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In this issue Student Involvement 1 Kidney Disease/Research 2 Healthier Tomorrow 3 Upcoming Events 4

FACULTY NOTES L-R, Monica Cape, Steve Hammersmith, Kelly Gaffney and Anik Patel Photo by Alan Molyet

Student Involvement PRE-PROFESSIONAL ORGANIZATION The Preprofessional Organization (PPO) was started in November 2010 as a way to keep preprofessional students on the main campus connected to the college’s faculty and professional division students. Monica Cape, president of PPO, is enthusiastic about this new student organization and its potential to build relationships within the college. At PPO’s monthly meetings, preprofessional students hear from UTCPPS faculty and professional division students whom they might not ordinarily meet. PPO students, closely engaged with Pharmacy Student Council (PSC), are now organizing additional activities and projects that will enhance the experience of preprofessional students and prepare them for what’s ahead. PPO’s executive board is rounded out by Kelly Gaffney as VP, Anik Patel and secretary, and Steve Hammersmith as treasurer. Pharmacy students who wish to get involved with PPO can find the organization’s information in their display case in Wolfe Hall or on the flyers posted in the Wolfe Hall computer lab. They can also contact advisor, Deb Sobczak, or Shawn Mills, PSC president.

Dr. Curtis Black, ’72, was recently featured in UT News following his election as national vice president for finance for Phi Kappa Phi. Read more

Pharmacology, Principles and Practice, edited and coauthored by UT’s Drs. Miles Hacker, William Messer, and Kenneth Bachmann, was “highly commended” by the British Medical Association 2010 Medical Books Awards. Read more

Kidney Disease and Research BY DR. WISSAM ABOUALAIWI

March is National Kidney Awareness Month, which makes it an ideal time to discuss kidney disease and the research that is changing the way kidney disease is treated. Autosomal dominant polycystic kidney disease (ADPKD), a genetic disorder characterized by fluid-filled cysts in the kidney nephrons, is caused by a mutation in PKD1 or PKD2, the coding genes for polycystin-1 and -2, respectively. Its prevalence is evaluated between 1/400 and 1/1000 live births and it accounts for 7 to 8 % of end-stage renal disease in developed countries. ADPKD is not only a kidney disease, but also a systemic disorder associated with cardiovascular complications such as cerebral intracranial and aortic aneurysms as well as cardiac valvular defects. These complications represent a continuous concern, particularly in older ADPKD patients. Although asymptomatic in most patients, extrarenal manifestations of ADPKD may become more clinically relevant with the increasing life expectancy of affected patients. They mainly encompass cysts in other organs than the kidney (liver: 94%, seminal vesicle: 40%, pancreas: 9%, arachnoid membrane: 8%, and spinal meningeal, 2%). As yet, the pathogenesis of this disease is not fully understood and there is no specific treatment available. The molecular mechanism in ADPKD has been associated with dysfunction in primary cilia. We in Dr. Surya Nauli’s lab are conducting cutting edge research that focuses on cilia biology and associated Polycystic Kidney Disease (PKD). Cilia are micro-sensory organelles that extend from the apical surface of cell membranes to the body lumen or

microenvironment. They are involved in diverse functions within the cells that range from fluid flow sensors to cell signaling regulators. Currently we are focusing our research interests on deciphering the mechanisms that lead to kidney and cardiovascular abnormalities due to abnormal cilia function. The research conducted in our lab involves the use of cell lines, genetically manipulated animal models and human cells and tissues from organ donors. Since joining Dr. Nauli’s lab, my research has contributed significantly to the advances made in the PKD field. This contribution was manifested through highly ranked research publications that were concurrently featured on the covers of the American Heart Association journal Circulation Research and Human Molecular Genetics. This was in addition to other review papers and book chapters. Our research has demonstrated for the first time the involvement of primary cilia in cell division, cell cycle regulation and chromosome segregation. This will contribute to deciphering the molecular mechanisms underlying the pathogenesis not only in Polycystic Kidney Disease, but in other diseases in which cell division is dysregulated. Dr. AbouAlaiwi is a postdoctoral researcher in Dr. Surya Nauli’s pharmacology research lab.

STUDENT FEATURES NACDS Scholarship The National Association of Chain Drug Stores (NACDS) Foundation announced the 2010 recipients of the NACDS Foundation Pharmacy Student Scholarship Awards, and Marisa Sochacki, a UT pharmacy student, was among the 58 scholarship recipients. Read more

FACULTY NOTES Dr. Amanda Bryant-Friedrich, associate professor of medicinal and biological chemistry, was elected president of the Northwest Ohio Association of African Women Scholars. Her term begins in Summer 2011.

Dr. Surya Nauli was granted tenure and promoted to associate professor of pharmacology.

Dr. Kenneth Alexander is The University of Toledo College of Pharmacy and Pharmaceutical Sciences’ voting delegate for the U.S. Pharmacopeial Convention.

