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Cisplatin (cas 15663-27-1) MSDS 1. 1.1

1.2

IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product identifiers Product name

:

cis -Diammineplatinum(II) dichloride

Product Number Brand CAS-No.

: : :

P4394 Anonymous 15663-27-1

Relevant identified uses of the substance or mixture and uses advised against Identified uses

2. 2.1

:

Laboratory chemicals, Manufacture of substances

HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Acute toxicity, Oral (Category 2) Serious eye damage (Category 1)

Classification according to EU Directives 67/548/EEC or 1999/45/EC May cause cancer. Toxic if swallowed. Risk of serious damage to eyes.

2.2

Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal word Hazard statement(s) H300 H318 Precautionary statement(s) P264 P301 + P310

Danger Fatal if swallowed. Causes serious eye damage. Wash hands thoroughly after handling. IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. none

Supplemental Hazard Statements Safety data sheet available on request.

According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R45 R25 R41 S-phrase(s) S53 S26

May cause cancer. Also toxic if swallowed. Risk of serious damage to eyes. Avoid exposure - obtain special instructions before use. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

S39 S45

2.3

Restricted to professional users. Other hazards - none

3. 3.1

COMPOSITION/INFORMATION ON INGREDIENTS Substances Synonyms

:

cis-Dichlorodiammine platinum(II) Cisplatin cis-Platinum(II) diammine dichloride


Formula Molecular Weight

: :

H6Cl2N2Pt 300,05 g/mol

Component

Concentration

cisplatin CAS-No. EC-No.

4. 4.1

15663-27-1 239-733-8

-

FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 4.3

Most important symptoms and effects, both acute and delayed Indication of any immediate medical attention and special treatment needed no data available

5. 5.1

FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

5.2

Special hazards arising from the substance or mixture nitrogen oxides (NOx), Hydrogen chloride gas

5.3

Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary.

5.4

Further information no data available

6. 6.1

ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

6.2

Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

6.3

Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

6.4

Reference to other sections For disposal see section 13.

7. 7.1

HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection.

7.2

Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

7.3

Specific end uses no data available

8. 8.1 8.2

EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls


Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

9. 9.1

PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) Appearance b) c) d) e)

Form: crystalline Colour: yellow no data available no data available no data available Melting point/range: 270 째C - lit.

k) Vapour pressure l) Vapour density

no data available no data available

m) Relative density n) Water solubility o) Partition coefficient: noctanol/water p) Autoignition temperature q) Decomposition temperature r) Viscosity

no data available no data available no data available

s) Explosive properties t) Oxidizing properties

no data available no data available

Odour Odour Threshold pH Melting point/freezing point f) Initial boiling point and no data available boiling range g) Flash point not applicable h) Evaporation rate no data available i) Flammability (solid, gas) no data available j) Upper/lower no data available flammability or explosive limits

9.2

no data available no data available no data available

Other safety information no data available

10. STABILITY AND REACTIVITY 10.1 Reactivity no data available

10.2 Chemical stability


no data available

10.3 Possibility of hazardous reactions no data available

10.4 Conditions to avoid no data available

10.5 Incompatible materials Strong oxidizing agents

10.6 Hazardous decomposition products Other decomposition products - no data available

11. TOXICOLOGICAL INFORMATION 11.1 Information on toxicological effects Acute toxicity LD50 Oral - rat - 25,8 mg/kg Remarks: Behavioral:Change in motor activity (specific assay). Diarrhoea Blood:Normocytic anemia.

Skin corrosion/irritation no data available

Serious eye damage/eye irritation no data available

Respiratory or skin sensitization Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals.

Germ cell mutagenicity no data available

Carcinogenicity Carcinogenicity - mouse - Intraperitoneal Tumorigenic:Neoplastic by RTECS criteria. Skin and Appendages: Other: Tumors. Tumorigenic Effects: Uterine tumors. Carcinogenicity - mouse - Intraperitoneal Tumorigenic:Carcinogenic by RTECS criteria. Lungs, Thorax, or Respiration:Tumors. Possible human carcinogen IARC:

2A - Group 2A: Probably carcinogenic to humans (Cisplatin)

Reproductive toxicity no data available

Specific target organ toxicity - single exposure no data available

Specific target organ toxicity - repeated exposure no data available

Aspiration hazard no data available

Potential health effects Inhalation Ingestion Skin Eyes Additional Information

May be harmful if inhaled. May cause respiratory tract irritation. May be fatal if swallowed. May be harmful if absorbed through skin. May cause skin irritation. Causes eye burns.

RTECS: TP2450000

12. ECOLOGICAL INFORMATION 12.1 Toxicity no data available

12.2 Persistence and degradability no data available

12.3 Bioaccumulative potential no data available

12.4 Mobility in soil no data available

12.5 Results of PBT and vPvB assessment no data available

12.6 Other adverse effects


no data available

13. DISPOSAL CONSIDERATIONS 13.1 Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.

Contaminated packaging Dispose of as unused product.

14. TRANSPORT INFORMATION 14.1 UN number ADR/RID: 3288

IMDG: 3288

IATA: 3288

14.2 UN proper shipping name ADR/RID: TOXIC SOLID, INORGANIC, N.O.S. (Cisplatin) IMDG: TOXIC SOLID, INORGANIC, N.O.S. (Cisplatin) IATA: Toxic solid, inorganic, n.o.s. (Cisplatin)

14.3 Transport hazard class(es) ADR/RID: 6.1

IMDG: 6.1

IATA: 6.1

IMDG: II

IATA: II

IMDG Marine pollutant: no

IATA: no

14.4 Packaging group ADR/RID: II

14.5 Environmental hazards ADR/RID: no

14.6 Special precautions for user no data available

15.

REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.

15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture no data available

15.2 Chemical Safety Assessment no data available

16.

OTHER INFORMATION Further information The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. guidechem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.

CAS 15663-27-1 Cisplatin Properties,manufacturers,suppliers,fob price  

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