S E M E S T E R
U P D A T E
S U B S TA N C E P
SUBSTANCE P IS A SMALL PEPTIDE THAT TRANSMITS PAIN SIGNALS FROM THE SENSORY NERVES TO THE CNS.
What is SUBSTANCE P? Substance P is a neurotransmitter responsible for carrying out pain information between nerve cells. It is a protein found in the brain and spinal cord as well as in sensory nerves, meaning it appears in both the PNS and CNS. Substance P is associated with
some inflammatory processes in the joints. A deficiency in Substance P causes insensitivity to pain as one experiences reduced responses to painful stimuli. High levels of Substance P contribute to eczema and fibromyalgia, a condition in which one is
extra sensitive to pain. Over-thecounter creams comprised of capsaicin help deplete Substance P from local nerve endings and relieve pain. The drug morphine is used to block pain by prohibiting the release of Substance P from sensory nerve endings.
PAINâ€™S THE NAME OF THE GAME
PHYSIOLOGIC ACTIVITIES 1. VOMITING REFLEX 2. DEFENSIVE BEHAVIOR 3. CHANGE IN CARDIOVASCULAR TISSUE 4. STIMULATION OF SALIVARY SECRETION 5. SMOOTH MUSCLE CONTRACTION 6. VASODILATION
Interesting Facts About Substance P: Substance P is implicated in pain syndromes such as lower back pain, fibromyalgia, and arthritis. It is also involved in other physiologic activities (listed to the left). Excitatory amino acids in the spinal dorsal horn are involved in the production of inflammatory hyperalgesia. In other words, Substance P is an excitatory neurotransmitter.
Article: http://www.ncbi.nlm.nih.gov/pubmed/ 6183072 Video: http://www.youtube.com/watch? v=5uQZfaURU_Y