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NATIONAL LEVEL TECHNICAL SYMPOSIUM ON

28th and 29th February 2012

NEOZION 2012 …….Redefining the evolution

SOUVENIR Organized by Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Gandipet, Hyderabad-500075 www.cbit.ac.in

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VASTUSHILPI Dr.B.N.REDDY CHAIRMAN, CBES

MESSAGE

I am happy to note that the Department of Biotechnology of CBIT is conducting for the third time, a National Level Technical Symposium ―NEOZION 2012‖ on the 28th and 29th of February, 2012. CHAITANYA BHARATHI INSTITUTE OF TECHNOLOGY is the Premier Institution in Technical Education in Andhra Pradesh, which strives to train the students to serve the Society. This type of symposium will give an opportunity for the up coming graduating students to develop overall personality and enable them to be the most preferred by Industry. I am given to understand that this symposium has attracted about 250 quality technical papers in about 7 topics of various applied areas of Biotechnology. Papers were received from AU, OU, JNTU ,VIT, SRM , SASTRA and also from other University departments and other Engineering colleges from different parts of the country. I am confident that ―NEOZION 2012‖ will pave way as a platform for young Biotechnologists all over the country to deliberate on the emerging technologies in the field of Biotechnology. I wish the Department of Biotechnology all success.

VASTUSHILPI Dr.B.N.REDDY

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Dr.D. KAMALAKAR REDDY SECRETARY & CORRESPONDENT CBES

MESSAGE

I congratulate the Department of Biotechnology for organizing a ―National Level Technical Symposium‖ for the students in their endeavor of sustained development.

I am delighted to note that this symposium has attracted quality technical papers from brilliant students from various institutions from all over country.

I am also happy to learn that number of guest lectures by experts from Industry and academia are arranged. I am sure that the judges from other institutions will select the best papers based on the technical content and presentation skills. This symposium, I am confident, will give an opportunity for the students for the overall development of personality - organizing capability and communication skills above all human interaction.

I take this opportunity to convey my sincere appreciation and best wishes for the success of symposium, to the organizers, students and staff of Biotechnology Department.

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Dr. B. CHENNAKESAVA RAO PRINCIPAL, CBIT.

MESSAGE

I have seen the brochure and poster, which were conceived in a best possible manner to highlight all the events that have taken place for the past 33 years in CBIT and for the past 7 years in the Department of Bio-Technology along with proposed students‘ activities. Everybody is aware that Bio-Technology Department of CBIT is well known for its academic standards and its various achievements like publishing more number of technical papers at national / international level by staff and students.

I am happy to note that the department is conducting a National Level Tech. Fest for students, titled “NEOZION 2012” during 28th & 29th February, 2012.

I wish that NEOZION 2012 will enhance the image of the Department and disseminate knowledge to Biotechnology students, who are going to participate across the country.

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DR.T.SAI KRISHNA PROFESSOR & HEAD DEPT. OF BIOTECHNOLOGY CHAITANYA BHARATHI INSTITUTE OF TECHNOLOGY GANDIPET, HYDERABAD-500 075.

MESSAGE In order to enlighten the upcoming and talented Biotechnology graduates and for getting to know the new horizons in the field of Biotechnology Department of Biotechnology, Chaitanya Bharathi Institute of Technology (CBIT), is organizing a National Level Technical Symposium entitled ‖NEOZION 2012”. The Department of Biotechnology was approved by AICTE, and course was recognized by Osmania University with an intake of 60 students. The department established laboratories as per University and AICTE norms. The Department of Biotechnology was established in the year 2005, and it aims to produce the Biotechnology engineering graduates to serve the Nation and the World. The department is well equipped with the latest facilities and ably supported by the well qualified staff. The department of biotechnology was approved by AICTE, and course was recognized by Osmania University with an intake of 60 students. The department has well established laboratories as per University and AICTE norms. It may not be out of place to proudly record the efforts put in and contributions made by staff and students for organizing this event. In this connection the department acknowledges and places on record with gratitude for the unlimited support and encouragement given by CBIT Management, Chairman, Secretary and above all the Principal of the college. I congratulate and appreciate efforts put in by the staff and the students to conduct Neozion 2012. I wish them all success

Dr.T.SAI KRISHNA Convener, NEOZION’2012

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ABOUT THE SYMPOSIUM NEOZION‘12 is to be a technical event on a grand scale organized by Department of Biotechnology. We invite to have a large audience attending the convention. Competition will be tough, with the participants vying for the top honors that such a prestigious even holds. We expect some of the most brilliant students across India to attend the symposium and to provide insights into both, the break-through and conventional technologies in biotechnology and applied aspects. Along with the students there will also be other prominent invitees who hold prestigious posts both in the educational as well as the professional fields in Hyderabad and other cities across the country to deliver key note addresses. Research and development in biotechnology requires the collaboration of scientists and engineers in the fields of biology, chemistry, computer science, chemical engineering, and electrical engineering. This symposium brings together scientists, engineers and scholars from relevant fields with practitioners from industry in order to help each group to understand progress made in the area as a whole. These symposia provide a great opportunity to learn about the latest advances in biotechnology from top scientists, and they are an ideal venue for meeting biotechnology and pharmaceutical company executives and decisionmakers face-to-face. Every attendee also has the opportunity to give a oneminute "Smart Pitch" at the meeting to introduce themselves to the audience for future collaboration. An event of such a nature will grant you the accessibility to the important people across the spectrum of technical education and industry. Most importantly you will be in contact with the engineers and entrepreneurs of tomorrow. Any form of sponsorship given by you shall be very encouraging to the talented students to strive for excellence in their respective fields.

Dr. Varimadugu Aruna Co Convener

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INSITITUTE’S PROFILE CBIT is one of the premier Engineering Colleges in the self-financing category in Andhra Pradesh. It has been accredited thrice (in 1998, 2004 and 2008) by NBA (AICTE). It is also the first ISO 9001:2000 certified Engineering Institute in the state of A.P. The total infrastructure is 32,000 sq. meters (3, 25,000 sft) worth about Rs. 20 crore. The grants received from AICTE are worth about Rs.1.2 crore. The college offers 9 U.G. Programmes and 7 P.G. courses. Brilliant and meritorious candidates with 500 ranks onwards in EAMCET seek admission in CBIT especially in ECE, EEE,CIVIL, CSE, IT, and Mechanical Engineering. The pass percentage has also been consistent with 92 % on an average. Out of this 70% of the students pass either in distinction or in first class. The Institution along with shaping its students in to disciplined young citizens of good character and culture, lays emphasis on practical experience so as to enable them to secure employment in industry; thereby helping them become entrepreneurs. CBIT stands as the only Engineering College in the State with 590 students placed in reputed organizations through campus interviews from July 2007 to December 2007 itself. In its keen commitment to offer quality education, CBIT, over the past 28 years has become a temple of knowledge and produced about 12,250 eminent and skillful graduate engineers, who are successful in their careers, serving all over the globe. The Institution has gained in stature. AICTE has given a Letter of Advice to the Vice Chancellor of OU, for granting deemed university/ autonomous status to CBIT. LOCATION AND INFRASTRUCTURE The institute is located at Gandipet near Osman sagar in eco friendly and lush green surroundings, 16 km away from Hyderabad on vast area. The institute possesses the entire necessary infrastructure with adequate buildings and well equipped laboratories, advanced instruments and updated software. Spacious library with 40,000 volumes and good transport are the other assets to the institute. GROWTH OF THE INSTITUTE The institute was started with an intake of about 200 students into three branches of engineering degree course. Presently, the institute offers four year engineering degree courses in 9 branches, post graduate courses in five of the same branches along with MCA and MBA. The institute has a unique position of having the largest annual intake of 709 into UG and PG programmes among the other self-financing institutes of A.P. The institute is the first of its kind to start postgraduate courses in Mechanical, Computer Science ECE, Civil and EEE engineering branches. The institute has on its rolls 250 well-qualified and dedicated teaching faculty of whom more than 50 are Ph.D. holders and many more are pursuing the same. More than 250 committed and experienced nonteaching staff members are rendering their services in various sections for the progress and functioning of the institute.

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COMPUTER CENTRE OF THE INSTITUTE The institute has a combined main computer centre in the departments of computer science and engineering and information technology equipped with the latest software. In addition to this, all the other departments have their own computer centers separately to cater to the needs of their students. Altogether, the institute has more than 1000 computer systems, which include Pentium processors, Pentium IV processors with multimedia systems, UNIX and network servers on LAN, plotters and several application packages. The CAD/CAM laboratory of Mechanical engineering department is equipped with a Denford vertical machinery center with eight-station automatic tool changer imported from the U.K which is the first of its kind in India. It also has a desktop tutor and the machines interfaced with the workstation. DIGITAL LIBRARY AND INFORMATION CENTRE The institute is supported by well established and spacious Library and Information center having a collection of 30,000 volumes worth Rs.30 lakh. The library has open access system and subscribes nearly 150 Indian journals. It also has access to 110 foreign journals in various engineering fields through Information Dissemination Center (IDC) of Osmania University, Hyderabad. The institute‘s library is the first engineering college library in our state to have acquired ―MODROBS‖ project from AICTE on ―Modernization Networking of the Library and Information Centre‖. This project is now being implemented to develop the library as a full-fledged online public access information centre. It has purchased LIBSYS (integrated library software package) and hardware. The library also maintains separate book banks for BC, SC, ST students. MEMBERSHIPS The staff and students of the institute have an opportunity to enroll themselves into various associations of India with an objective to update their knowledge in various fields of interest. (i) ISTE Students’ Chapter The institute has a students‘ chapter of Indian Society for Technical Education (ISTE), perhaps one of the largest of its kind in the country with memberships of about 1000. This students‘ chapter was established in the year 1996 with an objective to develop the application skills in the technical aspects of the students, expose them to the practical environment outside the college premises and also enable them to share and express ideas clearly with the eminent personalities of their relevant branches of engineering. The first programme of this chapter was conducted in the year 1997 as a national level technical symposium-NAVACHAITANYA‘97 on computer applications in engineering and management. The chapter was adjudged the best amongst the other chapters which conducted symposia. On similar lines two other programmes were conducted in 1999 and 2004.

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ABOUT THE DEPARTMENT The Department of Biotechnology was started in the year 2005 with an intake of 60 seats with AICTE approval. Since its inception the department has been striving to establish as an excellent academic and research ambience. It is situated in a separate Engineering Block (M Block-4 floors) with a total floor area of 10,715 Sq.fts/floor. The laboratories, classrooms and staff rooms are well integrated and provide better interactions among staff and students. Key strengths of the department include nine qualified full time faculty members from different academic backgrounds such as Biotechnology, Life sciences, Chemical Engineering etc. The Department of Biotechnology is fortunate in having assistance and guidance from various departments that include Department of Chemical Engineering, Department of Computer Science, Department of Mechanical, Department of EEE etc. The department has full pledged assistance and technological feed back for strengthening the areas of R and D from Osmania University, Hyderabad. The focus of the department is presently on training the students in various theoretical and practical aspects of biotechnology which includes the practices of Genetic Engineering, Bioprocess Engineering, Biochemistry, Microbiology, Mass transfer operations, Bio-informatics etc. At the same time department also encourages the faculty to carry out research work in the department. The 4 year graduate program is aimed at inculcating research orientation in the students on the broad range of active research areas conducted by faculty members in the department. The department has art of the best laboratory facilitates in the fields of Genetic Engineering, Microbiology, Immunology, Bioprocess Engineering, Biochemistry, Bioinformatics and other associated Engineering fields. The Biotechnology laboratories are planned in a spacious 1155 Sq.ft /lab. In addition to the formal education with an intensive practical exposure, the inherent talents of the students are explored and strengthened through regular counseling and personality development sessions, to improve the visualization, presentation capabilities, communication skills and leadership qualities etc. Students are encouraged and guided to conduct and present papers, attend workshops and seminars to get them acquainted with the latest and recent trends in science and technology. Objectives/Goals of the Department:  To establish as an Centre of excellence for R and D under the banner of CBIT  To infuse useful technologies to enhance quality education among the students  To collaborate with foreign universities for R and D activities, Video lectures, video conferences, staff exchange and student exchange programs.  Coordinating with R and D / Funding Organizations like DSIR, DST.

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     

To increase Industry Institute Interaction for knowing the needs and demands of the industry. To introduce Value added, industry oriented courses by involving industry in the curriculum planning. To conduct International and National level seminars/conferences regularly. To organize AICTE sponsored FDP, STTP, FTP programs in the college. To execute sponsored and Research Projects and consultancy Projects To further strengthen the Research activities, through Paper Publications, encouraging faculty for doing PhD.

Dr. T. Sai Krishna Head, Dept of Biotechnology .

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NATIONAL LEVEL TECHNICAL SYMPOSIUM

NEOZION 2012 Chief Patrons Vastushilpi Dr.B.N.Reddy, Chairman, CBES Chief Patrons Dr. D. Kamalakar Reddy, Secretary and Correspondent, CBES Chairman Dr. B. Chennakesava Rao, Principal CBIT Convener Dr. T. Sai Krishna, Prof., Dept of Biotechnology, CBIT Co Convener Dr. Varimadugu Aruna, Asst Prof., Dept of Biotechnology, CBIT Organizing committee-Teaching Mr. C. Obula Reddy, Asst. Prof., Mr. K. Rajagopal, Asst. Prof., Dr.G. Vijaya Laxmi, Asst. Prof., Ms. S. Sumithra, Asst. Prof., Dr. Soma Roy, Asst. Prof., Mr. M. A. Matheen, Asst. Prof., Ms. T.R.A. Vijaya Bharathi, Asst Prof., Dr. C. Anjaneyulu, Asst. Prof., Ms. P. Sujatha, Asst Prof. Non-Teaching Staff Mr.K.Sri Ram Reddy, Lab Assistant Mrs.D.Madhavi Latha, Lab Technician Mr. D. Mahboob Basha, Lab Technician Mr. G. Sanjeeva, Computer operator, Mrs. S. Kavitha, Lab Technician Mr. Shaik Amir, Lab Technician Mr. S. LavaKumar, Attender Mr. C. Sreenivas, Attender Student Coordinator Nitin (4/4)

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NEOZION 2012 PROGRAMME SCHEDULE

28th February, 2012 9:30am onwards 10:30am -11:30 am 11:30 am – 11:45 am 11:45 am -12:45 pm

12:45 pm -1:30 pm

1:30pm – 2:30pm 2:30pm – 4.00pm 4: 00 pm - 4: 15 pm 4: 30 pm onwards

Registration Inaugural Function Tea Break Key note address by Dr. M. Sai Ram, Head, R & D, Biological E Ltd, Hyderabad. Topic: High throughput technologies for application in healthcare. Invited lecture by Dr. M. Sasikala, Head, Basic Sciences and Research labs, Asian Institute of Gastroenterology, Hyderabad. Topic: Stem cells- Research to regeneration. Lunch Break Paper, Poster, Live projects presentation, Non technical events (In respective Halls) Tea Break Cultural night

29th February, 2012 10:00 am – 12:30pm 12:30 pm – 1:30 pm 1:30 pm – 2:15 pm

2:15 pm – 3:00pm

3: 00pm – 4:15pm

Paper presentation, Bioquiz, Non technical events (In respective Halls) Lunch Break Invited lecture by Dr. K.P. Sastry, Scientist F, Director, CIMAP, Hyderabad. Topic: India a key player in the medicinal plants sector in the world. Invited lecture Dr. Casturi Seshagiri Rao, Vice President, Dr Reddy’s Lab, Hyderabad. Topic: Drug discovery and development – Role and impact of Biotechnology. Valedictory function and Presentation of awards

