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L’Accademia del Fitness Precursors

HEME

L-arg

L-ser

L-Hcy

Enzymes

HO

NOS

CBS

CSE

C

Gas mediators

O

N

S H

Noneminic protein sensors

Eminic protein sensors

Targets

H

O

ing or worsening pre-existing disease conditions. In this fascinating scenario, traditional nutraceutics should not limit itself to simply proposing solutions to “contrast” the effects of these precious mediators, but must contribute, through a healthy diet and, when necessary, careful integration, to the harmony of various biogases, avoiding, for instance, extreme conditions of hypoxia and hyperoxia. Since ROS accomplish absolutely necessary biological roles for the economy of the entire organism, it is absolutely senseless to “contrast the effect of free radicals with antioxidants”, but it would be necessary “to modulate their action physiologically”. In this scenario Deutrosulfazyme® (Cellfood®) appears as the prototype of oxygen’s physiological modulators “on demand” (3), thanks to its documented capacity to stimulate APT synthesis without increasing lactate levels. Above all, it improves the expression of mitochondrial superoxidedismutase (figure 2) (4).

enzymes mitochondria vessel carrier s

Effectors

Eugenio Luigi Iorio, Domenico Siepi International Observatory of Oxidative Stress (Salerno)

Picture 1. Biogases as physiological modulators.

Picture 1. Biogases as physiological modulators.

ronment polluter for a long time - reduces leukocytes adhesion to epithelium and platelet aggregation, meanwhile fostering release of smooth vasal muscles thus preventing inflammation and ischemia. However, conditions of oxidative stress such as for instance a high level of anion superoxide (due to increased synthesis and/or reduced inactivation of superoxide dismutase), can foster the conversion of nitric oxide into peroxynitrite, which has an inflammation, aggregating and vase constricting action. More in general, pollution and unhealthy life styles, together with unfavourable genetic predispositions, can alter the delicate existing balance between the various biogases, thus caus-

Bibliography 1) Iorio EL, Balestrieri ML. Lo stress ossidativo. Trattato Italiano di Medicina di Laboratorio, (Oxidative Stress. Italian Treaty of Laboratory Medicine) by A. Burlina. Piccin, Padua. 2009. IX: 533–549. 2) Kajimura M et Al. Interaction of multiple gas-transducing systems: allmarks and uncertainties of CO, NO, and H2 gas biology. Antiox Redox Sign. 2010. 13 (2):157-192. 3) Iorio EL. Hypoxia, free radicals and antioxidants. The “Deutrosulfazyme®” paradox. Hypoxia Medical J. 2006. 1-2: 32. 4) Ferrero E et Al. CellfoodTM improves respiratory metabolism of endothelial cells and inhibits hypoxiainduced reactive oxygen species generation. J Physiol Pharmacol. 2011. 62(3):287-293

Stimulation of ATP synthase

**

ROS (increase%/NT)

160 120 80

50

1% O2 1% O2+CELLFOOD®

25

* 0 Reduction in the levels of lactic dehydrogenase

40

* **

0

-40 3 hours

1° day

3° day

5° day

8° day

LDH (U/mL of cell lysate)

ATP (mole µg/protein (compared to control)

200

Decrease in the levels of free radicals

0.5

0

**

-0.5

-1.0

3 hours

1° day

3° day

5° day

8° day

Picture 2. Effects of Cellfood® on the endothelial cells.

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Picture 2. Effects of Cellfood® on the endothelial cells.

N. 10 - July 2013  

Wellness & Antiaging magazine

N. 10 - July 2013  

Wellness & Antiaging magazine