entity Schuhmann M. U.1, Speil A.2, Haas-Lude K.2, Alber M.2, Bevot A.2 (1) Section of Pediatric Neurosurgery, Department of Neurosurgery, Eberhard Karls University Hospital, Tuebingen, Germany (2) Department of Pediatric Neurology, Eberhard Karls University Children‘s Hospital, Tuebingen, Germany o09. The management and the outcome of Intraventricular hemorrhage in babies with low birth weight Inagaki T.1, Kawamoto K.2, Kinoshita Y.3 (1) Pediatric Neurosurgery, Kansai Medical University, Japan (2) Neurosurgery, Kansai Medical University, Japan (3) Pediatrics, Kansai Medical University, Japan 12:00-13:00

Poster discussions


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Associated disorders P01. POSTCRANIECTOMY HYDROCEPHALUS Venetikidis A., Paleologos T.S., Markellos A., Papanikolaou P.G., Stamatiou S., Voidonikolas L., Georgoulis G., Damilakis K., Kiriakou T. Department of Neurosurgery, General Hospital Nikaia-Piraeus, Greece P02. Post-Traumatic Hydrocephalus in Severe Head INJURY - SERIES OF 9 CASES Syrmos N.1, Iliadis Ch.1, Barkatsa V.1, Valadakis V.1, Grigoriou K.1, Gavridakis G.2, Arvanitakis D.1 (1) Department of Neurosurgery, Venizeleio General Hospital, Heraklion, Crete, Greece (2) CT Scan Department, Venizeleio General Hospital, Heraklion, Crete, Greece P03. Lhermitte-Duclos disease presenting with HYDROCEPHALUS: case report and literature review Choong Hyun Kim MD PhD, Jin Hwan Cheong MD PhD, Jae Min Kim MD PhD Department of Neurosurgery, Hanyang University, Guri, Korea Discussion

Complications P04. Rare abdominal complications of ventriculo-peritoneal (VP) shunts Paidakakos N., Rokas E., Theodoropoulos S., Dimogerontas G., Rovlias A., Makrigiannakis G., Papadopoulos M., Konstantinidis E. Department of Neurosurgery, Asclepeion General Hospital of Voula, Athens, Greece P05. Infections after cerebrospinal fluid shunt in elderly patients Syrmos N.1, Iliadis Ch.1 , Barkatsa V.1, Valadakis V.1, Grigoriou K.1, Gavridakis G.2, Arvanitakis D.1 (1) Department of Neurosurgery, Venizeleio General Hospital, Heraklion, Crete, Greece (2) CT Scan Department, Venizeleio General Hospital, Heraklion, Crete, Greece P06. Ventriculoatrial Shunts: Predictors of failures Batra S., Solomon D., Moghekar A., Blitz A., Rigamonti D. The Departments of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA P07. Endoscopic brain-washing on treatment of ventricular infection Qing Xiao, Guo-qiang Chen, Jia-ping Zheng, Jin-ting Wu, Hui Liang, Huan-cong Zuo Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, China Discussion

Associated disorders P08. A 40-year series with 1070 Syrinx- and Chiari-Patients Aschoff A.1, Akbar M.2, Wiedenhöfer B.2, Muhcu S.1, Orakcioglu B.1, Geletneky C.1 (1) Department of Neurosurgery, University of Heidelberg, Germany (2) Department of Orthopaedics, University of Heidelberg, Germany


Final Programme

P09. Expression analysis of High Mobility Group Box-1 Protein (HMGB-1) in the cerebral CORTEX, HYPPOCAMPUS, cerebellum of the congenital hydrocephalus rat (H-Tx) Mitsuya Watanabe MD, Masakazu Miyajima MD, Madoka Nakajima MD, Hajime Arai MD, Ikuko Ogino, Sinji Nakamura, Miyuki Kunichika Department of Neurosurgery, Juntendo University, Bunkyoku, Tokyo, Japan P10. AtyPical meningioma in the posterior fossa associated with colpocephaly and corpus callous agenesis Choong Hyun Kim MD PhD, Jin Hwan Cheong MD PhD, Jae Min Kim MD PhD Department of Neurosurgery, Hanyang University, Guri, Korea

