Medicina Transfusional
Conclusión
16. Offner PJ, Moore EE, Biff WL, et al. Increased rate of infection associared with transfusión of old after severe injury. Arch Surg 2002;137:711-6
Aún no está dicha la última palabra. Se requiere no solo de los resultados de los estudios clínicos mencionados, conformados por un gran número de pacientes, sino también conocer más sobre la lesión de almacenamiento. Hess6 tiene dudas con relación a la posibilidad de obtener resultados ciertos aún con este tipo de estudios grandes y bien planificados, en caso de que la verdadera incidencia de estos efectos esté por el orden del cuatro por mil como ha sido sugerido haciendo correcciones al trabajo de Koch30. Los datos de estos trabajos siempre tendrán un componente empírico y serán desestimados cuando se logre mejorar el almacenamiento de la sangre. La meta deberá ser comprender completamente la lesión de almacenamiento y para ellos se necesitará de la colaboración de banqueros de sangre, fisiólogos de eritrocitos y químicos acompañados de equipamiento de última tecnología. Los científicos expertos en proteómica y metabolómica son los calificados en avanzar en esta área. De toda esa información se tomarán las decisiones futuras para el desarrollo de los mejores sistemas de almacenamiento.
17. Triulzi D, Yazer M. Clinical studies of the effect of blood storage on patient outcomes. Transfusion and Apheresis Science 2010;40:95-106
19. Zallen G, Ofnerr PJ, Moore EE, et al. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. J Surg 1999;178:570-572 20. Keller ME, Jean R, LaMorte WW, et al. Effects of age of transfused blood on length of stay in trauma patients: a preliminary report. J Trauma Injury Infect Crit Care 2002;53:1023-1025 21. Purdy FR, Tweeddale MG, Merrick PM. Association of mortality with age of blood transfused in septic ICU patients. Cab J Anaesth 1997;44:1256-1261 22. Ellis CG, Jagger J, Sharpe M. The microcirculation as a functional system. Crit Care 2005;9:53-58 23. Raat N, Ince C. Oxigenating the microcirculation: the perspective from blood transfusion and blood storage. Vox Sanguinis 2007;93:12-18
26. Walsh TS,McArdle F,McLellan SA et al. Does the storage time of transfusion red blood cells influence regional or global indexes of tissue oxygenation in anemic critically ill patients? Crit Care Med 2004;32:364-371
4. Zimrin AB, Hess JR. Current issues relating to the transfusión of stored red blood cells. Vox Sang 2009;96:93-103 5. Tinmouth A, Fergusson D, Chin Yee I, Hébert P. Clinical consequences of red cell storage in the critically ill. Transfusion 2006; 46:2014-2027 6. Hess J. Red cell storage. Journal of Proteomics 2010:368-373. 7. Hess J, Greenwalt G. Storage of red blood cells: New approaches. Trans Med Rew 2002;(4):283-295 8. Offner P. Age of blood: does it make a difference? Crir Care 204;8(Suppl2):S24-S26 9. Donadee Ch, Raat N, Kanias T, et al. Nitric Oxide Scavenging by Red Blood Cell Microparticles and Cell-Free Hemoglobin as a Mechanism for the Red Cell Storage Lesion. Circulation 2011;124:465-476 10. Dzik W. Three respiratory gases and the red cell: oxygen, carbon dioxide and nitric oxide. ISBT Science Series 2010;5:234-238 11. Bennett-Guerreo E, Veldman T, Doctor A, Telen M, Ortel T, Reid S, Mulherin M, Zhu H, Buck R,Califf R, McMahon T Evolution of adverse changes in stored RBCs. PNAS 2007;104(43): 17063-17068
27. Hèbert PC, Chin-Yee I, Fergusson D, et al. A pilot trial evaluating the clinical effects of prolonged storage of red cells. Anesth Analg 2005;100:1433-1436 28. Raat NJ, Berends F, Verhoeven AJ et al. The age of storage red blood cell concentrates at time of transfusion. Transf Med 2005;15:419-423 29. Koch C, Li L, Duncan A, Mihaljevic T, Cogrove D, Loop F t al. Morbility and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass blood-component transfusion insolated with red blood cell and blood component transfusion in isolated coronary artery bypass grafting. Cri Care Med 2006;34:1608-16 30. Koch C, Li L, Sessler D, Figueroa P, Hoeltge G, Mihaljevic T, Blackstone E. Duration of red cell storage and complications after cardiac surgery. N Engl J Med 2008;358:1229-39 31. Marik P, Sibbald W. Effect of stored blood transfusion on oxygen delivery in patients with sepsis . JAMA 1993;269 (23):3024-9 32. Fernandes C, Akamine N, DeMarco F, deSousa J, et al Red blood transfusion does not increase oxygen consumption in critically ill septic patients. Crit Care 2001;5:362-7 33. Sakr Y, Chierego M, Piagnerelli M, Verdant C et al. Microvascular response to red blood cell transfusion in patients with severe sepsis. Cri Care Med 2007; 35(7):1639-44 34. Wang D, Sun J, Solomon S, et al. Transfusion of older stored blood and risk of death: a meta-analysis. Transfusion 2012;52:1184-1195
12. Jesen F The dual roles of red blood cells in tissue oxygen delivery: oxygen carriers and regulators of local blood flow. The journal of Experimental Biology 2009;212:3387-3383
35. Vanvakas E. Meta-analysis of clinical studies of the purported deleterious effects of “old” (versus “fresh”) red blood cells: are we a equipoise? Transfusion 2010; 50:600-10
13. Tsai A, Cabrales P, Intaglietta M. Microvascular perfusión upon exchange transfusión with stored red cells in normovolemic anemia conditions. Transfusión 2004;44:1626-1634
36. Steiner ME, Assman SD, Levy JH, et al. Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS) Section7, Transf Apher Sci 2010;43:107-16
14. Raat NJ, Verhoeven AJ, Mik EG, et al. The effect of storage time of human red cells on intestinal microcirculatory oxygenation in a rat isovolemic Exchange model. Crit Care Med 2005;33:39-45
37. Fergusson D, Hutton B, Hogan D et al. The age of red blood cells in premature infants (ARIPI) randomized controlled trial:study design. Transfus Med Rev 2009;23:55-61
15. Leal-Noval SR, Rincon-Ferrari MD, Garcia-Curiel A, et al. Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery. Chest 2001:119:1461-1468
38. Age og Blood Evaluation (ABLE) trial in the resuscitation of critically ill patients DOI 10.1186/ISRCTN44878718 www.controlled–trials.com/ ISRCTN44878718. Enero 2013
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PONENCIA - Lesión de almacenamiento. Importancia clínica
24. Hogman C, Meryman H. Red blood cells intended for transfusión:quality criteria revisited. Transfusion 2006;46:137-147
Bibliografía
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día
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