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Research Report 2011 Our research. Our people.

About us Our Vision

Southern Health is Victoria’s most integrated public health service uniquely providing health care across the entire lifespan – from newborns and children, to adults, the elderly, their families and carers.

To be a health service that integrates excellence in clinical services, education and research. Southern Health provides a supportive and dynamic environment for health care professionals to conduct world-class clinical and translational research that drives improved clinical practice.

Strong medical, clinical and translational research across all clinical disciplines is integral to improving the health and wellbeing of our community.

Our Purpose To plan and deliver safe, effective and peoplefocused health care and services that anticipate and respond to our community’s health needs by:

Our services are provided from over 40 care locations across south east Melbourne, including major tertiary and secondary hospitals, an extensive network of rehabilitation, community health and mental health facilities and aged residential care centres.

collaborating with other service providers maximising the use of all available resources working together to realise people’s potential fostering knowledge-based practice and continuous improvement. To promote and provide quality education and research relevant to health care.

Our research locations

MELBOURNE CBD Deakin University

Monash Medical Centre Moorabbin

CSIRO

Monash Health Translation Precinct Southern Health Prince Henry’s Institute Monash Institute of Medical Research Monash University

Monash University Australian Synchrotron

Monash Medical Centre, Clayton Sgva Kingston Centre

Dandenong Hospital Dandenong

Cockatoo Doveton Berwick Casey Hospital Pakenham

Cranbourne Cranbourne Integrated Care Centre

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Contents 4 Message from the Chair of the Board and Chief Executive

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4 Director of Research Strategy’s report 5 Committed to improving health through research 6 Improving nutrition for cancer patients

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8 Enhancing aged care residents’ quality of life 10 World first research leads to slipped disc fusion 12 Drug trial improves development and movement

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14 Our commitment to investing in new researchers 15 Our research + your support = a life changing combination 16 Research governance

17 Research Services 23 Monash Health Translation Precinct Translation Facility 24 Southern Health Research Week 2011

26 Research Group Reports 26 Ageing - Monash Ageing Research Centre (MONARC) 34 Allied Health 36 Anaesthesia and Peri-operative Medicine

12 63 Mental Health: Early in Life (infant to youth) Mental Health Service 65 Mental Health: Psychology and Behavioural Medicine 66 Mental Health: Southern Synergy 70 Monash Children’s 73 Nephrology 75 Neurosciences 77 Neurosurgery 78 Nursing: Deakin – Southern Health Nursing Research Centre

37 Cardiology: MonashHEART and Monash Cardiovascular Research Centre

80 Occupational Therapy

41 Cardiothoracic Surgery

83 Ophthalmology

42 Clinical Haematology

84 Orthopaedics Department

109 Collaborations

44 Clinical Immunology

85 Pathology: Anatomical

109 BioGrid Australia

45 Community Services

87 Pharmacy

46 Diabetes and Vascular Medicine

88 Respiratory and Sleep Medicine

49 Diagnostic Imaging

90 Rheumatology

50 Emergency Medicine

81 Obstetrics and Gynaecology

94 Southern Academic Primary Care Research Unit

55 Gastrointestinal and Hepatology

97 Supportive and Palliative Care

56 Infection Control and Epidemiology

98 Urology

58 Intensive Care 59 Medical Oncology 61 Mental Health: Centre for Developmental Psychology and Psychiatry

112 Postgraduate Students

92 Southern Health Simulation Centre

53 Endocrinology

57 Infectious Diseases and Microbology

111 Victorian Cancer Biobank

123 Funding Sources 126 Southern Health and MHTP Publications 126 Journal articles

99 Monash Health Translation Precinct Partner Reports

159 Book chapters 160 Books

99 Monash Institute of Medical Research 104 Prince Henry’s Institute 106 Southern Clinical School

161

Strength in collaboration and partnerships

Southern Health Research Report 2011

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Message from the Chair of the Board and Chief Executive

We are pleased to present Southern Health’s 2011 Research Report. Southern Health has continued to evolve as an outstanding research organisation in collaboration with our valued Monash Health Translation Precinct research partners. 2011 has been a year of much activity and accomplishment in particular by the progression of the establishment of the Monash Partners’ Academic Health Science Centre.

Director of Research Strategy’s report

This has been an important year for developing a strong research base at Southern Health. There has been strong support and commitment from both the Southern Health Board and senior administration to ensure research is a major focus of the activities of the health service.

We were delighted to welcome Professor Stephen Holdsworth as Director of Research Strategy in 2011. Stephen has successfully continued the strong work of Professor John Funder and we are looking forward to working together to build on that excellent base.

Several important structural developments have occurred. The Academic Health Science Centre development now has a name, Monash Partners’ Academic Health Science Centre.

Stephen has gained immense respect from the Southern Health Board of Directors and Executive Management Team for his strong commitment to research and teaching.

Through a formal assessment process, seven major research themes have been defined, as follows:

In May 2011, our annual Research Week activities successfully showcased the diversity and productivity of our many researchers. A major highlight was the enthusiasm and vigour shown by our younger researchers as they participated in the poster competition which culminated in a vibrant poster display throughout the week. Another highlight of Research Week was the awarding of three Emerging Researcher Fellowships, a tangible example of our commitment to supporting talented health care professionals pursue research. We are confident these Fellows will make a significant contribution to Southern Health. We are incredibly fortunate to have a strong team of dedicated doctors, nurses and allied health staff who continually demonstrate their commitment to upcoming research. It is because of their efforts that Southern Health is recognised globally for research excellence. We would also like to thank and acknowledge the entire Research Directorate - led by Ms Malar Thiagarajan, Director of Research Services for their continued support of all research activities throughout the year. We are immensely proud of the remarkable research undertaken at Southern Health and we hope you enjoy the 2011 Research Report.

Barbara Yeoh Chair, Board of Directors

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Shelly Park Chief Executive

1: Cardiovascular: Innovation, Intervention, Imaging and Care 2: Critical Care, Trauma and Perioperative Medicine 3: Diabetes, Obesity, Men’s Health and Endocrinology 4: Infection and Inflammation 5: Integrated Programme in Cancer and Blood Disease 6: Neuroscience and Mental Health 7: Women’s, Children’s and Reproductive Health. These joint themes map closely those already selected by Southern Health. It is likely that funding for a new translational research facility building will be finalised in 2012, to allow for the physical home for many of the programs and provide much needed infrastructure for clinical research. Taken together these positive outcomes will consolidate the base for our future research growth and success.

Professor Stephen Holdsworth Director of Research Strategy

Committed to improving health through research In 2011, our researchers continued to conduct world-class translational research

739

$14 million

Projects underway

NHMRC grant funding

there were more than 739 research projects underway involving patients, either in clinical drug or device trials, or addressing key questions in clinical medicine, public health and the social sciences.

more than $14 million in NHMRC grant funding awarded to Southern Health and MHTP partners.

263

$4.8 million

New research projects

Commercially sponsored clinical trials

there were 263 new research projects approved by the Southern Health Human Research Ethics Committees in 2011.

more than $4.8 million funding for commercially sponsored clinical trials by leading pharmaceutical companies and biotechnology companies for national and international clinical research.

98

847

New clinical drug or device trials

Publications

approved in 2011 including 8 Phase I, 33 Phase II, 36 Phase III, 16 Phase IV and 5 Device trials.

there were 808 journal articles published in peer reviewed journals, 31 book chapters and 8 books.

Southern Health Research Report 2011

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Improving nutrition for cancer patients

John Hartnett

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Having played for the under 19’s St Kilda football team in the late sixties, Mr John Hartnett has always had an interest in diet and fitness. John was delighted with the assistance he received from the Southern Health dietetics team during his treatment for upper gastrointestinal cancer. John describes his wife of 47 years as his ‘guardian angel’. The couple agree that without the support and guidance of the dietetics team, in particular research dietitian June Savva, it would have been impossible to maintain and improve John’s overall weight after each bout of treatment. As a grandfather of six children, John believes that research is vital for the future health and care of every generation.

John successfully avoided malnutrition during cancer treatment by participating in an intensive nutrition intervention pilot study.

Facing page: John Hartnett This page: Left to Right - Mr John Hartnett, Ms June Savva and Ms MaryAnne Silvers

Fast facts This trial is directly improving the vitality of patients with upper gastrointestinal cancer. Upper GI cancer affects the upper areas of the digestive system including the oesophagus, liver, pancreas and stomach. Oesophageal and stomach cancer are amongst the most common of the upper GI cancers (www.canceraustralia.gov.au) Lifetime risk of developing upper GI cancer before the age of 75 is 1 in 156 (stomach), 1 in 261 (oesophagus) (www.canceraustralia.gov.au) Nutrition impact symptoms are those which negatively impact on nutritional status and increase the risk of malnutrition. Examples: nausea, heartburn, diarrhoea, fatigue, difficulty swallowing Malnutrition is associated with poorer health-related quality of life.

The availability of early dietary intervention is bringing relief to many cancer patients at Southern Health. Malnutrition affects between 40-80% of cancer patients, especially those with upper gastrointestinal (UGI) cancer. Whilst it is common for patients to receive nutrition support from dietitians during the course of their cancer treatment, the initial contact with a dietitian often occurs at the time of surgery or once chemotherapy or radiation therapy commences. By this stage many UGI patients have experienced difficulty with eating, weight loss and many are malnourished. Malnutrition may limit a patient’s response to chemotherapy and radiotherapy; diminish quality of life and overall survival. Southern Health’s Department of Dietetics in conjunction with Southern Melbourne Integrated Cancer Services revealed delays in the referral process of stomach and oesophageal cancer patients to a dietitian. Ms MaryAnne Silvers, Manager of the Dietetics Department based at Monash Medical Centre conducted a pilot study aimed at improving the health outcomes amongst patients with oesophageal or stomach cancers through early and intensive nutrition intervention. Health outcomes were compared to those of UGI cancer patients who had received usual nutrition care. Working closely with the UGI consultants has allowed Mary Anne and June Savva (research dietitian) to identify and recruit patients to participate in the study as soon as a diagnosis of oesophageal or stomach cancer was confirmed. The results from this pilot study will be published in 2012. Mary Anne and her team have piloted an improved model of care at Southern Health, much to the relief and improved vitality of UGI cancer patients.

Southern Health Research Report 2011

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Enhancing aged care residents’ quality of life

Dyonn Dimmock Resident Advocate at Chestnut Gardens

Dyonn was actively involved in implementing the new model of care that is changing residents’ lives for the better.

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We have to make changes because one day it will affect me and you.

Ms Dyonn Dimmock is an exuberant advocate for the residents at Chestnut Gardens. Dyonn embraced the Tri-Focal Model of Care and believes its implementation has opened up a series of opportunities for residents at Chestnut Gardens. The Tri-Focal Model of Care encourages resident and family involvement in activities such as the recent Gala Ball to feel more at home in the residential care environment. Communication has opened up between residents, staff, and family members to the benefit of all at Chestnut Gardens. Dyonn says:

Facing page: Dyonn Dimmock, Resident Advocate at Chestnut Gardens This page: Left to Right - Ms Lynne Bickerstaff, Prof Beverly O’Connell, Ms Mary Reside, Ms Dyonn Dimmock

Fast facts This new model of care is empowering our staff to provide the best patient-centred care for our elderly residents. The number of people over 65 years will double in the next 50 years and by 2050, people over 65 will account for more than a quarter of Australia’s population. Older people are at increased risk of frailty and having multiple health conditions that may include nutrition disorders, incontinence, dementia, delirium, and depression. In 2010, there were nearly 183,000 residential aged care places. Over half of all residents were aged 85 years or over, 70% of all residents were female and 71% of permanent residents were assessed as ‘high-care’ and the remainder as ‘low-care’. In 2009–2010, the total recurrent Australian and state and territory government expenditure on residential aged care services was $7.3 billion.

A new partnership-centred model of care has been developed by Professor Beverly O’Connell and the team at the Deakin-Southern Health Nursing Research Centre. A research grant of $307,000 in funding provided by the JO & JR Wicking Trust supported the development of the Tri-Focal Model of Care. This model recognises that all aspects of caring for the elderly are inter-related. It addresses the broad spectrum of abilities, needs and levels of care for different residents in aged care, and is designed to enhance the quality of life and dignity for residents in aged care facilities. The Tri-Focal Model of Care is operating at Chestnut Gardens in Doveton. Chestnut Gardens provides high level (nursing home) care for up to 100 residents and prides itself on using the latest in care and design philosophies. It will operate as a Teaching Nursing Home, demonstrating evidence-based practice to nursing students. Director of Nursing, Operations Director Rehabilitation and Aged Care Services, Lynne Bickerstaff chaired the Deakin – Southern Health Implementation Steering Committee. This committee worked closely with the educational coordinator, Ms Mary Reside, the Target Best Care team and staff at Chestnut Gardens to implement the Tri-Focal Model of Care. Mary consulted with staff, family members and residents throughout the implementation process. Together they have generated a more involved and evidence-based culture at Chestnut Gardens. The Tri-focal Model of Care comprises nine educational modules, including both professional support, and clinical modules. This model promotes best practice residential aged care that is partnership-focused, creates a positive work environment, and is designed to work in conjunction with accreditation standards in residential aged care facilities.

Southern Health Research Report 2011

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World first research leads to slipped disc fusion

Alice Begley

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Alice was proud to take part in this world-ἀrst treatment trial that will signiἀcantly improve patient care for patients with severe neck pain.

I felt important taking part in the trial. This research has improved my life and it will be an important procedure for many patients in the future.

Facing page: Alice Begley This page: Mr Tony Goldschlager and Ms Alice Begley

Fast facts In this world-first phase 2 clinical trial stem cells are used to encourage bone fusion between remaining discs following major surgery. About 10--15% of the population will be experiencing neck pain at any one time. 1 Less than one in 100 cases of neck pain are caused by a serious medical problem. 2 A slipped disc in the neck can caused pain in the arm or spinal cord compression which may require surgery. 3 1:

‘Acute Neck Pain’, National Health and Medical Research Council, Information Sheet No. 3 (February 2004) available at www.nhmrc.gov.au

2:

‘Neck Pain’, Arthritis Australia, Information Sheet (2007) available at www.arthritisvic.org.au

3:

Goldschlager T, Jenkin G, Ghosh, P, Zannetinno A and Rosenfeld JV, ‘Potential applications for using stem cells in spine surgery’, Current stem cell research and therapy, 2010 (5): 345-355

In 2011, Consultant Neurosurgeon, Mr Tony Goldschlager, and his team conducted a world-first phase 2 clinical trial in 12 patients suffering from severe neck pain at Monash Medical Centre Clayton. The trial involved the use of stem cells in a novel way and was sponsored by an Australian company, Mesoblast. The trial offers hope to sufferers of cervical spine degenerative disease (slipped disc), where the discs that lie between the vertebrae in the neck degenerate over years of wear and tear. It is reported that by the age of 60, most people have some form of degenerative disc disease, but not everyone has obvious symptoms. The usual procedure for a slipped disc involves major surgery to remove the disc and then insertion of a small cage in-between the remaining discs to allow bone fusion to occur. For some patients, fusion does not occur and their pain remains. Such patients were recruited for the trial and the standard operation for slipped discs was conducted. Some patients were randomised to receive an additional injection of adult stem cells into the cage to encourage fusion between the remaining discs. This was a blinded trial, meaning neither the patients nor their assessors were informed as to whether they received stem cells or not. Stem cells offer a unique treatment option as there is no evidence of rejection and the cells have the ability to turn into bone or to secrete factors which stimulate the body to make bone. Stem cells have known anti-inflammatory properties which can assist in the reduction of pain. To date, the stem cells have been safe and well tolerated without any adverse events. This is very exciting as previous therapies (such as bone morphogenetic proteins) have not been safe when used in the cervical spine. Tony plans to continue his stem cell research with an additional trial targeting back pain which is scheduled to begin in 2012. Tony will also spend time in 2012 completing a Clinical Fellowship in Vancouver, Canada.

