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How to Biohack Your Biochemistry: Is the Redox Potential the Missing Link? Ameer Rosic Tuesday April 22nd 2014 Read Full Article

What is the redox potential? And might it be what’s holding you back?

This is how important your redox potential is, whether you realize it or not. The cellular oxidation and reduction (redox) environment is influenced by the production and removal of reactive oxygen species (ROS). In recent years, several reports support the hypothesis that cellular ROS levels could function as “second messengers” regulating numerous cellular processes, including proliferation. Technology has gone wrong and what steps we need to take to sustain life on Earth. Man alone has the choice of staying too long at the industrial party, of continued overpopulation and mismanagement of our environment, of contaminating our spaceship we call Earth.

We also can change our behavior by altering our choices when we become informed of how incredibly important the redox potential in our cells is to wellness. In today’s Podcast, Dr Jack Kruse and I discuss the extreme importance of the Redox Potential and why should you really care about it.

Transcript (Listen to the Full Podcast Here) Ameer: Hey Dr. Kruse, how are you doing? Jack: Pretty good, how about you? Ameer: I’m good. I’m good. Thanks for coming on the Optimal Health Show. The reason we have you on the show today is I was reading your latest blogs about the redox potential, I was kind of blown away about it, so hopefully today we’re going to go a little bit more in details about that and talk about. Why don’t we actually quickly jump in and kind of explain to the audience, what in the world is a redox potential? Jack: There are several ways to describe it, but I think the easiest way to describe it is it’s the electric charge that is on all the membranes in your body. The one that we’re specifically interested in when we talk about the redox potential is the charge on the inner mitochondrial membrane. The higher the charges meaning the higher the redox potential, it means the lower the pH gradient, needs to move protons through up and if your listeners don’t know anything about mitochondria they probably know that it’s the power pack for the cell, but how it works seems to vex a lot of people. It works basically on positive and negatively charged subatomic parts, the ones that everybody knows, these electrons from food, and then it actually takes out protons from water. The way mitochondria is designed to work by evolution is they are like little small bacteria that make huge amounts of protons normally, and within each one of this proton is stored some potential energy, and that’s the energy that we use to run all our biochemical reactions throughout our whole body, the key factor being the electric charge is what starts the entire battery system to make your redox potential. There’s a lot of different places it can break down and for a lot of different reasons. For today’s modern world, the reason it’s breaking down is quite a bit different than say what somebody would have expected say 60, 70, 80 years ago, but that’s really what it comes down to. It’s an electric charge on a membrane that is done by the movement of electrons from fuse and it sets up a proton gradient that allows us to make ATP and do a whole bunch of other different things. Ameer: Is there a way that we can actually measure our redox potential? Jack: Well, you technically can. I talked about that in the blog post that you referenced earlier about the redox prescription on my blog post. I tell those people, the easiest way for a clinician or a patient is probably to look at their BUN-creatinine ration. The BUN-creatinine ratio, most people look at it as a measure of hydration versus dehydration but the reason it’s important is because mitochondria is surrounded by intracellular water and I told you before that mitochondria make a boatload of protons. Here’s the crazy thing, when the protons are made by mitochondria, it’s supposed to create a small little burst of superoxide which is a reactive oxygen species. That is actually the signal that mitrochondria regenerates. So, the mitochondria are making boatloads of protons but there’s no water around the mitochondria to accept the potential energy. The positively charged protons increase and it creates a huge amount of reactive oxygen species, much more so than like a micro nanomolar amount, and that can lead to major neolithic disease generation, because as you know, protons carry positive charge.

