Page 1

Malaria - History

Alphonse Laveran

Sir Patrick Manson

Sir Ronald Ross

Giovanni Grassi


Malaria – Geographic distribution


Malaria – United States

Malaria transmission 1957-1994


Malaria – Life cycle


Malaria - Vectors

Anopheles freeborni


Malaria – Vectors (cont.)

Anopheles balabacensis

A. freeborni

A. gambiae

A. stephensi


Malaria – Vectors (cont.)


Malaria - Sporogony


Malaria - Sporogony


Plasmodium falciparum Sporozoites and liver schizonts


Malaria - Merozoite


Malaria – Red blood cell invasion


Malaria – Red blood cell invasion


P. falciparum – Blood stages

Uninfected RBC

4 hr.

2 hr.

12 hr.


Malaria – Blood stages (cont.)


Malaria – Blood stages (cont.)


Malaria - Cytoadherence


Malaria and Sickle cell anemia


Malaria


Malaria - Immunity


Malaria – Immunity (cont.)


Malaria - Vaccination


Malaria - Diagnosis


Malaria – Diagnosis (cont.)

Po

Pf Pv

Pm

Immunofluorescent antibody Malaria PCR


Malaria - Treatment

Artemisinin


Malaria - Prevention

Malaria