Photo by Jordan Maddocks

For a Healthier Tomorrow BY JORDAN MADDOCKS, P2 PHARMD STUDENT Deep within the halls of the Health Science Campus, you can hear the forced piddle paddle of a labored jog, the distant clinking of heavy weights and the grunts and groans of a fierce basketball game. Where could all this racket be coming from? The Health Science Campus has its own YMCA called the Morse Center, and all UT students can use the facility by simply presenting their Rocket Cards at the front desk on the third floor of Dowling Hall. Pharmacy students have been heading there en masse for improved health and in preparation for the coming year. The health benefits of regular exercise are clear, but there may be more behind the eyes of the motivated Rx runners. Specifically, a sizable portion of the P2 PharmD class has enlisted in a brutal race in June called the Warrior Dash. The Warrior Dash is a mere 5k at first glance, but it is interlaced with a demanding series of rope climbs, bear crawls, mud pits, and even a line of fire that tired runners must jump before completing the race and proving their superior fitness. If you wish to join the Warrior Dash, you can find out more online. Even if you don’t participate, don’t

hesitate to head up to the Morse Center and submit yourself to your own bouts of physical endurance. If you need a workout buddy, motivator or trainer, fear not the name; Rx Warrior Runners will always be exercising and are always willing to add more runners to the pack. As a self-proclaimed Rx Warrior Runner, I have taken the liberty of registering for a few other racing events. This year I am taking the I-75 Marathon Challenge. That’s right, I am signed up for the Toledo Marathon in April, the Dayton Marathon in September, and the Findlay Marathon in October!

Each marathon is 26.1 miles with turns, hills, and thousands of people. The I-75 Marathon Challenge is truly an unforgettable experience and a great way to see the landscape of our lovely state. In addition, I plan on doing the MS Northwest Bike to the Bay and the MS Northeast Pedal to the Point. These two biking events involve distances of 100 and 125 miles, respectively, and will raise thousands of dollars for multiple sclerosis research. The events of physical endurance in which I plan to participate, along with the periodic 5k and triathlon, total some 325 miles of competitive racing. For each racing mile, I know I will have to train ten miles at the Y, the Rec, the park trails, and on the city streets; but every time I am about to throw in the towel and return to the couch, I realize that at every step I will have a warrior, a runner, a pharmacy student right there next to me. So don’t wait until next year or even next week. I’ll see you at the Morse Center tomorrow!

We want to hear from you! Email your news to us at utpharmacyreply@utoledo.edu.

Your college and your classmates want to know what you’re busy accomplishing. Send news about births, new jobs, marriages, and achievements to the college for publication in the biannual printed newsletter, Extracts & Graduates. You can even send photos! Alumni can also keep up with UT news and progress by joining the UT Alumni Association and its online community, www.toledoalumni.org.

On Our Website General College Information www.utoledo.edu/pharmacy UT Alumni Association www.toledoalumni.org

Upcoming Events UTCPPS Alumni Affiliate CE Program

Give to the College of Pharmacy & Pharmaceutical Sciences

Tuesday, March 15, 2011 at 7:00 pm , Driscoll Alumni Center Auditorium

Past issues of the college Newsletter

Join us for this one-hour seminar hosted by UT alum Mark Keeley, RPH '87,

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Legislative Affairs Administrator for the Ohio State Board of Pharmacy. He will be presenting information on contemporary topics in Ohio Pharmacy Law. Ohio Pharmacy Law Review (Ohio State Board of Pharmacy Approved) 0.1CEU , Experience ID Number: 036-234-11-01-L03. RSVP by Friday, March 11th. There is no charge, but reservations are required. Register online.

Kappa Psi STAG Event Saturday, April 9, 2011 at 3pm All Kappa Psi alumni are welcome to attend Stag this year at the Lucas County Recreation Center located on 2901 Key St., Maumee, OH 43537. The event will allow past and current brothers to catch up over food and games. For more information and to RVSP, please email Benjit at benjit_budwal@hotmail.com or call him at 419-377-9021.

Alumni Reception for Toledo Symphony Carnegie Hall Concert Saturday, May 7, 2011 from 5:30 pm to 7:00 pm Your Alumni Association invite you and your family to celebrate the appearance of The Toledo Symphony at Carnegie Hall in New York City. Join us from 5:30 pm to 7:00 pm in the Manhattan Skyline Room of the Park Central New York Hotel for a complimentary pre-concert reception with passed hors d'oeuvres. Representatives from the University and the Symphony will be in attendance at the reception. Tickets for the 7:30 pm Carnegie Hall performance are $25 each to the first 200 to register and may only be picked up at the celebratory pre-concert reception. Register online.

3000 Arlington Avenue, MS 1014 Toledo, OH 43614 419.383.1904 www.utoledo.edu/pharmacy


March 2011 Refill