Anything with a positive charge lowers pH. Anything with a lower pH decreases electric charges. So that’s where the feedback is. The low electron flow across the inner mitochondrial membrane can decrease proton charge and vice-versa is also true, but excessive amounts of protons can also diminish the electric charge on the inner mitochondrial membrane. So there is a perfect yin and yang balance to how mitochondria is designed to work. Ameer: Now, you mentioned earlier that there are many different things that are causing our redox potential to decrease, can you just name a few? Jack: Yeah. I would tell you the two that most people should focus on in our modern world is dehydration and non-native EMF, and the reason non-native EMF does it is two-folds. One, it dehydrates us, both intracellular and extracellular water in our cells, but the major reason is it releases calcium in cells specifically from the endoplasmic reticulum, and that calcium completely destroys cytochrome 1 signaling in the mitochondria, which ultimately destroys both the redox potential and it actually can destroy the proton gradient. It actually can do both. Ameer: What do you say as well, this does tie in with EMF affective heat shock protein inside the cells? Jack: Oh, dude, if you want to go there, listen. My next blog that’s coming out is basically called “quantum brain cancer” and this is actually exactly where I get into the mechanism of how this works. There is a protein called HIF-1 alpha that is absolutely critical. It’s a heat shock protein but it responds to hypoxia or what we call pseudo-hypoxia that are present in the cells. And the way this whole pathway works is very elegant, it’s very complex. I’m not sure I want to bore you with the details right now but I promise you the next blog post we’ll run it all up. But needless to say, heat shock proteins are a huge factor because what people need to understand is anytime you have high cytokines or you have increased temperatures, what does that mean for the water in and around your mitochondria, or inside or outside your cell? It means that the oxygen tension of that water is lower, it means that the potential energy in that water is lower. That’s the reason why I always use the classic example of crabs. Most people know that crabs up by here in Canada in the Bering Sea are massive. They’re Alaskan king crabs. They’re sometimes three feet across. Where the crabs down here by me in the gulf are small little crabs and the difference is, colder water has higher oxygen tensions where warmer water has lower oxygen tensions. That’s also the reason why there’s a big dead zone in and around the equator in our oceans because the water is too hot. That’s why you find most life in the polar seas, both in the North and South Pole, which is what I talked about in my book. The real funny part is a lot of people don’t realize that just temperature alone has a massive effect on water chemistry, and what you asked me earlier about the two major effects of the redox potential is basically tied to both non-native EMF and water, and anytime we’re face with any type of inflammation, we’re going to have excessive amounts of protons, we’re going to have to put more protons in our water than we can handle, and that’s going to change the pH gradient which ultimately decreases oxygen tension in tissues and activates all these proteins that we’re talking about, to create the nightmares that we see in many different diseases. The one I’m going to talk about in detail next in my series is quantum brain cancer, but honestly you could use it in just about any cancer, because I do get into talking about exactly the reason why metastasis happens, and why certain cancers like prostate cancer go to the places they go to and why breast cancer acts the way it does with hormones. All those are tied to the redox potential, and it’s directly tied to water chemistry. Very interesting stuff.

Ameer: It is. You’ve mentioned that non-native EMF. For people who don’t know what that is, can you explain little bit more in detail? Jack: Sure, that’s pretty simple. Native EMF that comes from our planet is 7.83 hertz. Most of the life on this planet is designed to work around extreme low frequency electromagnetic signals that come from our magnetic field. This is actually the resonant frequency that actually controls cow module and the calcium releasing cells naturally, but calcium and cow module and signaling is common to everything that’s living on this planet, whether it be plant or animal, and calcium and cow module and signaling directly impact circadian functioning and just about everything that’s alive on this planet. So when it goes awry, when calcium goes up, your redox potential falls dramatically, and if it happens to be off chronically or very freely, it can lead to things like autophagy or even apoptosis. When it happens chronically as it does in our modern world, that’s when we get the diseases that you and I both try to help people with such as autoimmune disease, Hashimoto’s, cancer, you name it, obesity. I just had somebody come in today with Sjogren’s disease and another patient that had a deep venous thrombosis in their brain due to ulcerative colitis. It’s kind to just about every single patient that walks in my door. Ameer: Now what would you say is, or in your mind, an optimal diet or a diet that would increase the health of our redox potential? Jack: Well, its’ a good question but it is pretty complex, and this is what I would say, and I tried to mention this to several people in my forum but I’ll try to frame it for you as best as I can. A guy like you has a really good redox potential, so that means that you can tolerate a lot more things in your diet than say somebody who has fibromyalgia who cannot because their redox potential is low. Why I bring this point up is because you have to realize where you are on that scale of that redox potential before you start, and then when you figure out where you are on that scale, that’s when you determine the type of diet you can have. For example, a Ameer Rosic clearly can use way more carbohydrates that someone who has fibromyalgia. Someone with fibromyalgia can’t really afford to eat many carbohydrates, and the reason is simple. Carbohydrates enter the electron chain transport in the mitochondrial membrane in cytochrome 1. When that happens, it raises NADH levels and it lowers NAD positive levels. NAD positive levels correlate to the redox potential. So, someone like Ameer can go out eat a stack of blueberries and not have any problems and because he’d be able to regenerate with NAD positive very quickly, so it does not cause this huge superoxide burst that it does in someone with fibromyalgia. Someone with fibromyalgia gets such a big huge superoxide burst and probably hydrogen peroxide burst and probably also will affect their reactive nitrogen oxide species like nitric oxide which is why we get the muscle pain that they get even when they do something as simple as walking around the block which for most of us is not a big deal. That’s part of the reason why a lot of people don’t accept fibromyalgia as a diagnosis because they don’t really understand it’s a quantum molecular dance that’s being done in people at the mitochondrial level, and it’s not the kind of disease that we think of pathophysiologically that’s printed in the textbook that we learned about in medical school. And you have to understand that neurons. The question you ask is a good one but you have to realize, everybody’s diet should be tailored to the redox potential. Now this is what I will say, anybody who’s on my form tends to be interested in reversing a disease or going for maximal performance. If you understand what we talked about in the beginning in this podcast that the redox potential is basically tied to water chemistry, the electric charge on the inner mitochondrial membrane and the way we separate protons, it becomes very clear that we

