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december 12, 2012 -- steph f, delaney r, julia c, pat r, ann l

A C ETY LC H O LIN E N

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Explanation

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Functions

Excitatory? Inhibitory?

Affects on the Body

Neurotransmitters are the

Found in PNS and CNS as a

General Excitatory facts found

Affects all of the muscles as

chemicals which allow the

neuromodulator.

on page 1 -- more in-depth

well as an explanation of the

transmission of signals from

Page 1

information found on page 2.

effects that different drugs do to

Page 1 & 2

the body.

neuron to the next across synapses. Page 1

Page 2

ACETYLCHOLINE Explanation of both: Neurotransmitters: Found at the axon endings of motor neurons, where they stimulate the muscle fibers. Produced by the pituitary and adrenal glands. There are 6 significant neurotransmitters. Acetylcholine: It is responsible for much of the stimulation of the muscles -- including the muscles of the gastro-intestinal system. It is also found in sensory neurons and in the autonomic nervous system -- Has a part in scheduling REM (dream or deep) sleep.

Functions of Acetylcholine: Acetylcholine: Has functions found in the peripheral nervous system as well as the central nervous system. Acetylcholine activates muscles in the peripheral nervous system, and serves as a major neurotransmitter in the autonomic nervous system. In the central nervous system, acetylcholine works with associated neurons and causes anti-excitatory actions.

Acetylcholine--Excitatory It conducts electrical impulses through a series of actions, making it possible for nerve cells to communicate with muscle cells - causing muscle contraction. Acetylcholine is an extremely sensitive action course that can either speed up or slow down to accommodate different bodily functions.

acetylcholine news • 1350 gardena avenue • Fridley, mn 55432 • 763-571-9116


december 12, 2012 -- steph f, delaney r, julia c, pat r, ann l

A C ETY LC H O LIN E

Excitatory facts continued Having too much Acetylcholine in

transmissions of Acetylcholine takes place. Also, Myasthenia Gravis occurs

Interesting Facts

when the body inappropriately produces antibodies to fight Acetylcholine.

-AcH was first isolated around 1914; its functional significance Acetylcholine regulates voluntary was first established in about movement - sleep, memory, and learning. Body parts that are 1921 by Otto Loewi, a German Having too much of Acetylcholine causes affected from Acetylcholine physiologist and later in 1936, a person to go into an “overdrive” of this, -Acetylcholine affects the Nobel laureate. which leads to depression. contractions of skeletal or voluntary -Acetylcholine acts as a Having too little -- because transmitter between motor nerves Acetylcholine enhances memory and is muscles. Also, it affects the and the fibers of skeletal muscle involved in learning and recalling, a contraction of smooth and cardiac at all neuromuscular junctions. shortage of Acetylcholine is usually muscle. AcH induces a decrease of -Without Acetylcholine, it would associated with those who have iris diameter which facilitates the be hard for our bodies to Alzheimer’s disease or dementia (a schedule deep sleep throughout loss of brain function). This is due to the flow of aqueous humor and tends to lower the intraocular pressure -- all the night. the body can cause depression.

damage to the pathways where

Further information on topic

• http://www.livestrong.com/ article/11327-needacetylcholine/

Drugs that interact with Acetylcholine Drugs that interact with Acetylocholine: Nicotine and

of these aspects are found in the eye. AcH increases digestive (abundant saliva), bronchial, sweat and lacrimal secretions throughout the body.

Atropine -- Drugs that act on the Actylcholine system will act in two different ways. Nicotine, an example of an agonist to the receptor, acts as a stimulant to the Acetylcholine system, thus speeding up the ability of the

Link to a movie/YouTube video www.youtube.com/watch?v=AyoySswpvso

“Neurotransmitters: Acetylcholine”

receptors. Atropine - on the other hand, an example of an antagonist to the receptors, inhibits or slows down the process of the Acetylcholine receptors, such as your heart rate.

acetylcholine news • 1350 gardena avenue • Fridley, mn 55432 • 763-571-9116


Acetylcholine