Southern Health Research Report 2011

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Drug trial improves development and movement

Penny Iudica Mother of Jonah Iudica

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The decision to administer 3,5-diiodothyropropionic acid (DITPA) to our son Jonah was something we didn’t take lightly. As parents taking a leap of faith into the unknown was very frightening. It was imperative that we had a doctor by our side in this process that we could trust, that would listen, that advised us accordingly and translated Jonah’s results in a manner we could understand. Dr Flora Wong was our leading physician in this clinical trial and not only did she meet all our expectations, she exceeded them. Today, our little boy Jonah is going from strength to strength, something we know wouldn’t have been achievable without DITPA.

Jonah is just one one of many children who will potentially benefit from this world first drug trial.

Facing page: Jonah Iudica This page: Dr Flora Wong

Fast facts Preliminary results from this world-first clinical drug trial are already seeing improved weight gain, a reduced heart rate and improved thyroid hormone levels. Allan-Herndon-Dudley Syndrome (AHDS) is a rare condition and is a x-linked disease, with only males affected and females being normal carriers. 1 AHDS is a rare disorder of a thyroid transporter called triiodothyronine (T3), leading to moderate to severe brain development and problems with movement. 2 Patients with AHDS have high triiodothyronine (T3) in their blood and therefore also manifest symptoms of hypermetabolic rate including high heart rate and failure to thrive. 3 More than 100 individuals belonging to more than 40 families have been identified with AHDS. 4 1: Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ. Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. The Journal of Biological Chemistry. 2003;278(41):40128-35. Epub 2003/07/23. 2: Refer to 1 above 3: Di Cosmo C, Liao XH, Dumitrescu AM, Weiss RE, Refetoff S. A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport. Endocrinology. 2009;150(9):4450-8. Epub 2009/06/065 4: Refer to 1 above

Dr Flora Wong is a Consultant Neonatologist at Monash Newborn, with a joint appointment as a senior research fellow at the Ritchie Centre, Monash Institute of Medical Research, Department of Paediatrics, Monash University located at Monash Medical Centre Clayton. Flora graduated with a Bachelor of Medicine and Bachelor of Surgery in 1993 from The University of Melbourne, and completed her specialty training in Paediatrics to become a Fellow of the Royal Australasian College of Physicians in 2002. Subsequently, Flora completed a PhD in 2009 at Monash University. In 2011, Flora was awarded an National Health and Medical Research Council Early Career Clinical Research Fellowship together with a project grant and has obtained $699,201 in research funding. Her research interests are in cerebral blood flow and oxygenation in relation to brain injury in newborn infants undergoing intensive care. In 2010, in collaboration with Dr Peter Simm, Consultant Endocrinologist, Flora commenced the identification and development of a treatment protocol for a young patient, Jonah Iudica who is a 6 year old boy diagnosed with Allan-Herndon-Dudley Syndrome (AHDS). Most children with AHDS have weak muscle tone and underdevelopment of many muscles. As they get older, they usually develop joint deformities which restricts the movement of certain joints. Abnormal muscle stiffness, muscle weakness, and involuntary movements of the arms and legs also limit mobility. As a result, many people with AHDS are unable to walk independently and become wheelchair-bound by adulthood. Flora commenced treatment of Jonah’s AHDS with a thyroid hormone analog - 3,5-diiodothyropropionic acid (DITPA) in May 2011 in a world-first clinical drug trial sponsored by Zarion Pharmaceuticals. The preliminary results of the clinical trial are promising and indicate that in our first patient Jonah that oral treatment of DITPA over 6 months has led to a significant improvement in his weight gain and reduction of his heart rate, with biochemical improvement in his thyroid hormone levels. Flora has since received requests from parents world-wide to commence their sons in this clinical trial.

Southern Health Research Report 2011

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Our commitment to investing in new researchers We have an ongoing commitment to celebrate and recognise our new researchers. Each year we announce three Emerging Research Fellows whose innovative research will lead to direct improvements in patient care. The 2011 Emerging Research Fellows are: Ms Donna Markham Ms Donna Markham is making a difference as the General Manager of Allied Health at Southern Health. Having the ability to directly impact the level and quality of care a patient receives initially attracted Ms Donna Markham to her training as an Occupational Therapist. After graduating from La Trobe University and working in Melbourne for a short time Donna relocated to the United Kingdom and developed her skills as an Occupational Therapist at a variety of Emergency Departments across the country. Two years later Donna returned and embarked on an Occupational Therapy role within the Jessie MacpPherson Private Hospital and then transferring into General Medicine, Rehabilitation and Aged Care and finally to the Emergency Department at the Monash Medical Centre in Clayton. Research has always been an area of interest for Donna, particularly when she became directly involved with patients in the Emergency Department. The focus of Donna’s Emerging Researcher Fellowship is researching the patterns and behaviours of older patients with chronic respiratory problems who frequently present to the Emergency Department. Initial research indicates that these frequent presenters may have little support in the home environment from friends or family. Donna’s research seeks to discover the best methods of support for such patients who have a complex myriad of problems, which will in turn alleviate the pressure on the Emergency Department. Donna believes research is a vital and important priority within the Allied Health field and across the health care system.

Dr Jimmy Shen The physiology of the human body has always intrigued Dr Jimmy Shen. A graduate of The University of Melbourne, Jimmy is flourishing in his medical career at the Monash Medical Centre in Clayton. The Emerging Researcher Fellowship provided Jimmy with the opportunity to conduct a basic research project in the Diabetes and Endocrinology Department. Cardiovascular disease is the leading cause of death and disability in the developed world. Novel treatment strategies are needed to combat the health and economic burden of cardiovascular disease. Jimmy’s project will focus on the role of novel mechanisms of mineralocorticoid receptor activity in macrophage (a type of white cell) in the development of heart disease and high blood pressure. This translational study is expected to provide valuable insight which may lead to future cardiovascular research at Southern Health. Jimmy will be supervised by Professor Peter Fuller during his Fellowship. After completing his PhD at Monash University, Jimmy plans to continue conducting basic research projects alongside his clinical role. Jimmy is very focused on translation medicine and the ability to translate basic science into improved healthcare for patients.

Dr Darcy Holt Obesity is an increasing health problem in Australia and a designated National Health priority by the National Health and Medical Council of Australia. As a Fellow in the Gastroenterology and Clinical Nutrition and Metabolism Units, Dr Darcy Holt comes into contact with many patients suffering from Crohn’s disease. Crohn’s disease is a type of inflammatory bowel disease which may affect any part of the gastrointestinal tract. There is little evidence of research into the role of intra-abdominal fat caused by obesity and the onset of various diseases. Darcy’s Emerging Researcher Fellowship project seeks to confirm that obesity is more prevalent than previously reported in Crohn’s Disease, that the visceral fat compartment plays a crucial role in disease pathogenesis and behaviour, and that visceral adipose tissue is an important therapeutic target. It is documented that obese patients suffer worse prognosis and symptoms when diagnosed with Crohn’s Disease. The additional resources required to treat an obese patients with Crohn’s disease puts a strain on medical facilities treating these patients. Darcy chose a career in medicine because of the interface between clinical, interpersonal and academic work – and the breadth of the field. Darcy plans to continue combining his clinical activities with a career 14

Our research + your support = a life changing combination Southern Health is Victoria’s most integrated health service, providing care across the continuum of life. Strong medical, clinical and translational research across all clinical disciplines is integral to improving the health and wellbeing of our community. Your generosity will help Southern Health’s Research Directorate to continue to make discoveries, improve technology and enhance patient-centred care. Please donate today to improve patient care tomorrow.

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Please forward to: Monash Health Foundation Locked Bag 29, Clayton South, VIC 3169 (ABN 82 142 080 338)

Southern Health Research Report 2011

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Research Governance The Research Directorate is responsible for implementing Southern Health’s research governance framework and provides comprehensive, practical assistance to researchers. This includes advice on research ethics, budgets, contracts, indemnities, grant applications, mentoring, advocacy and advice for our researchers and study co-ordinators. Southern Health has best practice research governance arrangements.

Executive Director of Nursing and Midwifery

Chief Executive

Corporate Counsel

Executive Director Medical Services & Quality

Executive Management Team

Research Advisory Council

Deakin – Southern Health Nursing Research Centre

Southern Health Libraries

Two Human Research Ethics Committees

Research Directorate

Research Week Organising

Research Report Editorial Committee

Victorian Cancer BioBank Steering Committee

BioGrid Australia Management Committee

Low Risk Review Panel

Research Directorate Staff Ms Malar Thiagarajan Director Research Services Ms Deborah Dell Administrative Officer (HREC)

Ms Julie Gephart Administrative Assistant (HREC)

Ms Julie Nicholson Administration and Communications Officer

Ms Kathryn Frowen Project Officer

Mrs Micheleine Uhe Research Governance Officer Mrs Heather Jackson Secretary

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Research Services

The Research Advisory Council maintains a key oversight role in the activities of the Research Directorate. The broad role of the council is to develop and guide research strategy and assist Southern Health to achieve our goal to be a health service of international standing in the improvement of health care. Membership of the Research Advisory Council reflects the close relationships between Southern Health, Monash and Deakin Universities, Prince Henry’s Institute and the Monash Institute of Medical Research.

The council had six meetings during 2011 and the following matters were discussed: Monash Health Translation Precinct funding success during the NHMRC funding rounds

Victorian Cancer Biobank update

Emerging Researcher Fellowships 2011

Research Governance

Update on the Terms of Reference for the Research Advisory Council and the Clinican-Researchers Leaders Forum

Clinical Trials Action Group – report recommendation

Advanced Health Care Centres Research Report 2010 Ms Malar Thiagarajan Director of Research Services

Research Week 2011 Accreditation for research standard in 2010

Hospital Research Directors’ Forum

Australasian Research Management Conference 2011 update Discussion Paper Health and Medical Research and The Future In NHMRC’s 75th Year: The virtuous cycle and the economic benefit of health and medical research (2011)

Academic Health Science Centres

Research performance measures, indicators and reporting

Update on Australian Cancer Research Foundation Centre for Cancer Genomic Medicine

2012 NHMRC Research Grants

Clinically competitive: boosting the business of clinical trials in Australia Biogrid Australia

‘Research as a Discipline’ paper Public relations and media strategies for Monash Health Translation Precinct Market Health Validation Program

National Health and Medical Research Council (NHMRC) direct research costs Southern Health Research Report 2011

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Research Services

Research Advisory Council Members 2011

Professor Julian Smith

Professor Stephen Holdsworth

Professor Helena Teede

(Chair) Southern Health/Monash University

Mr Paul Bennett Southern Health/ Deakin University

Professor David Clarke Southern Health/ Monash University

Professor Ross Coppell Monash University

Professor Peter Fuller Southern Health/ Prince Henry’s Institute

Professor Matthew Gillespie Prince Henry’s Institute

Southern Health/ Monash University

Southern Health/ Monash University

Ms Malar Thiagarajan Southern Health (Convenor)

Professor Euan Wallace Southern Health/ Monash University

Professor Steve Wesselingh Monash University

Professor Bryan Williams Monash Institute of Medical Research

Professor Barbara Workman Southern Health/ Monash University

Associate Professor Terry Haines

Secretariat in attendance

Southern Health/ Monash University

Ms Julie Nicholson

Professor Ian Meredith Southern Health/ Monash University

Administration and Communications Officer Research Directorate

Corporate Counsel

Professor Eric Morand Southern Health/ Monash University

Associate Professor Katrina Nankervis Southern Health

Associate Professor Wayne Ramsey Southern Health

Professor William Sievert Southern Health/ Monash University

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Southern Health Corporate Counsel, Mr John Snowdon and Legal Counsel, Ms Sue Allen provide legal support as required.

Human Research Ethics Committees There are two Human Research Ethics Committees (HRECs) at Southern Health. The committees operate in accordance with the National Statement on Ethical Conduct in Human Research (2007). The HRECs meet monthly, except in January, to review research applications for proposals involving patients and staff at Southern Health. The HRECs are supported by Ms Malar Thiagarajan, Director of Research Services, Ms Deborah Dell, Administrative Officer, Ms Julie Gephart, Administrative Assistant and Mrs Heather Jackson, Secretary. The Chairs of the Human Research Ethics Committees in 2011 were: HREC A Professor Mel Korman, HREC B Dr Simon Bower, and the Medical Administrators to the HRECs in 2011 were Dr James Doery and Dr Ian Woolley. The Low Risk Review Panel reviews proposals which range from surveys, and data collection studies, through to quality assurance projects which involve minor privacy concerns. The Therapeutics Committee, led by Professor Richard Harper, Chair, and Mr Ian Larmour, Executive Officer, reviews all drug trials and provides advice to the Committees.

Research Services

Projects summary There were approximately 739 research projects being conducted at Southern Health during 2011. The Southern Health HRECs and Low Risk Review Panel reviewed a total of 217 new ethics applications and approved 208 projects. Of those, 31 were Streamlined Ethical Review Process (SERP) projects and additionally there were 46 projects which were approved and will be conducted at Southern Health, however their ethical reviews were conducted at other health services via the SERP scheme. Hence, the total number of research projects approved by the Southern Health HRECs in 2011 was 263. The pie chart to the right shows the categories of research of the approved projects and within the 98 clinical trials approved, there were 8 Phase I, 33 Phase II, 36 Phase III, 16 Phase IV drug trials; and 5 device trials.

New research projects approved in 2011 by category (n=263)

86

15

clinical research

psychological

15

social and health sciences

13

98

public health

36

clinical drug/ device trial

other

Figure 1: The number of new research projects approved by the Southern Health HRECs in 2011 by category of research.

New research projects approved over 8 years by category (n=1,490)

Number of projects

120 100 80 60 40 20 0 2004

clinical drug/ device trial

2005

2006

clinical research

2007

psychological

2008

2009

social and health sciences

2010

public health

2011

other

Figure 2: The number of new research projects approved by Southern Health HRECs by research category from 2004 – 2011.