want to eat a diet that’s heavily electron dense. What does that mean? That means food that happens to live in electron dense environment. The name of my book is called the Epi-paleo prescription for a reason because the diet and the foods that I advocate are electron dense. Most of the marine seafood in my diet comes from what we call the pelagic water columns in the ocean that are loaded with electrons. So the more electrons you provide your mitochondria with, the much reactive oxygen species you make. What does that mean at the end point of mitochondria restoration? It means that you’re making enough ATP that binds with the protein around your body, and also means that you’re a shitload of oxygen in your body which you could use for restoration or respiratory issues. It also means that you’re not going to need a shipload of mitochondria in order to generate that oxygen. That’s far the reason why the more fit you are, the higher your VO2 max is because your VO2 max is a measure of just how efficient you are at the mitochondria level. A guy like you is extremely efficient, and that’s the reason why you have more fat on the bone in terms of how you can manage your diet. That’s part of the reason why several people in the paleo community would advocate a much higher carbohydrate template for most people. The problem that they’re not explaining to people and I think the main reason why they’re not is they don’t understand the redox potential and they don’t understand how mitochondria work, is because most people that are looking to change their life have an altered redox potential, and when you realize that, that’s when you start, at least in the beginning when you make the transformation, you need to have a lot more electrons in your diet and you also need to do things to improve the water chemistry in your body. These things can actually help offset your poor redox potential that you got for whatever reason you got it in the beginning. Ameer: You mentioned that it all goes back to the mitochondria and eating seafood, Epi-paleo prescription, so… Jack: I don’t want to sound like I’m plugging my book and what I wrote in the book for everybody because that’s not really accurate. What I’m saying is, and let’s make it pretty generic. My diet is good for most people but when you’re trying to tailor especially for some of your listeners who are probably into performance, here’s the key and I told you the key. The key is your NAD positive level at cytochrome 1. If it’s bad, you want to improve it. What dietary template increases NAD positive better than any other diet? A ketogenic diet. This is the reason why a ketogenic diet is used for kids with seizure disorders or neuro degeneration and people with cancer. It all comes down to cytochrome 1. Cytochrome 1, this is some really cool stuff. It’s not where I really wanted to go but it’s important because we’re talking about it. Cytochrome 1 is where carbohydrates enter. That’s where the electrons that come from carbohydrates enter. The electrons from fats enter at cytochrome 2 or FADH 2 and that reduces the co-enzyme Q10 couple at that level. So is there a way if you’re sick and you have a break from cytochrome 1 for whatever reason, let’s say you’re a type 2 diabetic or say you’re a guy that lives in the 20 th floor, you know, some building in Toronto that’s tallest that’s surrounded by EMF and you’re making shitloads of calcium that destroy cytochrome 1. Yeah. You can eat a high fat diet and feed your inner mitochondrial membrane that has a poor charge through cytochrome 2. And what will happen then? When you have a lower redox potential, you can foster reverse electron flow from cytochrome 1 and you can sometimes bypass a big problem. People don’t understand this issue because this is where quantum physics dictates how biology works. But will I definitively show that what I’m saying to you right know has absolutely been published both in physics and biology? Oh yeah. It’s published everywhere in biology. The problem is, nobody is putting