Potpourri P11. Effect of antibiotic impregnated shunts on infection rate in adult hydrocephalus: A single institution’s experience Harrison Farber S., Parker S.L., Adogwa O., McGirt M.J., Solomon D., Rigamonti D. The Departments of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA P12. The Obstructive Nature Of Pediatric Hydrocephalus Results Of A High-Resolution MRI Study Schuhmann M.U.1, Filip Z.1, Ries B.G.2, Tatagiba M.S.1, Nägele T.1 (1) Section of Pediatric Neurosurgery, Department of Neurosurgery, Eberhard Karls University Hospital, Tuebingen, Germany (2) Department of Neuroradiology, Eberhard Karls University Hospital, Tuebingen, Germany P13. SHUNT RELATED OCCLUSIVE EXTERNAL HYDROCEPHALUS Zinenko D. Moscow Pediatric and Children Surgery Research Institute, Russia Discussion 13:00-14:00

Lunch and poster viewing

Session III

Special session: The importance of Dr. Anthony Marmarou

14:00-14:30

Modeling of CSF dynamics and cerebral blood flow Marek Czosnyka PhD

14:30-15:00

The practice guidelines for the diagnosis and management of NPH History and perspectives Petra Klinge MD PhD

15:00-15:15

The NPH program at Medical College of Virginia: Patient Selection Gunes Aygok MD PhD

Moderators Harold L. Rekate, President of the 5th International Hydrocephalus Workshop Konstantinos Kouzelis, Vice President of the 5th International Hydrocephalus Workshop and President of the Hellenic Neurosurgical Society


TH ÜÜ).4%2.!4)/.!,Ý(9$2/#%0(!,53Ü7/2+3(/0 15:15-15:30

The NPH program at Medical College of Virginia: Surgical management Harold F. Young MD

15:30-16:00

Break with exhibitors

Session IV Engineering aspects Moderators Michael Pollay, Panagiotis Selviaridis 16:00-17:10 Oral presentations O10. Slow vasogenic fluctuations of Intracranial Pressure and Cerebral Near Infrared Spectroscopy – An Observational Study Czosnyka Z.1, Weerakkody R. A.1, Czosnyka M.1, Balédent O.2, Souraya Stoquart El-sankari2, Pickard J.1 (1) Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (2) Department of Medical Physics and Imaging, University of Amiens Hospital, Amiens, France (3) Department of Neurology, Cliniques Universitaires Saint-Luc, Brussels, Belgium o11. Who needs a shunt? CSF dynamics perspective Czosnyka M.1, Schuhmann M.2, Werrakody R.1, Keong N.2, Santarius T.1, Schmidt EA.4, Balédent O.1, Pickard JD.1, Czosnyka Z.1 (1) Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK (2) Department of Neurosurgery, University of Tuebingen, Germany (3) Department of Medical Physics and Imaging, University of Amiens Hospital, France (4) Neurosurgery, Hopital Pourpan, Toulouse, France o12. Simulation of shunt valves in a hydrocephalus model Krause I.1, Walter M.1, Kiefer M.2, Leonhardt S.1 (1) Chair for Medical Information Technology, Helmholtz-Institute, RWTH Aachen, Germany (2) Neurosurgery, Saarland University, Medical School, Homburg-Saar, Germany O13. Realistic phantom of cranio-spinal hydrodynamics Bouzerar R.1, Czosnyka M.2, Czosnyka Z.2, Balédent O.1 (1) Department of Medical Physics and Imaging, University of Amiens Hospital, Amiens, France (2) Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK O14. csf dynamic profile of potential shunt candidates in comparison with healthy elderly Frankel J. MSc1, Eklund A. PhD1,2, Malm J. MD PhD3 (1) Department of Biomedical Engineering, Umeå University Hospital, Sweden (2) Department of Radiation Sciences, Umeå University, Sweden (3) Department of Clinical Neuroscience, Umeå University, Sweden O15. Estimation of Outflow resistance – Model dependency Eklund A. PhD1,2, Andersson K. MSc2, Malm J. MD PhD3 (1) Department of Biomedical Engineering, Umeå University Hospital, Sweden (2) Department of Radiation Sciences, Umeå University, Sweden (3) Department of Clinical Neuroscience, Umeå University, Sweden


Final Programme

O16. Endoscopic IIIrd ventriculostomy (ETV). Surgical technique and pitfalls Bouramas D.1,2, Paidakakos N.2, Sotiriou F.1, Kouzounias K.1, Sklavounou M.2, Gekas N.1 (1) Department of Neurosurgery, Athens Naval Hospital, Greece (2) Department of Neurosurgery, Athens Bioclinic, Greece 17:10-18:10

