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2012

S E M E S T E R

U P D A T E

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S U B S TA N C E P

SUBSTANCE P IS A SMALL PEPTIDE THAT TRANSMITS PAIN SIGNALS FROM THE SENSORY NERVES TO THE CNS.

What is SUBSTANCE P? Substance P is a neurotransmitter responsible for carrying out pain information between nerve cells. It is a protein found in the brain and spinal cord as well as in sensory nerves, meaning it appears in both the PNS and CNS. Substance P is associated with

SENSORY NEURON

some inflammatory processes in the joints. A deficiency in Substance P causes insensitivity to pain as one experiences reduced responses to painful stimuli. High levels of Substance P contribute to eczema and fibromyalgia, a condition in which one is

CNS

extra sensitive to pain. Over-thecounter creams comprised of capsaicin help deplete Substance P from local nerve endings and relieve pain. The drug morphine is used to block pain by prohibiting the release of Substance P from sensory nerve endings.

IN ACTION


PAIN’S THE NAME OF THE GAME

PHYSIOLOGIC ACTIVITIES 1. VOMITING REFLEX 2. DEFENSIVE BEHAVIOR 3. CHANGE IN CARDIOVASCULAR TISSUE 4. STIMULATION OF SALIVARY SECRETION 5. SMOOTH MUSCLE CONTRACTION 6. VASODILATION

Interesting Facts About Substance P: Substance P is implicated in pain syndromes such as lower back pain, fibromyalgia, and arthritis. It is also involved in other physiologic activities (listed to the left). Excitatory amino acids in the spinal dorsal horn are involved in the production of inflammatory hyperalgesia. In other words, Substance P is an excitatory neurotransmitter.

EXTRA INFORMATION:

Article: http://www.ncbi.nlm.nih.gov/pubmed/ 6183072 Video: http://www.youtube.com/watch? v=5uQZfaURU_Y


Substance P