these concepts together, and the next blog that I come out with, it’s going to be one of those ones that split your head open, because it’s really specifically about what we’re talking about in this podcast. It’s about how we regenerate NAD positive and how we raise foods in our environment is critical to the redox potential, and how it directly ties to non-native EMF and water chemistry. People just don’t understand that water is basically a giant electric conductor for electromagnetic force. It basically takes the potential energy of the sun and transmits it to potential energy that’s stores in protons in our mitochondria. The mitochondria then are designed to kick out those protons and this is what electrifies the hydration cell around mitochondria, and the information that’s stored in these protons is actually disseminated all throughout the cell both in the intracellular water but also through collagen because collagen is fused with electric. What that means is anytime collagen has a mechanical force placed on it by the movement of water in and around organelles in the cell, it emits an electrical signal. That electrical signal then can travel to any other part of the cytometric architecture in the cell or in a tissue that is connected to it, and this is the reason why in every living system, collagen makes up 71% of the total protein in a cell and water makes up almost 72% by volume. Any place collagen exist is always above a water, and water binds the collagen, and the reason it binds to it has to do with the quantum effect of those three amino acids and collagen which is proline, hydroxyproline and glycine. The protons that are in the water that have this potential energy transfer their information and energy to collage and that gets distributed all throughout the organism. That’s really how cellular biology works. Unfortunately, you’re not going to find that written in any textbook, but it’s been written in many of the benchtop research places all over the world. It’s published. The problem is no one is putting it together, and that’s what I’m doing in my blog. I’m trying to explain this stuff to people so they understand that the disease that the disease that they go and see a clinician for that are totally hopeless, maybe isn’t so hopeless when you understand truly how this all works. Ameer: You talked a lot about your environment and how your environment controls the behavior of your body. Can you got a little bit more in detail about that? Jack: Yeah. I would tell people, get a piece of paper and pen out right now. I want you to write this name down. You’ll know a lot about there after my next blog, and you should know a little bit about there if you read the redox prescription like it sounds like Ameer did. Her name is Mina Bissell. She has become, how shall we say, a renegade oncologist. She’s digging to breast cancer. But what made her so revolutionary is that she was first person in the position of power to come out and say that the environment controls the cellular determination and what’s going to happen. In other words, the environment controls where cancer is going to form and where it doesn’t form. But if you go back and read my Quilt that I wrote a decade ago and published for the entire world to see on my blog, every one of that quiltbasically says the same thing different words. In my next blog, I’m going to show you exactly how this happens in detail with molecular mechanisms, and I will tell you that oncology today, and I would say most clinical medicine believes that everything is genetically determined. I’m going to tell you that everything is epi-genetically determined, that the environment dictates exactly how an organism will respond, and when you begin to understand the molecular mechanisms, and I do want to explain that clearly. When we have a chemical reaction in the cell, when you look at it in a biochemistry textbook, the molecular writing of the equation doesn’t change. It’s what happens to the bond angles, and what happens to the network molecules. So for example, water is designed at a bond angle of 105 degrees. If you change the bond angle of water, say 2, 3, 4, or even probably just 2 degrees, you have molecular ice. If you noticed, ice is still the

