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FUNDAMENTALS AND APPLICATIONS OF MICROFLUIDICS


CHAPTER 1 INTRODUCTION


MICROFLUIDICS – THE EMERGING TECHNOLOGY  1958 Jack Kilby & Robert Norton Noyce (IC)  1959 Richard Feynman : “ There’s Plenty of Room at the Bottom”  1960s microelectronic IC  1970s MEMS  1980s microflow sensor, microvalves, micropumps  1990s microfluidics

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History of Microfluidics

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MICROFLUIDICS – THE EMERGING TECHNOLOGY 05/05/13

What Is Microfluidics? What does the micro refer to in microfluidics? or is microfluidics determined by the device size or the fluid amount it can handle? How small can a microscopic fluid quantity be?

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MICROFLUIDICS – THE EMERGING TECHNOLOGY 05/05/13

Device size or the fluid amount

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MICROFLUIDICS – THE EMERGING TECHNOLOGY 05/05/13

Volume & concentration

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MICROFLUIDICS – THE EMERGING TECHNOLOGY 05/05/13

Commercial & scientific aspects

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MICROFLUIDICS – THE EMERGING TECHNOLOGY Human Genome Project(HGP) by microfluidics chip Killer applications

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Commercial aspects

 Single-use

disposable microfluidic devices  Medical diagnostics, Genetic sequencing, Chemistry production, Drug discovery & proteomics  High throughput by parallel analysis

Market : 2011(5.1B), 2012(5.6B), 2017(10.3B)

Scientific aspects New applications in chemistry and bioengineering  New

effect, new chemical reactions, new microinstruments

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MILESTONES OF MICROFLUIDICS 05/05/13

Device development Miniaturization : 1980s~mid-1990s Power

limit Size limit

Exploration of new effects : mid-1990s Electrokinetic Surface

tension Electromagnetic Acoustic streaming 9


MILESTONES OF MICROFLUIDICS 05/05/13

Device development Application development Flow

control Chemical analysis Biomedical diagnostics Drug discovery New applications  Distributed energy supply  Distributed thermal management  Chemical production(micro-reactor)

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MILESTONES OF MICROFLUIDICS Before mid-1990s Silicon

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Technology development micromachining (expensive cost)

 Integrated circuits → Transport electron

 Microfluidics → Transport molecules and fluids

After mid-1990s Plastic

micromachining (cheap cost)

 Stamp and mold  Microcutting  Laser machining  Microelectro discharge machining  Laminting

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Fundamentals and Applications of Microfluidics  

Fundamentals and Applications of Microfluidics

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