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Why BioTel Heart MCOT™ to detect AF * in cryptogenic stroke patients? At 21 days, the likelihood of detecting post-stroke AF was more than five times higher with mobile cardiac outpatient telemetry than with implantable loop recording.‡ 2

We’d know about it. AHA/ASA† Stroke Prevention Guidelines:

For patients who have had an acute ischemic stroke or TIA with no other apparent cause, prolonged AF monitoring (≈30 days) is reasonable within 6 months of the event.1

BETTER DETECTION

BETTER REPORTING

VALIDATED BY CLINICAL DATA

MOBILE CARDIAC OUTPATIENT TELEMETRY


Why BioTel Heart MCOT™ prior to ILR for post-stroke patients?

Cumulative Probability of Diagnosis of PSAF (%)

MCOT vs ILR — Post-Stroke AF (PSAF) Detection2

20

15

Hazard ratio 5.8 (95% CI 3.3–10.2) Log-rank p<0.0001 MCOT Mobile Cardiac Outpatient Telemetry

10

5

0

Implantable loop recording

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

Days between start of cardiac monitoring and first diagnosis of PSAF Days between stroke or transient ischaemic attack and first detection of post-stroke AF (PSAF) with MCOT and ILR

•D  ata pooled from six studies for implantable loop recording and from four studies for mobile cardiac outpatient telemetry were adjusted for age, sex, and time to initiation of monitoring •B  ioTel Heart MCOT was used in all four studies evaluated • Primary endpoint of study: proportion of patients diagnosed with post-stroke AF, any duration • Only MCOT has 100% sensitivity and 100% positive predictivity in the detection of ≥30-second AF episodes§ “In the analysis of post-stroke atrial fibrillation detected at 21 days, the likelihood of being diagnosed with post-stroke atrial Fibrillation was more than five times higher with mobile cardiac outpatient telemetry than with implantable loop recording.” 2 * AF = Atrial Fibrillation † AHA/ASA = American Heart Association/American Stroke Association ‡ ILR = Implantable loop recording § Based on MIT-BIH (Massachusetts Institute of Technology-Beth Israel Hospital) Arrhythmia Database testing of ≥30-second AF episodes References: 1. Kernan, WN, et al. Guidelines for the Prevention of Stroke in Patients with Stroke and Transient Ischemic Attack: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. STROKE. July, 2014; p.5. 2. Sposato LA, Cipriano LE, Saposnik G, et al. Diagnosis of atrial fibrillation after stroke and transient ischaemic attack: a systematic review and meta-analysis. The Lancet Neurology. 2015;14:377–387. 1000 Cedar Hollow Road, Suite 102, Malvern, PA 19355 | 1.866.426.4402 | gobio.com Copyright © 2019. All rights reserved. Doc. 220-0299-01 Rev. D

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MCOT to detect cryptogenic stroke  

MCOT to detect cryptogenic stroke