Southern Health Research Report 2011

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Research Services

Certification of the Southern Health HRECs by the National Health and Medical Research Council The Southern Health HRECs in September 2010 received Certification by the National Health and Medical Research Council in accordance with the National Certification Scheme for its institutional processes relating to the ethical review of multi-centre research. Southern Health’s HRECs have been certified to provide ethical review for multi-centre research in the following categories of research:

Clinical Trials Phase I Clinical Trials Phase II Clinical Trials Phase III Clinical Trials Phase IV Paediatric Research Clinical Interventional Research other than Clinical Trials

Population Health/ and or Public Health Mental Health The period of Certification is valid between 01 January 2011 to 31 December 2013.

Streamlined Ethical Review Process

Research governance activities

The Southern Health HRECs are accredited by the Consultative Council for Human Research Ethics of the Department of Health (Victoria) for the Streamlined Ethical Review Process of multi-site clinical trials in Victoria. The initiative operated throughout 2011 and streamlined the ethical review for commercially sponsored multi-site trials.

In 2011, Research Governance Officer, Ms Micheleine Uhe created 21 Standard Operational Procedure documents which are complemented by an array of supporting documentation. The documents were uploaded onto the Southern Health Prompt document system for access by all staff members.

Southern Health reviewed 31proposals for multi-centre clinical research on behalf of a number of Victorian institutions. Southern Health accepted the review of other accredited institutions in Victoria who reviewed 46 projects that involved researchers at Southern Health. The accreditation status of the Southern Health HRECs were re-affirmed by the Consultative Council on Human Research Ethics (Department of Health in Victoria) (‘CCHRE’) in late November 2011. In 2011, the Victorian, Queensland, Departments of Health and the New South Wales Ministry of Health signed a Memorandum of Understanding to introduce mutual acceptance of ethical and scientific review in public hospitals regarding multicentre, clinical trials being conducted in more than one of these states. Mutual acceptance of ethics review for multi-centre clinical trials for Queensland and Victoria commenced from Monday 24 October 2011. Commencement of mutual acceptance for NSW is from 1 February 2012.

Quality assurance applications There were 147 quality assurance proposals received during 2011. In accordance with the NHMRC guidelines, the scope of the activities considered to be a quality assurance activity are defined as all the various activities designed to evaluate, monitor and improve the quality of health services.

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Micheleine co-ordinated the presentation of the VMIA Research Governance Toolkit comprising of five modules. Educational presentations were given at Southern Health and externally on topics such as ‘The Auditing Process’ and ‘The Consent Process’. Micheleine attended the CCHRE workshops and seminars and maintained professional networks with other Research Governance Officers from other institutions within Victoria.

Biostatistics support Biostatisticians of the Monash University School of Public Health and Preventive Medicine review many research proposals for the HRECs. This biostatistics review is in accordance with the National Statement requirements to ensure that the sample size is adequate to demonstrate both clinically and statistically significant effect. This expert support is now provided by Associate Professor Sophia Zoungas, Mr Eldho Paul and Mr Sanjeev Ranasinha. The HRECs would like to extend a special thank you to Associate Professor Damien Jolley who provided biostatistics reviews for many of the research proposals that have been submitted to Southern Health over the past decade. Associate Professor Jolley’s reviews of the proposals have value-added to high standard of research conducted at Southern Health and his approachability with assisting researchers is appreciated not only by the HREC, but by the many researchers he has worked with over the years.

Research Services

Mutual Acceptance Programs (MAP) Southern Health has established Mutual Acceptance Programs for Human Research Ethics Review in accordance with the NHMRC National Statement on Ethical Conduct in Human Research (2007). The statement advises that institutions that regularly have review responsibilities for the same research should agree on a single review body to review the research. The establishment of the following agreements helps avoid any duplication in review:

Southern Health and Monash University to assist researchers to conduct healthservice based research

Monash Children’s Cancer Centre

at Southern Health and the Royal Children’s Hospital Children’s Cancer Centre for Children’s Oncology Group studies

Southern Health and Cancer Trials

Australia for clinical trials facilitated by Cancer Trials Australia

Southern Health and Deakin University

to assist researchers to conduct healthservice based research

Human Research Ethics Committee A Members Professor Mel Korman Chair

Dr Peter Briggs Medical Researcher

Mr Doug Gimesy

Professor George Braitberg

Lay Man

Health Care Professional

Professor Andis Graudins

Dr Justin Brown

Medical Researcher

Health Care Professional

Dr Peter Kempster

Dr Beverley Castleman

Health Care Professional

Lay Woman

Ms Margaret Kingston

Dr Ali Crichton

Lawyer

Health Care Professional

Ms Ellen Kitson

Mr Trent Curtain

Lay Woman

Lay Man

Ms Helen Kopp

Dr James Doery

Health Care Professional

Health Care Professional

Mr Ian Larmour

Associate Professor Terry Haines

Health Care Professional

Medical Researcher

Reverend Tony Poole

Dr Rupert Hinds

Minister of Religion

Health Care Professional

Ms Helen Stubbs

Mr Allan Manser

Lay Woman

Health Care Professional

Ms Bobbee Terrill

Dr Bill Mulley

Health Care Professional

Medical Researcher

Associate Professor Kumar Visvanathan

Mr Bernard O’Shea

Medical Researcher

Dr Ian Woolley Medical Researcher

Ms Emma Carnovale Lawyer

Dr Bruce Carroll Lay Man

Dr James Doery Health Care Professional

Associate Professor David Ernest Medical Researcher

Human Research Ethics Committee B members Dr Simon Bower Chair

Dr Steve Alatakis Medical Researcher

Lawyer

Associate Professor Christine Rodda Health Care Professional

Associate Professor Krishna Vaddadi Medical Researcher

Ms Claire Vosk Health Care Professional

Father Albert Yogarajah Minister of Religion

Dr Pascal Bernard Medical Researcher Southern Health Research Report 2011

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Research Services

Low Risk Review Panel members

Therapeutics Committee members

Mr Robin Lee

Ms Denise Brookes

Professor Richard Harper

Dr Heath Liddell

Health Care Professional

Chair

Dr Damien Castanelli

Mr Ian Larmour

Health Care Professional

Executive Officer

Dr Diana Egerton-Warburton

Dr Peter Briggs

Medical Researcher

General Medicine Program

Ms Maggie Emmerton

Professor George Braitberg

Health Care Professional

Emergency Medicine

Ms Nicole Fairweather

Dr Anjali Dhulia

Health Care Professional

Medical Administration

Ms Joanne Mockler

Ms Maggie Emmerton

Health Care Professional

Pharmacy at Dandenong Hospital and Kingston Centre

Dr Anna Murphy Medical Researcher

Ms Wendy Ewing QUM Pharmacist

Associate Professor Brendan Murphy

Dr Mark Fajgman

Medical Researcher

Anaesthetics

Dr Beena Kumar

Dr Dimitri Giannios

Medical Researcher

Emergency Medicine

The Low Risk Review Panel was also assisted by members of the Human Research Ethics Committee.

Dr Victor Gordon Neurosciences

Associate Professor Kate Jackson Palliative Care

Associate Professor Terrence Johns Centre for Cancer Research Monash Institute of Medical Research

Pharmacy at Casey Hospital

General Medical Representative

Mr Allan Manser Pharmacy at Monash Medical Centre Clayton

Dr Andrew Martin General Medical Representative

Dr Geoff Matthews External Representative

Ms Angela Melder Clinical Effectiveness

Dr Alex Padiglione Infectious diseases and Clinical Epidemiology

Ms Silvana Pignataro QUM Pharmacist

Dr Hang Quach Clinical Haematology

Dr Boyd Strauss Clinical Nutrition

Ms Marianne Wadsley General Medical Representative

Dr Amanda Walker Paediatrics

Dr Leeroy William Palliative Care

Dr Norman Zimmerman Mental Health Program

Ms Elaine Kennedy Nursing Representative

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Research Services

Research Group Reports MonashHEART and Monash Cardiovascular Research Centre

Monash Health Research Precinct – Translation Facility During 2011, a re-scoped business case for the Monash Health Research Precinct – Translation Facility was submitted to the Health and Hospital’s Fund Advisory Board.

Vision

Aims

Research focus

Monash Health Translation Precinct (MHTP) will be a world leader in delivering the best healthcare by translating innovative scientific discoveries into best clinical practice in a dynamic and collaborative environment.

The MHTP aims are:

Our researchers will focus on health conditions and diseases recognised as having major social and economic impact.The research themes of the Translation Facility will be specifically aligned to national health priorities.

Purpose The Monash Health Translation Precinct (MHTP): is dedicated to translating medical research to improve healthcare uses clinical insights to focus the agenda of basic research is committed to innovative research development enhances research collaboration locally, nationally and internationally.

to develop the precinct’s capacity for world-leading innovative translational research to identify new opportunities for the translation of research into advances in healthcare• to improve the health and wellbeing of the population

These priorities are: Cancer

to encourage collaboration and partnerships between clinicians and researchers

Cardiovascular

to optimise productive interactions between MHTP partners and external stakeholders

Inflammatory and infectious diseases

to increase efficiency in the utilisation of shared resources and cutting edge platform technologies.

Endocrinology and metabolism

Men’s health Mental health and neurosciences Paediatrics Women’s health.

Southern Health Research Report 2011

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Research Services

MHTP Steering Committee

Southern Health Research Week 2011

Ms Shelly Park Chair Chief Executive Southern Health

Associate Professor Wayne Ramsey Executive Director Medical Services and Quality Southern Health (Project Director)

Ms Malar Thiagarajan Director of Research Services Research Directorate Southern Health (Project Manager)

Professor Matthew Gillespie Director Prince Henry’s Institute

Professor Stephen Holdsworth Director of Research Strategy Southern Health

Members of the Research Week Great Debate team with Ms Shelly Park, Chief Executive: Left to Right: Dr Bill Shearer, Mr John Snowdon, Ms Shelly Park, Dr Erwin Loh, Dr Bruce Waxman, Professor Stephen Holdsworth, Professor Don Campbell, and Dr Craig Noonan

Professor Eric Morand Head Southern Clinical School Monash University

Professor Bryan Williams

In collaboration with our many university and institute partners, Southern Health hosted its annual Research Week from 9 – 13 May 2011.

Director of Monash Institute of Medical Research

Professor William Sievert Director of Gastroenterology Department Southern Health

Professor Steve Wesselingh Dean Faculty of Medicine Nursing and Health Sciences Monash University

Secretariat

Ms Julie Nicholson Administration and Communications Officer Research Directorate

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The week began with the annual comedy debate chaired by Professor Stephen Holdsworth, as the Surgeons battled against the Physicians on the topic ‘To cut is to cure’.

A variety of seminars and presentations were held during the week including a keynote address by Professor Lloyd Sansom on ‘Medicines subsidy in Australia – its strengths and challenges’.

Professor Graeme Clark delivered an insightful and inspiring keynote address on his journey of surgical innovation which led to the development of the Cochlear implant. The Cochlear implant can restore hearing in patients suffering deafness due to loss of sensory hair cells in their cochlea. In those patients, they can often restore sufficient hearing to allow unaided understanding of speech in a quiet background.

Over 140 entries were received for the annual poster competition. Chief Executive Shelly Park presented the poster winners with their certificates during the Prize Award ceremony.

Research Services

Prizes for the Poster competition were awarded as follows:

Cancer 1st Prize: CA 12 – Sarah To 2nd Prize: CA13 – Kyren A Lazarus 3rd Prize: CA7 – Justin L Chen

Cardiovascular Disease 1st Prize: CV4 – Laura Bienvenu 2nd Prize: CV2 – Yasmean Kalam 3rd Prize: CV3 – Siobhan Lockwood

Public Health & Health Services Research 1st Prize: HS10 – Janella Christie 2nd Prize: PH1 – Donna Markham 3rd Prize: HS4 – Janet Hough

Women’s Health &/or Men’s Health 1st Prize: WM11 – Rajini Sreenivasan 2nd Prize: WM18 – Mohamad Aljofan 3rd Prize: WM8 – Cheryce Harrison

Inflammatory &/or Infectious Diseases

Neurosciences 1st Prize: NS2 – Daniel Czech 2nd Prize: NS5 – Tamara Yawno 3rd Prize: NS6 – Lauren Sanders

Child Health or Neonatal Health Clinical Winner:

1st Prize: ID19 – Udani Ratnayake 2nd prize: ID21 – William Mulley 3rd Prize: ID22 – Damien Eeles

CN10 – Rosemary Horne PhD Winner: CN13 – Stacey Ellery Allied/Nursing Winner: CN1 – Glenda McLean

Mental Health

Endocrinology & Metabolism

1st Prize: MH7 – Sonia McCallum

1st Prize: EN8 – Kelly Walton

2nd Prize: MH5 – Heather Rowe

2nd Prize: EN1 – Jun Yang

3rd Prize: MH6 – Jane Fisher

3rd Prize: EN2 – Anju Joham

Southern Health Research Report 2011

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Research Group Reports

Ageing: Monash Ageing Research Centre (MONARC) Director: Professor Barbara Workman

MONARC was established in 1999 during the International Year of the Older Person. MONARC is based at the Kingston Centre and has three divisions: the Academic Unit of Geriatric Medicine (AUGM), the Aged Mental Health Research Unit (AMHRU), and the Clinical Research Centre for Movement Disorders and Gait (CRCMD&G). Each division is autonomous and retains its own identity. They are headed by Monash University Professors Barbara Workman, Daniel O’Connor, and Robert Iansek respectively.

MONARC’s charter: The research activities of MONARC will be directed towards providing fundamental new knowledge and understanding through research into diseases associated with ageing and neurological disorders.

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MONARC clinician researchers will promote the rapid transfer of the results of clinical research into clinical management. MONARC will encourage and conduct high quality research which translates to quality of care and addresses gaps in health service delivery.

MONARC’s units: Academic Unit of Geriatric Medicine (AUGM) Head of Division Professor Barbara Workman The AUGM focuses on clinical research in Geriatric Medicine which can be rapidly introduced into clinical practice. The Unit has interests in the utilisation of best evidence, clinical ethics, health care of older people and medical education. It links Southern Health to Monash University in the teaching

and training of future health care practitioners and actively promotes translational research as this is an integral part of health care delivery and quality of care. Aged Mental Health Research Unit (AMHRU) Head of Division Professor Daniel O’Connor The research interests of AMHRU include behavioural and psychological symptoms of dementia; the care needs of people with dementia from culturally and linguistically diverse backgrounds; caregiver support; depression in residential care and brain stimulation therapies. AMHRU is a partner of the Commonwealth Government’s Dementia Collaborative Research Centre with responsibility for identifying non-pharmacological treatments of the behavioural and psychological symptoms of dementia and then mounting trials of their efficacy.

Research Group Reports Ageing: Monash Ageing Research Centre (MONARC)

Clinical Research Centre for Movement Disorders and Gait (CRCMD&G) Head of Division Professor Robert Iansek The CRCMD&G investigates neurological conditions with particular reference to basal ganglia and cerebellar disorders such as Parkinson’s disease and autism. The CRCMD&G has continued to expand its fields of research with new studies in Parkinson’s disease, Huntington’s disease, and Attention Deficit Hyperactivity Disorder (ADHD).

