In recent decades, scientists have been suggesting that the earth’s climate is fast changing and these changes are expected to have serious economic and social impacts particularly on farmers whose livelihoods depend on agriculture. Adaptation is a necessary option to the adverse impacts of climate change. However, for farmers to manifest adaptation options, they must be aware of changes in climatic conditions and the negative effects on crop yields. This study assessed farmers’ perception of climate change and adaptation options in the Southwest Region of Cameroon. Questionnaires were administered to 680 farmers randomly selected for the study. Results revealed that most farmers perceived climate change as late start and early cessation of rains, decrease intensity of rainfall, increase temperature and intensity of sunshine. Meteorological data coborrates farmers’ perceptions. Despite the fact that climate change had negatively affected cocoyam, plantain, cassava and cocoa cultivated