same as water, it’s H2O but what’s changed? The crystalline lattice is changed. Can biochemistry explain looking at a piece of paper what’s the difference between H2O in solid and liquid form? No, they really can’t. And that’s the point that Mina Bissell and I am trying to make when we talk about diseases, because the same thing happens in us. I’m going to use the simple example of rhodopsin in our eyes. When rhodopsin is the same, whether it hits light or not, it’s got the same chemical formula, but what happens when any proton hits rhodopsin? One bond in it changes its angle, and that bond angle change is signaled to the neurons in the retina, and that information is passed on to the brain and it uses it to process exactly what we’re seeing. People need to begin to understand the exact same thing happens in your mitochondria. That’s part of the reason why I wrote a blog post three years ago that was very controversial, that said “Are the electrons from carbohydrates different than the electrons from fat?” On the surface it seems like a preposterous statement, because Richard Feynman, Nobel-prize winning physicist, said in the 1960s that all electrons are the same, and he’s right. From subatomic particle standpoint they are but what is difference? The only difference if how much energy they carry and they differ in their spent. They’re only different in two things. Well here’s the crazy thing. The molecular demons, I call it Maxwell demons in your mitochondria. They’re located in cytochrome 1, 2, 3 and 4. Those demons are special proteins that have figured out how to collect the energy and the information from electrons, to keep that information and add it to the system. I guess your dog is pretty excited. Ameer: Yeah. He wants to join the ketogenic diet. Jack: There you go. Remember, dogs should be eating ketogenic diet. Ameer: That’s right, they’re carnivores, exactly. Now, what would you say is some recommended supplements or extra items that people can take to kind of like optimize their redox potential? Jack: Well, that’s a slippery slope question to ask a guy like me because I think you already know the answer to this. I’m not a fan of supplements. I’m okay with using supplements when your redox potential is low. To truly answer that question, we have to know where you are on the redox slope, and the way I would do that is I have to order all the labs that are in the chapter of my book about how I measure things and from that testing, that’s what I would put people on. But to do it in a podcast, remember, everybody’s [inaudible - 00:26:50] is different, just like I tried to explain to you before. Ameer Rosic is different from Jack Kruse and Jack Kruse and Ameer Rosic are different than say, the lady with fibromyalgia or the guy that lives in the 15th floor of a high rise building in New York City. We need to start as a community, not only bloggers and podcasters, also clinicians. We need to start talking about these contextual differences a lot more frequently, because unfortunately I think on most of our sites and forums, you have guys talking supplements now like Nikoley and Chris Kresser, now Robb Wolf is doing the same thing. Look, if your diet is good enough, why do you need to have supplements? Well, the answer is it doesn’t mean your diet sucks or your recommended diet sucks, it means that your redox potential is lower and I think the way public constantly holds people accountable or giving people advice to say “Explain to me why my redox potential is low,” and that’s something that I do everyday in my forum. I try to help people with that. I do it in my webinars, I do it in my blog posts. It’s not easy science to try to talk to people about because it is complex, but I do not want anybody coming to me ever again and saying “Hey Dr. Kruse, you never told me that,” because 10 years ago, a lot of my patients can come up to me and say that, because I didn’t have these answers then. I didn’t know

what I know today. I’m a different person today than I was then, and back then ignorance was bliss, well I’m not ignorant anymore. I’ve applied all the things that I’ve learned in my entire life fixing me, and now that I’ve fixed me, I want to fix other people. And I think the way to fix other people is through this knowledge, and if you ask me, the redox potential is the final common pathway that every biochemical pathway goes through. Without a good redox potential, nothing works. I don’t give a shit how much you supplement, I don’t give a damn how good your paleo or your Epi-paleo diet is. If your redox potential sucks, you will never taste optimal. Ameer: Now, you’re talking a lot about water. We are dehydrated from EMF, there’s a lot of issues going on. How can one rebalance the level of water in their body? Jack: Well, that is probably a podcast in and of itself, but let’s make it simple. You can use, even if you don’t know any of the signs, you can use the BUN-creatinine ratio to your advantage but I till everybody in my forum, that iodine is critical in keeping water in the cell. What else is critical? Potassium. And this is goes back to Gilbert Ling’s work. Potassium is the glue that holds intracellular water together. When you have hyperkalemia or hypokalemia, you can beat your sweet behind that you got a major problem with intracellular, extracellular water. This is a huge effect. As a neurosurgeon, I see this all the time, because anytime you order an MRI, we’re getting to see neural activation in three dimensions, because neural activation decreases the diffusion of water in the central nervous system, and we actually can generate pictures to show this. This is part of the reason why I said in the redox prescription blog post that in my hands, as a neurosurgeon, the best way for me to assay someone’s redox potential is have me look at their MRI. I can tell more from looking at someone’s MRI than I can looking at their labs. That’s how much information is on the MRI. The problem is, most physicians don’t learn that because they don’t understand how an MRI was developed and how it was formed. It was based on Gilbert Ling’s work on water, and the physician Ray Damadian. He runs a company called FONAR, and the stuff that he did was just truly absolutely amazing. But his whole body of work that he’s focused in on directly ties to water chemistry. If you want to get healthy, you need to understand everything you possibly can about water. Water is a universal issue anytime life’s involved. That’s why NASA looks for it everywhere it looks for life. Remember that when electromagnetic signal called visible light, it’s water anywhere on this planet. Its charge separates into negative and positive charges. Why is that important? Because the electromagnetic force that comes from the Earth which we talked about earlier which was the [inaudible - 00:32:05] resonance only controls negatively and positively charge ions. So when you begin to realize the very foundation alone, that light has the natural ability to hit water and separate it into positive and negative charges, we start to realize “Hey, that’s kind of what happens in mitochondria too isn’t it?” “Yup it is.” And you also being to realize that’s how plants and trees work. They don’t eat food, they don’t need it. Why? Because they’re 100% connected to the ground, where they are connected to [inaudible00:32:41] and they’re getting all their life from the sun every single day, and their canopy of leaves are absorbing those protons, and those protons charge separate the water that they’re absorbing from the root system, and they use those protons that are charge separated just like we use in the mitochondria. Problem is a lot of people don’t realize this. Mitochondria are the coolest invention from animals because it allows us to be disconnected from Earth. It allows us to be disconnected from the electromagnetic signal of the planet, yet still do the things that we can do. And we need to get people to that level of understanding to realize how damn important the water really is. We need to take water way more seriously than we do. We need to understand that what