Research achievements for 2011: Successful NHMRC Project Grants: Researchers from the Academic Unit of Geriatric Medicine were involved in a successful NHMRC Project Grant for the project: SNORE-ASA (Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea) for $850,000. SNORE-ASA is a sub-study of the Aspirin in Reducing Events in the Elderly (ASPREE) study being run by the Monash University School of Public Health and Preventive Medicine and the Berman Center, Minneapolis. SNORE-ASA will investigate the long term impact of sleep apnoea- which is highly prevalent in older adults, on cognition, and whether any effect is modified by aspirin therapy. 3,500 participants in the ASPREE study in Australia will be recruited and will undergo a sleep study at home. A sub-set will have both an MRI and retinal vascular imaging to examine correlations between sleep apnoea and white matter hyperintensity, silent brain infarct, and retinal vascular abnormalities related to sleep apnoea.

Invited presentation at the 2011 International Psychogeriatrics Association International Congress: Aged Mental Health Research Unit researcher Dr Eva Van Der Ploeg was invited to participate in a debate on the use of pharmacological intervention to reduce agitation associated with dementia at the 2011 International Psychogeriatrics Association International Congress in the Netherlands, 6-9 September 2011. Dr Van Der Ploeg also presented the results of a recently completed study that looked into personalised activities based on the Montessori approach as a treatment of agitation associated with dementia, presented a poster, and co-chaired 2 sessions at the conference.

Prestigious publications: MONARC researchers published a number of articles in 2011, including papers in the prestigious journals: Bone, Parkinsonism and Related Disorders, Neuroscience, and Movement Disorders. The Clinical Research Centre for Movement Disorders and Gait received $US180,000 grant funding from the National Parkinson Foundation (USA). Four senior members of staff presented at the 3rd International Congress on Gait and Mental Function, Washington DC and two senior members of staff presented at the 2nd World Parkinson Congress, Glasgow, Scotland.

Research activities Completed projects A controlled trial of topical lavender oil as a treatment of behavioural symptoms of dementia. Investigators: Professor Daniel O’Connor MONARC / School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University. Dr Susannah Runci, (Research Fellow) - Aged Mental Health Research Unit, MONARC / School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University, Professor Madeleine King, (Cancer Australia Chair in Cancer Quality of Life and Director of the Quality of Life Office), School of Psychology, University of Sydney; Prof. George Lees (Department of Pharmacology and Toxicology, Otago University) Outcome: Pure lavender oil proved no more effective than a placebo in reducing agitation in nursing home residents with dementia. A randomised controlled trial of personalised goal-directed activity to treat agitation in dementia. Investigators: Professor Daniel O’Connor, MONARC / School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University. Dr Susannah Runci and Dr Eva Van Der Ploeg (Research Fellow) - Aged Mental Health Research Unit, MONARC / School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Dr Cameron Camp (Senior Researcher) - Hearthstone Alzheimer’s Care, Woburn MA. Outcome: This trial of one-to-one personalized activities delivered using Montessori principles reduced agitated behaviours compared to control activities, particularly for people from non-English speaking backgrounds who had lost fluency in English.

Southern Health Research Report 2011

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Research Group Reports Ageing: Monash Ageing Research Centre (MONARC)

Examining the utility of the Aged

Care Funding Instrument (ACFI) as a vehicle for improving staff skills and knowledge in care planning and management of behavioural and psychological symptoms of dementia (BPSD).

Investigators: Dr Denise O’Connor, Australasian Cochrane Centre, Faculty of Medicine, Nursing and Health Sciences, Professor Daniel O’Connor, School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Professor Lynn Chenoweth - Professor of Aged & Extended Care Nursing, Faculty of Nursing, Midwifery and Health, University of Technology, Sydney; Dr Lee-Fay Low (Research Fellow) Dementia Collaborative Research Centre, Assessment and Better Care, UNSW; Associate Professor Victoria Traynor (Rehabilitation, Continuing and Aged Care), School of Nursing, Midwifery and Indigenous Health, University of Wollongong; Outcome: Clinical files in NSW aged residential facilities were checked to see what assessments had been made of residents’ behavioural and psychological symptoms of dementia and what plans were made to address these symptoms. Assessments were limited and symptoms were rarely addressed in care plans. Providing staff education made little difference. Translating good practice into clinical reality is very difficult in stressed, under-resourced residential settings.

Unlocking the potential of volunteers in aged residential facilities to support residents with behavioural and psychological symptoms of dementia: a pilot feasibility study.

Investigators: Dr Eva Van Der Ploeg (Research Fellow) - Aged Mental Health Research Unit, MONARC / School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Professor Daniel O’Connor, School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University. 28

Outcome: Interviews with volunteers revealed that they were keen to engage with a broader range of residents, and to acquire new skills, provided that they were given adequate training and ongoing support from staff.

The impact on mental health of frequent deaths that occur in high care in aged care settings on individuals and the resident community.

Investigators: Professor Daniel O’Connor, School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Professor Margaret O’Connor - School of Nursing and Midwifery, Faculty of Medicine, Nursing and Health Sciences, Monash University; Professor Barbara Workman, Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences Monash University. Outcome: Residents of aged care facilities were very accepting of co-residents’ deaths and did not want staff members to conceal when this had happened.

Identification of cerebral electrical potentials and wave forms in the control of gait.

Investigators: Dr Anna Murphy and Dr Mehrnaz Shoushtarian, Faculty of Medicine, Nursing and Health Sciences Monash University; Professor Robert Iansek, Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences Monash University; Dr Peter Enticott, Central and Eastern Clinical School, Faculty of Medicine, Nursing and Health Sciences Monash University. Outcome: This study explored a new avenue of documenting the organisation and planning of gait function. It involved a combination of electroencephalogram and gait analysis to reveal cortical mechanisms associated with gait activity, and investigated cortical abnormalities among individuals with movement disorders. Data is being analysed with view to publication.

Preventing falls and improving mobility in people with PD: a community based program.

Investigators: Professor Robert Iansek, Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences Monash University; Dr Anna Murphy, Faculty of Medicine, Nursing and Health Sciences Monash University; Meg Morris Melbourne School of Health Sciences, The University of Melbourne; Dr Frances Huxham - Melbourne School of Health Sciences, The University of Melbourne; Dr Jenny McGinley (Senior Research Fellow) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Professor Hylton Menz - Musculoskeletal Research Centre, Faculty of Health Sciences, La Trobe University; Ms Jennifer Watts Melbourne School of Health Sciences, The University of Melbourne / Centre for Health Economics, Monash University. Outcome: This project has the potential of discovering a treatment that reduces falls and increases mobility in people with Parkinson’s disease. The interventions being trialled have unique potential for a very rapid clinical translation and uptake across the entire world and are novel, safe and viable. Data is been analysed. The prime results are yet to be submitted for publication.

Neuro developmental disorders:

Autism, Asperger’s Disorder and Attention Hyperactivity Disorder Furthering current neurobehavioural and clinical definitions.

Investigators: Associate Professor Nicole Rinehart - School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Dr Julie Bradshaw - School of Languages, Cultures and Linguistics, Faculty of Arts, Monash University; Dr Jenny McGinley (Senior Research Fellow) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Ms Nicole Papadopoulos, School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences Monash University.

Research Group Reports Ageing: Monash Ageing Research Centre (MONARC)

Outcome: This study will increase our knowledge of the neurobehavioral presentation; most specifically the neuromotor profile of children diagnosed with Attention Deficit Hyperactivity Disorder and will allow us to explore similarities and differences of motor difficulties in the context of other neuro developmental disorders (Autism & Asperger’s disorder). Data is being analysed with a view to publication in 2013.

Outcome: Using a theoretical framework to identify and address barriers to the uptake of evidence-based practice guidelines for the management of people with dementia in general practice.

Current projects

Investigators: Professor Daniel O’Connor, School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Dr Cameron Camp (Senior Researcher) - Hearthstone Alzheimer’s Care, Woburn MA; Dr Eva Van Der Ploeg (Research Fellow) - Aged Mental Health Research Unit, MONARC / School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University.

Spouses of aged care residents: promoting wellbeing through support groups.

Investigators: Dr Kate McSweeney School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Professor Daniel O’Connor and Miss Renee Kharsas School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University.

Re-establishing a good relationship

when a person with dementia resides in long-term care: Training dementia carers to conduct activities with their relatives in the nursing home setting.

The language needs of residents

from culturally and linguistically diverse backgrounds with dementia in Victorian aged care facilities.

Outcome: Findings from this study are being analysed at present.

Evidence-based care of people with dementia.

Investigators: Professor Daniel O’Connor, School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Dr Denise O’Connor Australasian Cochrane Centre, Faculty of Medicine, Nursing and Health Sciences, Monash University; Professor Barbara Workman, Department of Medicine, Monash Medical Centre, Faculty of Medicine,Nursing and Health Sciences Monash University; Professor Sally Green - Co-Director of the Australasian Cochrane Centre and a Professorial Fellow in the Faculty of Medicine, Nursing and Health Sciences at Monash University; Professor Colette Browning - School of Primary Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University; Professor Leon Flicker Western Australian Centre for Health and Ageing, and others.

Investigators: Professor Daniel O’Connor, School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Dr Susannah Runci (Research Fellow) - Aged Mental Health Research Unit, MONARC / School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Mrs Barbara Eppingstall (Senior Lecturer) - Aged Mental Health Research Unit, MONARC / School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University.

Investigators: Professor Daniel O’Connor, School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Professor Colette Browning - School of Primary Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University; A/Professor Christopher Trotter - Department of Social Work, Faculty of Medicine, Nursing and Health Sciences, Monash University; Professor Paul Michael Collier Department of Accounting and Finance, Faculty of Business and Economics, Monash University; Associate Professor Rosemary Sheehan - Department of Social Work, Faculty of Medicine, Nursing and Health Sciences, Monash University.

Clinical register of older patients attending a specialist geriatric pain service.

Investigators: Professor Barbara Workman, Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences Monash University; Dr Seema Parikh, Academic Geriatrician - Academic Unit of Geriatric Medicine, MONARC / Adjunct Senior Lecturer, Department of Medicine, Alfred Hospital, Faculty of Medicine, Nursing and Health Sciences, Monash University; Marcus Bowler, Manager/Physiotherapist, Pain Clinic, Kingston Centre, Southern Health and others. Outcome: Aims to establish a longitudinal clinical register of patients attending a specialist pain consultation service for people aged 60+ years experiencing chronic non-malignant pain.

Ageing in prison: a strategic framework for the management of ageing offenders in the Australian criminal justice system.

Southern Health Research Report 2011

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Research Group Reports Ageing: Monash Ageing Research Centre (MONARC)

ASPREE / ALSOP / SNORE-ASA. Investigators: Professor Barbara Workman, Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences Monash University; Professor Elsdon Storey - Department of Neurosciences and Van Cleef Roet Centre for Nervous Disease, Faculty of Medicine, Nursing and Health Sciences; Dr Robyn Woods - Department of Epidemiology and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences; Professor John McNeil - Department of Epidemiology and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences and others. Outcome: ASPREE is ‘Aspirin in Reducing Events in the Elderly’ being run by the Monash University School of Public Health and Preventive Medicine at the Berman Center, Minneapolis. ASPREE sub- studies include: SNORE-ASA (Study of Neurocognitive Outcomes, Radiological and retinal Effects of Aspirin in Sleep Apnoea) which will investigate the long term impact of sleep apnoea on cognition, and whether any effect is modified by aspirin therapy. ASPREE-ALSOP aims to improve understanding of the problems of aging including: mobility, hearing, eyesight, dental care, diet, exercise.

Deep brain stimulation in patients

with advanced Parkinson’s disease.

Investigators: Professor Robert Iansek, Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences Monash University; Ms Dianne Cameron (Physiotherapist / Adjunct Research Fellow) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Ms Mary Danoudis (Physiotherapist) - Clinical Research Centre for Movement Disorders and Gait, MONARC, Dr Thorlene Egerton Clinical Research Centre for Movement Disorders and Gait, MONARC. Adjunct Clinical Associate Professor Andrew Churchyard - School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences Monash University,

Adjunct Clinical Associate Professor Krishnarao Sitaramra Vaddadi - School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences Monash University, Assoc. Professor Nellie Georgiou-Karistianis - School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences Monash University. Outcome: This study provides detailed quantitative information about each patient’s progress following deep brain stimulation, assisting in optimisation of the stimulation settings. The dissemination of results from the new techniques being used is an important facet for further improvements in technique and development of new technologies.

Normal walking patterns of adults

Outcome: This broad study aims to determine whether stride length is the key control variable used by the brain to initiate walking. The results will improve therapy management of neurological conditions affecting gait.

in Victoria.

Investigators: Professor Robert Iansek, Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences Monash University; Ms Dianne Cameron (Physiotherapist / Adjunct Research Fellow) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Dr Anna Murphy, Faculty of Medicine, Nursing and Health Sciences Monash University; Ms Mary Danoudis (Physiotherapist) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Adjunct Clinical A/ Professor Barry Rawicki - Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences, Monash University Outcome: This project will lead to the development of a database of normal walking patterns of adults in Victoria across a range of age groups. The database will be used to compare the walking of people with and without disability to assist in understanding how and why differences in walking occur in people with a particular diagnosis.

A systematic investigation of normal

and abnormal gait: What can the spatiotemporal parameters of walking tell us about central control of gait in healthy adults and in people with disorders involving the basal ganglia?

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Investigators: Professor Robert Iansek, Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences Monash University; Ms Dianne Cameron (Physiotherapist / Adjunct Research Fellow) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Dr Anna Murphy, Faculty of Medicine, Nursing and Health Sciences Monash University; Ms Mary Danoudis (Physiotherapist) - Clinical Research Centre for Movement Disorders and Gait, MONARC, Dr Thorlene Egerton Clinical Research Centre for Movement Disorders and Gait, MONARC.;

A RCT (Randomised Controlled Trial) to determine the optimum frequency of Botulinum Toxin injections to the calf in children with cerebral palsy.

Investigators: Professor H Kerr Graham - Murdoch Children’s Research Institute / Professor of Orthopaedic Surgery, Royal Children’s Hospital; A/Prof Richard Baker - Murdoch Children’s Research Institute; Adjunct Clinical A/ Professor Barry Rawicki - Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences, Monash University; Ms Tandy Hastings-Ison (Senior Physiotherapist) - Hugh Williamson Gait Analysis Laboratory, Department of Orthopaedics, Royal Children’s Hospital, Melbourne; Ms Christine Blackburn - Centre for Developmental Disability Health Victoria, Faculty of Medicine, Nursing and Health Sciences, Monash University; Associate Professor Rory Wolfe - School of Applied and Clinical Public Health Sciences, Monash University / Murdoch Children’s Research Institute. Outcome: This study will compare the effects over a two year period of annual Botulinum toxin A injections as against injections every four months. The primary outcome measure will be the rate of development of contractures over that period.

.

Research Group Reports Ageing: Monash Ageing Research Centre (MONARC)

Measurement and reliability of

spatial-temporal gait variables and activities of daily living using inertial measurement units.

