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DrehscheibeCOBAS_ScheibeA_12cm.pPage 1

14.03.2008

15:31:31 Uhr

Clinical La

y tenc

+ +

Clinical Stages Hepatitis/HIV sce Convale

nt

-

C

te Acu

+

+

+

Relative Concentration

+

-

ALT

+ + +

Anti-HCV

ly

r Ea

Im mu nolo riod gical Window Pe t Mon

hs

H I V Ag e

n Rela tive con cent ratio

- Weeks to +

t on

Ti m

H IV

M

hs to Ye An ar tiHI Va RN nti bo A die

+

Ac ute

-

+

HE PC - A LT - A nti-H CV + Ta q M a n ( P C R )

Late s tage

Time

s

+

has

S uz are , S tra wi de tze m rla ark nd s o ,w fR ww och .roc e. he.c om

+

HIV i omb + H IV c g + +

K

tic P toma

CMY

R) ER H IV A W tkre n (PC NS Ro TaqMa S A 43 ED 63 NE CH001 IFE d., 0627 nd L s lt . 0518 N a stic Mat. Nr , TAQMA iagno COBAS Roche D Š 2008 e

CY

Late Symp

MY

+

CM

Chronic Infection

Y

RNA

rsion Seroconve

Hepatitis C

M

H IV

Ag

Wi gical Immunolo

d ri o Pe w ndo


DrehscheibeCOBAS_ScheibeA_12cm_oPage 1

14.03.2008

15:32:16 Uhr

Clinical Stages Hepatitis/HIV

C

Hepatitis C RNA

Relative Concentration

M

Y

CM

ALT

Anti-HCV

ont oM

hs

H I V Ag e

t Weeks

RN

H IV

t on

A

M

An

Ta q M a n ( P C R )

tiH

hs to Ye ar IV an t ib odi e

s

PC A LT Anti-H CV

Ti m

S uz are , S tra wi de tze m rla ark nd s o ,w fR ww och .roc e. he.c om

HE

n Rela tive con cent ratio

K

HIV mbi H I V co g

CMY

R) ER H IV A W tkre n (PC NS Ro TaqMa S A 43 ED 63 NE CH001 IFE d., 0627 nd L s lt . 0518 N a stic Mat. Nr , TAQMA iagno COBAS Roche D Š 2008

CY

Late s tage

Time MY

H IV

Ag


DrehscheibeCOBAS_ScheibeA_12cm_uPage 1

14.03.2008

15:31:53 Uhr

Clinical La

y tenc

+ + nt

+

+ + +

+

+

+

+

+

+

+

+

Ac ute

-

-

r Ea

ly

K

tic P toma

CMY

+ + +

CY

Late Symp

MY

+

CM

Chronic Infection

Y

te Acu

-

M

e has

Im mu nolo riod gical Window Pe

+

Wi gical Immunolo

d ri o Pe w ndo

rsion Seroconve

sce Convale

C


DrehscheibeCOBAS_ScheibeB_12cm.pPage 1

Late Phase Ac ut e

re Recove

+

-

+ + y: olog : *ada-pted fromyer's Hepatse, Zakim and BoLiver Disea xtbook of dition A Te+ e h t rs; 5

Saunde

H Be NA

-

-

-

+

DN

Ti m

e

Wi gical Immunolo

A

d ri o Pe w ndo

La te

AL T HB VD

g

eA

HB

-

-

ALT H BV

In Ti m fec e tio n/ Ear ly A cute

Anti-

HB

sAg

B*

ute Ac

ep ati tis

Ch ro ni cH

n

+

tio

Rela tive conc entr ation

ra

s

e

+

+

-

HB

co

-

Be

tiAn

Ag H Bs Ag H Be

tiv

+

HE

c ti-H H B An

un m Im

iant

B*

nt

a in cc

te d

IgM

+

sitive

tis ati

Re la

a d/V

-

H Be

ms

e

A DN

H BeAg-po

p He nic chro

e Early Acut

-

+

Relative Concentration

+

Sy m p t o

ALT Ti m

HBV

P A An t A n i - H AV ti-H AV I g ol M og ica H lW EP indo + w Period B

H + - A Bs +/ / - H n t i - A g B - A eA H Bs + An nti-H g + A ti- Be Ta n t i - H H B c I qM Bc gM Ch an ro (P C ni R) cI nfe c ti on

-

+ * is B patit Ag Acute He H Bs Bc i-H A g Ant

adapted from: Brundage S et al. Am Fam Physican. 2006; 73(12): 2162-2168

nc e

n tio -

IgM ALT

+ + -

Recovered

K

Anti-HAV

Viremia

Weeks

Relativ e concen tration

+

ec Inf

+

CM

+

ute

+ + + + +

+

co ve ry

Y

CMY

Hepatitis A

+

c of A

Ea rl yR e

M

CY

16:26:04 Uhr

Clinical Stages Hepatitis/HIV

C

MY

14.03.2008


DrehscheibeCOBAS_ScheibeB_12cm_oPage 1

14.03.2008

16:27:05 Uhr

Clinical Stages Hepatitis/HIV

Anti-HAV

e

sAg

B*

Ti m

A

HB

e

eA

g

NA

HB

ep ati tis

Ch ro ni cH

Rela tive conc entr ation

DN

co

ALT H BV

e

n

s

Ag H Bs Ag H Be

tiv

B*

tio

HB

sitive

tis ati

ra

Be

tiAn

H BeAg-po

p He nic chro

nt

c ti-H H B An

EP HB B A sA H nti- g A n B e A gH B s A tiA nti- H Be Ta n t i - H H B c I qM Bc gM an (P C R)

nc e

iant

H

Anti-

HE

H Be

adapted from: Brundage S et al. Am Fam Physican. 2006; 73(12): 2162-2168

P A An t A n i - H AV ti-H AV I g M

H Be

IgM

e

A DN

Ti m

HBV

K

ms

ALT

CMY

* is B patit Ag Acute He H Bs Bc i-H A g Ant

Sy m p t o

CY

ALT Weeks

Relativ e concen tration

IgM

AL T HB VD

Relative Concentration

CM

Viremia

Re la

Y

MY

y: olog : *adapted fromyer's Hepatse, Zakim and Bo iver Disea A Textbook of Ledition h t Saunders; 5

Hepatitis A

M

Ti m

C


DrehscheibeCOBAS_ScheibeB_12cm_uPage 1

14.03.2008

16:26:35 Uhr

Late Phase a d/V

a in cc

te d

+

M

+ + +

Y

CM

ute

+

+

Ch

ro n

ic I

nfe c ti on

-

-

-

-

-

+

Wi gical Immunolo

+

+

+

La te

+

+ +/ / -

ol og ica lW indo w Period

+

K

In fec tio n/ Ear ly A cute

-

Ac

-

un m Im

CMY

+ + -

CY

Recovered

MY

e Early Acut

-

re Recove

+

+

-

-

+

+

-

-

n tio

+

+

ec Inf

+

co ve ry

+

ute

+ + + + +

Ac ut e

+

c of A

Ea rl yR e

C

d ri o Pe w ndo


Clin interpretation wheel 12cm rz