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NEOZION 2012 WORKING COMMITTEES Core Committee

Student Volunteers

Dr. T. Sai Krishna

Mr. Divyanshu (II/IV)

Dr. V. Aruna

Mr. Sarfaraz (II/IV)

Student Representative

Mr. Naresh (II/IV)

Mr.Saketh Ram(IV/IV)

Mr. Vinay (II/IV)

Student Coordinator

Mr. Ragavendra (II/IV)

Mr. Nitin (IV/IV)

Mr. Ashok (II/IV)

Mr.Goutam (IV/IV)

Ms. Josua (II/IV)

Event Organizing Committee

Mr. Pradeep (II/IV)

Staff Coordinators

Mr. Nagarjuna (II/IV)

Dr. V. Aruna,

Ms. Rohini (II/IV)

Mr. C. Obula Reddy

Ms. Yashika (II/IV)

Dr. G. Vijaya laxmi

Ms. Sirisha (II/IV)

Mr. Sri Ram Reddy

Reception and Registration

Student Coordinators

Committee

Ms. Anupam (IV/IV)

Staff Coordinators

Ms. Mahak (IV/IV)

Ms. T.R.A. Vijaya Bharathi

Ms. Meenakshi (IV/IV)

Ms. S. Sumithra

Mr. Saketh (IV/IV)

Ms. P.Sujatha

Mr. Laxmi narayana (IV/IV)

Student Coordinators

Mr. Mohan vamsi (IV/IV)

Ms. Bhargavi (IV/IV)

Ms. Heta (IV/IV)

Ms. Mouneesha (IV/IV)

Ms.Spruthi (IV/IV)

Ms .Nonita (IV/IV)

Student Organizers

Mr. Koushik (IV/IV)

Ms. Manoranjani (III/IV)

Ms. Sunitha (IV/IV)

Ms. Shravani (III/IV)

Student Organizers

Mr. Bhushan (III/IV)

Ms. Lolitha. (III/IV)

Mr. Likhith (III/IV)

Ms. Vidya (III/IV)

Mr. Sabapathy (III/IV)

Ms. Jyothi,G (III/IV)

Mr. Nikhil (III/IV)

Ms. Monika (III/IV)

Mr. Phani (III/IV)

Ms Deepthi (III/IV)

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Mr. Siddhartha (III/IV)

Mr. Santosh (III/IV)

Ms. Himaja (III/IV)

Paper Presentation Committee

Student Volunteers

Staff Coordinators

Ms. Anusha (II/IV)

Dr. Soma Roy, Co-ordinator

Ms. Anjana sravanthi (II/IV)

Dr. G. Vijaya laxmi

Ms. Chirisha (II/IV)

Mr. Sanjeeva

Ms. Sharanya (II/IV)

Student Coordinators

Ms. Mrudula (II/IV)

Mr. Dharma Teja (IV/IV)

Mr. Asif (II/IV)

Mr. Santosh (IV/IV)

Mr. Prathap reddy (II/IV)

Mr. Naveen (IV/IV)

Mr. Prashanth (II/IV)

Ms. Poonam (IV/IV)

Mr. Manoj (II/IV)

Ms. Yusra (IV/IV)

Ms. Shilpa (II/IV)

Ms. Lavanya (IV/IV)

Ms. Sudarshini (II/IV)

Mr. Sukumar (IV/IV)

Infrastructure Committee

Ms. Sri vidya (IV/IV)

Staff Coordinators

Student Organizers

Mr.Sri Ram Reddy

Mr. Sandeep (III/IV)

Mr. Shaik Amir

Mr. Abhinav (III/IV)

Student Coordinators

Mr. Raju (III/IV)

Mr. Charishma (III/IV)

Ms. Pooja (III/IV)

Ms. Karuna (III/IV)

Ms. Shamili (III/IV)

Ms. Anisha (III/IV)

Mr. Atufa (III/IV)

Ms. Neelima (III/IV)

Ms. Vahini (III/IV)

Ms. Pooja (III/IV)

Mr. Vasundhara (III/IV)

Ms. Priyanka (III/IV)

Ms. Vidyani (III/IV)

Ms. Shakera (III/IV)

Ms. Deepthi (III/IV)

Ms. Sowmya (III/IV)

Ms. Manoja (III/IV)

Ms. Sri viday (III/IV)

Mr. Lasya (III/IV)

Mr. Vipula (III/IV)

Ms. Keerthana (III/IV)

Mr. Avinash (III/IV)

Ms. Kirthi (III/IV)

Mr. Devendra (III/IV)

Ms. Himaja (III/IV)

Mr. Phani (III/IV)

Student Volunteers

Mr. Devi kumar (III/IV)

Ms. Mahathi (II/IV)

Mr. Raju (III/IV)

Mr. Raoof (II/IV) 14


Ms. Deepthi (II/IV)

Staff Coordinators

Ms. Omama (II/IV)

Dr. C. Anjaneyulu

Ms. Priyanka (II/IV)

Ms. P.Sujatha

Ms. Santoshi (II/IV)

Ms. D. Madhavi latha

Mr. Vijay kumar (II/IV)

Student Coordinators

Ms. Ujwala (II/IV)

Ms. Archana (IV/IV)

Ms. Revathi (II/IV)

Ms. Nikitha (IV/IV)

Ms. Sharanya (II/IV)

Ms. Suhasini (IV/IV)

Poster Presentation Committee

Ms. Madhumathi (IV/IV)

Staff Coordinators

Mr. Prasanth (IV/IV)

Dr. G. Vijaya laxmi

Mr. Mukesh (IV/IV)

Dr. C. Anjaneyulu

Ms. M. Nikitha (IV/IV)

Mr. Shaik Amir

Student Organizers

Student Coordinators

Mr. Charishma (III/IV)

Ms. Padmavathi (IV/IV)

Ms. Harshitha (III/IV)

Ms. Tejaswini (IV/IV)

Ms. Komali (III/IV)

Ms. Yusra (IV/IV)

Ms. Neelima (III/IV)

Ms. Shravani (IV/IV)

Ms. Sarala (III/IV)

Ms. Poonam (IV/IV)

Ms. Shakera (III/IV)

Ms. Nonita (IV/IV)

Ms. Sowmya (III/IV)

Mr. Ganesh (IV/IV)

Ms. Sravya (III/IV)

Ms. Mamatha (IV/IV)

Ms. Lolitha (III/IV)

Ms. Bhavana (IV/IV)

Mr. Teja (III/IV)

Mr. Ramu (IV/IV)

Mr. Devendra (III/IV)

Ms. Kavitha (IV/IV)

Mr. Fauzan (III/IV)

Student Organizers

Bio Quiz Committee

Ms. Apoorva (III/IV)

Staff Coordinators

Ms. Jyothi (III/IV)

Mr. C. Obula Reddy,

Ms. Vidya (III/IV)

Ms. T.R.A. Vijaya Bharathi

Ms. Vipula (III/IV)

Mr. Mahaboob Basha

Student Volunteers

Student Coordinators

Mr. S. Ragavendra (II/IV)

Ms. Archana (IV/IV) Ms. Prasanthi (IV/IV)

Live Projects Committee

Ms. M.Nikitha (IV/IV) 15


Ms. M.Shravani (IV/IV)

Ms. Vikitha (III/IV)

Student Organizers

Mr. Abhinav (III/IV)

Ms. G. Jyothi (III/IV)

Mr. Bhusan (III/IV)

Ms. Priyanka (III/IV)

Mr. Sandeep (III/IV)

Ms. Atufa (III/IV)

Mr. Susana (III/IV)

Ms. Vidya (III/IV)

Mr Sudheer (III/IV)

Mr. Santosh (III/IV)

Mr. Kiran (III/IV)

Mr. Siddhartha (III/IV)

Student Volunteers

Mr. Sudheer (III/IV)

Ms. Chirisha (II/IV)

Student Volunteers

Ms. Bharathi (II/IV)

Ms. Navya (III/IV)

Ms. Shravani (II/IV)

Ms. Juveria (III/IV)

Mr. Adithya (II/IV)

Ms. Rayeesha (III/IV)

Mr. Karteek (II/IV)

Mr. Venugopal (III/IV)

Ms. Viswa (II/IV)

Mr. Sunil kumar (III/IV)

Mr. Harish (II/IV)

Publicity Committee:

Mr. Yaswant (II/IV)

Staff Coordinators

Transport Committee

Mr. C. Obula Reddy

Staff Coordinators

Dr. G. Vijaya laxmi

Mr. K.Rajagopal,

Mr. Sri Ram Reddy

Mr. C. Obula Reddy

Student Coordinators

Mr. Mahaboob Basha

Ms. Divya (IV/IV)

Student Coordinators

Ms. Parinika (IV/IV)

Mr. Bharath (IV/IV)

Mr. Sowmith (IV/IV)

Mr. Koushik (IV/IV)

Mr. Dheeraj (IV/IV)

Mr. A Shravan (IV/IV)

Mr. Gowtham (IV/IV)

Student Organizers

Mr. Amith (IV/IV)

Ms. Vidyani (III/IV)

Student Organizers

Mr. Avinash (III/IV)

Ms. Archana (III/IV)

Mr. T. Nikhi (III/IV)

Ms. Keerthana (III/IV)

Mr. Rajashekar (III/IV)

Ms. Karuna (III/IV)

Hospitality Committee:

Ms. Manisha (III/IV)

Staff Coordinators

Ms. Manoranjani (III/IV)

Ms. S. Sumithra,

Ms. Monalisa (III/IV)

Dr. C. Anjaneyulu 16


Mr. Sri Ram Reddy

Staff Coordinators

Student Coordinators

Mr. Md. K.A. Matheen,

Mr. Anudeep (IV/IV)

Mr. K.Rajagopal

Mr. Harish (IV/IV)

Mr. Shaik Amir

Ms. Suhasini (IV/IV)

Student Coordinators

Ms. J.Nikitha (IV/IV)

Ms. Monica.M (IV/IV)

Ms. Prasanthi (IV/IV)

Ms. Sindhuja (IV/IV)

Ms. Lavanya (IV/IV)

Student Organizers

Student Organizers

Ms. Shravani (III/IV)

Ms. Apoorva (III/IV)

Student Volunteers

Ms. Harshitha (III/IV)

Mr. Vivek (II/IV)

Ms. Kirthi (III/IV)

Rangoli Committee:

Ms. Komali (III/IV)

Staff Coordinators

Ms. Monika (III/IV)

Ms. P.Sujatha,

Ms. Sarala (III/IV)

Dr. V. Aruna

Ms. Sravya (III/IV)

Ms. D. Madhavi latha

Ms. Sri vidya (III/IV)

Student Coordinators

Mr. Atufa (III/IV)

Ms. Lavanya (IV/IV)

Ms. Vasundhara (III/IV)

Ms. Suhasini (IV/IV)

Ms. Vahini (III/IV)

Ms. Nikitha.M (IV/IV)

Ms. Teja (III/IV)

Student Organizers

Mr. Nikhl (III/IV)

Ms. Jyothi.P (III/IV)

Mr. Rajashekar (III/IV)

Ms. Shamili (III/IV)

Student Volunteers

Student Volunteers

Ms. Lavanya (II/IV)

Ms. Sharanya (II/IV)

Ms. Sahithi (II/IV)

Ms. Laxmi gayatri (II/IV)

Ms. Sanjana (II/IV)

Ms. Monica (II/IV)

Ms. Sheetal (II/IV)

Ms. Keerthi (II/IV)

Ms. G.Monica (II/IV)

Website Designing :

Ms. C.Shruthi (II/IV)

Staff Coordinators

Ms. Sangam (II/IV)

Dr. T.Sai Krishna

Ms. Sudarsini (II/IV)

Mr. Md. K.A. Matheen

Ms. Sheefa (II/IV)

Mr. Sanjeeva

Souvenir Committee:

Student Coordinators 17


Mr. MD.Taquliah shariff (IV/IV)

Ms. Mona lisa (III/IV)

Student Organizers

Ms. Devi kumar (III/IV)

Ms. Lasya (III/IV)

Student Volunteers

Ms. Fauzan (III/IV)

Mr. Afia Fatima (II/IV)

Mr. Devendra (III/IV)

Ms. Rohina ansari (II/IV)

Student Volunteers

Ms .A.Preethi (II/IV)

Mr. Ranjith (II/IV)

Ms. Manasa (II/IV)

NON TECHNICAL EVENTS

Ms. Chethana reddy (II/IV)

Staff Coordinators

Mr. Divyanshu Tomar (II/IV)

Ms. S. Sumithra,

Ms. Sherisha (II/IV)

Dr. Soma Roy

Ms. Raoof (II/IV)

Mr. Mahaboob Basha

Ms. Mahathi (II/IV)

Student Coordinators

Ms. Sai mahathi (II/IV)

Mr MD.Taquliah Shariff (IV/IV)

Ms. Deepthi sree (II/IV)

Ms. Anupam singh (IV/IV)

Ms. Priyanka P (II/IV)

Ms. Meenakshi singh (IV/IV)

Ms. Q. Md. Mustafa sayeed (II/IV)

Ms. Monika.V (IV/IV)

Mr. Naresh (II/IV)

Ms. Mahek golechha (IV/IV)

Mr.Sarfaraz ahmed (II/IV)

Ms. Sphurthi kiran P (IV/IV)

Mr. Anjani (II/IV)

Ms. Gandhi heta (IV/IV)

Mr. Shiva (II/IV)

Ms. Shruthi (IV/IV)

Mr. Bharathi (II/IV)

Student Organizers

Mr. Chirisha (II/IV)

Mr. Likhith (III/IV)

Mr. Karthik (II/IV)

Mr. Nikhil (III/IV)

Mr. Adithya (II/IV)

Ms. Vipula Y (III/IV)

Ms. Sravani (II/IV)

Mr. Venkatesh (III/IV)

Ms. Rohini (II/IV)

Mr. Santhosh madhav A. (III/IV)

Ms. Priyanka

Mr. Vishnu (III/IV)

Ms. Mrudhula (II/IV)

Ms. Manisha (III/IV)

Mr. Pratap (II/IV)

Ms. Susana (III/IV)

Mr. Nagarjuna (II/IV)

Ms. Archana (III/IV)

Ms. Shraddha (II/IV)

(II/IV)

18


Key Note Address By

Dr. Sai Ram Head, R & D, Biological E Ltd, Genome Valley, Hyderabad, India & DRDO Scientist year of the award Given by PM, Dr. Manmohan Singh in 2005

19


High Throughput Technologies for Application in Healthcare DR. M. SAI RAM Head, R & D, Biological E Ltd, Genome Valley, Hyderabad, India

The emergence of sophisticated technologies in molecular and cellular biology spurred a relatively rapid evolution in life sciences especially in the area of biopharmaceuticals development. Combinatorial chemistry, bio-informatics and high throughput technologies make product development faster and more efficient. Using these approaches it is possible to prepare vast numbers of samples, under widely different processing conditions, very quickly. As a result, the product development cycle time and most importantly the cost get reduced significantly. In the present competitive market, a number of pharma and biotech products are released in the market every year. All these molecules are to be tested for their safety and efficacy. These biologicals require an extensive batch-related quality control, to ensure that the products are both safe and potent. In particular, the conventionally produced biologicals (that is, biological not produced by sophisticated new technologies such as rDNA) require further consideration. Vaccines, for instance, are produced in batches of 100-500 litres by inactivation or attenuation of the virulent microorganism or toxin, respectively. As a consequence, successive vaccine batches can differ in quality, such as in the epitope configuration of the relevant antigen, which might affect the efficacy or safety of the product. This makes a batch related quality control an essential instrument in the regulatory batch-release process. As vaccines belong to the basic tools of preventative human and veterinary health-care programmes, and as part of the control tests rely on animal models, it is inevitable that large numbers of animals are used. An additional aspect is that some of the animal tests, and in particular, the animal-demanding potency tests, are still based on the basic principle of protection, introduced by Ehrlich and Behring in the 1890s, that is, survival or death after challenge with the virulent micro-organism/toxin. This makes biologicals a category that involves a high level of pain and distress for the animals used. Recently there is an increased pressure from animal activists and regulatory bodies to develop alternative tests to replace animal‘s tests. Many initiatives have been undertaken in the last few decades to reduce, refine and replace the use of animals in this area. Some of the important high-throughput technologies that are used in product development and testing are being discussed.