Investigators: Dr. Mehrnaz Shoushtarian, Faculty of Medicine, Nursing and Health Sciences Monash University; Professor Subhash Challa (Senior Principal Researcher) - National Information and Communication Technology Australia (NICTA), The University of Melbourne; Dr Tharshan Vaithianathan - National Information and Communication Technology Australia (NICTA), The University of Melbourne. Outcome: This project aims to develop a wireless compact activity monitor using Inertial Measurement Units (IMUs) that can be worn around the ankle. Three dimensional inertial measurement units (IMUs) allow the recording of body segment movements in space and time. This can be used to collect information on a person’s gait and daily activities in their usual living environment.

Comparison of Parkinson’s-related

quality of life and cost effectiveness of a comprehensive service delivery model compared to usual care for the management of people with Parkinson’s disease.

Investigators: Professor Robert Iansek, Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences Monash University; Dr Anna Murphy, Faculty of Medicine, Nursing and Health Sciences Monash University; Meg Morris - Melbourne School of Health Sciences, The University of Melbourne; Ms Jennifer Watts - Melbourne School of Health Sciences, The University of Melbourne / Centre for Health Economics, Monash University; Adjunct Clinical A/Professor Peter Kempster - Monash Medical Centre, Southern Health. Outcome: This project aims to compare a complex care model, the Victorian Comprehensive Parkinson’s Disease Program (VCPP) with usual care (conventional care), to determine which caters best for the complexity and cumulative morbidity over time of this condition and at what cost.

Identification and quantification

of motor abnormalities will lead to the implementation of effective treatment and clinical interventions with Botulinum toxin A injections for treatment of lower limb dystonia.

Investigators: Adjunct Clinical A/ Professor Barry Rawicki - Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences, Monash University; Dr Anna Murphy, Faculty of Medicine, Nursing and Health Sciences Monash University; Dr Ettie Ben-Shabat, Ms Ashley Mooney and Ms Adele Winter, Department of Physiotherapy, Caulfield Hospital, Alfred Health; Dr Mithu Palit, Professor John Olver and Dr Stephen De Graaff, Department of Rehabilitation, Caulfield Hospital, Alfred Health; A/Professor Anne Holland - Department of Physiotherapy, Alfred Health / La Trobe University. Outcome: The aim of this observational study is to use detailed and sensitive walking measurements obtained with Gait Analyses to assess whether BoNT/A injections actually improve the walking patterns of clients with lower limb dystonia. The outcomes and significance of this study will be in providing an objective measure to assess the effectiveness of BoNT/A injections for management of lower limb dystonia.

Identification and quantification of

the common gait abnormalities in adult patients with Hereditary Spastic Paraparesis (HSP), Cerebral Palsy (CP) and Spinal Cord Injury (SCI).

Investigators: Adjunct Clinical A/ Professor Barry Rawicki - Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences, Monash University; Dr Anna Murphy, Faculty of Medicine, Nursing and Health Sciences Monash University; Mr Grant Scroggie Department of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, Monash University / Senior Physiotherapist – Rehabilitation Ward, Kingston Centre - Southern Health; Ms Dianne Cameron (Physiotherapist / Adjunct Research Fellow) - Clinical Research Centre for Movement

Disorders and Gait, MONARC; Ms Robyn Gardiner, Physiotherapist, Movement Disorders Program, Southern Health. Ms Susan Wilson, Biomedical Engineer, Clinical Research Centre for Movement Disorders & Gait (CRCMD&G), MONARC Outcome: This project is a retrospective descriptive study aiming to identify and quantify the more common/prevalent gait abnormalities observed in adult patients diagnosed with HSP, CP, and SCI. Abnormalities of gait are observed and reported frequently in adult patients diagnosed with HSP, CP and SCI. Patients are frequently referred for 3D clinical gait analysis to assist in clinical decision making, monitor disease progression, or assess benefit of therapeutic interventions. Yet there is a paucity of literature that describes the common deviations of gait observed in these diagnostic groups when compared to healthy normal people, or that quantifies the prevalence and/or extent of these gait deviations.

A randomised clinical trial to

determine the relative benefits of Botulinum Toxin injections, ankle foot orthosis or a combination of both on knee hyperextension during walking in people with chronic stroke.

Investigators: Adjunct Clinical A/ Professor Barry Rawicki - Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences, Monash University; Dr Anna Murphy, Faculty of Medicine, Nursing and Health Sciences Monash University; Mr Grant Scroggie - Department of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, Monash University / Senior Physiotherapist – Rehabilitation Ward, Kingston Centre - Southern Health; Ms Dianne Cameron (Physiotherapist / Adjunct Research Fellow) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Ms Stella Kravtsov - CGAS, Southern Health; Megan Kneebone is a Senior Orthotist at OAPL, Clayton. Ms Stella Kravtsov - CGAS, Southern Health; Ms Robyn Gardiner, Physiotherapist, Movement Disorders Program, Southern Health. Southern Health Research Report 2011

31

Research Group Reports Ageing: Monash Ageing Research Centre (MONARC)

Outcome: Knee hyperextension during walking is a commonly occurring feature in people with stroke. This pilot study aims to compare the efficacy of three interventions used clinically to control knee hyperextension during walking in people with chronic stroke (at least 12 months post-stroke). The results will also be used to determine the number of participants required for a future comprehensive study.

Evaluation of the step to step

variability in Frontal Gait Apraxia.

Investigators: Professor Robert Iansek, Department of Medicine, Monash Medical Centre, Faculty of Medicine, Nursing and Health Sciences Monash University; Dr Anna Murphy, Faculty of Medicine, Nursing and Health Sciences Monash University ; Ms Dianne Cameron (Physiotherapist / Adjunct Research Fellow) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Ms Mary Danoudis (Physiotherapist) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Dr Ganga Ganesvaran, Department of Neurology, Southern Health. Outcome: Frontal Gait Apraxia (FGA) is characterised by a wide based, slow and unsteady walking pattern. Many people with FGA also experience shuffling and sudden ‘blocking’ (stopping) when walking, especially when doing dual tasks. The underlying cause of this abnormal stepping pattern is unknown. This project aims to comprehensively describe the gait characteristics of participants with FGA (in comparison with participants not affected by FGA), and to determine if changes to the footstep pattern in people with FGA is associated with the severity of the changes in the deep white matter of the brain.

Motor functioning in young

people with Attention Deficit Hyperactivity Disorder combined type: a three-dimensional motion analysis study.

32

Investigators: A/Prof Nicole Rinehart School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University; Dr Jenny McGinley (Senior Research Fellow) Clinical Research Centre for Movement Disorders and Gait, MONARC; Professor Robert Iansek, Department of Medicine, Monash Medical Centre Southern Health, Faculty of Medicine, Nursing and Health Sciences Monash University; Dr Anna Murphy, Faculty of Medicine, Nursing and Health Sciences Monash University; Dr Julie Bradshaw - School of Languages, Cultures and Linguistics, Faculty of Arts, Monash University; Professor Bruce Tonge – Centre for Developmental Psychology and Psychiatry, Monash University / Southern Health; Professor Kim Cornish - School of Psychology and Psychiatry, Faculty of Medicine, Nursing and Health Sciences, Monash University.

Publications, postgraduate students and funding summary

Outcome: The primary aim of this study is to examine motor and cognitive functioning in individuals with ADHD-CT using a range of clinical, motor and cognitive assessment techniques and to compare the performance of children with ADHD-CT to typically developing children.

Alzheimer’s Australia National Quality

Deep brain stimulation in patients

with advanced Parkinson’s disease.

Investigators: Professor Robert Iansek, Department of Medicine, Monash Medical Centre Southern Health, Faculty of Medicine, Nursing and Health Sciences Monash University; Ms Dianne Cameron (Physiotherapist / Adjunct Research Fellow) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Ms Mary Danoudis (Physiotherapist) - Clinical Research Centre for Movement Disorders and Gait, MONARC; Dr Thorlene Egerton Clinical Research Centre for Movement Disorders and Gait, MONARC. Outcome: This study provides detailed quantitative information about each patient’s progress following deep brain stimulation, assisting in optimisation of the stimulation settings.

Journal articles

12

Conference presentations

33

Postgraduate research students

4

Funding: Competitive

Health Education and Assessment

Research Team - Monash University, Project Grant. Review of aged care service system - Peninsula Clinical Placement Network. B Workman, et al. 2011: $120,000. 2009-2012: $120,000 (Monash University). Dementia Care Initiative, Project Grant. Re-establishing a good relationship when a person with dementia resides in long-term care: Training dementia carers to conduct activities with their relatives in the nursing home setting. E van der Ploeg, D O’Connor, S Runci, C Camp. 2011: $60,000. 2011-2013: $250,000 (Monash University).

Lions John Cockayne Memorial

Fellowship Trust Fund, Project Grant. The language needs of residents from culturally and linguistically diverse backgrounds with dementia in Victorian aged care facilities. S Runci, D O’Connor, E van der Ploeg E, B Eppingstall. 2011: $14,143 (Southern Health).

Dementia CRC, Project Grant.

Examining the utility of the Aged Care Funding Instrument (ACFI) as a vehicle for improving staff skills and knowledge in care planning and management of behavioural and psychological symptoms of dementia (BPSD). YH Jeon, L Chenoweth, LF Low, V Traynor, P Crookes, D O’Connor, G Brien. 2011: $37,450 (University of Sydney).

Research Group Reports Ageing: Monash Ageing Research Centre (MONARC)

Department of Health and Ageing -

Local Palliative Care Grants Program, Project Grant. The impact on mental health of frequent deaths that occur in high care in aged care settings on individuals and the resident community. M O’Connor, B Workman, D O’Connor. 2011: $91,063 (Monash University).

NHMRC, Project Grant. A randomised

controlled trial of personalised goal- directed activity to treat agitation in dementia (NHMRC #606639). D O’Connor, C Camp, S Runci, M King. 2011: $128,250. 2010-2012: $300,625 (Monash University).

JO & JR Wicking Trust, Project Grant.

Spouses of aged care residents promoting wellbeing through support groups. K McSweeney, D O’Connor, R Kharsas. 2011: $99,612. 2010-2011: $147,472 (Monash University).

National Parkinson Foundation

(NPF), Project Grant. Comparison of Parkinson’s-related quality of life and cost effectiveness of a comprehensive service delivery model compared to usual care for the management of people with Parkinson’s disease. R Iansek, M Morris, J Watts, P Kempster, A Murphy. $81,235. 2010-2011: US$180,000 (Southern Health).

Allergen Pty Ltd, Project Grant.

Identification and quantification of the common gait abnormalities in adult patients with Hereditary Spastic Paraparesis (HSP), Cerebral Palsy (CP) and Spinal Cord Injury (SCI). A Murphy, B Rawicki. 2011: $10,886. 2009-2012: $20,000 (Southern Health).

ARC Linkages, Project Grant. Ageing

in prison: a strategic framework for the management of ageing offenders in the Australian criminal justice system (ARC Linkages #100100599). CJ Trotter, C Browning, D O’Connor, P Collier, R Sheehan. 2011: $72,000. 2010-2011: $132,000 (Monash University).

NHMRC, Project Grant. Motor

functioning in young people with Attention Deficit Hyperactivity Disorder combined type: A three-dimensional motion analysis study. N Rinehart, JL McGinley, B Tonge, R Iansek, A Murphy, K Cornish, J Bradshaw. 2011: $125,356. 2011-2013: $369,417 (Monash University).

Lions John Cockayne Memorial

Fellowship Trust Fund, Project Grant. Investigation of the stride lengthcadence relationship in Huntington’s Disease to map changes in the gait control pathways. M Danoudis, D Cameron. 2011: $5,161 (Southern Health).

Southern Health Research Report 2011

33

Allied Health General Manager: Ms Donna Markham Director Research: Associate Professor Terry Haines

Allied Health departments of Southern Health comprise a diverse group of health professionals working across the spectrum of services offered by the organisation. The Allied Health Research Unit is a collaborative network of Monash University and Southern Health researchers. The unit seeks to facilitate the development of research by and in collaboration with allied health clinicians and others across Southern Health, to conduct innovative research that advances clinical practice, and to enable allied health clinicians to judiciously use evidence to guide their clinical practice.

Research achievements for 2011: Completion of PhD’s by Dr Louise Corben and Dr Elizabeth Skinner. Provision of the first year of the Allied Health Research Training Seminar Series. Growth to 14 Allied Health PhD candidates.

Research activities The Allied Health Research Unit has continued to build on its success from recent years. Research income has grown to over $1 million in 2011; there were 41 peer-reviewed journal articles, 2 book chapters and 1 book published. Journal articles have been published in field leading journals such as: Archives of Internal Medicine, BMJ (British Medical Journal), Journal of Medical Internet Research, Neuroscience and Critical Care Medicine, reflecting the diverse fields of research endeavour undertaken by allied health clinicians and researchers based at Southern Health. Building upon our core business of developing research capacity and culture in allied health, there were 2 PhD completions (Dr Louise Corben and Dr Elizabeth Skinner), completion of 5 coursework Master’s degrees, and one Graduate Certificate. In addition, there are currently 14 allied health PhD candidates, 6 Master’s degree candidates and 1 enrolment in a Graduate Certificate that are ongoing. Supporting these clinicians and others interested in undertaking research has been the Allied Health Research Training Seminar series. Monthly presentations in research skills have been provided by senior allied health research academics with additional opportunities for early career researchers and clinicians to practice their presentation skills. An allied health research showcase was also held during Southern Health Research Week with Annette Barron (Music Therapy) and Annette Davis (Podiatry) being awarded the presenter prizes.

34

Publications, postgraduate students and funding summary Journal articles

41

Book chapters

2

Books

1

Conference presentations

31

Postgraduate research students

30

Funding: Competitive NHMRC, Career Development Fellowship. T Haines. 2011: $94,500. 2010-2013: $377,000 (Monash University) Butterfly Foundation, Project. Evaluating the efficacy of the school based program “Girls on the Go!” to improve self esteem, body satisfaction and physical activity in a multicultural environment: a randomized controlled trial. H Truby, T Haines, L Tirlea. 2011 : $100,000. 2010-2012 : $200,000 (Monash University). NHMRC, Partnership Project. Evidence-based targeting of state-wide strategies for preventing falls among community dwelling older people in Victoria. L Day, C Finch, K Hill, T Haines, L Clemson. 2011: $100,000. 2010-2013: $400,000 (Monash University).

Research Group Reports Allied Health

Department of Health (Victoria), Partnership project. Evidence-based targeting of state-wide strategies for preventing falls among community dwelling older people in Victoria. L Day, C Finch, K Hill, T Haines, L Clemson. 2011: $39,063. 2010-2013: $156,271 (Monash University). Monash University, Strategic Grant Scheme. Investigating reduced awareness of falls risk in an older population: A pilot study. R Stolwyk. 2011: $17,500. 2011-2012: $35,000 (Monash University). Australian Primary Health Care Research Institute, Project. Utilisation of allied health services by people with chronic disease: differences across health insurance coverage and policy change. M Foster, M Haynes, T Haines, G Mitchell. 2011: $75,000. 2010-2011: $149,364 (University of Queensland). South East Healthy Communities Partnership, Project. Evaluation of the Making a Move project phase 2. T Haines. 2011: $16,666. 2011-2012: $25000 (Monash University). NHMRC, Project. The 6-PACK program to decrease falls and fall injuries in older people in hospital—measuring effectiveness, potential cost savings and capacity to be a long term solution. A Barker, C Brand, T Haines, K Hill, S Brauer, D Jolley, M Botti. 2011: $294,962. 2011-2014: $1,179,850. (Monash University). Monash University, Strategic Grant Scheme. Appetite satiety responses in children at risk of lifetime obesity. C Huggins, E Manickam, H Truby, T Haines, Z Andrews. 2011: $26,650. 2011-2012: $53,300 (Monash University).

