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CLINICAL EXPERIENCE | PDO THREAD LIFTING

Thread work Dr Gabriela Mercik on Polydioxanone (PDO) lifting threads

Summary Polydioxanone(PDO) - a substance previously used to produce absorbable surgical sutures, found many currently used in aesthetic medicine. Due to its collagen production stimulating properties, it is well suited for usage in face lift and neck, abdomen, buttocks or thighs treatments and as well skin tightening and firming around the shoulders. A high safety profile of polydioxanone and confirmed clinical observations, make PDO threads treatments safe and fully predictable. Properly applied PDO thread obtains results similar to a surgical face lift. Keywords: Polydioxanone, face lift, aesthetic medicine, thread lifting, PDO threads. Dr. Gabriela Mercik Cosmetic Doctor. Dr. Gabriela Mercik is Medical Director of Hebe Anti-Aging and Aesthetic Medicine Clinics and Medical Director of Dermagenica Ltd. Her research career began in Poland 15 years ago in cardiology and internal medicine. She worked in the hospital for the transplantation of hearts and lungs for 10 years. She carried out research in field of LDL-apheresis and publicated in American Journal of Cardiology. She is an advanced aesthetic trainer in biomimetic mesotherapy, dermal fillers and Botox. Dr. Gabriela practices cosmetic medicine in her clinics in Belfast and Omagh. She provides mesotherapy and Dermaroller courses across UK and Ireland. Figure 1.1 Polydioxanone synthesis diagram p-dioxanone

Introduction Aesthetic Medicine is one of the branches of medicine, which in recent years have been dynamically growing, both in terms of new surgical procedures and introducing newer and more advanced preparations. Recently the real milestone, in terms of new surgical procedures, was the introduction of PDO(polydioxanone) threads on the market. Through application of PDO threads in treatments, you can achieve the most effective and safest way to prevent and treat symptoms associated with ptosis of tissues, skin stretching and improving its density. This is due to specific feature of polydioxanone that causes mild tissue response, leading to the production of new collagen. Polydioxanone itself is kind of a synthetic fibre, which in turn is produced by the polymerization with opening ring of a monomer p-dioxanone. Figure 1.1 shows the preparation of polydioxanone. In vivo, polydioxanone is slowly hydrolyzed to form monomers of 2-hydroxy-ethoxyacetic. The monomers are further degraded, which results in obtaining water and carbon dioxide - the neutral compounds for the body and completely absorbable through the skin. Fiber made of polydioxanone does not have the pyrogenic properties, therefore does not induce any response from the

immune system. In medicine polydioxanone have been used for more than twenty years. It has been applied to monofilaments, absorbable surgical sutures and orthopaedic implants. Because of that, the material is well known and tested. It features a high safety profile, which plays a key role, when it comes to new products entering the aesthetic medicine market. It often appears that after a few years, some novelties that captured the aesthetic market at the time, are of falling into oblivion, due to a number of complications and side effects. In this case we can be completely confident of the PDO threads’ performance in the human body, as the polydioxanone had been used in suturing materials, in tens of millions surgical procedures, that had been performed around the world over twenty years. When introduced into the body, the polydioxanone is absorbed within 180 (up to 240) days. The twenty-first century is a period of time, when the first attempts of using polydioxanone as a tissue-specific promoter, which stimulates the production of a new collagen were made. In 2008, South Korea patented one of the first polydioxanone thread systems positioned on a special needle for use in aesthetic medicine and plastic surgery. Since then the PDO threads permanently become a commonplace in tender procedures in the leading clinics, involved in aesthetic medicine and plastic surgery around the world. The treatments are very popular in Korea, Japan, North and

Table 1.1 Comparison of lifting threads catalyst + heat

polydioxanone (PDO)

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Threads

PDO threads

Aptos Happy Lift

Contour Thread

Silhouette lift

active substance

Polydioxanone

Polylactic acid derivative

Polypropylene

Polypropylene

effect

flabby skin elevation, collagen synthesis stimulation

flabby skin elevation, collagen synthesis stimulation

flabby skin elevation, collagen synthesis stimulation

flabby skin elevation, collagen synthesis stimulation

anaesthesia

local anaesthesia

local anaesthesia

general anaesthesia

general anaesthesia

treatment time

30 minutes

30 minutes

60 minutes

60 minutes

side effects

Hematoma, mild swelling

Pain at the site of implantation, hematoma, swelling, asymmetry, mechanical damage to the threads

Pain at the site of implantation, hematoma, swelling, asymmetry, mechanical damage to the threads

Pain at the site of implantation, hematoma, swelling, asymmetry, mechanical damage to the threads

Country of origin

Korea

Russia/Italy

USA

USA

Profile for Aesthetics

Cosmetic news september 2013  

Cosmetic news september 2013