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Actinomyces & Nocardia


Actinomyces 

A.israelii, A.naeslundii; Gram positive; sulfur granule; Related to decay tooth and peridentitis


ACTINOMYCES Anaerobic, filamentous, gram positive bacillus • Exhibit true branching  

“Mykes” – Greek for “fungus” Thought by early microbiologist to be fungi because of: • Morphology • Disease they cause


Clinical specimens:Actinomycosis-pus


ACTINOMYCOSIS Not highly virulent (Opportunist) • Component Flora   

of

Oral

Periodontal pockets Dental plaque Tonsilar crypts

• Take advantage of injury to penetrate mucosal barriers   

Coincident infection Trauma


Actinomycosis 

A chronic suppurative and granulomatous 肉 芽肿 disease of the cervico-facial, thoracic or abdominal areas


ACTINOMYCOSIS Form indurated masses with fibrous walls and central loculations with pus • Pus contains "Sulfur Granules"   

Gritty, yellow white Average diameter - 2mm Composed of mineralized “mycelial” mass

Chronic infection • Form burrowing sinus tracts to skin or mucus membranes 

Discharge purulent material


Actinomycosis - sulfur granule


Pulmonary Actinomycosis  

15% of cases Aspiration of organism from the oropaharynx Slowly progressive process involving lung and pleura • May be mistaken for malignancy

Chest pain, fever, wgt


Mycetoma ( 足菌病)

Streptomyces species?


Nocardiosis ď Ž

ď Ž

Subcutaneous infections, pulmonary infections, and brain abscesses N. asteroides; N. brasiliensis


Lab. Diagnosis ď Ž

Clinical Specimens:Sputum,Pus,Biopsy tissue

Sulfamethoxazole-Trimethoprim

Actinomyces & Nocardia  
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