Southern Melbourne Integrated Cancer Service (SMICS), Supportive Care Research Project Grant 2010-2011. Upper gastrointestinal cancer pilot study comparing usual nutrition service delivery with early and intensive nutrition intervention- A randomised control trial. MA Silvers, T Haines, H Truby, J Savva. 2011: $25,600 (Southern Health). Department of Health Victoria, Project Grant. Investigating Practices Relating to Malnutrition in Victorian Cancer Services. Marshall, K Nolte, N, Loeliger, J Researcher: J Savva. 2011: $3, 500 (Southern Health). Australian and New Zealand Society of Nephrology (ANZSN), Grant. Effect of supplementation on nutritional status, appetite and quality of life of peritoneal dialysis patients. K. Salamon J. Woods. 2011: $10,000 (Southern Health).

ARC, Linkage. Modelling management decisions in mental health care through applications of advanced simulation modeling: Meadows,G. Inder, Patten, S.Gordon-Browne, Kamruzzaman, McDermott, F Albrecht, S. 2011: $184,000. 2011-2014: $247,000 (Southern Health/Monash University). AASW, Literature review grant. Self-management programs for haemodialysis clients with complex chronic conditions: an eclectic ecosystemic social work perspective. Smith, K. 2011: $3000 (Southern Health).

Other Travelling fellowship, Southern Health. Developing a Clinical Education and Support Program (Hand Therapy) for Remote Based Clinicians. Z. Milner. 2011: $20,000 (Southern Health).

Lions John Cockayne Trust, Research Grant. Development of a validation scale to rate intensity of balance challenge. Farlie, M. 2011: $14949.00 (Southern Health). Lions John Cockayne Trust, Research Grant. Investigation into the validity and reliability of three objective clinical tests for high level mobility: the 20m run test, the horizontal leap test and the 4 bound tests. Gorski, M. 2011: $7,500. 2011-2012: $14,791.70 (Southern Health). Lions John Cockayne Trust, Research Grant. Does botulinum toxin improve function in patients with Friedrich’s Ataxia? Milne, S. 2011: $7,500. 2011-2012: $15,000.00 (Southern Health). Lions John Cockayne Memorial Fellowship Trust Fund, Project Grant. Inter-rater reliability of the Cranial Nerve Assessment Tool (CNAT). Nicholls, R. 2011: $5,622 (Southern Health).

Southern Health Research Report 2011

35

Anaesthesia and Peri-operative Medicine Department Director: Dr Mark Adams

Anaesthesia and Pain Management is a multi-site department providing services to all sites of Southern Health and covering all aspects of the craft of anaesthesia. Research is primarily collaborative with other centres focusing on anaesthetic outcome investigations. Internally there is a focus on research around education and trainee assessment, as well as assessment of senior medical staff performance.

Publications and funding summary Journal articles

10

Conference presentations

11

Funding: Competitive NHMRC, Project Grant. The Gas Study. Fajgman, M. 2007-2012: $18590.00. (To end of recruitment, estimated to be in 3 months). NHMRC, Project Grant. The ENIGMA II study. McRae, R. 2008-2011: $5588.00 (Per patient). The Austin Anaesthetic Department, Project grant. The Liver study. Siu,L.

36

Cardiology: MonashHEART and Monash Cardiovascular Research Centre Director: Professor Ian Meredith Director of Research: Professor James Cameron

MonashHEART is responsible for provision of international standard clinical cardiology services, academic cardiology and translational research in the Southern Health group of hospitals and in the Department of Medicine, Southern Clinical School, Monash University. MonashHEART’s research arm is the Monash Cardiovascular Research Centre (MCRC), an accredited independent, self-funding research centre of the Department of Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University. MonashHEART and MCRC are nationally and internationally recognised for strength in a range of key facets in translational cardiology research and clinical care. Substantial ongoing programs are operative into acute coronary syndromes, and the MonashHEART interventional service group is an acknowledged leader in new approaches to percutaneous coronary and cardiac intervention. The MonashHEART team are national leaders in structural heart disease and significant research programs in the application of evolving percutaneous therapies in valvular disease are underway. MonashHEART and MCRC are national leaders in cardiac CT, having established one of the largest international clinical services as well as an active research centre of international status in cardiac CT especially as a leading site for CT perfusion and dose reduction research. MonashHEART supervises PhD and MD postgraduate programs as well as providing specialist educational programs in cardiac CT, echocardiology, cardiac rhythm management and interventional cardiology.

Research achievements for 2011 Continued development of the first 320-multidetector CT system in Australia into a cardiac imaging translational research facility supported by the busiest cardiac CT service in Australia and through a Luminary Site partnership with Toshiba Medical Systems. The site has achieved an international reputation in cardiac CT imaging in chest pain syndromes and myocardial perfusion. Major output: Ko BS, Cameron JD, Meredith IT, et al Computed tomography stress myocardial perfusion maging in patients considered for revascularization: a comparison with fractional flow reserve. Eur Heart J. 2011 Aug 2. Nasis A, Meredith IT, Nerlekar N, Cameron JD, et al. Acute Chest Pain Investigation: Utility of Cardiac CT Angiography in Guiding Troponin Measurement. Radiology. 2011 Jun 14. The establishment by Cardiologist, Dr Tony White, of a translational research facility at the intersection of basic science (utilising techniques of molecular and cell biology) and clinical cardiology. This major project currently investigates the role of micro-RNA molecules in directing cardiac differentiation of embryonic stem cells. The work has the potential to provide insight into mechanisms of cardiogenesis, with the hope that an understanding of the molecular networks involved in cardiac differentiation will assist efforts toward the ultimate goal of myocardial regeneration.

Other research interests of this laboratory include the potential of cell therapy to assist recovery from myocardial infarction and the possibility of new insights into the biology of myocardial infaction, as provided by recent large collaborative genome wide association studies. Major output: Lee S-T, White AJ, Matsushita S, Malliaras K, Steenbergen C, Zhang Y, Li T-S, Terrovitis I, Simsir S, Makkar R, Marbán E. Intra-myocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. Journal of the American College of Cardiology. 2011;57(4):455 Transarterial Aortic Valve Implantation Programme. The MonashHeart NII department’s TAVI research focuses on the hypothesis that an improved assessment of the aortic root and an increased understanding of both normal aortic root anatomy as well as aortic root pathology can be obtained using multi-modality non-invasive imaging tools, both existing well validated modalities and novel cardiac imaging techniques. The work is also assessing the impact of valve design on long-term cardiac structure and function, the influence of improvement of the aortic root and ascending aorta assessment for accurate TAVI prosthesis sizing and the evaulation of post-implantation paravalvular regurgitation and its impact on patient clinical and functional status. Data presented at Hong Kong Mayo Clinic meeting March 2011, ACC April 2011 and CSANZ Aug 2011.

Southern Health Research Report 2011

37

Research Group Reports Cardiology: MonashHEART and Monash Cardiovascular Research Centre

Research activities Basic research activities in MonashHEART and Monash Cardiovascular Research Centre are centred on central haemodynamics and investigation of the underlying principles of ventriculovascular interaction (Prof Jim Cameron, Assoc Prof Sarah Hope), this programme is a logical follow on of previous studies in in vivo human coronary physiology and aims to better establish the relationships between cardiac function, aortic elasticity and patient outcome (ie AMI stroke and renal dysfunction). Major translational research programmes are in the practical application of improved technology and systems in the treatment of acute chest pain syndromes (Prof Ian Meredith, Assoc Prof Sujith Seneviratne, Dr Paul Antonis). Of significant impact has been a continuing research program in chest pain syndromes, including ongoing research into ECG based field triage of chest pain patients by first responder paramedical officers (the MonAMI project) and also the use of the first 320-multidetector CT system in Australia as a cardiac imaging facility for cardiac CT imaging in chest pain syndromes. The cardiac CT research programme has developed an international reputation in myocardial perfusion as well as being a leading national and international site in cardiac CT training and certification and it continues to supports a Luminary Site partnership with an industry partner. These targeted fields of clinical research exemplify the goals of MonashHEART and Monash Cardiovascular Research Centre in the translation of benefits established in the first instance by well designed research programs into paradigm changing provision of clinical services that inform the local, national and international provision of best practice health delivery. Cardiac CT Services Key research projects:

CT stress perfusion: CT stress perfusion is an emerging new strategy to assess functional significance of lesions seen on CT. MonashHeart is a world leader in this field and previous data have already published in EHJ. Study continues with the FFR as the gold standard. (B Ko, I Meredith, P Antonis, A. Nasis, S Seneviratne).

Acute Chest Pain: Current strategies

of biomarker and ECG guided risk stratification in acute chest pain setting remains inadequate. CT guided strategy implemented at Monash provides quicker diagnosis times with an excellent safety record and initial data is already published in Radiology. The study is ongoing. (A. Nasis, J Cameron, M Leung, P Antonis, I Meredith, S Seneviratne)

Radiation Minimisation: While Cardiac CT is able to provide excellent anatomical information on coronary vessels non invasively, it involves varying doses of radiation depending on the scanner type and protocols. We have been studying changes of radiation doses in response to changes in hardware, software and algorithm using the 320 slice scanner. (J Cameron, M Tung, I Meredith, S Seneviratne)

Graft Patency post CABG: The cut

off values used to assess the left main stenosis significance by IVUS has changed over time. Current study examines whether long term graft patency is dependant on the left main stem stenosis severity. (M Tung, J Cameron, S Seneviartne).

In addition, MonashHEART cardiac CT services provide research and educational programme. We have provided a well received CT course at least twice a year that has trained over 80 cardiologists/ radiologists from around the country and internationally during the last 3 years. MonashHeart also provides highly sought after onsite training in live cardiac CT cases in accordance with the current training requirements of the conjoint committee on cardiac CT accreditation.

The MonashHEART Non-Invasive Imaging group has active research programs including:

Investigation of the incremental value of transoesophageal echocardiography in the diagnosis of infective endocarditis. This study is in collaboration with the Southern Health Infectious Diseases Department and also provides valuable information for the purposes of audit, quality control and development of clinical pathways. (Tim Barton, Stuart Moir, Philip Mottram, Rhonda Stuart).

Investigation of patients who have

transient global hypokinesis in response to exercise with markers of subclinical myocardial dysfunction and CT coronary angiography. (Arthur Nasis, Stuart Moir, Philip Mottram).

Feasibility and accuracy of automated assessment of left ventricular ejection fraction with 2-D echocardiography. (Giovanni Romanelli, Stuart Moir, Philip Mottram),

Publications, postgraduate students and funding summary Journal articles

34

Conference presentations

40

Postgraduate research students

Funding: Competitive

NHMRC/Heart Foundation, PhD

Scholarship. Novel imaging techniques for the diagnosis of coronary artery disease and myocardial ischaemia: Implications for the assessment of patients with chest pain. Dr Arthur Nasis. 2011:$35,750. 2011-2013 $81453.00 (Monash University).

NHMRC, CJ Martin Travelling

Fellowship. Dr Anthony White. 2011: $76,991.00. 2007-2011: $153,982.00 (Monash University).

CSANZ,PhD Scholarship. Dr Adam

Hutchinson. 2011: $35,579.00 20092012: $71,158.00 (Monash University).

38

4

Research Group Reports Cardiology: MonashHEART and Monash Cardiovascular Research Centre

Commercial

Abbott. Absorb Physiology.

I.T. Meredith (Southern Health).

St Jude Arsenal. I.T. Meredith (Southern Health).

Biotronic. Biolux I. I.T. Meredith.

2011: $6,350.00 (Southern Health).

Coherex. Coherex. I.T. Meredith (Southern Health).

Medtronic Core Valve. I.T. Meredith.

2011: $83,779.00 (Southern Health).

Abbott Vascular. Excel. I.T. Meredith (Southern Health).

AstraZeneca Pegasus. I.T. Meredith (Southern Health).

BSC Reprise I. I.T. Meredith (Southern Health).

MSD Rhythm AF. J Allison.

2011: $11,250.00 (Southern Health).

Abbott Absorb Cohort B. I.T. Meredith. 2011: $4,313.00 (Southern Health).

Abbott. EXTEND Absorb. I.T. Meredith. 2011: $7,847.00 (Southern Health).

Novartis Aquarius. J.D.Cameron.

2011: $16,222.00 (Southern Health).

CathRx. CathRx. I.T. Meredith (Southern Health).

PCRG. DAPT. I.T. Meredith. 2011: $33,921.00 (Southern Health).

Devax Inc. Diverge. I.T. Meredith (Southern Health).

BSC. Evolve. I.T. Meredith Elixir Medical Corporation Excella II. I.T. Meredith (Southern Health).

NIH. Freedom. I.T. Meredith.

2011: $194.00 (Southern Health).

BSC Perseus. I.T. Meredith.

2011: $3,354.00 (Southern Health).

BSC Platinum. I.T. Meredith.

Medtronic. Protect. I.T. Meredith.

2011: $27,786.00 (Southern Health).

OrbusNeich Remedee. I.T. Meredith. 2011 $99,200.00 (Southern Health).

Abbott Spirit Prime. I.T. Meredith.

2011 $87,14.00 (Southern Health).

Other

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 09128B: Myocardial Sress Perfusion Imaging with 320 slice Multidetector Computed Tomograqphy: Comparison with Fractional Flow Reserve – Pilot Study. Brian Ko, James Cameron, Sujith Seneviratne, Ian Meredith. Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 08186B: Relationship of Cardiac Computed Tomograpic Assessment of Ascending Aortic Strain and Non-Invasive Assessment of Aortic Mechanical Function. Sarah Hope, James Cameron. Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 08135B: Project Title: An Investigation of Non-Invasive Coronary CT Angiography Using AquilionONE 320-slice Multi-Detector CT Imaging in Comparison to Invasive Angiography and Intravascular Ultrasound Imaging For Assessment of Stable Coronary Artery Disease. Sujith Seneviratne, James Cameron, Yuvi Malaiapan (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 08159B: Utility of 320 Slice CT for planned cardiac resynchronisation therapy: Anatomical assessment to assist device implantation. Logan Bittinger, Jeff Allison. Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 08135B: An investigation of non-invasive coronary angiography using Aquillion One 320-slice multidetector CT imaging in comparison to invasive angiography and intravascular ultrasound imaging for assessment of coronary artery disease. James Cameron, Sujith Seneviratne, Sarah Hope. Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 08115B: 320-slice CT in the diagnosis of arrhythmagenic right ventricular cardiomyopathy, a comparison with MRI. Jeff Allison. Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 02086A: Coronary artery pressure and velocity waveform analysis in the time and frequency domain in patients with coronary artery disease. Michael Leung, Ian Meredith, James Cameron. Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 01063A: Utility and validity of transfer function assessment in assessing arterial mechanical properties. Sarah Hope, James Cameron. Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 09313B: Evaluation of myocardial delayed contrast enhancement by 320-slice cardiac computed tomography for the prediction of viability prior to coronary revascularisation. Ben Dundon, James Cameron. Infrastructure, costs and consumables (Southern Health).