20


21


Live Projects

22


EFFECT OF OPTIMIZATION OF ALKALI CONCENTRATION ON SUBSTRATE SWEET SORGHUM BAGASSE BY RESPONSE SURFACE METHODOLOGY DURING PRETREATMENT STUDIES FOR THE ENZYME HYDROLYSIS AND ESTIMATION OF SUGARS BY HPLC LAVUDI SAIDA1, M.LAKSHMI NARASU1, SATAYA PARAMESHWAR KONDA1SANDEEP SINGH DHALIWAL2 AND H.S.OBEROI2* 1. CENTRE FOR BIOTECHNOLOGY, INSTITUTE OF SCIENCE AND TECHNOLOGY, JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD, HYDERABAD – 500 085ANDHRA PRADESH, INDIA 2. SAROJINI NADIU VANITHA MAHAVIDYALAYA, NAMPALLY, HYDERABAD 3. CENTRAL INSTITUTE OF POST HARVEST ENGINEERING AND TECHNOLOGY, LUDHIANA-141004, PUNJAB, INDIA ABSTRACT Pretreatment studies were done by using both acid and alkali on agro-waste material, sweet sorghum bagasse(SSB) and further enzyme hydrolysis was done with a blend of commercial enzymes such as Celluclast, Novozym and pectinase mixtures as well as crude enzymes produced by Aspergillus niger by solid state fermentation. This was done to evaluate different pretreatment parameters such as time, temperature and acid/alkali concentration with the intention of finding conditions which generate high sugar yields. The pretreatment conditions assessed for acid treatment: temperature: 125-140ºC; time: 10 -25 minutes; and acid concentration 0.5%-1.5%. Similarly alkali pretreatment conditions selected were in the range of: temperature: 125-140ºC; time: 10 -30 minutes; and alkali concentration. 1.5%-4%. In both the cases substrate, the amount of sweet sorghum bagasse selected was 5 grams. The results showed that alkali treated sweet sorghum bagasse yielded higher sugar levels. Acid treated substrate exhibited non-significant yielding levels of sugars. Hence, in present study , alkali concentration optimization studies were performed by statistical designed experiment using Response Surface Methodology in order to establish to optimally high level yields of sugars such as glucose, arabinose & xylose.Further to perform enzyme hydrolysis studies to generate high yields of sugars, process parameter optimization was done by using Response Surface Methodology. Enzyme hydrolysis studies were done on sweet sorghum bagasse by selecting commercial enzymes includes celluclast, novozym & pectinase as well as crude enzyme obtained from Aspergillus niger cultures grown on sweet sorghum bagasse. Such an Enzyme hydrolysis experiments were conducted from 12 hours to 48 intervals of time. The enzyme hydrolysed products were fed to HPLC to estimate the concentrations of sugars like glucose, arabinose and xylose. Keywords: Acid and Alkali Pretreatment, Enzyme Hydrolysis, Response Surface Methodology

23


STUDY OF ENZYME KINETICS ON PRETREATED AND ENZYME HYDROLYSIS OF SUBSTRATE, SWEET SORGHUM BAGASSE BY USING STATIATICALLY DESIGNED CENTRAL COMPOSITE DESIGN METHODOLOGY. SATAYA PARAMESHWAR KONDA1, LAVUDI SAIDA2 AND H.S. OBEROI 3 1. SAROJINI NADIU VANITHA MAHAVIDYALAYA, NAMPALLY, HYDERABAD. 2.CENTRE FOR BIOTECHNOLOGY, INSTITUTE OF SCIENCE AND TECHNOLOGY, JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD, HYDERABAD – 500 085ANDHRA PRADESH, INDIA 3.CENTRAL INSTITUTE OF POST HARVEST ENGINEERING AND TECHNOLOGY, LUDHIANA-141004, PUNJAB, INDIA ABSTRACT Aim of the present investigation is to study Michaels & Mentens Kinetic parameters determination by using the different concentrations of substrate, sweet sorghum bagasse(SSB) and effect of temperature on the stability of enzyme through enzyme kinetics. In this study, enzyme hydrolysis was done after subjecting the sweet sorghum bagasse for pretreatment with both acid & alkali in order make available high yields of sugars. Pretreatment studies were optimized by statistical design expert , Central Composite Design Methodology selecting the parameters such as incubation time(10-30minutes) , temperature(125-140ºC) and concentrations of alkali/acid(1.5-4%/0.5-1-5%) and the amount substrate was taken as 5 grams. As, alkali treated substrate yielded higher sugar yields, further optimization was done for process parameters of enzyme hydrolysis to enhance the higher release of sugars by using the central composite design of Response Surface Methodology. Comparative analysis of enzyme hydrolysis were performed by obtaining commercial enzymes(celluclast, novozym & pectinase) and crude enzymes isolated from growing the cultures of Aspergillus niger using substrate, sweet sorghum bagasse by solid state fermentation. In order to determine the Michaels & Mentens kinetic parameters by LineWeaveerBurk method and to realize the effect of substrate concentration, various ranges selected were 10%, 12%, 14%, 16%, 18% & 20% percentiles. The impact of substrate concentration was studied in relation to time intervals between 12hours -48 hours. The graphs were plotted on the basis of results obtained in Y & X axis, sugar content versus time respectively. Similarly to identify stability of enzymes, kinetic study was performed taking temperature ranges such as 10, 20 , 30 , 40 , 50 , 60 , & 70 degrees of Celsius. The graphs were plotted against temperature & glucose Vs time on Y & X axis respectively. The validation of the results were done with the help of mathematical model of MM Kinetics and also effect of temperature on enzyme hydrolysis

24


PHARMACEUTICAL EFFECT OF INDIAN GOOSEBERRY ON ESBL (EXTENDED SPECTRUM OF Β-LACTAMASES) PRODUCING MULTIDRUG RESISTANT BACTERIA S. SRAVANAMMA AND V. RAMAKRISHNA DEPT. OF BIOTECHNOLOGY & BIOINFORMATICS, YOGI VEMANA UNIVERSITY, KADAPA – 516003.

ABSTRACT

The extracts of many plants used in traditional medicine contain curative agents that are used in many modern medicines. As part of the quest for potentially valuable plants of medicinal value, the Indian gooseberry (Phyllanthus emblica L.) is one of the most celebrating plants in Indian traditional medicine, Ayurveda. The fresh and dry Indian gooseberry fruits were collected from the agricultural farms in Kadapa region and used in our experiment focusing on biochemical characterization, and antibacterial effect against ESBL producing multidrug resistant bacteria – E. coli, Enterbacter aerogenes, Proteus mirabilis, Klebsiella pneumonaie, Pseudomonas aeruginosa, Staphylococcus aureus, Haemophilus influenza, and Salmonella typhi. The fruit materials (pulp and seed) were used for extraction of natural products by using initial reflux with 80% methanol and then solvent fractionation. All the extractions were biochemically characterized for polyphenols, flavanoids, tannins, lignans and alkaloids and antioxidant status and antibacterial effect. The present results were revealed the presence of high levels of tannins, polyphenols, and flavanoids and their high antioxidant activity is inhibiting the growth of many of ESBL producing multidrug resistant bacteria. It is concluded that the amla fruits with rich sources of these secondary metabolites may be attribute to the pharmacological properties against multidrug resistant bacteria.

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COMPARATIVE PRODUCTION OF PROTEASES FROM LOCALLY ISOLATED ASPERGILLUS SPECIES ASPERGILLUS FLAVUS AND ASPERGILLUS ORYZAE THROUGH SOLID STATE FERMENTATION V.S. KRANTHI1, DR. D. MURALIDHAR RAO2, AND P. JAGANMOHAN3. 1.DEPARTMENT OF BIOTECHNOLOGY, SRI RAMAKRISHNA DEGREE COLLEGE, NANDYAL, KURNOOL, ANDHRA PRADESH 2.DEPARTMENT OF BIOTECHNOLOGY, SRI KRISHNADEVARAYA UNIVERSITY, ANANTAPUR, ANDHRA PRADESH. 3.HARRISON INSTITUTE OF BIOTECHNOLOGY, SHRIMP CARE UNIT, RAMAMURTHY NAGAR, NELLORE, ANDHRA PRADESH. Proteases are the most important industrial enzymes and comprise about 25% of commercial enzymes in the world. Two third of the industrially produced proteases are from microbial sources. The proteolytic fungi was isolated from local soil .Two strains of Aspergillus spp Aspergillus flavus and Aspergillus oryzae were evaluated and wheat bran based Solid state fermentation was selected for protease production. Along with wheat bran, four oil seed cakes namely sesame oil cake, groundnut oil cake, cotton seed oil cake and mustard oil cake were selected and results shown that enzyme production was maximum when wheat bran was used as a substrate for both A.flavus and A.oryzae. With A.oryzae, groundnut oil cake was also found to be effective substrate after wheat bran. Various process parameters influencing protease production including fermentation time, temperature, pH and nutrient supplements were optimized under solid state conditions. The medium was supplemented with different nutrients in the form of organic and inorganic nitrogen and carbon sources. In both the strains ammonium nitrate was used as best nitrogen source. After 72hrs, A.flavus was shown to be a good producer of protease at pH 7.5 and 40째C temperature and where as with A.oryzae the maximum activity was at pH 7.0 and 35째C temperature after which the production was declined in both the cases. Among the various activators used A.flavus. protease activity was enhanced with ZnSO4 but for A.oryzae the activity was increased with FeSO4. In case of inhibitors EDTA inhibited the protease activity of A.flavus PMSF inhibited A.oryzae protease activity. Key words : Aspergillus flavus, Aspergillus oryzae, Protease production and optimization, Wheat bran, groundnut oil cake, EDTA, PMSF, Solid state fermentation

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PHYLOGENETIC ANALYSIS OF DNA POLYMERASE β NARENDRA KUMAR SAVALA, MANGAMOORI LAKSHMI NARASU* CENTRE FOR BIOTECHNOLOGY, INSTITUTE OF SCIENCE AND TECHNOLOGY, JNTUH, HYDERABAD - 500085,

Various DNA polymerases involved in DNA repair activity and these enzymes are involved in enhancing genomic stability by repairing the DNA damage. We attempted to categorize these enzymes as per the Base Excision Repair and find the relation between DNA polymerase β. This will help in the further analysis of repair enzymes. Sequences are taken from NCBI or KEGG. Phylogenetic analysis was done for this crucial enzyme and relationship was analyzed. This study may help in finding the diversity of this enzyme and scientific community can use it as therapeutic agent for DNA polymerase β associated disorders. Construction of Phylogenetic trees for DNA polymerase beta which plays a key role in short patch BER is analyzed. These analyses confer the evolutionary change in the repair enzymes, which is shown in the depicted results. However, these in turn will dictate the life span of the living organism. This is evident by the key role of DNA repair pathways in aging esp., DNA polymerase β in BER. BER plays very crucial role in the aging factor. An attempt was made here to understand the evolutionary relationship of DNA polymerase β to its nearbyrelated organism. However, it opens new avenue for further possible exploration for understanding the aging related phenomenon to under the Phylogenetic analysis to understand the differences in the lifespan of living organisms. Key words: DNA polymerase β, Phylogenetic analysis

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SCREENING, ISOLATION AND IDENTIFICATION OF EXTRACELLULAR LIPASE PRODUCING BACTERIA Bacillus sp BONALA KALYANA CHAKRAVRTHY, MANGAMOORI LAKSHMI NARASU* CENTRE FOR BIOTECHNOLOGY, INSTITUTE OF SCIENCE AND TECHNOLOGY, JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD, HYDERABAD

ABSTRACT

Lipase-producing bacterial strains were isolated from soil by employing enrichment culture techniques. An agar plate medium containing trybutryin agar was employed for isolation studies. Based on the radius of lypolytic halo, one strain which has shown maximum lipase activity was coded as K1 and was selected for further studies. The morphological, physiological and cultural characteristics of K1were determined according to Bergey's Manual of Determinative Bacteriology. 16S rRNA analysis of the culture K1 also was carried out for phylogenetic analysis.

Keywords: Lipases; Extracellular, and Bacillus sp

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MYOELCTRIC PROSTHETIC ARM K. NITISH REDDY, AMIT RAJ, KATKURI MAHENDAR DEPARTMENT OF BIOMEDICAL ENGINEERING GOKARAJU RANGARAJU INSTITUTE OF ENGINEERING & TECHNOLOGY ABSTRACT Objective: Our project is aimed at making an electromechanical prosthetic arm which has three degrees of motion that will be under the complete control of a person who has been amputated from the elbow-down. The prosthetic arm will be controlled by picking up the myoelectric signals of the muscles in the shoulder region which are voluntarily activated by the amputee. Methods: Two independent myoelectric signals are captured from two voluntary muscles in the shoulder region using surface electrodes fed to an instrumentation amplifier. Desirable square waves are generated from the muscle signals which will be used to control the motors of the prosthetic arm. Three distinct combinations of signals are generated from the two sets of electrodes each corresponding to a degree of motion. Conclusion: The final aim is to grab an object from a table and place is on another table using the prosthetic arm. This technology can be used for various parts of the body and can help restore full movement and control over different prostheses for an amputated or disabled person

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THE EVALUATION OF ANTI GENOTOXIC POTENTIALS OF INDIAN GOOSEBERRY /AMLA (PHYLANTHUS EMBLICA) IN HUMAN LEUKOCYTE CULTURES. SHARA SPURTHI BILLA JOGINPALLY B.R. ENGINEERING COLLEGE HYDERABAD. ABSTRACT In genetics, genotoxicity or mutagenicity describes a deleterious action on a cell's genetic material affecting its integrity. Genotoxic substances are known to be potentially

mutagenic or carcinogenic,

specifically

those

capable

of

causing genetic mutation and of contributing to the development of tumors. In chemotherapy, most of the anti-neoplastic drugs are also known mutagens, few studies have revealed that these drugs have equal adverse side effects along with their tumor killing mechanism. In this study, the genotoxicity of various anticancer drugs is taken into consideration as many previous studies show that, as a side effect, these drugs are causing secondary cancers as well in the patients consuming them, mostly by causing mutations in the surrounding non targeted cells. The health benefits of Indian Gooseberry is realised long back. This fruit is consumed in the form of pickles, sharbath and powders and also in ayurvedic preparations in India. It has been reported this fruit has anti-bacterial, anti-oxidative and anti-aging activities but this fruit has not been systematically studied for its anti genotoxic effects. In order to understand chemopreventive pharmacological importance of this fruit and encourage its use as functional food, we aim to study its potential anti genotoxic effects in using in-vitro cytogenetic assays. The results will be analyzed using appropriate statistical tools Key words: Anti bacterial, Anti oxidative, Anti genotoxic, Chemopreventive, Cytogenetic

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Paper Presentation

31


ANALYSIS OF VALPROIC ACID TREATED BREAST CANCER DATASETS USING MICROARRAY TECHNIQUES VENKATESWARAN RAJAN, KARTHICK SRINIVASS, NITHYA MATHIVANAN. DEPARTMENT OF BIOINFORMATICS, SASTRA UNIVERSITY, TANJORE. Breast cancer is the malignant growth of cells in the breast tissue. â&#x20AC;&#x2022;Interpersonal variabilityâ&#x20AC;&#x2013; occurs in response to the same drug treatment. This propels the need to identify the genes on it predicted sensitivity to treatment for a better response. The identification of prognostic markers and inherent polymorphisms shall play a vital role in comprehending the phenotypic variations pertaining to the same treatment. A microarray data set consisting of 12 samples (cancer lines) were treated for their predicted sensitivity to Valproic acid. Processed data is extracted and checked for quality using boxplot . Further the genes were filtered based on constraints levied on them. Multi-dimensional scaling is done to explore similarities of data. Relevant dataset is then tested for its statistical significance using ANOVA and is FDR corrected (p<0.05). The significant dataset is then validated

using

hierarchical

clustering.

