2010 Pipeline Report

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TAG 2010 Pipeline Report female macaques from repeated intravaginal low-dose challenges with simian HIV162P3. (Paper #520.) Paper presented at the Sixteenth Conference on Retroviruses and Opportunistic Infections, Montreal, 8-11 February 2009. Buchbinder SP, Mehrotra DV, Duerr A, et al. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet. 2008;372(9653):1881–93. Epub 2008 Nov 13. Chakupurakal G, Onion D, Cobbold M, Mautner V, Moss PA. Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin alpha4beta7. AIDS. 2010;24(2):205–10. Chisembele M, Crook A, Gafos M, et al. PRO2000 vaginal gel is ineffective in preventing HIV infection: Results of the MDP301 phase III microbicide trial. (Paper # 87LB.) Paper presented at the Seventeenth Conference on Retroviruses and Opportunistic Infections, San Francisco, 16–19 February 2010. Corti D, Langedijk JP, Hinz A, et al. Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals. PLoS One. 2010;5(1):e8805. Curlin ME, Huang M-L, Lu X, Celum CL, Sanchez J, et al. 2010 Frequent Detection of Human Adenovirus from the Lower Gastrointestinal Tract in Men Who Have Sex with Men. PLoS ONE 5(6): e11321. Desai S, Landay A. Early immune senescence in HIV disease. Curr HIV/AIDS Rep. 201;7(1):4–10. DiGiusto DL, Krishnan A, Li L, et al. RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma. Sci Transl Med. 2010;2(36):36ra43. Earl PL, Cotter C, Moss B, et al. Design and evaluation of multi-gene, multi-clade HIV-1 MVA vaccines. Vaccine. 2009;27(42):5885– 95. Epub 2009 Aug 3. Effros RB, Dagarag M, Spaulding C, Man J. The role of CD8+ T-cell replicative senescence in human aging. Immunol Rev. 2005;205(1):147–57. Fauce SR, Jamieson BD, Chin AC, et al. Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J Immunol. 2008;181(10):7400–7406. Fernandez-Cruz E, Navarro J, Abad ML et al. Augmentation of HIV-1-specific memory subsets of T lymphocytes and decrease of immune activation in HIV-1+ individuals treated with a therapeutic vaccine plus antiretrovirals: Impact on viral load. (Paper 318-W.) Paper presented at the Ninth Conference on Retroviruses and Opportunistic Infections, Seattle, 24–28 February 2002. Flynn NM, Forthal DN, Harro CD, Judson FN, Mayer KH, Para MF; rgp120 HIV Vaccine Study Group. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis. 2005;191(5):654–65. Epub 2005 Jan 27. Fry TJ, Mackall CL. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol. 2005;174(11):6571–76. Gudmundsdotter L, Nilsson C, Brave A, et al. Recombinant Modified Vaccinia Ankara (MVA) effectively boosts DNA-primed HIV-specific immune responses in humans despite pre-existing vaccinia immunity. Vaccine. 2009;27(33):4468–74. Epub 2009 May 29. Gupta SK, Johnson RM, Mather KJ, Clauss M, Rehman J, Saha C, Desta Z, Dubé MP. Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study. AIDS. 2010;24(9):1377–1380. Harari A, Bart PA, Stöhr W, et al. An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses. J Exp Med. 2008;205(1):63–77. Epub 2008 Jan 14. Sealy R, Slobod KS, Flynn P, et al. Preclinical and clinical development of a multi-envelope, DNA-virus-protein (D-V-P) HIV-1 vaccine. Int Rev Immunol. 2009;28(1):49–68. Heringer-Walther S, Eckert K, et al. Angiotensin-(1-7) stimulates hematopoietic progenitor cells in vitro and in vivo. Haematologica. 2009;94(6):857–60. Epub 2009 Apr 18.

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