2011: $22,492.00 (Southern Health).

Southern Health Research Report 2011

39

Research Group Reports Cardiology: MonashHEART and Monash Cardiovascular Research Centre

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 09312B: 320-slice multidetector computed tomography imaging of the left atrial appendage (LAA) post WATCHMAN LAA occlusion implantation for comparison with transoesophageal echocardiogram. Jeff Allison Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 09311B: In vivo studies on ventriculo-vascular coupling in humans – The influence of Aortic Mechanical Properties on Coronary Blood Flow and the contribution of left ventricular systolic myocardial motion to arterial pressure waveform morphology – a Pilot study. Brian Ko, James Cameron, Sarah Hope, Om Narayan. Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 09182B: Left Atrial Assessment: A comparison of 3-dimensional transthoracic echocardiography and 320-slice multidetector computed tomography. Siobhan Lockwood, Philip Mottram, James Cameron, Stuart Moir. Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 09147B: Myocardial stress perfusion imaging with 320-detector row computed tomography – comparison to myocardial SPECT imaging and invasive cardiac catheterisation. Arthur Nasis, James Cameron, Sujith Seneviratne. Infrastructure, costs and consumables (Southern Health).

40

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 10326B: The diagnostic accuracy of cardiac CT in detection of myocardial ischaemia compared with fractional flow reserve. Brian Ko, James Cameron, Sujith Seneviratne. Infrastructure, costs and consumables (Southern Health).

Monash Cardiovascular Research

Centre Internal Allocation. Project Support. 10373B: Evaluation of Graft Patency after intravascular ultrasound and coronary artery bypass surgery for intermediate left main disease by 320-slice cardiac computed tomography. James Cameron, Sujith Seneviratne, Matthew Tung. Infrastructure, costs and consumables (Southern Health).

Research Group Reports MonashHEART and Monash Cardiovascular Research Centre

Cardiothoracic Surgery Director: Professor Julian Smith

2011 has seen the ongoing maintenance of excellent patient outcomes in Cardiac and Thoracic Surgery. The Department of Cardiothoracic Surgery continues to contribute patient outcome data to the Australian and New Zealand Society of Cardiac and Thoracic Surgeons National Cardiac Surgery Database. The observed and risk adjusted mortality rates and complication rates from cardiac surgery are equal to or superior to national and international benchmarks. Particularly gratifying were the low incidence of patients returning to the operating theatre for post-operative haemorrhage and the low incidence of peri-operative and post-operative blood and blood product transfusion. The Department continues to publish widely on basic, clinical and collaborative cardiac and thoracic surgical research. Particular recent research interests have focused on the inflammatory response to cardiopulmonary bypass, patient outcomes after bioprosthetic aortic valve replacement, cardiothoracic surgery databases, and less invasive and robotically assisted cardiac valve surgery.

Research achievements for 2011 Establishment of a minimally invasive mitral valve surgery program Ongoing studies with activins in cardiopulmonary bypass Further publications arising out of the ANZSCTS Cardiac Surgery Database

Research activities Completed and current projects include the following:

Activins in cardiopulmonary bypass (Y. Chen, J. Goldstein, J. McMillan, J. Smith): Activin A, a member of the transforming growth factor-superfamily, is a novel cytokine released early in a broad range of inflammatory disorders. Its role has not been investigated in the setting of cardiac surgery. Our study aimed to determine whether cardiopulmonary bypass or ischemia-reperfusion injury – two primary sources of inflammation in cardiac surgery – is a trigger for activin A release. A sheep model of cardiopulmonary bypass was used to establish the release profile of activin A. A biphasic pattern of release of this critical cytokine similar to that seen in endotoxemia was found. Using a mouse model of ischemiareperfusion injury, we identified that the activin A gene was rapidly up-regulated during reperfusion. Myocardial infarct size was significantly reduced if follistatin, a high-affinity activin A binding protein, was preadministered. Further, we found that neutrophils contained pre-stored activin A and were thus a possible source of activin A released in vivo. Taken together, this series of experiments suggest that activin A is released systemically during cardiac surgery and may be an important orchestrator of the inflammatory response to cardiac surgery. Neutralising its action using follistatin may be a useful therapeutic option in the future. Australian and New Zealand Society of Cardiac and Thoracic Surgeons database: outcomes in multiple patient subsets (All Department members) Excellent outcomes have been achieved in the elderly, some high risk groups and in cases performed by trainees. Australian and New Zealand Society of Cardiac and Thoracic Surgeons database: acute kidney injury after cardiopulmonary bypass (A.Cochrane)

New post-operative renal impairment resulted in major mortality, and prolonged ICU (Intensive care Unit) and hospitalisation. A risk prediction model has been created from a large Australian database, with the 10 most important risk factors demonstrated. The most important predictive factor was the pre-operative creatinine level. Establishment of a program of minimally invasive mitral valve surgery (A. Almeida, R. Moshinsky, S. Chouta) Excellent early and mid-term results have been obtained with this recently introduced technique. The influence of unit and surgeon volume on patient outcome after cardiac surgery (S. Ch’ng, A. Cochrane, J. Smith) Preliminary findings suggest that there may be a relationship between unit and surgeon volume and patient outcome after cardiac surgery.

Publications, awards, postgraduate students and funding summary Journal articles

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Book chapters

1

Conference presentations

15

Postgraduate research Students

2

Funding: Competitive ARC, Discovery 110104970. Robotic microsurgery: intra-operative measurement, modelling & micromanipulation control. Shirinzadeh, B Zhong, Y, Smith, JA. 2011: 150,000. 2011-2013: 450,000 (Monash University)

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Clinical Haematology Clinical Director: Associate Professor Stephen Opat

The Clinical Haematology Department cares for patients with blood-related disorders including cancers, clotting and bleeding disorders, and pregnancyrelated haematological complications. The unit comprises of 5.6 equivalent consultant haematologists, 5 advanced trainees (registrars), 1 research fellow and 5 research coordinators. This is supported by a busy haematopathology service. In addition to routine clinical work, the department conducts numerous clinical trials.

Research achievements for 2011 Jake Shortt won the most prestigious HSANZ Albert Baike Memorial Medal, for the best oral presentation by a new investigator, for his oral presentation titled: “The Discovery and Assessment of n-Methyl-2-Pyrrolidone (NMP) as a Biologically Potent Anti-Myeloma IMiD Subunit” SMICS (Southern Melbourne Integrated Cancer Service) Grant Noel Chan was runner up for the ASTH Scientific Medal for his presentation on “Retrospective Audit of Pregnancy Related Venous Thromboembolism”.

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Funding:

Research activities Eng Tran, Huyen Tran and Sanjeev Chunilal share a strong interest in venous thrombosis and continue to participate in the conduct of numerous clinical trials involving the use of new anticoagulants to treat and prevent thrombosis. Compared with vitamin K antagonists such as warfarin, these oral drugs have superior pharmacologic properties with minimal food- or drug to drug interaction and require no monitoring.

Competitive Victorian Cancer Agency, VCA Clinical Fellowship. Targeting the PI3-kinome for cure in Acute Myeloid Leukaemia. Wei A. 2011-2014: $400,000 (Monash University).

The demonstrated non-inferior or superior efficacy with similar safety compared with warfarin will improve upon the current standard of care for patients afflicted by venous thrombosis. Stephen Opat, Hang Quach and Jake Shortt have a strong interest in malignant haematology and actively participate in several clinical trials involving the use of novel agents in patients with haematopoietic malignancy, particularly Lymphoma and Myeloma. They are also involved in biomarker discovery using archived biopsy material. Jake Shortt has completed his PHD: “Targeting the P13K/m TOR signalling pathway in MYC-driven models of B-cell neoplasia”.

Leukaemia Foundation, Grant in Aid. Inositol phosphatase regulation of PI3-kinase activity: defining their role as collaborators in leukaemogenesis. Wei A. 2011-2014: $100,000 (Monash University). Leukaemia Foundation, Clinical Trial Grant. A phase 2 randomized study investigating the FLT3 inhibitor Sorafenib in sequence after intensive chemotherapy for untreated adult AML harboring FLT3 mutations. Wei A. 2011-2014: $600,000 (Monash University). Haematology Society of Australia & New Zealand, Young Investigator Scholarship. Pre-test probability models, biomarkers and imaging in diagnosis of Venous Thromboembolism in Pregnancy. Cutts B. 2010-2011: $50,000.

Publications, post graduate students and funding summary

Haematology Society of Australia & New Zealand, Young Investigator Scholarship. Understanding how the loss of NFκB1 function promotes the development of T-cell neoplasms. Grigoriadis G. 2011: $50,000.

Journal articles

CTMS/VCTL. Opat S. 2010-2011: $5,000 (Southern Health).

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Conference presentations

9

Postgraduate students

2

SMICS, Supportive Care Studies. Exploring the supportive care experiences of people with blood cancers from non-English speaking backgrounds: A qualitative study. Opat S, Di Corletto. 2011: $30,000 (Southern Health).

Research Group Reports Clinical Haematology

Commercial PPD/Pfizer. Amplify. Gan, E. 2011: $32,724.50 (Southern Health). PPD/Pfizer. Amplify ETN. Gan, E. 2011: $39,331.25 (Southern Health).

ROCHE. Ofocir. Opat, S. 2011: $1000.00 (Southern Health). NOVARTIS. Pillar II (RAD001). Opat, S (Southern Health).

Sanofi Aventis. ARD12042.Shortt, J (Southern Health).

ALEXION AUSTRALIA. PNH Registry. Tran, H. 2011: $1600.00 (Southern Health).

Sanofi Aventis. ARD12130. Opat, S (Southern Health).

GSK. Prolong. Quach, H (Southern Health).

The Alfred. Brim. Quach, H (Southern Health).

BOEHRINGER INGELHEIM. Recover II. Gan, E. 2011: $29,500.00 (Southern Health).

ROCHE. CLL11. Opat, S. 2011: $50,793.60 (Southern Health). TRIDENT FOR INCYTE. ComfortI. Quach, H. 2011: $10,497.00 (Southern Health). ALLG/Novartis. CML6. Opat, S (Southern Health). GENZYME. EDGE. Opat, S. 2011: $17,170.72 (Southern Health). COVANCE. Einstein VTE. Gan, E. 2011: $57,570 .00(Southern Health). GENZYME. Encore. Opat, S (Southern Health). NOVARTIS. ENESTxtnd (Parexel). Quach, H (Southern Health).

BOEHRINGER INGELHEIM. Remedy. Gan, E. 2011: $5,731.00 (Southern Health). OMNICARE Resonate. Gan, E. 2011: $3,146.00 (Southern Health). ROCHE. Roche ITP. Tran, H. 2011: $4,810.00 (Southern Health). AMGEN. Romipolostim. Tran, H. 2011: $5,310.00 (Southern Health).

Other Two Weeks of Low Molecular Weight Heparin for Distal Vein Thrombosis (TWISTER Study). Investigator Initiated. Tran H (Southern Health).

ROCHE. GALLIUM. Quach, H. 2011: $11,840.00 (Southern Health). ROCHE.GOYA. Opat, S. 2011: $23,304.00(Southern Health). QUINTILES/DIICHISANKYO. Hokusai. Tran, H. 2011: $95,704.00 (Southern Health).

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Clinical Immunology Director: Professor Stephen Holdsworth

The Department provides laboratory, diagnostic and clinical consultative and support services for patients with various forms of immune disease including immunodeficiency, autoimmunity and allergy. These diseases collectively afflict 20% of all Australians. The Department employs a number of diagnostic platforms that not only provide high quality diagnostic tests but are also critical to research efforts of many of the research groups in the whole network. The flow cytometry services provide a network wide research service and supports many productive research projects listed below under Research Activity in 2011.

Research achievements for 2011 Poh-Yi Gan (PhD student) was recognised at the ANZ Society of Nephrology’s Annual Scientific Meeting as the best Young Investigator 2011. This was the second time she has won this award (previous 2009). This has only been achieved once before in the last 30 years. Leukocytes recognise common bacterial proteins through surface expressed pattern recognition receptors called toll like receptors (TLRs). We found TLRs can drive the development of autoimmunity and that the pattern and outcome of this autoimmunity varies with the TLR pattern of stimulation (part of Dr Shaun Summers’ PhD).

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Paul King examined lung tissues taken at open from patients with COPD (Chronic Obstructive Pulmonary Disease. For the first time lung lymphocytes were examined to assess the patterns of inflammation in the chronically damaged lungs. He found T cell receptor oligoclonality suggesting that cells were responding to a single dominant protein and their pattern of response was one likely to be the cause of inflammation and fibrosis during the disease.

Research activities The flow cytometry service supports a number of research projects including: Dr Anthony White (Monash Cardiovascular Research Centre) Cardiac stem cells Professor Stephen Holdsworth (Monash Centre for Inflammatory Diseases) T cell subsets in glomerulonephritis. Professor Richard Kitching (Monash Centre for Inflammatory Diseases) T regulatory cells in glomerulonephritis. Dr Shaun Summers (Monash Centre for Inflammatory Diseases) TLRs in autoimmunity. Dr Paul King (Monash Centre for Inflammatory Diseases) Characterisation of the T-lymphocyte response to NTHi infection by studying lung samples from patients with chronic obstructive pulmonary disease (COPD).

Professor Eric Morand (Arthritis Research Group, Monash Centre for Inflammatory Diseases): Investigation of the expression and function of the protein GILZ in animal models of rheumatoid arthritis in order to find alternatives to glucocorticoid therapy in rheumatoid arthritis.

Publications, awards, postgraduate students and funding summary Journal articles

9

Conference presentations

3

Postgraduate research students

2

Funding: Competitive NHMRC, Project. Mechanisms of disease in humans with MPO-ANCA associated glomerulonephritis. Holdsworth, S. 2011: $177,887. 2010-2012: $514,500 (Monash University) NHMRC, Project. Immunoregulation in the pathogenesis and therapy of autoimmune anti myeloperoxidase glomerulonephritis. Holdsworth, S. 2011: $96,648. 2010-2012: $273,750 (Monash University). NHMRC, Project. The role of mast cells in renal disease. Holdsworth, S. 2011: $173,902. 2011-2013: $521,706 (Monash University).

Research Group Reports Clinical Immunology

Community Services Report Director: Alana Russo (Health Promotion Practitioner)

This research explored the way in which Afghan women experience mothering within Australia. Throughout this research, findings emerged which highlighted the process of acculturation revolving around the role of the mother, taking a primary focus on the period spanning between the pregnancy and the postpartum period. A particular focus was taken to explore the relationship between Afghan and Australian experiences of motherhood, and to observe the way in which women react and respond to the various structures, social institutions, standards, and practices implicit within each culture. This research documented their experiences and demonstrated how these impacted their social and emotional wellbeing, and affected their role as mothers. Ultimately, this research explored the way that contrasting social and cultural structures intersect with Afghan women’s experiences of mothering and impacts on their social and emotional health.