The

subset

of

genes

(ADAM17,VWF,TEK,PIDD,GOLGA4) is scrutinized for its biological process and molecular

functions

thereby

identifying

candidate

molecular

pathways

(PI3K,NOTCH,EGFR signaling) that affect tumorogenesis. A sequence based approach that predisposes to the identification of pathogenic variants is employed.

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PRODUCTION OF CELLULASE FROM ANTIGONUM LEPTOPUS USING TRICHODERMA REESEI NCIM 1186 V.VARALAKSHMI, M.MANASA. CENTRE FOR BIOTECHNOLOGY, DEPARTMENT OF CHEMICAL ENGINEERING, ANDHRA UNIVERSITY.

Cellulolytic enzymes are essential for the maintenance of global carbon cycle since they initiate the degradation of cellulose, the major individual biomolecule in nature. Cellulase, hemicellulase, and pectinases are industrially important enzymes that are sold in large volumes for use in different applications; like starch processing, animal feed production, alcohol fermentation, malting and brewing, pulp and paper industry, textile industry, etc. Cellulases are one of the most extensively investigated multicomponent enzyme system because of their ability to decompose cellulosic biomass into glucose, which in turn can be converted to other valuable chemicals and energy. Complete cellulose systems can be produced by large diversity of microorganisms. In the present study, Cellulase was produced using Antigonum leptopus leaves as substrate by the fungus Trichoderma reesei. Various substrates and micro organisms were screened for their maximum cellulose production. Trichoderma reesei

and

Antigonum

FPU/ml).Production

leptopus

parameters

combination like

incubation

produced

maximum(4.36

time(72h),

incubation

temperature(30o C), particle size(180Âľm), inoculums volume(2 ml), pH(7.0) were found to be optimum for maximum enzyme production.

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SOLID STATE FERMENTATION OF ORANGE BAGASSE TO FERMENTATION TO PECTINASE BY ASPERGILLUS NIGER 616 CHANDRA DEEPTHI.A, REETU.P. CENTRE FOR BIOTECHNOLOGY, DEPARTMENT OF CHEMICAL ENGINEERING, ANDHRA UNIVERSITY VISAKHAPATNAM â&#x20AC;&#x201C; 530003

Pectinase or pectinolytic enzymes are a group that hydrolyses the pectic substances, mostly present in plants pectinolytic enzymes are widely distributed in higher plants and microorganisms .Pectinases are today one of the upcoming enzymes of the commercial sector . Primarily these enzymes are responsible for the degradation of the long and complex molecules called pectin that occur as structural polysaccharides in the middle lamella and in the primary cell walls of young plant cells. Pectinases are now an integral part of fruit juice and textile industries as well as having various biotechnological applications .They also aid in maintaining ecological balance by causing decomposition and recycling of waste plant materials. Plant pathogenicity and spoilage of fruits and vegetables by rotting are some other major manifestations of pectinolytic enzymes. It has been reported that microbial pectinases account for 25% of the global food enzymes sales. Almost all the commercial preparations of pectinases are produced from fungal sources. Aspergillus Niger is the most commonly used fungal species for the industrial production of pectinolytic enzymes. The present study is carried out on the production of pectinase by solid state fermentation with Aspergillus Niger NCIM 616 using orange bagasse. Maximum pectinase of 37-47 u/gds. Process parameters like fermentation time (3 days), temperature (32°c), pH (5.0), moisture content (80%v/w), molecular age (6 days), inoculums volume (2.5ml) were found to be optimum for maximum pectinase production.

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PRODUCTION OF XYLINASE BY ISOLATED BACTERIAL STRAIN CH. L. N. V. GANESH KUMAR, S. MANOJ KUMAR,D. SRI RAMI REDDY. CENTRE FOR BIOTECHNOLOGY, DEPARTMENT OF CHEMICAL ENGINEERING, ANDHRA UNIVERSITY, VISAKHAPATNAM â&#x20AC;&#x201C; 530003.

Xylan is the most abundant non cellulosic polysaccharide in hardwood (20-30%) and softwood (5%), which constitutes approximately 1/3 rd of all renewable carbon sources on earth, Is composed of a back bone chain of β-1,4-linked xylosyl residues and the short chains of arabinosyl, glucoronosyl and acetyl residues. The cost of the enzymes is one of the main factor determining the economics of a process, reducing the costs of enzyme production by optimizing process parameters and fermentation medium is the basic research for industrial application. Inorder to make the enzyme applications more cost effective at industrial level its production using low costs substrates such as agro-wastes has been recommended and the use of agro-wastes has been possible by Solid State Fermentation(SSF), which is closer to natural system and has proved to be more efficient in producing certain enzymes and metabolites. Xylan degrading enzymes have many important practical applications in various industrial processes, including the modification of cereal based food stuff, improving the digestibility of animal feed stocks and delignification of paper/paper product manufacture and recycling, textile manufacture, in baking, the release of aroma and anti-oxidant molecules, and in the production of biopharmaceuticals. The main objective of this present investigation is the production of xylinase enzyme using biological waste products which were rich in carbon sources by isolated bacterial strain. Process parameters like fermentation time, temperature, pH and rpm were optimized. Maximum xylinase enzyme was recorded with 7999 U/gds under pH 6.3, 370 C, 150 rpm and 24 hours duration.

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ALLELOPATHIC EFFECT OF LANTANA CAMARA AND L.PONGAMIA PINNATA LEACHATES ON SEED GERMINATION,SEEDLING GROWTH AND BIOCHEMICAL CHANGES ON PHASEOLUS.AUREUS AND BRASSICA.NIGRA. C.SOUMYA, K.KAULINI, K.JAYA SANDHYA, DR.G.VIJAYA LAKSHMI. GITAM UNIVERSITY. Molisch(1937)coined the term to describe all the chemicals interactions among plants.In the crop fields there is altleast one plant species grown together.When they grown together interact with each other either stimulating or inhibibiting their growth.The present paper illustrate about the how lantana camara and pongamia leachates effect the popular pulse crops,phaseolu species(p.aureus)there are hunderends of secondary metabolites in plant kingdom,many are known as phytotoxic.Alleopathic effect these compounds are often observed to occur early in the life cycle causing inhibition of seed germination and seedling growth.Inorder to obtain the results we have undertaken methods like extraction of lechates,effect of leachate on seed germination, effect of lechates on seedling growth,biochemical analysis,chlorophyll estimation,carbohydrate extraction.All the work done consisting of taking the different concentration of lechate with respect to percentage seed germination with two time intervals of 24 hours and 48 hours.

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PHARMACOGENOMICS ANJANI KUMAR, NAWAZ KHAN AND DIPTI. AMITY UNIVERSITY, LUCKNOW. Combinatorial pharmacogenetics seeks to characterize genetic variations that affect reactions to potentially toxic agents within the complex metabolic networks of the human body. Polymorphic drug-metabolizing enzymes are likely to represent some of the most common inheritable risk factors associated with common 'disease' phenotypes, such as adverse drug reactions. The relatively high concordance between polymorphisms in drug-metabolizing enzymes and clinical phenotypes indicates that research into this class of polymorphisms could benefit patients in the near future. Characterization of other genes affecting drug disposition (absorption, distribution, metabolism and elimination) will further enhance this process. As with most questions concerning biological systems, the complexity arises out of the combinatorial magnitude of all the possible interactions and pathways. The high-dimensionality of the resulting analysis problem will often overwhelm traditional analysis methods. Novel analysis techniques, such as multifactor dimensionality reduction, offer viable options for evaluating such data.

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NANOTECHNOLOGY ENABLED PLATFORMS FOR CONVERTING SALTWATER INTO DRINKING WATER SANKARANARAYANANN. SRI MANAKULA VINAYAGAR ENGINEERING COLLEGE. Nanotechnology sometimes shortened to "nanotech") is the study of manipulating matter on an atomic and molecular scale. Generally, nanotechnology deals with developing materials, devices, or other structures possessing at least one dimension sized from 1 to 100 nanometers. Quantummechanical effects are important at this quantum-realm scale. Nanotechnology entails the application of fields of science as diverse as surface science, organic chemistry, molecular biology, semiconductor physics, micro fabrication, etc. Nanotechnology may be able to createmany new materials and devices with a vast range of applications, such as in medicine, electronics, biomaterials and energy production. This paper deals the concept of making saltwater into drinking water by using nanotechnology.

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MUTATIONAL ANALYSIS OF FAS RECEPTOR GENE PROMOTER REGION IN BREAST CANCER AT -1377 NAGA SAGARIKA. SREENIDHI INSTITUTE OF TECHNOLOGY, HYDERABAD. Cancer is a multi-factorial and a complex disease with genetic basis. Number of mutations in Oncogenes have been found to cause various types of cancer. There has been an increase in the prevalence of cancers. One mutation, a single nucleotide polymorphism in the FAS receptor gene has been shown to be associated with variety of cancers, in Western population. This study is intended to examine whether the SNP (FAS -1377 G>A) has any association with female breast cancer in Indians. The SNP detection was carried out by using PCR â&#x20AC;&#x201C; RFLP.

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MICROBIAL AND BIOCHEMICAL ANALYSIS OF BACTERIA DEGRADING MERCURY ISOLATED FROM PESTICIDE INDUSTRIAL WASTE AKHILA. DANDAMUDI. VIGNAN UNIVERSITY.

Present scenario of studying microorganisms interacting with metal ions has increased worldwide in an interesting pattern. These studies are focussed in many fields for many applications, among which, studies concentrating bioremediation of soils and water, gains more attention. Environmental problems associated with heavy metals are very difficult to solve in contrast to organic matters because incineration or biodegradation can transform the latter. As a fact, most of heavy metals have toxic effects on living organisms when exceeding a certain concentration. The degradation processes of environmental pollutants can be considered from one side in the context of using these processes in natural and man-designed ways, which are introduced to technological practice in order to clean up particular environmental compartments (remediation). Here in this project bacterial strains were isolated from pesticide industrial waste and are further subjected to microbial and biochemical analysis to study their ability to degrade mercury present in those polluted lands.

40


PHYTOREMEDIATION SAIRAM BALASUBRAMANI, K. RAJASEKHAR. C.V.S.R COLLEGE OF ENGINEERING, HYDERABAD.

Phytoremediation is the use of living green plants for removal of contaminants from contaminated soil, water, sediments, and air. Specially selected or engineered plants are used in the process. Phytoremediation is an energy efficient method of remediating sites with low to moderate levels of contamination and it can be used in conjunction with more traditional remedial methods as a finishing step to the remedial process. It is very much advantageous over other conventional remediation processes when we consider the cost factor. Breeding programs and genetic engineering are powerful methods for enhancing natural phytoremediation capabilities, or for introducing new capabilities into plants. Genes for phytoremediation may originate from a micro-organism or may be transferred from one plant to another variety better adapted to the environmental conditions at the cleanup site.

41


MINIMAL INVASIVE TREATMENT OF CANCER BY USING RFHYPERTHERMIA BY APPLICATION OF NICKEL-FERRITE NANOPARTICLES Y.SAI CHAITANYA, B.S.RAHUL BHARADWAJ, K.SAMEENDRA. OSMANIA UNIVERSITY, HYDERABAD. Cancer is a disease caused by an uncontrolled division of abnormal cells in a part of the body, which is affecting millions of people leading to death. Even though there have been tremendous developments taken place over the last few decades the effective therapy for Cancer is still not a reality. The existing techniques of cancer therapy are Chemotherapy and radio therapy which are having their limitations in terms of the side effects, patient discomfort, radiation hazards and the localization of treatment. The novel method for cancer therapy is by using RF-hyperthermia application of Nano particles. The synthesized Ferro magnetic Nano particles and characterized by using XRD and TEM. These Nano particles after the bio compatibility studies will be injected in to the body with a suitable tracer element having affinity to the specific tumour site. When RF energy is applied to the Nano particles at the tumour site it produces heat of excess room temperature and nearly 41-45째C is sufficient to kill the tumour cells.The RF source generator designed for this purpose is provided with a temperature feedback controller to control the radiation induced temperature of the tumour site. The temperature control is achieved through a negative feedback mechanism of the thermocouple and a relay connected to the power source of the RF generator. This method has advantages in terms of its effect like localized therapy, less radiation, and no side effects. It has several challenges in designing the RF source provided with coils suitable for the tumour site, Biocompatibility of the Nano materials, cooling system design for the RF coil. If we can overcome these challenges this method will be a huge benefit for the society.

42


REGENERATIVE MEDICINE M.VIJAYASREE. TEEGALA RAM REDDY COLLEGE OF PHARMACY, HYDERABAD. Umbilical cord blood is blood that remains in the placenta and in the attached umbilical cord after child birth. Cord blood is collected because it contains stem cells which can be used to treat hematopoietic and genetic disorders. While stem cells have been hailed as providing wondrous treatments for illnesses, it is their ability to form into completely new organs that is truly miraculous. Weâ&#x20AC;&#x2DC;ve seen the creation of organs such as the bladder, and even witnessed the beating of an artificially grown heart, but the work at Columbia University is the first development of bone. Slowly but surely, it seems that we are developing the means by which every portion of the human body could be replicated or grown in a lab. This may one day lead to the creation of entirely new bodies for those damaged irrevocably, or even for the recently deceased. Stem cells are biological cells found in all multicellular organisms, that can divide (through mitosis) and differentiate into diverse specialized cell types and can self renew to produce more stem cells. As we are not much aware of stem cells we didnâ&#x20AC;&#x2DC;t preserved our cord blood during our birth. We still have an opportunity to store our stem cells by preserving the single tooth. It might be surprising but its true. A Single tooth can save our life from chronic diseases like cancer, diabetis, thalaseemia etc.