Poster presentations

Engineering aspects 1 P14. ICMPlus software used for assessment of CSF dynamics Czosnyka Z., Czosnyka M., Pickard J.D., Smielewski P. Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK P15. Programmable Shunt Assistant tested in Cambridge Shunt Evaluation Laboratory Czosnyka M., Czosnyka Z. Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK P16. Fast Fourier Transformation (FFT) for ICP slow waves detection Kiefer M.1, Schmitt M.1, Antes S.1, Krause I.2, Eymann R.1 (1) Department of Neurosurgery, Medical School, Saarland University, Homburg-Saar, Germany (2) Philips Chair for Medical Information Technology, Helmholtz-Institut, Aachen, Germany p17. Examination of deposits in CSF shunt valves using Scanning Electron Microscopy Charalambides C., Sgouros S. Department of Neurosurgery, “Attikon” University Hospital, University of Athens, Greece Discussion

Engineering aspects 2 P18. ICP analysis in NPH: Comparison of time-domain derived versus frequencydomain derived pulse wave amplitude and related parameters Schuhmann M.U.1, Buddhakoralage S.1, Speil A.1, Helm J.2, Jaeger M.2, Eide P.3 (1) Section of Pediatric Neurosurgery, Department of Neurosurgery, Eberhard Karls University Hospital, Tuebingen, Germany (2) Department of Neurosurgery, University of Leipzig, Leipzig, Germany (3) Department of Neurosurgery, Rikshospitalet, Oslo University Hospital, Oslo, Norway P19. An Innovative Permanently Implanted Wireless Intracranial Pressure Monitor Using MEMS Technology and Microwave Telemetry for the Diagnosis of Hydrocephalus Kralick F.A.1, Kawoos U.2, Warty R.3, Tofighi M.R.4, Rosen A.2 (1) Department of Neurosurgery, Hahnemann University Hospital, Philadelphia, USA (2) Department of Biomedical Engineering, Drexel University, Philadelphia, USA (3) Department of Electrical Engineering, Philadelphia, USA (4) Penn State University, the Capital College, Middletown, USA


TH ÜÜ).4%2.!4)/.!,Ý(9$2/#%0(!,53Ü7/2+3(/0 P20. Microstructural alterations of silicone catheters in an animal experiment: histopathology and SEM-findings Eymann R.1, Kim Y.J.2, Bohle R.M.2, Kiefer M.1 (1) Department of Neurosurgery, Medical School, Saarland University, Homburg-Saar, Germany (2) Department of Pathology, Medical School, Saarland University, Homburg-Saar, Germany Discussion

Selecting the right shunt P21. WHAT IS THE APPROPRIATE SHUNT SYSTEM FOR NORMAL PRESSURE HYDROCEPHALUS? Chrissicopoulos C.¹, Mourgela S.¹, Kirgiannis K.¹, Petritsis K.¹, Ampertos N.¹, Sakellaropoulos A.², Spanos A.¹ (¹) “Agios Savvas” Anticancer Institute, Department of Neurosurgery, Athens, Greece (2) “Neon Athineon” Hospital, Pulmonary and Critical Care Medicine, Athens, Greece P22. SURGICAL MANAGEMENT OF ADULT CHRONIC HYDROCEPHALUS BY USING VENTRICULO-PERITONEAL SHUNTS WITH ADJUSTABLE VALVES Paidakakos N., Rokas E., Theodoropoulos S., Dimogerontas G., Makrigiannakis G., Rovlias A., Papadopoulos M., Konstantinidis E. Department of Neurosurgery, Asclepeion General Hospital of Voula, Athens, Greece P23. Adjustable Gravitational Valves – Technical Overkill or Necessity? Aschoff A.1, Kiefer M.2, Kehler U.3, Jung C.1, Dictus C.1 (1) Department of Neurosurgery, University of Heidelberg, Germany (2) Department of Neurosurgery University of Homburg/S, Germany (3) Department of Neurosurgery, Asklepios Klinik Hamburg-Altona, Germany Discussion

