92
Gene name
Q61147
P01027
P01027
P14847 Q61646 Q60574 Q60574 Q60574 P07724 P07724 P07724 P07724 P07724 P07724 P07724 P07724 P07724 P07724 Q91X72
28
26
27
33 53 54 55 56 14 12 11 13 15 9 16 6 7 8 57
Crp Hp Hp Hp Hp Alb Alb Alb Alb Alb Alb Alb Alb Alb Alb Hpx
C3
C3
Cp
Ahsg
Blood coagultation 77 P32261 Serpinc1
P29699
4
Acute-phase response 73 Q00897 Serpina1d
No.
Uniprot Accession No.
Antithrombin-III
Alpha-1-antitrypsin 1-4 Alpha-2-HSglycoprotein Ceruloplasmin Complement C3 precursor Complement C3 precursor C-reactive protein Haptoglobin Haptoglobin Haptoglobin Haptoglobin Serum albumin Serum albumin Serum albumin Serum albumin Serum albumin Serum albumin Serum albumin Serum albumin Serum albumin Serum albumin Hemopexin
Protein description
8.6E-02
2.4E-04 8.0E-08 2.2E-04 0.12 5.8E-04 1.1E-16 1.4E-15 9.6E-13 4.4E-10 2.1E-08 3.8E-04 1.9E-03 1.3E-02 1.1E-09 3.4E-08 6.5E-08
0.12
2.9E-03
6.0E-02
1.8E-05
5.1E-04
2.3E-01
5.0E-06 5.3E-05 4.8E-09 8.4E-11 1.1E-11 4.8E-09 5.8E-10 5.4E-08 7.8E-08 1.4E-03 2.1E-08 2.0E-05 2.2E-04 4.4E-04 5.5E-03 2.4E-06
0.0097
2.8E-06
1.3E-01
6.0E-01
1.2E-01
5.6E-01
8.5E-01 3.0E-01 9.5E-02 0.14 5.5E-02 7.1E-03 8.3E-04 5.3E-03 4.3E-04 2.5E-04 2.4E-04 7.3E-02 1.6E-01 4.5E-03 3.5E-02 5.6E-02
0.0048
2.5E-01
8.1E-01
1.7E-01
4.9E-02
P-value Two-way ANOVA TreatInteractTime ment ion
1.02
1.15 -1.01 -1.08 -1.07 -1.04 1.13 1.1 1.09 1.1 -1.02 1.1* 1.04 -1.14 -1.06 1.07 -1.03
-1.04
-1.11
-1.04
-1.02
-1.03
Apap/C
1.06
1.15 -1.05 -1.03 -1.03 1.05 1.18 1.17 1.17 1.11 1.12 1.13 1.12 -1.12 1.03 -1.11 1.2
-1.08
1.21
1.03
1.01
-1.02
Amio/C
24 hour
‡
1.27
-1.41 -1.88* -1.72‡ -1.39 1.24 5.49 3.48* 2.55* 1.79‡ 1.35* -1.36 -1.23 -1.66 2.05‡ 1.81 2.29*
-2.06
-2.38
1.36
1.47
-1.41
CSA/C
1.32
1.36 1.38 1.42 1.43 1.56 1.72 1.68‡ 1.8‡ 1.94* 1.38‡ 1.82 1.56* 1.58 1.72 1.78 1.52
1.94
1.42
1.28
1.32
1.39‡
Apap/C
Fold Change 48 hour
1.09
1.2 1.08 1.13 1.2 1.38 1.28 1.33 1.18 1.24 1.16 1.12 1.29 1.07 1.16 1.15 1.16
1.21
1.27
1.16
-1.02
-1.04
Amio/C
Table 4.2: differentially secreted proteins from primary mouse hepatocytes after exposure to acetaminophen, amiodarone or cyclosporin A.
-1.12
-1.41 -2.01‡ -1.14 1.16 2.25* 13.48* 9.16* 6.32* 4.57* 2.96* 1.38 1.15 -1.19 4.99* 4.26* 4.13*
1.66
-1.21
1.87
Yes‡
Yes Yesns Yesns Yesns Yesns No No Yesns No No No Yes* No Yesns No Yesns
ns
Yes
Yes
*
Yes
*
Yes
*
*
2.00
Yes*
-1.15
CSA/C
Blocked on 20°C
Yes
Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes
yes
Yes
Yes
Yes
Yes
Secreted
Chapter 4