43


STEM CELL TECHNOLOGY N.V.S.M KARTIK. NIZAM COLLEGE, HYDERABAD. This presentation will provide a brief overview of the functions and characteristics of stem cells and the applications of stem cell technology in effective treatment for a variety of malignant and non- malignant diseases.Stem cells are defined as totipotent progenitor cells capable of self renewal and multilineage differentiation. Stem cells have the remarkable potential to develop into many different cell types in the body during early life and growth. Stem cells are distinguished from other cell types by two important characteristics. First, they are unspecialized cells capable of renewing themselves through cell division. Second, they can be induced to become tissue- or organ- specific cells with special functions. Stem cells are categorized into two classes, embryonic stem cells and non- embryonic ―somatic‖ or ―adult‖ stem cells. Stem cell technology is a rapidly developing field. Stem cell technology could be used to produce replaceable tissues or organs. It would also be possible to genetically engineer stem cells to accomplish activities that they would ordinarily be programmed to do. Part of this engineering could involve the delivery of chemotherapeutic agents for treatment of cancers and tumors.

44


BRAIN GATE SYSTEM VINAY KUMAR.B, DHEERAJ KUMAR.K VIGNAN INSTITUTE OF TECHNOLOGY AND SCIENCE, NALGONDA. The mind-to-movement system that allows a quadriplegic man to control a computer using only his thoughts is a scientific milestone. It was reached, in large part, through the brain gate system. This system has become a boon to the paralyzed. The Brain Gate System is based on Cyber kinetics platform technology to sense, transmit, analyze and apply the language of neurons. The principle of operation behind the Brain Gate System is that with intact brain function, brain signals are generated even though they are not sent to the arms, hands and legs. The signals are interpreted and translated into cursor movements, offering the user an alternate Brain Gate pathway to control a computer with thought, just as individuals who have the ability to move their hands use a mouse. The 'Brain Gate' contains tiny spikes that will extend down about one millimeter into the brain after being implanted beneath the skull, monitoring the activity from a small group of neurons. It will now be possible for a patient with spinal cord injury to produce brain signals that relay the intention of moving the paralyzed limbs, as signals to an implanted sensor, which is then output as electronic impulses. These impulses enable the user to operate mechanical devices with the help of a computer cursor. Matthew Nagle,a 25-year-old Massachusetts man with a severe spinal cord injury, has been paralyzed from the neck down since 2001.After taking part in a clinical trial of this system, he has opened e-mail, switched TV channels, turned on lights. He even moved a robotic hand from his wheelchair. This marks the first time that neural movement signals have been recorded and decoded in a human with spinal cord injury. The system is also the first to allow a human to control his surrounding environment using his mind.

45


MICROCONTROLLER BASED ANESTHESIA INJECTOR E. PRASANNA KUMAR, J. B. S. MAHESH

In the hospitals when any major operation is performed, the patient must be in anesthetize condition. If the operation lasts for a long time, say for suppose for 4 or 5 hours, complete dose of anesthesia cannot be administered in a single stroke. It may lead to the patientâ&#x20AC;&#x2DC;s death. If lower amount of anesthesia is administered, the patient may wakeup at the middle of the operation. To avoid this, the anesthetist administers few milliliters of anesthesia per hour to the patient. If the anesthetist fails to administer the anesthesia to the patient at the particular time interval, other allied problems may arise. To overcome such hazardous problems the design of an automatic operation of an anesthesia machine based on a micro-controller is effective. In this system a keypad is provided along with the microcontroller and syringe infusion pump. The anesthetist can set the level of anesthesia in terms of milliliters per hour to administer anesthesia to the patient with the help of keypad. After receiving the signal from the keypad, the microcontroller controls the signal to the desire level and fed into the stepper motor to drive the infusion pump in proper manner. The anesthesia is administered to the patient according to the stepper motor rotation (the syringe will move forward or backward direction). This particular paper will be very much useful to physicians to see the current position of anesthesia of the patients. If the level of anesthesia is decreased to lower level (set value), the alarm will be initiated to alert the physician to refill the anesthesia in the Syringe Pump to continue the process.

46


NANOROBOTS IN CANCER TREATMENT S.PAVANI, M.VANI PRIYADARSHINI. SANTHIRAM ENGINEERING COLLEGE. The long time endeavour to find a weapon to fight cancer became fruitful with the invention of nanorobots. Nanorobotics is a blend of nanotechnology and robotics. Nanorobots are tiny robots of a size of bacteria which are highly efficient, skilled, accurate and specific in their work. They can easily move through the cell walls of human body. They are capable of detecting cancerous cells in the early stage by analyzing the mutation from the normal genetical and molecular structure. Once they trace the cancerous cell they starts to destroy them by using various tools of nanotechnology. Nanorobots see to it that they does not harm the healthy cells. This avoids the harmful side effects as like in the contemporary chemotherapy. Thus the patient doesnâ&#x20AC;&#x2DC;t get isolated from the common world and recovers faster. In this paper we bring to light the basic structural outline of a nanorobot, various tools used by a nanorobot to trace and cure cancer, challenges faced by a nanorobot and future hope of nanorobotics in cancer treatment.

47


PHOTOTROPHIC BIOFILMS. SRI RAMYA. JBREC, HYDERABAD.

Phototrophic biofilms (or) Microbial mats occur on surfaces exposed to light in a range of terrestrial and aquatic environments. Oxygenic phototrophs like diatoms, green algae, and cyanobacteria are the major primary producers that generate energy and reduce carbon dioxide, providing the system with organic substrates and oxygen. Photosynthesis fuels processes and conversions in the total biofilm community, including the metabolism of heterotrophic organisms. A matrix of extracellular polymeric substances (EPS) secreted by phototrophs and heterotrophs enhances the attachment of the biofilm community. In this paper the cultivation of phototrophic biofilms in laboratory and its range of applications in wastewater

treatment,

bioremediation,

fish-feed

production,

biohydrogen

production, development of biofouling agents and soil improvement for overcoming the global environmental problems like pollution, scarcity of food and non-renewable sources etc. are discussed.

48


TERMITICULTURE: ENVIRONMENTAL TECHNOLOGY FOR NEW MILLENIUM. JYOTHI.M AND RANJITHA.U. DEPARTMENT OF BIOTECHNOLOGY, J.B.I.E.T. It is utmost an urgency to develop a protocol for termite mediated bioconversion of lignocellulosic wastes to animal biomass. As our population continues to grow two important considerations arise, firstly the increase in the amount of waste produced, and secondly the increased demands on our food production systems. The utilization of termites for the bio conversion of waste is able to address both these problems. Most of the waste generated in India contains more than 60%of lignocellulosic and 0.7% of plastic item, matter of major concern. Termites are a selected group of animals that are able to derive energy from these lignocellulosic (Agricultural, paper, forest, dairy, dead wood etc.) wastes. The production of biomass through termite system is almost 10 times greater than that of traditional grazer system. Termites are able to convert efficiently lignocellulosic waste material to animal biomass. The production system may generate useful by products resulting potentially be utilized as a food source for poultry and aquiculture. In this paper a brief ideas has been introduced as to how termiticulture is better than vermiculture and other decomposers organisms in major part of solid waste disposal. This will be a new 21st century environmental technology for waste disposal problem in our country.

49


NOVEL METHODS IN DRUG DESIGN AND DELIVERY V. BHARADWAJA. JBREC, HYDERABAD. Most drugs are designed to act on proteins that somehow malfunction in ways that lead to damage and disease in the body. The active ingredient in these medicines is typically a single molecule that can interact with a protein to stop its misbehavior. Finding such a molecule, however, is not easy. It ideally will be shaped and configured in a way that allows it to bind with a protein on what are known as ―hot spots‖ on the protein surface – and the more hot spots it binds to, the more potential it has to be therapeutic. To accomplish this, many drug molecules are composed of units called fragments that are linked through chemical bonds. An ideal drug molecule for a specific protein disease target should be a combination of fragments that fit into each hot spot in the best possible way. New computer modeling method of drug design has the potential to complement and increase efficiency of more time-consuming methods like Nuclear Magnetic Resonance and X ray Crystallography. With this new computer simulation technique, called multiple ligand simultaneous docking, we can instruct molecular fragments to interact with each other before the actual experimental trials, removing weak and ―noisy‖ fragments so only the promising ones are left. ―They sense each other‘s presence through molecular force. They suppress the noise and go exactly where they are supposed to go. ―You find the right fragment in the right place, and it‘s like fitting the right piece into a jigsaw puzzle.‖ A novel method, RASSE, has been developed to suggest reasonable structures which can fit well to the binding sites of receptors. Molecules are generated by an iterative growing procedure in which atoms are added to existing fragments. Potential ligands are then picked out by special scoring rules. This atom-growing based method is characterized by combinatorial searching of atom types and conformations. To some extent, it is the computer simulation of combinatorial chemistry. Conventional forms of drug administration generally on pills, eye drops, ointments, intravenous solutions. Recently a lot of novel drug delivery approaches have been developed. These approaches include drug modification by chemical means, drug entrapment into small vesicles that are injected into the bloodstream and drug entrapment within pumps or polymeric materials that are placed in desired bodily compartments( eg: eye or beneath the skin). These techniques have already led to delivery systems that improve human health and continued research may revolutionize the way many drugs are delivered.

50


VIRAL VECTOR TECHNOLOGY-A NOVEL APPROACH OF GENE THERAPY FOR THE MANAGEMENT OF GENETIC DISORDERS AND CHRONIC PAIN SPURTHI AND SIDDHARTHA. JBREC, HYDERABAD. Gene therapy is a recent advancement which was found to be effective and a viable alternative for treating various genetic disorders. It has many approaches of delivering the desired gene of which the viral vector technique is known to show better efficacy. The viral vector technique uses various viruses like adenoviruses, lentiviruses, retroviruses, Adeno-associated virus (AAV) and herples simplex virus (HSV) of which the AAV and HSV were found to be a successful means of gene transfer. This viral vector technology has proven effective in treating genetic disorders like Heamophilia B and chronic pain caused due to diseases like cancers and auto immune and neurological disorders. Inspite of many therapeutic medical approaches towards the treatment of these disorders, management of chronic pain still remains a challenge. Apart from inadequacy of relief, there are concerns about adverse effects and addiction in the case of certain drugs like opiods. The recent significant and constant advances in vector systems designs in gene

therapy imply that these

techniques will be available in the near future for safe and long-lasting applications in humans for treating chronic pain and other genetic disorders.

51


ADVANCED COMPUTATIONAL STRUCTURAL BIOINFORMATICS KOUSAR BEGUM. DECCAN SCHOOL OF PHARMACY.

Bioinformatics is the application of computer science and information technology to the field of biology and medicine. Bioinformatics deals with algorithms, databases and information systems, web technologies, artificial intelligence and soft computing, information and computation theory for generating new knowledge of biology and medicine, and improving & discovering new models of computation (e.g. DNA computing, cellular-computing etc.,). Bioinformatics was applied in the creation and maintenance of a database to store biological information at the beginning of the "genomic revolution", such as nucleotide sequences and amino acid sequences. Development of this type of database involved not only design issues but the development of complex interfaces whereby researchers could both access existing data as well as submit new or revised data. Since the Phage ÎŚ-X174 was sequenced in 1977,[5] the DNA sequences of thousands of organisms have been decoded and stored in databases. This sequence information is analyzed to determine genes that encode polypeptides (proteins), RNA genes, and regulatory sequences. Analysis of mutations in cancer for e.g.: In cancer, the genomes of affected cells are rearranged in complex or even unpredictable ways. Massive sequencing efforts are used to identify previously unknown point mutations in a variety of genes in cancer. Structural Bioinformatics approaches as protein structure prediction is another important application of bioinformatics. The Bioinformatics and Computational Biology (BCB) program is an interdisciplinary program that involves the application of mathematics and computing to the study of genes and proteins; computational biology addresses more general questions involving computing applied to cellular and sub-cellular structures.

52


STEM CELL THERAPY FOR TYPE-1 DIABETES SHAIKH SHABNAM. DECCAN SCHOOL OF PHARMACY, HYDERABAD.

Stem

cells are biological

cells found

in

all

multicellular organisms,

that

can divide and differentiate into diverse specialized cell types and can self-renew to produce more stem cells. The economic and psychological tolls of chronic, degenerative, and acute diseases in the world are enormous. The total costs of treating diabetes, for example is approaching $100 billion in the United States alone. As more research takes place, the developmental potential of different kinds of stem cells will become better understood. As the science is understood now, adult stem cells are limited in their potential to differentiate. Embryonic germ cells have a great differentiation capacity, and embryonic stem cells are thought to be able to differentiate into almost any tissue. Search for a cure for type-1 diabetes mellitus has lead to many avenues of research, all having the same objective: to replace the lost beta cells and prevent their further destruction by the immune system. With the recent advancement in stem cell technology, it may be possible to gather enough stem cells for transplantation purposes. But some legal and ethical issues are still there, causing stem cell research to turn its head towards adult stem cells. Moreover, it may take many years to convert this research into a clinically useful application within reach of mankind. ―Stem Cell therapy is safe, and in individuals with moderate or severe [Type-1 diabetes], a single treatment produces lasting improvement in metabolic control,‖ the study concludes that: ―Initial results indicate Stem Cell therapy reverses autoimmunity and promotes regeneration of islet beta cells.‖

53


NETWORK SECURITY THROUGH BIOMETRICS (PALM VEIN TECHNOLOGY) K.T.MALLIKA & K.RAMYA SRI. GUDLAVALLERU ENGINEERING COLLEGE. With the increase in technology threat to personal data and national security had also increased .The methods that were developed to secure important information from outside intervention were not up to safe mark .There was a need to introduce a technology that secures our data more efficiently from unlawful intervention . Fujitsu has developed a palm vein pattern authentication technology that uses vescular patterns as personal identification data .Vein recognition technology is secure because the authentication data exists inside the body and is therefore very difficult to forge. It is highly accurate. This technology can be used in various fields like banking, hospitals, government offices, in passport issuing etc. Business growth will be achieved with these solutions by reducing the size of the palm vein sensor and shortening the authentication time. This paper is about the palm vein technology, its applications, how this technology is applied in real time applications and the advantages of using this technology.

54


BIOMETRICS NITISHA AND SINDHURI. PRASAD V. POTLURI SIDDHARTHA INSTITUTE OF TECHNOLOGY. Fingerprint system is an important biometric technique for personal identification. We have discussed the design and implementation of a prototype fingerprint authentication system. The system incorporates high precision floating point digital signal processor for capturing the image from the scanner, realizing parameters extraction algorithm and authentication of the user. Entire system is a standalone module with LCD and key pad units user accessibility. Frequency domain based enhancement and template extraction algorithm is implemented since DSP processor efficiently performs image and signal processing algorithms with less processing time. The standalone system allows the user to enroll, authenticate, deletes fingerprints and data base management within a short span of time. The authentication procedure, on average, takes about less than 0.1 seconds.