Neuroendoscopy P24. Adult Endoscopic Third Ventriculostomy in Obstructive Hydrocephalus Woodworth G.F., See A., Batra S., Jallo G.I., Solomon D., Rigamonti D. Departments of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA P25. Efficacy and Safety Of The 2micron Continuous Wave Laser In Neuro-Endoscopic Procedures Schuhmann M.U., Nagel C., Ebner F.E., Tatagiba M.S. Section of Pediatric Neurosurgery, Department of Neurosurgery, Eberhard Karls University Hospital, Tuebingen, Germany P26. BENIGN CEREBRAL AQUEDUCT STENOSIS IN AN ADULT Chrissicopoulos C.¹, Mourgela S.¹, Ampertos N.¹, Sakellaropoulos A.², Kirgiannis K.¹, Petritsis K.¹, Spanos A.¹ (1) “Agios Savvas” Anticancer Institute, Department of Neurosurgery, Athens, Greece (2) “Neon Athineon” Hospital, Pulmonary and Critical Care Medicine, Athens, Greece Discussion 20:00

Cretan night (optional – please consult the Workshop Secretariat)


Final Programme

Saturday May 22, 2010 The basic science of hydrocephalus

Session V

Moderators John Kestle, Vasilios Varsos

08:00 – 10:00

Oral presentations

Ο17. CHANGES OF FRACTIONAL ANISOTROPY (FA) AND APPARENT DIFFUSION COEFFICIENT (ADC) IN PATIENTS WITH IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS Mase M.1, Demura K.1, Osawa T.1, HattoriI M.2, KasaiI H.3, Miyati T.4, Yamada K.1 (1) Department of Neurosurgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan (2) Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan (3) Department of Radiology, Nagoya City University Hospital, Nagoya, Japan (4) Faculty of Health Science, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan O18. MR-Elastography in Normal Pressure Hydrocephalus pre- and postshunt – Evaluation of a new in-vivo method and implications for pathogenesis Sprung C.1, Freimann F.B.1, Streitberger K.J.2, Wiener E.3, Sack I.2 (1) Department of Neurosurgery, Charité - University Berlin, Campus Rudolf Virchow, Berlin, Germany (2) Department of Radiology, Charité - University Medicine Berlin, Campus Charité Mitte, Berlin, Germany (3) Department of Neuroradiology, Charité - University Medicine Berlin, Campus Charité Mitte, Berlin, Germany O19. NEW EPENDYMAL CELLS ARE BORN POSTNATALLY AND SUPPORT VENTRICULOMEGALY IN HYDROCEPHALIC MICE Bátiz L.F.1, Jiménez A.J.2, Toledo C.D.1, Guerra M.1, Vio K.1, Rodríguez-Pérez L.M.2, Páez P.2, Pérez-Fígares J.M.2, Rodríguez E.M.1 (1) Instituto de Anatomía, Histología y Patología, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile (2) Departamento de Biología Celular, Genética y Fisiología, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain O20. GENE EXPRESSION PROFILING OF CHOROID PLEXUS IN ALZHEIMER’S DISEASE REVEAL IMPORTANT IMPLICATIONS FOR CSF DYNAMICS Stopa E.G.1, Nikonova E.V.2, Tanis K.Q.2, Podtelezhnikov A.A.2, Finney E.M.2, Stone D.J.2, Camargo L.M.2, Parker L.2, Verma A.2, Baird A.3, 4, Miller M.C.1, Donahue J.E.1, Gonzalez A.M.4, Eliceiri B.3, Silverberg G.D.1, Klinge P.M.1, Johanson C.E.1 (1) Departments of Neurosurgery and Pathology (Neuropathology Division), Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, RI, USA (2) Molecular Profiling & Research Informatics, Merck Sharp & Dohme, West Point, PA, USA (3) Department of Surgery, University of California San Diego Medical Center, San Diego, CA, USA (4) School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, UK