charge separation basically means is another acronym for the redox potential. If you ask me, the redox potential is 100% tied to water chemistry on this planet. Ameer: You talk a lot about reversed osmosis water and you mentioned that for people who have a lot of metabolic issues, one should consume, I think you mentioned something like 2 liters a day of reverse osmosis water. Jack: Yeah. The reason why, it doesn’t mean reverse osmosis water is the only water we should all drink. Reverse osmosis water has no impurities in it. What you need to realize in our modern world, we have shitloads of impurities. Those impurities, the ones that I’m most concerned about are probably fluoride, bromine, and chloride, and the reason why, these halogens are in most pesticides. Halogens when they touch water, decreases the ability to charge separate. In other words, when light hits that water, it cannot do the things that we just talked about. When you can’t charge separate water, it means that water is no longer a battery. When water is no longer a battery, does it work well? No it does not. Reverse osmosis water is pure, so when light hits it, it charge separates 100%. It becomes the best battery it has. So when you’re really sick, you need a good battery to crank up your really old ‘57 Chevy. That is the point that I’m trying to make. What else is really interesting about reverse osmosis water? Because it’s pure, because it’s able to charge separate, it also has the ability to carry more oxygen and more energy than regular water or what we call bulk water. This is something that people don’t know. Yet the military knows about it and the military has now employed this, and when I say military, I know you’re Canadian and I’m an American but we kind of mostly been on the same page for most of our national careers, but here’s the point. Everybody knows with all the wars that America has been fighting the last 50 years that the amount of PTSD has gone through the roof. What the military has recently found out that reverse osmosis water actually mitigates a lot of the effects of PTSD. What’s the main reason for that Ameer is very, very simple. Reverse osmosis water charge separates and it allows that water to carry more oxygen on it than normal. In other words, oxygen tensions are much higher in that type of water. So just think about what we said. PTSD is a brain disorder caused by trauma, so if you were to deliver more oxygen to the brain, remember the brain and spinal cord are surrounded by what? PSF, which is made of 93% water. So if you’re using reverse osmosis water, you’re delivering more oxygen to what needs be, surface of the brain called the neocortex where basically our used [inaudible-00:36:40] does not need to use its mitochondria as it would if low oxygen tension there because what your mitochondria do, they make protons that make a lot of oxygen, and the brain can only live 4 minutes without oxygen. So the more oxygen you deliver to it, the better it functions. That’s the reason why hyperbaric oxygen chambers are used for [inaudible-00:37:05] with hypoxia. As these little scales, all these little fractal self-similar things we’re talking about, I’m trying to explain about actually how your mitochondria work optimally. Anytime you can increase your tissue oxygen tension means that you have massive charge separation of water that surrounds your mitochondria and yourself. Just like we’re talking about the plants, just we’re talking about the reverse osmosis water with people in the military. The concept is absolutely the same. This is where quantum physics makes its play. I’m giving you scales, taking you from the macrocosm to the microcosm, showing you exactly how the same principle works. It’s based on visible light hitting really good water. That is built in by design. That’s where life starts. And then it builds layers of complexity on top of that based on how much energy is left in the system. The more energy is left in the system, the more evolution can evolve. Ameer: It’s interesting though. I wonder the whole geographical equation then. For example, if I live in a high altitude place versus living in close to seawater. What’s your take on that?