55


ADVANCED COMMUNICATION THROUGH FLESH- RED TACTION. MOUNIKA AND VISHNU PRIYA. QIS COLLEGE AND TECHNOLOGY. Our body could soon be the backbone of a broadband personal data network linking your mobile phone or MP3 player to a cordless headset, your digital camera to a PC or printer, and all the gadgets you carry around to each other. RedTacton is a new; it is completely distinct from wireless and infrared. A transmission path is formed at the moment a part of the human body in contact with a RedTacton transceiver. Physically separating ends the contact and thus ends communication. Human Area Networking technology that uses the surface of the human body as a safe, high speed network transmission path. Uses the minute electric field emitted on the surface of the human body .Technically according to the user's natural, physical movements. Communication is possible using any body surfaces, such as the hands, fingers, arms, feet, face, legs or torso. RedTacton works through shoes and clothing as well. Here, the human body acts as a transmission medium supporting half-duplex communication at 10Mbit/s. The key component of the transceiver is an electric-field sensor implemented with an electro optic crystal and laser light.

56


NANOBOTS G.SAI KUMAR, M.VARUNDEEP. AUDISANKARA COLLEGE OF ENGG. AND TECH., GUDUR.

Ongoing

developments

in

current

engineering

technology

enable

the

manufacturing of nanobots â&#x20AC;&#x201C; nanoscale bio molecular machine systems. These are intended for treatment or elimination of medical problems where accumulation of undesired organic substances interferes with normal body function, such as tumors, arteriosclerosis, blood clots, accumulation of scar tissue and others. They can also be applied in chemotherapy to combat cancer and to deliver anti HIV drugs. In this paper emphasis is laid with much speculation on possible future applications of nanotechnology.

Solutions are proposed

regarding nanobotâ&#x20AC;&#x2DC;s method of entry into the body, means of propulsion, maintaining a fixed position while operation, control of device, power source, means of locating substances to be eliminated, elimination of unwanted substances and finally the removal of the device from the body. This will not only help in curing the ailments but will also provide valuable empirical data for further developments in the arena.

A little information regarding the appropriate

manufacturing techniques for the construction of the device is also provided and also about a innovative device which acts as an electronic eye to blind people.

57


ORGANIC ELECTRONICS RAJ SEKHAR. KOTTAM COLLEGE OF ENGINEERING, KURNOOL. Many of the people had had been saying cell phones become a part of our body but this presentation will lead you to know a fact that the major component of our body, carbon will become a part in future cell phones. What this presentation exactly says is we know that silicon material is major component in many of the electronics devices like transistors, diodes, op-ampsâ&#x20AC;Ś, and what not. We canâ&#x20AC;&#x2DC;t judge anything as big until we place a small thing besides it similarly up to now we are thinking that silicon is the only most useful material in making the electronic components. But there is one material carbon which is going to replace silicon with its attractive properties. Now this presentation will made you to realize how this CARBON replaces SILICON and what is the necessity of GRAPHENE.

58


BIODIESEL FROM JATROPHA OIL AS AN ALTERNATIVE FUEL FOR DIESEL ENGINE BARGHAVI AND SPANDANA. CMRIT, HYDERABAD. The world is getting modernized and industrialized day by day. As a result vehicles and engines are increasing. But energy sources used in these engines are limited and decreasing gradually. This situation leads to seek an alternative fuel for diesel engine. Biodiesel is an alternative fuel for diesel engine. The esters of vegetables oil animal fats are known as Biodiesel. This paper investigates the prospect of making of biodiesel from jatropha oil. Jatropha curcas is a renewable non-edible plant. Jatropha is a wildly growing hardy plant in arid and semi-arid regions of the country on degraded soils having low fertility and moisture. The seeds of Jatropha contain 50-60% oil. In this study the conversion of oil into biodiesel by the well-known transesterification process is discussed and also how it is used it to diesel engine for performance evaluation.

59


NANO ROBOTS IN MEDICINE VENKATESH AND HEMANTH KUMAR. SRI SIVANI INSTITUTE OF TECHNOLOGY. Better tools could provide both better knowledge and better ways to apply that knowledge for healing. Today‘s surgery can rearrange blood vessels, but is far too coarse to rearrange or repair cells. Today‘s drug therapies can target some specific molecules, but only some, and only on the basis of type. Doctors today can‘t affect molecules in one cell while leaving identical molecules in a neighboring cell untouched because medicine today cannot apply surgical control to the molecular level. The solution for this problem is the emerging field ―NANO ROBOTICS‖.It can be simply termed as the use of robots of nano-scale to daigonise and cure of a disease at a particular ailment.This paper gives an overview of the applications of nanorobotics in bio-medicine and the need for upliftment of present medical technology to nanorobotics.

NANOTECHNOLOGY Nanomedicine, Biomedical applications of Nanorobotics, properties of Nanomedical robots, Drug Encapsulation , drug discovery, Example applications are as follows: 1.Retina Implants 2.Cochlear Implants 3.Surgical aids 4. Operating Tools 5.Surgical Robotics 6.Diagnostic tools 7.Genetic Testing 8.Artificial mitochondria

60


ENERGY HARVESTING TREES SAILESH. Sun, wind, water, earth and life touch our living senses immediately always, everywhere and without any intervention of reason. They simply are there in their unmatched variety, moving us, our moods, memories, imaginations, intensions and plans. Solar Botanic will introduce artificial trees that make use of renewable energy from the sun and wind, they are an efficient clean and environmentally sound means of collecting solar radiation and wind energy. Here at Solar Botanic, they have amassed a wealth of information relating to Solar Botanic Trees and Nanoleaves and the field of photovoltaic thermo-voltaic and piezovoltaic technology. we will be amazed how efficient these Trees are, how they make use of light, heat and wind and turn it into useable electricity for your home or car. In this biomimicry concept of trees are fitted with Nanoleaves, a combination of Nano-photovoltaic- Nano-thermo voltaic and Nano-piezo generators converting light, heat and wind energy into green electricity .These Nanoleaves convert the complete solar spectrum converting visible light, infrared and UV in combination with piezo electric generators that convert wind energy into electricity providing you with efficient, cost effective and aesthetic solutions, providing maximum electric power. The area of combined photothermovoltaic with piezovoltaic is concerned primarily with converting sunlight and wind energy into electricity. This task is accomplished through the use of natures design, artificial trees shrubs, plants and flowers all equipped with nanoleaf technology PV cells. We believe in trees and plants and their thermo-photovoltaic qualities 

Triple efficiency.

Durable.

Low investment/high return.

Easy to install.

Weather resistant: rain, hail, dust, lightning, wind.

Good monetary values for private homes.

Various sizes, colors and species

Aesthetic natural design, in harmony with nature.

61


ď&#x201A;ˇ

Application for designer gardens, penthouses, balconies

ď&#x201A;ˇ

Wide arrangement of Solar flowers, shrubs (solar shrub fencing) water plants.

Solar Botanics can be used for: Windshield, Shade, anti glare, objectionable views, sound barrier, windbreak, wind obstruction and much more. With the progress in Nano technology, the photovoltaic, thermo voltaic and piezo electric materials are becoming more efficient and combined in one system it will give our products more efficiency and we believe that soon, Solar Botanic will be a mainstream green energy provider, more reliable/cheaper and above all better looking. To capitalize on the wealth of designs and processes found in nature, engineering and technology gave us the ingredients, creative thinking, and unique solutions made it possible to bring all this together into a natural looking trees.

62


ENVIRONMENTALBIOTECHNOLOGY AISHWARYA AND PAVANI KALYANI. GNITS, HYDERABAD.

Environmental Biotechnology is the multidisciplinary integration of sciences and Engineering in order to utilize the huge biochemical potential of biological systems for the protection, restoration and preservation of the environment and for the sustainable use of natural resources. The session will cover technology developments of environmental biotechnology reinvigorated by advances in emerging genomics, proteomics and metabolomics and developments of how biotechnological and engineering techniques are applied to solve environmental problems. With their novel biological properties,biotechnology products may also pose unique regulatory challenges. Therefore, this session will address potential ecological impacts of biotechnology products in support of regulatory policies on environmental biotechnology. This session provides a perfect resource for people needing to develop a sound understanding of environmental biotechnology, to have better knowledge of how it can be applied to address important environmental issues, and to have better understanding of risk assessment and management

of

new

applications

of

environmental

biotechnology.

New development of environmental biotechnologies (in both Omics and engineering areas) New development of applications of environmental biotechnology (bacterial source

tracking,

bioremediation,

degradation,

environmental

effects

bio-processing,

renewable

biotechnology

products;

resources, etc.) Detection

of

of

Monitoring, regulatory compliance, and policies.

63


GENETHERAPY KOUSHIK AND MOUNIKA. TKR ENGINEERING COLLEGE, HYDERABAD.

gene therapy is the insertion of genes into an individual's cell and biological tissues to treat disease, such as cancer where deleterious mutant alleles are replaced with functional ones. scientists have taken the logical step of trying to introduce genes directly into human cells, focusing on diseases caused by singlegene defects, such as hemophilia, sickle cell anemia. there are two types of gene therapy, they are1)germ line therapy and somatic gene therapy,in germline therapy,germ cells i.e. sperm cells or eggs are modified by the introduction of functional genes.and in the case of somatic gene therapy,the therapeutic genes are transferred into somatic cells of a patient certain steps are included in that and also in somatic gene therapy

there are 1)invivo gene therapy 2)exvivo

gene therapy. the hope of gene therapy is to have the cell produce more of the cured cells and spread throughout the rest of the body. if successful, the patient would never need factor replacement therapy again and would be cured of hemophilia. some of the gene delivery system are retrovirus, adenovirus etc.

64


USE OF BIOMASS ENERGY FOR RURAL ELECTRIFICATION M.AVINASH & A.LAKSHMIPATHI. G. PULLA REDDY ENGINEERING COLLEGE, KURNOOL. The development of Renewable Energy Sources is necessary for the sustainable development of India. Of these Renewable energy sources biomass accounts for about 76% of energy generation in India. As rural areas produce sufficient biomass and agricultural residues, its energy demands can be met through the conversion of these biomass into energy. The continuous availability of biomass at cheaper price makes it an efficient source for the generation of electricity in rural India. This paper presents an idea to solve energy related problems in rural India using biomass energy sources.

65


PONGAMIA OIL DADAPEER AND NIZAMUDDIN. SRI KRISHNADEVARAYA ENGG. COLLEGE. ANANTAPUR Petroleum products resources are limited and their consumption in increasing very fast with globalization and high technology development since last decade. Diesel consumption is about 45% of the total consumption of petroleum products. The present and expected consumption rates imply that these reserves may not last beyond the next 30 years. Over the last 15 years the demand for petroleum products in India has risen at an annual compound rate of 6.1% and the situation could be more difficult for diesel engines. Apart from conservation there is a global threat to the environment due to polluting nature of conventional fuels. The solution to these twin problems will be utilizing the vegetable oils. There are more than 300 different species of trees, which produce oil-bearing seeds. A lot of research is going on the potential use of many vegetable oils â&#x20AC;&#x201C;neem, castor, Soya bean, cottonseed, rapeseed, sunflower, palm oil, pongamia oil etc. This paper provides detailed information, based on some experimental work, on the use of pongamia oil as biofuel. This includes highlighting the production methods, presenting some technical data in comparison with diesel and its economics. Tucked away in forests where electricity was ruled out due to practical problems, tribes in Adilabad district have been resorting to tapping this tree for oil. The efforts are richly rewarded. Today, they have power supply from generators run on pongamia oil. Presently research agendas include testing engine durability, engine durability and some recommendations are made regarding suitability of pongamia oil as an alternative fuel in the Indian context.

66


CRYONICS PRAVEEN KUMAR AND PRUTHVINATH REDDY. RAJHIV GANDHI MEMORIAL ENGG. COLLEGE. Today technology plays a vital role in every aspect of life. Increasing standards in technology in many fields , has taken man today to high esteem. But the present available technologies are unable to interact with the atoms, such

a

minute

particles. Hence Nanotechnology has been

developing.

Nanotechnology is nothing but a technology which uses atoms with a view to creating a desired product. It has wider applications in all the fields. The important application is Cryonics. Cryonics is nothing but an attempt of raising the dead - making them alive. First we preserve the body then by using molecular machines based nanotechnology we could revive the patients by repairing damaged cells. In this technical paper we would like to discuss cryonics, how the process of

cryonics

goes on

and

why

nanotechnology

is

being

used

and

description of molecular machines which has the capability of repairing damaged cells. Therefore Cryonics is an area in which most of the work is to be done in future.

67


ENVIRONMENTAL BIOTECHNOLOGY SANA TABASSUM DECCAN SCHOOL OF PHARMACY, HYDERABAD. Biotechnological processes to protect the environment have been used for almost a century now, even longer than the term â&#x20AC;&#x2014;biotechnologyâ&#x20AC;&#x2DC; exists. Municipal sewage treatment plants and filters to purify town gas were developed around the turn of the century. They proved very effective although at the time, little was known about the biological principles underlying their function. Since that time our knowledge base has increased enormously. This briefing paper describes the state-of-the-art and possibilities of environmental biotechnology. It also deals with the societal aspects of environmental biotechnology. Biotechnological techniques to treat waste before or after it has been brought into the environment are described and exemplified in the section on bioremediation. Biotechnology can also be used to develop products and processes that generate less waste and use less non-renewable resources and energy. In this respect biotechnology is well positioned to contribute to the development of a more sustainable society, a principle which was advocated in the Brundtland Report in 1987 and in Agenda 21 of the second Earth Summit in Rio de Janeiro in 1992 and which has been widely accepted in the mean time. The development of modern biotechnology has been accompanied by the establishment or adaptation of regulations to deal with genetically modified organisms. What this means for environmental biotechnology is embodied in the section on legislation. The section on public opinion, dialogue and debate highlights how people feel about environmental biotechnology and ways in which their opinion is influenced.

68


GENE THERAPY WITH ENGINEERED STEM CELLS M.V.N.MAHATHI, T.CHAITANYA BOJJAM NARASIMHULU PHARMACY COLLEGE FOR WOMEN.

Gene therapy is a technique which uses type of stem cell, a lymphocyte, or a fibroblast for correcting defective genes responsible for disease development. The strategy involves the use of living cells to deliver therapeutic transgenes into the body. The stem cells are majorly used in gene therapies as they are a selfrenewing population of cells and thus may reduce or eliminate the need for repeated administrations of the gene therapy. Initially, gene therapy clinical trials focused on cancer, infectious diseases, or disorders in which only a single gene is abnormal, such as cystic fibrosis. However, efforts are being directed towards complex, chronic diseases that involve more than one gene.

69


STEM CELLS REPAIR DAMAGED SPINAL CORD SRAVYA. JBREC, HYDERABAD.

The discovery of the potential utility of stem cells in neurological repair and regeneration is an exciting development in neuroscience. The mechanical force incurred by spinal cord injury results in degenerative neural tissue damage beyond the site of initial injury. By nature, the central nervous system (CNS) does not regenerate itself. Cell therapy, in particular, stem cell implantation has become a possible solution for spinal cord injury. Isolation and preparation of specific populations of adult stem cells have evolved to the point of stable, longterm culturing with the capability to differentiate into neural phenotypes from all three of the neural lineages: neurons, astrocytes, and oligodendrocytes. A variety of adult stem cells have been implanted in a rat model of spinal cord injury, ranging from olfactory ensheathing cells, cultured spinal cord stem cells, bone marrow derived stem cells, dermis derived stem cells.