TH ÜÜ).4%2.!4)/.!,Ý(9$2/#%0(!,53Ü7/2+3(/0 O21. HYDROCEPHALUS AND AQUAPORINS. THE ROLE OF AQUAPORIN-1 Kalani MYS, Filippidis A.S., Rekate H.L. Division of Pediatric Neurosurgery, Barrow Neurological Institute, Phoenix, AZ O22. HYDROCEPHALUS AND AQUAPORINS. THE ROLE OF AQUAPORIN-4 Filippidis A.S., Kalani MYS, Rekate H.L. Division of Pediatric Neurosurgery, Barrow Neurological Institute, Phoenix, AZ O23. EXPERIMENTAL HYDROCEPHALUS INDUCES CHANGES IN CONSTITUTIVE AQUAPORIN-4 EXPRESSION AND CHANGES MORPHOLOGY OF AQUAPORIN-4 POSITIVE EPENDYMA Skjolding A.D.1, Rowland I.2, Soegaard L.V.2, Praetorius J.3, Penkowa M.4, Juhler M.1 (1) University Clinic of Neurosurgery, Rigshospitalet, Copenhagen, Denmark (2) Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark (3) The Water and Salt Research Center, Department of Anatomy, Aarhus University, Aarhus, Denmark (4) Section of Neuroprotection, Department of Neuroscience and Pharmacology, Faculty of Health Science, Copenhagen University, Copenhagen, Denmark O24. Prenatal molecular diagnosis and Stem cell research in severe type of L1CAM syndrome (X-linked hydrocephalus) Yamasaki M. MD PhD1,2, Nonaka M. MD PhD2, Shofuda T. MS1, Kanemura Y. MD PhD1,2 (1) Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Japan (2) Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Japan O25. Effect of Acetazolamide on Aquaporin-1 Expression of Cultured Choroid Plexus Cells Pouya Ameli, Meenu Madan, Srinu Chigurupati, Amin Yu, Sic L. Chan, Jogi V. Pattisapu Hydrocephalus Research Laboratory, University of Central Florida College of Medicine O26. EXPERIENCE WITH FRONTO-TEMPORAL DEMENTIA IN PATIENTS SHUNTED FOR HYDROCEPHALUS Williams M.A., Wilson R.K., Smith C.A. Sandra and Malcolm Berman Brain & Spine Institute, Adult Hydrocephalus Center, Sinai Hospital of Baltimore, Baltimore, MD USA O27. Diffusion tensor imaging exposes further lesions to white matter in INPH Lenfeldt N. E.P. PhD MSc1,5, Larsson A. PhD2, Nyberg L. PhD2,3, Birgander R. MD PhD2, Eklund A. PhD2,4,5, Malm J. MD PhD1 (1) Department of Clinical Neuroscience, Umeå University, Sweden (2) Department of Radiation Sciences, Umeå University, Sweden (3) Department of Integrative Medical Biology, Umeå University, Sweden (4) Department of Biomedical Engineering and Informatics, Umeå University, Sweden (5) Centre for Biomedical Engineering and Physics, Umeå University, Sweden O28. Quantitative Evaluation of CSF Circulation at the Aqueduct of Sylvius in 3T MR Unit Kapsalaki E.1, Tsougos I.2, Theodorou K.2, Paterakis K.N.3, Fountas K.N.3 (1) Department of Diagnostic Radiology, University Hospital of Larisa, School of Medicine, University of Thessaly, Larisa, Greece (2) Department of Medical Physics, University Hospital of Larisa, School of Medicine, University of Thessaly, Larisa, Greece (3) Department of Neurosurgery, University Hospital of Larisa, School of Medicine, University of Thessaly, Larisa, Greece 10:00-10:30

Break with exhibitors


Final Programme

Physiology and neuroimaging

Session VI

Moderators Jogi Pattisapu, Spyros Sgouros

10:30-11:00

Overview of the dual CSF outflow system Michael Pollay MD PhD

11:00-11:30

Cranial pulsatility: Physiologically important or just a passing wave Mark Luciano MD PhD

11:30-12:00

Disproportionately enlarged subarachnoid-space hydrocephalus Matsasune Ishikawa MD PhD

12:00-12:30

Neuro-imaging of hydrocephalus What’s missing from the picture? Norman Relkin MD PhD

12:30-13:30

Lunch and poster viewing

Level 0, Minos Hall Session VII

Clinical studies

13:30-14:00

Ethical considerations in hydrocephalus research in children and adults Michael Williams MD

14:00-14:30

Alzheimer disease, systemic hypertension and congenital factors What are their roles in normal pressure hydrocephalus? Neil Graff-Radford MD