Jack: Well, you and I have a friend and it seems like everytime I do a podcast, I [inaudible-00:38:34] but he’s on our Circardian Biohackers website, and he brought this point up and I’ll make it to use. The higher we go away from the earth, the more disconnect we are, that means the more EMF we face. Today’s world because the EMF is in the ionosphere, it’s even worse. But let’s think about 200 years ago when Sherpas were climbing up to the top of Mount Everest. When they went up higher, oxygen tensions went lower. That was a frenetic stimulus to their cells. So what would that do? It would cause them to make more mitochondria. That’s the reason why over 25,000 years, Sherpas have been selected out as a group of group of humans that have a higher mitochondrial density in their muscles. That’s the reason they can do things that other people can’t do. Their performance has been hand selected out because of where they live. But here’s the key metric today. Today, you can’t get away with that when you are sitting. The reason why is the amount of non-native EMF the higher you go up is two to three million times what it was when you evolve. What did I tell you before about the major effect of non-native EMF in our atmosphere? It increases calcium from the endoplasmic reticulum, and that increases calcium, means it effluxes into the cell. That high calcium level destroys cytochrome 1. What does that mean? That means that you can’t handle electrons from food anymore. So you immediately have reduced your redox potential because you screwed with lady evolution’s magical recipe of how mitochondria normally work. Sherpas don’t because in and around them is not a lot of life although I bet you today on Everest, there’s probably shitloads of EMF because of all the guys that climb it, but the point that I’m trying to make to you is I’m trying to explain how it works when man doesn’t get involved and just with lady evolution, versus what we’re dealing with today. I will tell you today, the more time you spend disconnected from the earth, the lower your redox potential is and the more chance you’re going to get disease later in your life. Ameer: That’s why people feel good when they go on vacation. A, they’re close to the water, they’re swimming, they’re grounded, they got some sun. It’s a no-brainer. Jack: Right, it is. But the crazy part Ameer is people don’t understand how this science works and that’s what my job is. I look at my job right now is teaching people. When you’re at sea level in an environment that has massive amounts of EMF, you need to be walking barefoot at the sea edge because that’s going to increase the oxygen tension in and around the mitochondria best. When the oxygen tension around your mitochondria is best, that means your mitochondria get a break, you don’t have to work as much. It also means you don’t have to eat a shitload of electrons to offset the proton gradient loss. It’s a very interesting yin and yang kind of effect and it’s really, really important that people understand this. That’s part of the reason why I’ve spent greater than the last year on my blog in this energy and epigenetics series. This series has lasted incredibly long. Why? Because what I’m basically showing people is physics dictates biology and the way it dictates it is physics is how our cells are set up. Biology happens based on that equation. Life is designed to be meta stable, meaning that it’s designed to react on all kind of insults from the environment, and then have an answer to it. The concern that I have today is that the insults that our environment is bringing to our mitochondria is probably at our limits, and that’s the reason why we have autism, that’s the reason why we get neurodegeneration, that’s the reason why brain cancer raised to 400-500% what they were 50 years ago. It’s no mystery to me but it seems like it’s a mystery to anybody who read any of the research about this. No one can explain why everybody is obese. No one can explain why everybody is falling apart. No one can explain why our immunity is going crazy. I think I can. The reason why, it’s all tied to a poor redox potential that’s all tied to the environmental signals that we are giving our mitochondria.