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BIOFUEL PRODUCTION FROM ALGAE KIRANMAI B, BHARGAVI K. SREENIDHI INSTITUTE OF SCIENCE & TECHNOLOGY, HYDERABAD. Fossil fuels are finite and their continuous exploitation releases green house gases which causes global warming. Bio fuels are natureâ&#x20AC;&#x2DC;s alternative to fossil fuels. They can be derived from plants sources and microalgae. Algae based biofuel definitely has the potential to revolutionize the energy industry and play leading role in fight against green house gas emissions and climate change. Biofuels produced from algae appears to be only feasible solution today for replacing petrol-diesel completely. No other feedstock has the oil yield high enough for it to be in a position to produce such large volumes of oil. To elaborate, it has been calculated that in order for a crop such as soybean or palm to yield enough oil capable of replacing petro-diesel completely, a very large percentage of the current land available needs to be utilized only for biofuel crop production, which is quite infeasible. Growth of algae in bioreactor is one of the current trends due to less doubling time. By harvesting method, we can extract sweet crude oil. By using separation techniques, sugars and fatty acids are separated. Biofuel is produced by the Transesterification. Native algal species like BOTRYOCOCCUS, CHLORELLA and SCENEDESMUS etc.., occur in waste water has great potential to produce biofuels and concomitantly clean up the aquatic environment. Bio fuels production from algae has the beneficial byproduct of reducing carbon and NOx emissions from power plants if algae grown using exhausts from the power plants.

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EMERGING TRENDS OF INSULIN DELIVERY THROUGH BUCCAL ROUTE. JAMPANI REVATHI, PEDDAPATLA RAGHU VAMSHI GOUD. VISHNU INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH, VISHNUPUR, NARSAPUR, MEDAK. Diabetes is attaining epidemic proportions across the world. The most prevalent treatment strategy for diabetes focuses on the control of postprandial blood glucose which is found to be associated with cardiovascular diseases. In recent years, insulin delivery routes have undergone a radical change. The subcutaneous route may not necessarily succeed in providing satisfactory postprandial hyperglycemic management. The ultimate goal of exogenous insulin regimen in diabetics is to closely and correctly imitate the physiological profile observed in non-diabetics. Over the last decade, many routes including pulmonary, nasal, rectal, transdermal, buccal and ocular have been studied for insulin delivery to achieve the therapeutic insulin levels using non-invasive drug delivery systems. Recently the buccal route has been evaluated for safe, simple, fast and flexible insulin delivery. The objective of this review is to provide an update on various promising approaches that have been explored for buccal delivery of insulin. The buccal insulin spray has provided an alternative form of insulin to the patient as well as to the physician.

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NEEDLE-FREE INSULIN DRUG DELIVERY PRIYANKA MADDIRAL, S.NARENDER REDDY VISHNU INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH, VISHNUPUR, NARSAPUR, MEDAK- 502313.

For most patients with type 1 diabetes, the worst part of the disease is to tolerate needle after needle, both for glucose measurement and to deliver insulin. In the last two decades, concept of insulin therapy by multiple-dose injection has undergone a miraculous change. Needle-free insulin delivery appeared to be a wonderful approach, and its allure rested in being comfortable and safe. In today's era, insulin delivery by alternative route is a topic of current interest in the design of drug delivery system. Major global pharmaceutical companies are showing encouraging progress in their attempts to develop alternative insulin delivery technologies. Many such drug delivery systems have been developed for oral, buccal and nasal route. Emerging technologies, include insulin inhalers, insulin spray, insulin pill, insulin analogues, insulin complement, islet cell transplant, implantable insulin pumps and guardian continuous glucose monitoring system.

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LEECHES TO SUCK YOUR BLOOD T.S MRINALINI VISHNU INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH VISHNUPUR, NARSAPUR, MEDAK DISTRICT.

Leech Therapy, also known as Hirudotherapy [from the Latin hirudo-leech] has been recognised since ancient times and is still widely used today as a natural treatment for many areas and diseases .Leeches are 'worms' with suckers on each end. Leeches can range in size from one centimeter to over 25 centimeters long. They are brown or black in colour. Some feed on decaying plant material. Others are parasites, feeding on blood and tissue of other animals. Leech saliva contains several bioactive substances, including anti-coagulants, vaso-dilators, and anesthetics. Hirudin, a potent anticoagulant in leech saliva, inhibits the conversion of fibrinogen to fibrin, preventing blood from clotting. Leech therapy is experiencing resurgence in healthcare today, primarily in plastic and reconstructive surgery as a treatment for venous congestion, which can threaten surgical outcomes. Leeches are miraculous creatures and utilized to restore and assist health. Nowadays, more and more people are seeking natural treatments to gain health benefits without the harmful side-effects that medications often create.

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MULTIMODAL-BIOMETRICS CH.CHAITANYA KRISHNA & S. LAVANYA. NARASARAOPETA ENGINEERING COLLEGE. With the increase in technology threat to personal data and national security had also increased .The methods that were developed to secure important information from outside intervention were not up to safe mark .There was a need to introduce a technology that secures our data more efficiently from unlawful intervention .this can be done by using biometrics While the word ―Biometrics‖ sounds very new and ―High -Tech‖, it stands for a very old and simple concept: Human .Recognition. In technical terms, Biometrics is the automated technique of measuring the physical characteristics or personal trait of an individual and comparing that characteristic or trait to a database for purpose of recognizing that individual. 

Security systems have realized the value of biometrics, use biometrics for 2 basic purposes...to verify and to identify users.

The use of finger prints, facial recognition and other biometrics for identification is becoming more common.

The paper overviews best of biometric application for security management.

The paper focus Iris is the best biometric feature for Identity Management.

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VIRTUAL SURGERY AAMIR SOHAIL, RISHANTH KANAKADRI. V .R. SIDDHARTHA ENGG COLLEGE., Rapid change is under way on several fronts in medicine and surgery. Advance in computing power have enable continued growth in virtual reality, visualization, and simulation technologies. The ideal learning opportunities afforded by simulated and virtual environments have prompted their exploration as learning modalities for surgical education and training. Ongoing improvements in this technology suggest an important future role for virtual reality and simulation in medicine.

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BIOMECHANICS MANASA. CBIT, HYDERABAD. Biomechanics is one of the more significant disciplines in the field of Exercise Science and Human Movement. The word is derived from the Greek term ‗bio‘ meaning ‗living‘ and ‗mechanic‘ meaning ‗forces.‘ The primary purpose of biomechanics is to evaluate a living organism‘s motion as well as its applications of force. In other words, biomechanics is a discipline that applies the laws of mechanics and physics to study the bodily movements and the causes of movements, both internally and externally.

77


BRAIN COMPUTER INTERFACE A.SINDHU, ARSHI NAYAAR.

Brain-computer interface (BCI) also called brain-Machine interfaces or neural interface systems is collaboration between a brain and a device that enables signals from the brain to direct some external activity. The interface enables a direct communications pathway between the brain and the object to be controlled. BCI uses a human thought as a communication channel between Brain and Computer. A BCI is able to detect the userâ&#x20AC;&#x2DC;s wishes and commands while the user remains silent and immobilized. By reading signals from an array of neurons and using computer chips and programs to translate the signals into action. BCI can enable a person suffering from paralysis to write a book or control a motorized wheelchair or prosthetic limb through thought alone. It holds the promise of bringing sight to the blind, hearing to the deaf, and the return of normal functionality to the physically impaired.

78


NANOBIOTECHNOLOGY::BIOCHIPS CONNECTING TO THE DNA COMPUTERS. A TOOL FOR BIOMEDICAL APPLICATION. KRITHIKA SANKARAN. Mankind ought to get marvelled by the enigma of what the nano-future holds for it! Feeling the biotech atmosphere every moment of our day, all of us ought to know a gist of what the scintillating DNA computers are! These computers as we know do everything right from the most basic arithmetic operation to detecting encrypted signals, hacked codes, crime detection at the forensics etc etc. And ofcourse does it a zillion times faster than a normal computer that are made of the microprocessors, microcontrollers/ integrated circuits etc given that the error propability rates are ridiculously high. The DNA computer works almost the same as any electronic computer except that it follows a biological route. More than 10 trillion DNA molecules can fit into an area of than 1 cubic centimeter (0.06 cubic inches). With this small amount of DNA, a computer would be able to hold 10 terabytes of data, and perform 10 trillion calculations at a time. By adding more DNA, more calculations could be performed The DNA logic gates rely on DNA code. They detect fragments of genetic material as input, splice together these fragments and form a single output. These logic gates might be combined with DNA microchips to create a breakthrough in DNA computing. One great barrier that comes in front is the error rates. When a normal computer that uses a signal integrated IC this DNA computer would obviously have great error rates as here we aren't dealing with completely manmade artificial electronics. If just this small problem could be avoided the DNA computer would just be ground breaking success. So it is a proposal that instead of just using the biochips in DNA computer we can use both the integrated circuits and the biochips as well, that are connected by transmission lines. Coming to the technical aspect of it, (the gene) DNA embedded on the chip, lets say the to it that the radio frequency is accurate), so that the problems that are in the height of necessity to us can be performed by the biochip, the other normal operations by our IC. The PIT(Programmable Intreval Timer that triggers an interrupt when it reaches the programmed count ) acts as a mediator between the biochip and the integrated circuit. This PIT is categorized under CMOS( A

79


BASIC CIRCUIT) used in whichever form can act as a mediator. It can be a oneshot timer or an periodic one. Depends on our requirement. . The same principle can be extended to the biomedical applications wherein The biochips would detect any mismatch or complications in our bio-samples to be detected( just the same principle applied in the biosensors , after this the connection is missed and would go with the signal IC where other programming is right royally done and the outputs are given out. The whole of this proposal is possible unequivocably only if the logic I/O signals are appropriate and the transmission lines work at the right time and ofcourse if the equipments are adequate. This would prove to be economically viable and highly efficient in less time.

80


OPTICAL BIOSENSOR SENSITIVITY OF PHOTONIC CRYSTAL RESONANT MIRROR S.GEETHA SRAVANI, G.BHAGYASREE. SWARNANDHRA COLLEGE OF ENGG & TECHNOLOGY.

This paper presents the detail analysis of sensitivity of optical biosensor using typical photonic crystal resonant mirror. The Maxwell equations have been solved initially to determine the optical field intensity. In due course the effective index method has been utilized to determine the effective index of the optical biosensor device. The effective index has significant impact on sensitivity, hence it has been deduced and the result reveals that with the increase in the effective index the sensitivity decreases. Hence, to compensate the optical sensor device dimensions and material properties the other crucial parameters have been also realized to achieve the optimized device dimensions and material properties for better sensitivity of the optical biosensor.

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BRAIN - COMPUTER INTERFERENCE D.L.PRIYANKA, B.SINDHU PRIYA. RCEW. The field of Human Computer Interaction (HCI) is an interdisciplinary development having roots in computer graphics, operating systems, human factors, ergonomics, cognitive psychology, and others [SIGCHI_HCI]. This term implies that there is a bidirectional communication between the computer and the user where each communication channel may utilize very different techniques and devices for effective communication (one channel for user input and one channel for feedback to the user by the computer). Current devices for achieving input into the computer mainly require physical or more precisely mechanical operation by the user, e.g. mouse and keyboard. Feedback from the computer is commonly given by audio/visual elements, e.g. speakers and monitors showing GUIs. However, the limitations in terms of usability and accessibility are well understood and have become apparent throughout the course of time. The main principle in overcoming these limitations is called Multimodal Interaction and there is a lot of ongoing research in this field. For example, current developments in Multimodal Interaction propose a combination of a visual modality with a voice modality for better usability and accessibility. A somewhat unconventional approach to achieving human-computer-interaction involves directly translating thoughts of the user into commands to the computer. In this context the term â&#x20AC;&#x2022;thoughtâ&#x20AC;&#x2013; refers to the computer-aided interpretation of neuronal activities of the user. Neuronal activities may be recorded either at certain extremities of the human (arms, legs, etc.) or at the brain itself by analyzing brain waves. In principle, this approach is not limited to input into the computer but moreover may include methods for the computer to give feedback to the user by directly stimulating neurons. This paper gives an overview of this small subset of HCI putting an emphasis on Brain-Computer-Interaction (BCI). We will elaborate on its historical background, technologies used for implementing it and finally we will discuss possible and current applications.

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83


Poster Presentation

84


ANTI HIV TREATMENT USING NANOROBOTS D.R.S.PRANEETHA &SK.SALEEM BABA RAMI REDDY SUBBARAMI REDDY ENGG.COLLEGE

Nanorobotics is the technology of creating machines or robots at or close to the microscopic scale of a nanometers (10-meters).More specifically, nanorobotics refers to the still largely hypothetical nanotechnology engineering discipline of designing and building nanorobots. Nanorobots would be typically devices ranging in size from 0.1-10 micrometers they could work at atomic, molecular and cellular level to perform work Nanorobots are likely to be constructed of carbon atoms, generally in diamond structure because of inert properties and strength, glucose (or) natural body sugars and oxygen might be source at propulsion. Nanorobots will respond to acoustic signals. The credential part of this paper gives the theoretical application of nanodevices in the treatment of AIDS. There is no technology for the treatment of AIDS. Some of the drugs of specific composition are given to the patients depending on the intensity of the disease. Nowadays the drugs are able to increase the lifetime to a few years only. To make the treatment more specific, we use the nanodevices that use nanosensors to sense the AIDS infected WBC‘s. In this we are using nanorobots to get back the HIV infected WBC‘s. By doing so, constant levels of WBC‘s are maintained in the blood stream. Thus the AIDS patient is provided with the immune system so that he can defend himself from diseases.

85


BIONIC EYE Y.CHANDRA KANTH REDDY, D.A PURUSHOTHAM A.S.C.E.T / J.N.T.U.A, GUDUR, ANDHRA PRADESH-524101, INDIA

In a healthy eye, the rods and cones on the retina convert light into tiny electrochemical impulses that are sent through the optic nerve and into the brain, where they‘re decoded into images. If the retina no longer functions correctly— due to conditions such as Retinitis pigmentosa (RP) or Age-related Macular degeneration (AMD)—the optic nerve can be given information from an artificial source bypassing the photoreceptor mechanism in the path. Capturing images and converting them into electrical signals is the easy part. The much trickier part is wiring the input into a person‘s nervous system. Retinal implants currently being tested pick up radio signals from a camera mounted on a pair of glasses and then directly stimulate the nerve cells behind the malfunctioning rods and cones. Subretinal implantation proves to be a better solution than epiretinal implantation in leading the blind into light.

Keywords: Subretinal implantation, images to electrical signals, retinal implant

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NANOBOTS-NANOMEDICINE G.SAI KUMAR, M. VARUNDEEP RAJU AUDISANKARA COLLEGE OF ENGINEERING AND TECHNOLOGY GUDUR, ANDHRAPRADESH.

Ongoing

developments

in

current

engineering

technology

enable

the

manufacturing of nanobots â&#x20AC;&#x201C; nanoscale bio molecular machine systems. These are intended for treatment or elimination of medical problems where accumulation of undesired organic substances interferes with normal body function, such as tumors, arteriosclerosis, blood clots, accumulation of scar tissue and others. They can also be applied in chemotherapy to combat cancer and to deliver anti HIV drugs. In this paper emphasis is laid with much speculation on possible future applications of nanotechnology.