14:30-15:00

Adjustable valves in the treatment of INPH Carsten Wikkelso MD PhD

15:00-15:30

Lessons learned and questions raised during 20 years of ETV Andre Grotenhuis MD

15:30-16:00

Break with exhibitors

Session VIII

Neuroendoscopy

16:00-18:00

Oral presentations

Moderators Michael Kiefer, Alexander Andreou

Moderators Martin Schuhmann, George Stratzalis


TH ÜÜ).4%2.!4)/.!,Ý(9$2/#%0(!,53Ü7/2+3(/0 O29. Endoscopic fourth ventriculostomy on treatment of fourth ventricle obstructive hydrocephalus Guo-qiang Chen, Qing Xiao, Jia-ping Zheng, Jin-ting Wu, Hui Liang, Huan-cong Zuo Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, China O30. A PROSPECTIVE, RANDOMISED, CONTROLLED TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF ENDOSCOPIC CHOROID PLEXUS COAGULATION WITH THIRD VENTRICULOSTOMY IN THE TREATMENT OF IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS (ISRCTN29863839) Edwards R.J., Aquilina K., Bunnage M., Pople I.K. Department of Neurosurgery, Frenchay Hospital, Bristol, UK O31. Normal Pressure Hydrocephalus (NPH): Indications for Endoscopic Third Ventriculostomy (ETV) Paidakakos N., Borgarello S., Naddeo M. Department of Neurosurgery, C.T.O. Hospital, Turin, Italy O32. Complications of Endoscopic Third Ventriculoscopy. A meta-analysis Bouras T., Sgouros S. Department of Neurosurgery, “Attikon” University Hospital, University of Athens, Greece O33. The Role of Endoscopic Third Ventriculostomy in the Treatment of Selected Patients with Normal Pressure Hydrocephalus Fountas K.N. MD PhD1, Kapsalaki E.Z. MD PhD2, Paterakis K.N. MD PhD1, Lee G.P. PhD3, Hadjigeorgiou G. MD PhD4 (1) Department of Neurosurgery, University Hospital of Larisa, University of Thessaly, School of Medicine, Larisa, Greece (2) Department of Diagnostic Radiology University Hospital of Larisa, University of Thessaly, School of Medicine, Larisa, Greece (3) Department of Neurology, Medical College of Georgia, Augusta, GA, USA (4) Department of Neurology, University Hospital of Larisa, University of Thessaly, School of Medicine, Larisa, Greece O34. The role of artificial cerebrospinal fluid as perfusate in neuroendoscopic surgery-basic investigationMasakazu Miyajima, Misuya Watanabe, Madoka Nakajima, Ikuko Ogino, Hajime Arai Department of Neurosurgery, Juntendo University, Tokyo, Japan O35. A TWELVE-YEAR HOSPITAL OUTCOME ON PATIENTS WITH idiopathic hydrocephalus Stranjalis G.1,2, Kalamatianos T.1,2, Koutsarnakis C.1,2, Loufardaki M.1,2, Stavrinou L.1,2, Sakas D.E.1,2 (1) Department of Neurosurgery, University of Athens, Athens, Greece (2) HCNR “Professor Petros S. Kokkalis”, Athens, Greece O36. Intracranial pressure analysis in patients with Chiari 1 malformation Radek Frič, Per Kristian Eide Department of Neurosurgery, Rikshospitalet, Oslo University Hospital, Norway O37. A 22-Year-Series of 1042 Patients with 1271 Adjustable Valves Dictus C., Biedermann N., Piotrowicz A., Unterberg A., Vienenkoetter B., Schiebel P., Hertle D., Haux D., Jung C., Aschoff A. Department of Neurosurgery, University of Heidelberg, Germany O38. THE IDIOPATHIC ADULT’S HYDROCEPHALUS. A HISTORICAL RESEARCH Missori P.1, Paolini S.2, Currà A.1 (1) Department of Neuroscience, Neurology and Neurosurgery, University of Rome “Sapienza”, Italy (2) University of Perugia, Neurosurgery, IRCCS “Neuromed” Pozzilli, Italy


Final Programme

O39. Dynamics of CSF flow in slit ventricle syndrome Eymann R.1, Schmitt M.1, Antes S.1, Shamdeen M.G., Kiefer M. (1) Department of Neurosurgery, Medical School, Saarland University, Homburg-Saar, Germany (2) Department of Pediatrics, Medical School, Saarland University, Homburg-Saar, Germany 20:30