Ameer: That’s right. As Bruce Lipton talks about biology, I believe your environment controls how your cells behave pretty much. Jack: Absolutely true. That’s what I wrote 10 years ago in one of my quilts. I quilt optimal system in my site. I don’t know how many of your listeners or even you have ever gone to look at it but labeled it from step 1 to step 30, what was most important to least important. What we’re talking about today is likely one the quilt. Ameer: If you have to summarize, what would be your number one optimal health tip. Like, out of everything from the quilt, from the all the information, if you have to give one piece of advice, what would that be? Jack: There’s no one bit of advice. I would say there are two pieces that you need to do in this environment. The two parts, the three-legged stool of life is the photoelectric effect of water chemistry, and the Earth’s magnetic field. The two issues that are being assaulted right now in modern life is water chemistry and non-native EMF. You need to make sure you maximize your intracellular and extracellular water, and you need to minimize the amount of non-native EMF that you face. Unfortunately, you and I both know that in this modern world, it’s going to be really hard to take people’s iPhones, iPads, internet wi-fi all out of the way, but I’m going to be honest with you, that has a way bigger effect that you eating a paleo and an epi-paleo diet. This is one of the main reasons that makes me controversial in the paleo community because if you believe the diet is the be-all, end-all, it basically tells me you don’t know jack shit about how a mitochondria work. Ameer: I’ll be the first one to say. A lot of my business is online, it’s on the computer and I deal with a lot of clients online and I kid you not, if I’m on my computer for past three hours, and this is even with a grounding mat, I feel a headache right away. I know as the longer I spend around any electronics, sometimes I feel just dumber. Jack: Well, let me tell you this Ameer. I know you’re friends with me on Facebook but I don’t know how many of your listeners know this, but I posted something about, and this is three to four weeks ago, and it bares mentioning here because it will show you the effect. I posted a picture of a kid who made a 15minute phone call on an iPhone 5S. He used the thermal camera to take a picture of him before and after. Before, you saw a normal blood flow pattern through his face. Fifteen minutes later, he had a white-out over his parotid gland, temporomandibular joint, and his temporal lobe. Why did that happen? What does this thermal camera measure? It measures blood flow. But what did I just tell you that non-native EMF does, it dehydrates you. What did I say in this podcast, blood 93% made of water. Why do we increase blood flow to an area that’s been hit by EMF? Well it’s very simple. EMF dehydrates you of intracellular and extracellular water. Your body reacts by vasodilating and delivering blood to that area to offset the loss, to take the load off your mitochondria which would have to make up the difference. This is the point that I’m trying make to people. The more time you spend bathing your mitochondria in these non-native signals, the quicker you’re digging your own grave and buying your own casket. Ameer: Yeah. That’s the reality and sometimes it hurts for people to hear that because we are surrounded by electronics. Jack: Listen, I have a famous saying. I’ve said it on my forum and I’ll say it here. The truth often pisses people off the first time they hear but you know what, when you keep telling them the same thing over and over again and they begin to connect the dots themselves by educating themselves and taking

knowledge and stringing together with wisdom, then they start to look at a guy like me and say “You know, this guy is not bat shit crazy. He’s actually way ahead of the game. He gets where this is going.” Look, I faced plenty arrows in paleo community. I knew I was going through. I said all these stuff when I was at Paleo FX in 2011 and literally they didn’t like the message. They didn’t like the fact that I said “The diet wasn’t the be-all, end-all. There was a greater level to where all this is going.” The greater level is what we’re really talking about tonight. Where the rubber meets the road is at the redox potential, and anybody who argues with that, I’ll lay the goblet down. You don’t know jack shit about jack. Ameer: Awesome Dr. Kruse. Where can people find more information about you? Jack: I would tell you, there’s a lot of different places, but if you want access to me, come on my forum at I answer all the questions on my blog. I always have done that from the time my blog has been out there for three years. I also have an Ask Jack portion in my forum that you can join. There’s a free membership called the bronze membership. If you want more access to me, you want my website, you want my webinars, you want things like that, then they have a silver, gold and platinum membership. I have a book on Amazon that gets into a lot of what we were talking about today. I’m on Facebook. I’m on twitter. You can find me @DrJackKruse on twitter. You know Ameer, I’m on a lot of the Facebook groups you’re on. I try to make myself accessible. I try to do podcasts because I look at it like this. Once you begin to have some truth and wisdom and understanding, our job is to share that with people so that they can help themselves. I can’t cure anybody just so you can’t cure anybody. But you know what, I can shine a flashlight on the path that people probably need to consider travelling upon and get off the path that they’re on now. Ameer: Wise words. I agree 100%. That’s right. We’re all a beacon of light. Well Dr. Kruse, I want to thank you so much for coming on the Optimal Health Show. Definitely, we’ll love to have you back on for round 3, maybe this time talking about water. Until then my friend, have an amazing day. Jack: Alright, thank you Ameer and take care. Ameer: Cheers.

Ameer Rosic Ameer Rosic is obsessed with health. A Registered Holistic Nutritionist, Functional Diagnostic Practitioner and Functional Medicine Practitioner, Ameer has spent years empowering himself with knowledge about optimal health, and now his passion is to share that with you! From interviews with top health experts to fitness and nutritional advice and more, Ameer Rosic can help you live a life of optimal health!

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How to Biohack Your Biochemistry: Is the Redox Potential the Missing Link?  

Have you heard of the redox potential? It's a concept developed by Dr. Jack Kruse, And, scientifically speaking, it might be one of the most...

How to Biohack Your Biochemistry: Is the Redox Potential the Missing Link?  

Have you heard of the redox potential? It's a concept developed by Dr. Jack Kruse, And, scientifically speaking, it might be one of the most...