Solutions are proposed

regarding nanobotâ&#x20AC;&#x2DC;s method of entry into the body, means of propulsion, maintaining a fixed position while operation, control of device, power source, means of locating substances to be eliminated, elimination of unwanted substances and finally the removal of the device from the body. This will not only help in curing the ailments but will also provide valuable empirical data for further developments in the arena.

A little information regarding the appropriate

manufacturing techniques for the construction of the device is also provided and also about a innovative device which acts as an electronic eye to blind people.

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POWERSAT P.C.NAGA JYOTHI & K.HEMALATHA MALINENI LAKSHMAIAH WOMEN‘S ENGINEERING COLLEGE PULLADIGUNTA, GUNTUR – 522017

The oil shocks of 1970s led to spiraling crude oil prices in the world market which prompted planners to view energy security as an issue of national strategic importance. Energy security has an important bearing on achieving national economic development goals and improving the quality of life of the people. World‘s dependence on crude oil will continue for most part of the 21st century but the continued dependence on crude oil is loaded against it with inherent price volatility linked to finite global reserves. In addition, global warming, caused largely by greenhouse gas emissions from fossil fuel energy generating systems, is also a major concern. So, there is a need to develop alternate fuels like nonconventional sources, considering the aforesaid two concerns.

This paper describes about the solar energy, one of the non-conventional sources and different ways of using it to convert to electric energy.

88


BIOLOGICAL COMPUTER THAT CAN READ DNA R. BHARARTH & R.JAGADEESH A.S.C.E.T / J.N.T.U.A, GUDUR, ANDHRA PRADESH-524101

Californian and Israeli researchers have created a biological computer — a machine made from biological molecules — that has successfully decoded two images stored and encrypted within DNA. Storing data in DNA isn‘t all that hard — its primary purpose is to store genetic data and creating a biological computer to decode those long strings of nucleotides is impressive. In the original Turing machine, a long strip of paper contains data and instructions. The data is fed into the machine, and rules (software) decide what kind of computation is done to the data. Basically, Keinan the scientist and co created a mixture of molecules in a test tube that were capable of performing the same, repeatable set of instructions on a helix of DNA. Encoded DNA goes into the biological computer and decoded DNA comes out the other. To track the progress of the machine, the DNA was tagged with fluorescent markers. The end result, a biological computer that can take an encoded image and decode it into fluorescent images. The power source is ATP — the same adenosine triphosphate that powers the metabolism of every cell in your body. Still, it‘s impossible to ignore that these systems are completely biological. There‘s no electricity, no silicon, no external display; we‘re storing usable data in DNA and processing it using molecules. Who‘s to say that, one day, we won‘t have a biotech implant that reads (or rewrites!) our DNA when needed? Imagine a future where you can store data in your bloodstream.

Keywords: Decoding &encoding DNA, storing data in DNA & processing it with molecules.

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TREATMENT OF PATIENTS WITH BLOOD VESSEL OBSTRUCTION USING NANOROBOTS S. SRIMATHI & R. HEMAVATHY

This paper presents the study of nanorobots control activation for stenosed coronary obstruction, with the everyday use of chemical and thermal ascents for biomedical evils. The use of thermal and chemical in the treatment of stenosed blood vessels is the most natural process for nanorobot transducer effective development. The

recent advances on nanotechnology new

materials

associated with electronics device shrinking may empower nanorobots for the next few years. Nanorobots are expected to enable new treatments for patients suffering from different diseases, and will result in are makeable advance in the history of medicine. It may help in the treatment of a wide number of diseases: cardiovascular problems, neurosurgery, cancer, diabetes and new cell remedies. Organic nanorobots that work on ATP and DNA based molecular machines, are known as bionanorobots. In this case the idea is the development of ribonucleic acid and adenosine triphosphate devices, and even the use of modified microorganisms to achieve some kind of biomoleculer computation, sensing and actuation for nanorobots. Another approach for the development of molecular machines is organic nanorobot. Inorganic nanorobots development is based on tailored

nanoelectronics.

In

comparison

with

bionanorobots,

inorganic

nanorobots could achieve a considerably higher complexity of integrated nanoscale components. The implementation of new methodologies to help on manufacturing studies and system plan for the development of nanoscale molecular machine is one of the most important fields for research. The use of 3D physically based simulation in conjunction with clinical data may provide ways to design practical approaches for control and transducers development.

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THE ROLE AND SIGNIFICANCE OF IMMUNOHISTOCHEMICAL METHOD IN ORAL NEOPLASIA J.V.AADITYA1, CH.APARNA SHARMA,1 DR.J.SARADA2 & DR S.SUDHA MURTHY3 1. DEPARTMENT OF BIOTECHNOLOGY, CMR COLLEGE OF ENGINEERING & TECHNOLOGY. 2. DEPARTMENT OF MICROBIOLOGY, BHAVANS VIVEKANANDA COLLEGE. 3. BASAVA TARAKAM INDO-AMERICAN CANCER HOSPITAL & RESEARCH INSTITUTE.

Immunohistochemistry (or IHC) is a method for demonstrating the presence and location of antigens in cells of tissue sections. Though less sensitive quantitatively than immunoassays such as Western blotting or ELISA, it enables the observation of processes in the context of intact tissue. This is especially useful for assessing the progression and treatment of diseases such as cancer. In general, the information gained from IHC combined with microscopy literally provides a â&#x20AC;&#x2022;big pictureâ&#x20AC;&#x2013; that can help make sense of data obtained using other methods. Immunohistochemical staining is accomplished with antibodies that recognize the target protein. Since antibodies are highly specific, the antibody will bind only to the protein of interest in the tissue section. The antibody-antigen interaction is then visualized using either chromogenic detection, in which an enzyme conjugated to the antibody cleaves a substrate to produce a colored precipitate at the location of the protein, or fluorescent detection, in which a fluorophore is conjugated to the antibody and can be visualized using fluorescence microscopy. Oral cancer is the sixth most common malignancy and is a major cause of cancer morbidity and mortality worldwide. The potential benefits of early diagnosis are reduced mortality, reduced incidence of invasive carcinomas, and improved treatment of smaller lesions of lower morbidity. Histological diagnosis might be improved by a more specific diagnostic biomarker that could help to identify premalignant and malignant lesions more precisely. The study of cell cycle control has shown that the capacity for malignant growth is acquired by the stepwise accumulation of defects in specific genes regulating cell growth. Tumor cells are therefore believed to result from deregulation of two major pathways of cell cycle control: the p53 and pRB pathways mediated by p16 INK4A. We describe the Immunohistochemical method employed in identifying molecular markers involved in oral cancers and hence contributing in enhancing the treatment strategies by focusing on the clinical samples evaluated at Basavatarakam Indo American Cancer Hospital & Research Institute, Hyderabad. Key words: Oral neoplasia, Immunohistochemistry, p16, Biomarker.

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IN-SITU BIOREMEDIATION OF URANIUM (VI) N.NAGAMMAL &T.R. PREETHI NARAYANI SASTRA UNIVERSITY, THANJAVUR, TAMIL NADU.

Nuclear waste is a major threat to the environment with Uranium as the major hazardous pollutant which exists in the oxidation state of +6 and is highly soluble in ground water. Though many laboratory scale remediation techniques are under way, efficient large scale bioremediation has not been carried out. To solve this problem, we propose a technique using Geobacter species for the reduction of soluble Uranium (VI) to insoluble Uranium (IV).

The technique

involves the usage of acetate as electron donor for the reduction process. Here we genetically engineer the microorganism to increase its tolerance for the other toxic substances present in the soil (which might reduce its reduction capacity).This genetic manipulation is done by insertion of rbo gene from desulfovibrio for managing oxidative stress. The major drawback of the conventional process is the re-oxidation of Uranium (IV) back to Uranium (VI) which is due to the presence of dissolved oxygen, nitrate, methanogens, etc. This can be prevented by the formation of a stable complex of Uranium with a chelating agent. This facilitates the formation of a coordination complex which ensures that the oxidation state of +4 is maintained. The insoluble Uranium can then be removed either by biosorption using inactive biomass or by gravity settling. Biosorption also ensures that the Uranium particles are trapped and does not percolate deeper into the soil. The economics of the process is mainly dependent on the large scale production of engineered microorganism and the equipments required for drilling into the contaminated site for supply of carbon source and nutrients. But if such a process is carried out and found to be efficient, it will serve as a productive technique for protecting the environment from the rapidly increasing hazardous nuclear wastes.

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THE BRAIN FINGERPRINTING TECHNOLOGY A PATENTED NEW TECHNIQUE OF PROVEN ACCURACY CH.SAI PRIYANKA & B.SRI LAKSHMI NARAYANA COLLEGE OF ENGINEERING, NELLORE ABSTRACT

Brain Fingerprinting is a new computer-based technology to identify the perpetrator of a crime accurately and scientifically by measuring brain-wave responses to crime-relevant words or pictures presented on a computer screen. Brain Fingerprinting has proven 100% accurate in over 120 tests, including tests on FBI agents, tests for a US intelligence agency and for the US Navy, and tests on real-life situations including felony crimes.

93


MICROBIOVORES A.RAJANI, P. MANJUSHA, BOJJAM NARASIMHULU PHARMACY COLLEGE FOR WOMEN, VINAY NAGAR, SAIDABAD, HYD.

Nanomedicine offers the prospect of powerful new tools for the treatment of human diseases and the improvement of human biological systems using molecular nanotechnology. This presents a theoretical Nanorobot scaling study for artificial mechanical phagocytes of microscopic size, called "microbivores," whose primary function is to destroy microbiological pathogens found in the human bloodstream using a digest and discharge protocol. The microbivore is an oblate spheroidal nanomedical device measuring 3.4 microns in diameter along its major axis and 2.0 microns in diameter along its minor axis, consisting of 610 billion precisely arranged structural atoms in a gross geometric volume of 12.1 micron. The device may consume up to 200 pW of continuous power while completely digesting trapped microbes at a maximum throughput of 2 micron of organic material per 30-second cycle. Microbivores are up to ~1000 times fasteracting than either natural or antibiotic-assisted biological phagocytic defenses, and are ~80 times more efficient as phagocytic agents than macrophages, in terms of volume/sec digested per unit volume of phagocytic agent.

Keywords: microbiovores-nanomedicine-nanorobot study-phagocytic defenses.

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NANOMEDICINE â&#x20AC;&#x201C; A REVOLUTIONARY DRUG DELIVERY SYSTEM T.VIJAYA LAKSHMI, B. PREETHI, G.SRAVAN G.PULLA REDDY COLLEGE OF PHARMACY, HYDERABAD

Nanotechnology is the engineering of functional systems at the molecular level. This involves the nano particles! Particles measuring one-billionth of a meter, a 100,1000th width of a human hair! Nanomedicine is the medical application of nanotechnology. Nanomedicine seeks to deliver a valuable set of research tools and clinically useful devices in the near future. As the nanomedicine industry continues to grow, it is expected to have a significant impact on the economy. Nanomedical approaches to drug delivery center on developing nanoscale particles or molecules to improve drug bioavailability. This can potentially be achieved by molecular targeting by nano-engineered devices. Nanotechnology is also opening up new opportunities in implantable delivery systems, Because of the blood brain barrier (BBB) many new chemical entities aimed at treating brain disorders have proved not to be clinically useful. Nanoparticles have been demonstrated to cross the BBB with little difficulty .It is all about targeting the molecules and delivering drugs with cell precision. Drug delivery systems, lipidor

polymer-based

nanoparticles,

can

be

designed

to

improve

the

pharmacological and therapeutic properties of drugs. When designed to avoid the body's defense mechanisms . Potential nanodrugs will work by very specific and well-understood mechanisms; one of the major impacts of nanotechnology and nanoscience will be in leading development of completely new drugs with more useful behavior and less side effects. Current problems for nanomedicine involve understanding the issues related to toxicity and environmental impact of nanoscale materials.

95


NANO-MATERIALS TOXICITY RAMYA SRI & SAHITHI

Nano-pollution is a generic name for all waste generated by nano devices or during the nano materials manufacturing process. This kind of waste may be very dangerous because of its size. It can float in the air and might easily penetrate animal and plant cells causing unknown effects. Most human-made nano particles do not appear in nature, so living organisms may not have appropriate means to deal with nano waste. To properly assess the health hazards of engineered nano particles the whole life cycle of these particles needs to be evaluated, including their fabrication, storage and distribution, application and potential abuse, and disposal. The impact on humans or the environment may vary at different stages of the life cycle. Environmental assessment is justified as nano particles present novel (new) environmental impacts. Scrinis raises concerns about nano-pollution, and argues that it is not currently possible to â&#x20AC;&#x2022;precisely predict or control the ecological impacts of the release of these nano-products into the environment.â&#x20AC;&#x2013;

Key words: Nano-pollution, nano-waste, health hazards, environment impacts

96


NANOTECHNOLOGY: A PROMISING QUEST CHAITANYA THAKUR DECCAN SCHOOL OF PHARMACY

The term nanotechnology was defined by Tokyo Science University Professor Norio Taniguchi in a 1974. The word nanotechnology can be split to nano (very small

usually

0.1

to

100nm

and

technology

(comprise

technological

developments) Nanotechnology mainly consists of the processing of, separation, consolidation, and deformation of materials by one atom or one molecule. Nanotechnology or, as it is sometimes called, molecular manufacturing, is a branch of engineering that deals with the design and manufacture of extremely small electronic circuits and mechanical devices built at the molecular level of matter, Nano science and nanotechnology are an extension of the fields of material science, nanotechnology is used to describe the interdisciplinary fields of science devoted to the study of nanoscale phenomena employed in nanotechnology

and

nanoscience

is

the

world

macromolecules assemblies and is dominated

of

atoms,

molecules,

by surface effects such as

Vander Waals force attraction, hydrogen bonding, electronic charge,etc. Two concepts associated with nanotechnology are positional assembly and selfreplication. Positional assembly deals with the mechanics of moving molecular pieces into their proper relational places. Molecular robots are devices that do the positional assembly. Self-replication deals with the problem of multiplying the positional arrangement in some automatic way, both in building the manufacturing device and in building the manufactured product.

97


NANOBOTS-THE NEXT CURE FOR CANCER SNIGDHA.K AND AKHILA.R G.NARAYANAMMA INSTITUTE OF TECHNOLOGY AND SCIENCE, HYDERABAD

Nanobots the size of living cells swimming around our bodies, doing our bidding to fight disease, make repairs, and augment our abilities. Nanotechnology can help to prevent cancer is through the use of nanobots. Nanobots are microscopic computerized robots that have components which are as small as one nanometer in size. They can be programmed to do different jobs around the body, and one of them will be to locate and destroy cancerous cells. There will be different nanobots to do different jobs to help kill the cancer. These nanobots are very sensitive to the acoustic signals. Therefore these nanobots can be programmed using the sound waves. To perform the specified task the nanobots can get the energy from the body itself. Nanobots identify the particular harmful cells and try to quarantine it. If not possible to quarantine, it may destroy the harmful cell itself. Advanced nanobots will be able to sense and adapt to environmental stimuli such as heat, light, sounds, surface textures, and chemicals; perform complex calculations; move, communicate, and work together; conduct molecular assembly; and, to some extent, repair or even replicate themselves.

Keywords: Nanobots, Nanotechnology, Nanobot-scan, Cancer cells.

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