Gala dinner

Sunday May 23, 2010 Session IX

NPH and diagnosis

Moderators Michael Pollay, Marek Czosnyka

09:00 – 10:30 Oral presentations O40. Idiopathic Normal Pressure Hydrocephalus (iNPH) in a Defined Population – Long-term Outcome of 172 Shunted Patients Pyykkö O.T. BM1, Koivisto A. MD PhD3,4, Alafuzoff I. MD PhD3,5, Vainikka S. MD, Tamminen J. MD2, Tillgren T. MD2, Savolainen S. MD PhD2, Fraunberg M. MD PhD2, Pirttilä T. MD PhD3,4, Jääskeläinen J.E. MD PhD1,2, Soininen H. MD PhD3,4, Rinne J. MD PhD2, Leinonen V. MD PhD2 (1) Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland and University of Eastern Finland (2) Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland (3) Unit of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland (4) Department of Neurology, Kuopio University Hospital, Kuopio, Finland (5) Unit of Pathology, Department of Clinical Medicine, University of Eastern Finland, Kuopio, Finland O41. THE VALUE OF CEREBROSPINAL FLUID DYNAMICS (CSF) AND ITS CORRELATION WITH TAP TEST FOR THE PREOPERATIVE ASSESSMENT OF IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS (INPH) PATIENTS Aygok G.A.1, Kayis C.2, Marmarou A.1, Young H.F.1 (1) Department of Neurosurgery, Medical College of Virginia, Commonwealth University, USA (2) Department of Electrical Engineering, Virginia Commonwealth University, Richmond, VA, USA O42. Correlation between tap test results and CSF aqueductal stroke volume in Idiopathic Normal Pressure Hydrocephalus ElSankari S.1,2, Fichten A.3, Gondry-Jouet C.4, Csoznyka M.5, Legars D.3, Deramond H.4, Balédent O.2 (1) Neurology Department, Amiens University Hospital, Amiens, France (2) Imaging and Biophysics Unit, Amiens University Hospital, Amiens, France (3) Neurosurgery Department, Amiens University Hospital, Amiens, France (4) Radiology Department, Amiens University Hospital, Amiens, France (5) Academic Neurosurgical Unit, Department of Clinical Neurosciences, University of Cambridge, Addenbroke’s Hospital, Cambridge, UK O43. TAP TEST - time window and consistency Virhammar J.1, Cesarini K.G.2, Laurell K.1 (1) Department of Neuroscience, Uppsala University Hospital, Sweden (2) Department Neurology and Neurosurgery, Uppsala University Hospital, Sweden


TH ÜÜ).4%2.!4)/.!,Ý(9$2/#%0(!,53Ü7/2+3(/0 O44. Neuropsychological changes following shunt treatment in the European multicentre study on iNPH Hellström P., Klinge P., Tans J., Wikkelsø C. Institute of Neuroscience and Physiology, Göteborg University, Sweden O45. CHARACTERIZATION OF URINARY INCONTINENCE IN PATIENTS WITH NORMAL PRESSURE HYDROCEPHALUS (NPH) Klausner A.P.2, Aygok G.A.1, Young H.F.1, Boling P.A.3, Wolfe L.2, Koo H.P.2, Marmarou A.1 (1) Department of Neurosurgery, Medical College of Virginia Commonwealth University, Richmond, VA, USA (2) Department of Urology, Medical College of Virginia Commonwealth University, Richmond, VA, USA (3) Department Internal Medicine, Medical College of Virginia Commonwealth University, Richmond, VA, USA O46. PROPOSAL AND EVALUATION OF A COMPUTERISED NEUROPSYCHOLOGICAL TEST BATTERY FOR IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS (INPH) Behrens A.1, Eklund A.2,3,4, Elgh E.5, J. Malm1 (1) Department of Clinical Neuroscience, Umeå University, Sweden (2) Department of Biomedical Engineering and Informatics, Umeå University, Sweden (3) Centre for Biomedical Engineering and Physics, Umeå University, Sweden (4) Department of Radiation Sciences, Umeå University, Sweden (5) Department of Community Medicine and Rehabilitation, Umeå University, Sweden O47. Assessing trial design choices in a device-based AD efficacy study: a post hoc analysis of chronic CSF drainage Silverberg G. MD1, Saul T.1, Williams J. MD2 (1) Warren Alpert Medical School, Brown University, Providence RI, USA (2) Oxford University, Oxford, UK O48. THE VALIDITY OF JAPANESE INPH GUIDELINES IN A PROSPECTIVE STUDY OF INPH (SINPHONI) Hashimoto M.1, Ishikawa M.2, Mori E.3, Kuwana N.4 (1) Noto General Hospital, Japan (2) Rakuwakai Otowa Hospital, Japan (3) Touhoku University Graduate School of Medicine, Japan (4) Tokyo Kyosai Hospital, Japan 10:30 – 10:50

Break with exhibitors

Session X

NPH and shunts

10:50-13:00

Oral presentations

Moderators Mark Luciano, Konstantinos Polyzoidis

O49. Atrial shunts – Neurosurgical atavism or essential second-choice procedure? Aschoff A., Sakowitz O., Dictus C., Haux D., Steiner-Milz H. Department of Neurosurgery, University of Heidelberg, Germany


Final Programme

O50. Diverse morphology in arachnoid cysts indicates different embryological origin Rabie K.MD3, Tisell M. MD PhD2, Högfeldt M. MD2, Wikkelsø C. MD PhD3, Johansson BR. MD PhD1 (1) Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Sweden (2) Department of Neurosurgery, Sahlgrenska Academy, University of Gothenburg, Sweden (3) Department of Neuroscience, Sahlgrenska Academy, University of Gothenburg, Sweden O51. Conservative versus surgical treatment of idiopathic normal pressure hydrocephalus Toma A., Papadopoulos M., Stapleton S., Kitchen N., Watkins L. O52. amplitudes of ICP pulsations in a wide pressure range Qvarlander S. MSc1, Malm J. MD PhD2, Eklund A. PhD1,3 (1) Department of Radiation Sciences, Umeå University, Sweden (2) Department of Clinical Neuroscience, Umeå University, Sweden (3) Department of Biomedical Engineering, Umeå University Hospital, Sweden O53. SYMPTOMS AND SIGNS IN 158 PATIENTS WITH IDIOPATHIC NORMAL PRESSURE HYDROCEPHALUS Tullberg M. MD PhD, Skagervik I. MD, Edsbagge M. MD, Hellström P. MSc, Blomsterwall E. RPt MSca, Wikkelso C. MD PhD Hydrocephalus Research Unit, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden O54. TEN YEARS OF EXPERIENCE WITH THE USE OF PROGRAMMABLE AND FIXED PRESSURE VALVES. A RETROSPECTIVE COMPARATIVE STUDY OF 159 PATIENTS Gatos H., Mpakopoulou M., Paterakis K., Fountas K. Department of Neurosurgery, University Hospital of Larisa, School of Medicine, University of Thessaly, Larisa, Greece O55. A 25-Year-Series of 700 Patients with Gravitational Valves Vienenkoetter B., Haux D., Jung C.S., Unterberg A., Dictus C., Aschoff A. Department of Neurosurgery, University of Heidelberg, Germany O56. Subdural or intraparenchymal placement of Long-term telemetric ICP measurement devices? Schmitt M., Eymann R., Antes S., Kiefer M. Department of Neurosurgery, Medical School, Saarland University, Homburg-Saar, Germany O57. Ventriculoatrial (VA) shunt can improve safely higher cortical function in the patients with idiopathic normal pressure hydrocephalus (iNPH) Kiyoshi Takagi1,2, Katsuhiko Takeda3 (1) Department of Neurosurgery, Chiba-Kashiwa Tanaka Hospital, Japan (2) Department of Neurosurgery, Fujita Health University, Japan (3) Department of Neurology, Mita Hospital, International University of Health and Welfare, Japan O58. Virchow-Robin spaces in idiopathic normal pressure hydrocephalus: a surrogate imaging marker for microvascular disease? Tarnaris A., Tamangani J., Fayeye O., Murphy H., Kombogiorgas D., Gan Y.C., Flint G. O59. Brain CT scan indexes in the normal pressure hydrocephalus: predictive value in the outcome of patients and correlation to the clinical symptoms Stamatiou S., Chatzidakis E., Fratzoglu M., Barkas K., Markellos A., Voidonikolas L., Kyriakou T. Department of Neurosurgery, General State Hospital of Nikaia, Piraeus, Saint Panteleimon, Greece


TH ÜÜ).4%2.!4)/.!,Ý(9$2/#%0(!,53Ü7/2+3(/0 O60. Prosaika - programmable Shuntassistant in initial clinical application. Design of a prospective multicenter study Kehler U.1, Kiefer M.2 (1) Department of Neurosurgery, Asklepios Klinik Hamburg-Altona, Germany (2) University Homburg/Saar, Germany O61. Brain Localization of Leucine-Rich α2 Glycoprotein and its Role Nakajima M.1, Miyajima M.1, Ogino I.1, Hagiwara Y.2, Arai H.1 (1) Department of Neurosurgery, Juntendo University School of Medicine, Japan (2) Department of Pathology and Oncology, Juntendo University, School of Medicine, Japan 13:00-13:30

Summary of the accomplishments of the meeting Harold L. Rekate, Kostantinos Kouzelis, Michael Pollay

5th INTERNATIONAL HYDROCEPHALUS WORKSHOP  

FINAL PROGRAMME

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