Research achievements for 2011 This research was undertaken through a partnership between Southern Health and Monash University. This research was used to attain an Honours Degree in Health Social Science, for which the named director received First Class Honours.

The findings of this research presented several implications for practice and future research which are being considered for action throughout 2012. These include further exploring support models that could be implemented to assist Afghan mothers living in Australia, and a well planned, thorough evaluation of Southern Health’s current initiatives which work with this population group. Further participatory action research is also recommended to explore the types of outcomes that Afghan women would like to achieve, identifying what they perceive as the indicators to improved social and emotional health. This research will be summarised and disseminated throughout Southern Health, Southern Academic Primary Care Research Unit (SAPCRU), and other relevant networks.

Research Overview for 2011 This was qualitative exploratory research which involved two focus groups and ten in-depth, semi-structured interviews with women from Afghanistan living in Melbourne, Australia. All participants were from refugee backgrounds and had children below the age of five years.

The findings of this research indicated that Afghan women undergo an acculturation process throughout the period surrounding childbirth. This involves transactions between Afghan culture and Australian practices, in which women are consistently negotiating between these colliding cultures. This project explored the way that women interact and react to their experiences, and how this impacts on their role as a mother and their social and emotional health. Generally, throughout the antenatal period and birth process, these transactions meet little resistance. Women willingly adopt increased levels of antenatal care and comply with the advice of healthcare staff. Participants overwhelmingly reported positive feedback about the Australian health service. However, post birth experiences are met with emotional difficulties, which correlate with a lack of social support within Australia. This is a result of the migration experience, but also a result of broadly contrasting Western and Middle-Eastern cultures. This has implications for practice and future research.

Publications Journal articles

3

This research strongly employed participatory action methods, and participants were involved in selecting the appropriate data collection methods, which ensured the cultural appropriateness of the research design.

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Diabetes and Vascular Medicine Director: Professor Helena Teede

The Monash site of SPHPM School of Public Health and Preventive Medicine encompasses the Monash Applied Research Stream (MARS). We aim to deliver better health outcomes by taking a cross sector approach through applied research, education, advocacy, translation into practice and innovation in the areas of clinical care, service delivery, public health and health policy, with a strong focus on prevention, lifestyle related diseases including obesity, gestational diabetes and diabetes, mental health with a strong focus on women’s health.

Research achievements for 2011 We led a cross sector, multidisciplinary national initiative to develop and disseminate evidence based guidelines for the Assessment and Management of Polycystic Ovary Syndrome (PCOS). This 3 year project, funded by DoHA, will be completed in June 2012. In 2008, an independent PCOS Australian Alliance was formed, comprised of key leaders from the research and multidisciplinary clinical sectors, with consumers providing a driving force through the peak national support group in PCO’s (Polycystic Ovary Syndrome ), POSAA (Poly the Polycystic Ovary Syndrome Association of Australia).

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One of the priorities identified by the Alliance was to develop an evidencebased guideline for PCOS. The purpose of the guideline is to integrate the best available evidence with clinical expertise and consumer preferences; to provide health professionals, consumers and policymakers with guidance on timely diagnosis, accurate assessment and optimal management of PCOS; and to promote consistency of care and prevention of complications in primary care and specialist settings In 2009, four multidisciplinary guideline development groups (GDGs) (each group comprised of 8 – 10 members of the PCOS Alliance) were established to consider evidence reviews and develop recommendations in four major topic areas of PCOS: Diagnosis and Assessment Lifestyle and Weight Management Therapy for Infertility Emotional Wellbeing These four GDGs, including many Southern Health and Monash University staff, met monthly over a ten month period, considering evidence reviews for twenty-two clinical questions and developing thirty-eight recommendations. The guideline was developed as outlined in the National Health & Medical Research (NHMRC) standards and procedures for externally developed guidelines and approved by the Chief Executive Officer of the NHMRC on 29 July 2011, following recommendation for approval by NHMRC Council. In approving these guidelines, NHMRC considers that they meet NHMRC standard for clinical practice guidelines.

In July 2011, the pioneering and extensive guideline translation and PCOS education program being delivered by Jean Hailes for Women’s Health was launched by the Minister for Health and Ageing, the Hon Nicola Roxon MP and ongoing translation and dissemination activities are near complete. We were joined by two new senior NHF/ NHMRC research fellows, Assoc Prof Sophia Zoungas (diabetes) and Dr Jacqui Boyle (indigenous health) and their teams as well as the Women’s Mental Health Research team who transferred from Melbourne University. We completed a large, internationally funded, successful project showing improved healthy lifestyles in pregnancy in women receiving antenatal care at Southern Health.

Research Group Reports Diabetes Unit

Research activities Completed projects Menopause and Breast Cancer, Sayakot, P, Vincent A, Teede H. This VCA funded project investigated the perception/diagnosis of menopause in younger women with breast cancer; their experience of menopausal symptoms, psychological function, body image and effect of different breast cancer treatments on these parameters; describe the partners’ perception, understanding and personal experience of menopause/ menopausal therapy in women with breast cancer; determine current clinical understanding and management of menopause in women with breast cancer by different groups of Australian clinicians involved in their care; examine cultural influences on women’s understanding and management of menopausal symptoms between Australian and Laotian women; and to provide informed education and translation to consumers and health professional. Healthy Lifestyles in Pregnancy. Harrison C, Lombard C, Teede, H. To address the critical public health need for prevention of excess weight gain in pregnancy, this internationally funded project focused on overweight and obese women at increased risk of developing gestational diabetes in pregnancy. In an antenatal clinic setting, this randomised controlled trial compared standard antenatal care with basic health information (control) to standard antenatal care with a four session behavioural lifestyle intervention developed to optimise gestational weight gain and lifestyle behaviours including diet and physical activity. By twenty-eight weeks gestation the intervention group had gained significantly less weight compared to the control group with the greatest effect noted in non-obese women and non-Australian born women.

Following pregnancy, at six weeks postpartum there was a dramatic three day old reduction in weight retention in non-obese women. Several key publications arising from this project have been published, with results presented at conferences nationally and internationally. Role of exercise in treatment of women with polycystic ovary syndrome: Mechanisms of action. This NHMRC funded project focused on the underlying mechanisms of insulin resistance in PCOS. Across four key groups: Lean PCOS and controls, Obese PCOS and controls, comprehensive measures of mitochondrial function, insulin signalling, visceral and intramuscular fat and insulin resistance were completed. Obese women were then exercised for twelve weeks, three times a week) and these endpoints were reassessed. To date several key publications in high impact journals have reported on impact on fitness, differential improvements in insulin resistance and lipids in PCOS with exercise, visceral fat responses, mitochondrial functional changes and intramuscular lipid changes. Final endpoint analysis is still underway. Results have informed national evidence based guidelines and consumer resources on PCOS, which have been translated nationally.

Current projects Randomised sham-controlled trial of acupuncture for post-menopausal hot flushes. Pirotta, M, Teede, H, Xue, C, Chondros, P, Myers S. NHMRC funded. This clinical trial will test whether needle acupuncture is more effective than a sham needle control acupuncture in relieving post-menopausal women’s hot flush symptoms.

Measurement of glycemia in diabetic kidney disease, This prospective observational study examining the relationship between average glucose and HbA1c in patients with advanced CKD has completed recruitment and data capture. Initial results were presented in 2011 at the Australian Diabetes Annual Scientific meeting. Since then comparable data from a control group of patients without advanced CKD has been secured in a new collaboration with the US led investigators of the ADAG study. Data synthesis and analysis is now underway and manuscript presentation and submission is anticipated for later this year at the European Diabetes Meeting.

Awards and prizes Associate Professor Sophia Zoungas NHF Health professional Research Fellowship (2011-2014). Dr Jacqueline Boyle NHMRC Post-Doctoral Fellowship, Aboriginal and Torres Strait Islander Health Research (2011-2014) Dr Cheryce Harrison Women in Endocrinology Young Investigator Award from the US Endocrine Society, 2011 SPHPM travel grant to attend the 2011 Endocrine Society Annual Meeting in Boston 4-7 June Postdoctoral Fellowship Professor Jane Fisher Monash Fellowship, Monash University (2011-2015) Dr Karen Wynter SPHPM travel grant to attend the Marcé Society Conference in Fremantle, 13-14 October.

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Research Group Reports Diabetes Unit

Dr Anju Joham Postgraduate Scholarship Endocrine Society of Australia Travel Grant to attend the ESA annual scientific meeting in Perth, 28-31 August.

Publications, postgraduate students and funding summary Journal articles

38

Dr Padaphet Sayakhot

Conference presentations

52

Monash University Postgraduate Research Travel Grant to attend the World Congress on Menopause in Rome 8-11 June.

Postgraduate research students

9

Funding: Southern Health Research Week 2011 Poster Competition Dr Cheryce Harrison 3rd prize in Women’s Health and Men’s Health Category Limiting Excess Weight Gain in High Risk Pregnancies: A Randomised Controlled Trial Dr Sonia McCallum 1st prize in Mental Health Category Sustained postnatal depression in women: The need to consider the partner in interventions Dr Heather Rowe 2nd prize in Mental Health Category “What were we thinking” – an innovative psycho-educational program to prevent common postpartum mental disorders in women Dr Jane Fisher 3rd prize in Mental Health Category Common perinatal mental disorders in the north of Viet Nam: Community prevalence and health care use Dr Anju Joham 3rd prize in Endocrinology and Metabolism Category Pigment Epithelium Derived Factor – Marker of Insulin Resistance and Cardiometabolic Risk Factors in Obese Women with PCOS

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Competitive NHMRC, Project Grant. Insulin resistance in polycystic ovary syndrome and the role of skeletal muscle and adipose tissue. Teede H, Stepto N, Cameron J, Strauss B. 2010–2011: $404,000 (Monash University). NHMRC, Project Grant. Randomised sham-controlled trial of acupuncture for post-menopausal hot flushes. Pirotta M, Teede H, Xue, C, Myers, S, 2011-2015: $382,000 (Monash University). NHMRC, Project Grant. What matters to women diagnosed with breast cancer during their reproductive years? A qualitative investigation of fertility, reproductive health, heritability, and related psychosocial needs using a population-based sample. Fisher JRW, Kirkman M, Keogh L, Apicella C, Winship I, Hickey M. 2011-2012: $314,208 (Monash University). NHF, Fellowship. A Prof Zoungas, Zoungas S. 2011-2014: $296,000 (Monash University). NHMRC, Fellowship. Prof Teede, Teede, H. 2009-2012: $204,500 (Monash University). NHMRC, Fellowship. Dr Boyle, Boyle J. 2011-2014: $320 032 (Monash University). ARC Discovery and Linkage Projects, Project Grant. Maternal mental health and anaemia as determinants of infant health and development in resource-constrained settings. Fisher JRW, Biggs B, Dwyer T, Tran T, Nguyen NT. 2009-2011: $220,000 (Monash University).

ARC Discovery and Linkage Projects, Project Grant. Understanding fertility management in contemporary Australia. Fisher JRW, Rowe H, Bayly C, Jordan L, McNamee K, McBain J, Sinnott V. 2010-2013: $291,660 (ARC). $225,000 (industry partners) (Monash University).

Commercial Janssen Cilag, CANVAS. G Soldatos. 2011: $ 19,300 (Southern Health). Sanofi, ORIGIN. H Teede. 2011: $6,040 (Southern Health).

Other Perpetual Trustees Grant. ‘Building Research Capacity’, Fellowship (Jean Hailes). Department of Health and Ageing. ‘PCOS Alliance and Evidence Based Guidelines’, Project grant. PCOS national evidence based guidelines. Teede, H, Deeks A, Michelmore J. 2009-2012: $1,134,000 (Jean Hailes/ Monash). Bupa Health Foundation, Project grant. Application of integrated disease self-management in type 2 diabetes mellitus. David Clarke, Donita Baird, Virginia Hagger, Helena Teede. 2011: $34,187 (Monash). Australian Government Department of Families, Housing, Community Services and Indigenous Affairs Mothers, fathers and newborns: preventing distress and promoting confidence, Project grant. Mothers, fathers and newborns: promoting confidence and preventing distress. Fisher JRW, Rowe H. 2011-2014: $486,466 (Monash). Parenting Research Centre Social and emotional support in facilitated peer groups: a multiple method investigation of peer support, Project grant. Social and emotional support in facilitated peer groups: a multiple method investigation of peer support. Fisher J, Rowe H, Kirkman M, Hammarberg K. 2011-2012: $200,000 (Monash).

Diagnostic Imaging Director: Professor Stephen Stuckey

Southern Health Diagnostic Imaging is a tertiary level service, teaching and research entity which has grown substantially in the last four years, with a doubling of consultant staff numbers coupled with eight concomitant high level (professorial or associate professor level) academic appointments. Hence, there is an expectation that we will continue our steep trajectory of research achievement. Paediatrics, neuroradiology, ENT (Ear,Nose,Throat), body imaging and cardiac CT have thus far been the focus of our endeavours. We continue to extend this scope while the scale of these endeavours, exemplified by the world-first ground –breaking vocal cord movement assessment by CT is reaching a level of maturity.

Research achievements for 2011

Publications and funding summary Journal articles

28

Conference/poster presentations

66

Funding: Competitive Department of Health and Aging, Project Grant. National Paediatric CT Dose Survey. Prof. M Ditchfield, Prof S Goergen, Ms D Jackson and Ms J Clark. 2009-2011: $187,152 (RANZCR). Victorian Department of Health, Fetal MRI- cost effectiveness and change to diagnosis and management. Prof S Goergen, Dr M Fink (RCH). 2006-2011: $265,000 (Southern Health).

Vocal cord movement analysis by CT in asthma – roll-out of larger studies this year coupled with joint intellectual property software development with Toshiba; Award winning CT dose optimisation project across the network; Collaboration established with world class Monash University Monash Biomedical Imaging site with Southern Health joint appointments and Southern Health staff running the 3T Siemens Skyra operations from January 2012 (Official opening May 30).

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Emergency Medicine Director: Professor George Braitberg

The Southern Health Emergency Medicine Research Group (SHERG) oversees the research program encompassing the three emergency departments (ED’s) of Monash Medical Centre, Clayton, Dandenong Hospital and Casey Hospital, Berwick as well as an academic emergency medicine research affiliation with Monash University. There is an active clinical research program across the three EDs with specific focus on the core research interests of the network including: best-practice antiemetic and acute analgesia use in the ED, preventive health measures in emergency medicine, medical education of emergency medicine trainees, point-of-care testing in the ED, as well as a specific toxicology research laboratory for in-vitro and invivo research in aspects of applied and translational clinical toxicology. 2010 has been a productive year for emergency medicine research at Southern Health with an ever-increasing number of peer-reviewed publications, conference presentations and trainee and honours student research project presentations.

Research achievements for 2011 Southern Health Emerging Researcher Award (2011) awarded to Ms Donna Markham for research into the epidemiology and management of recurrent emergency department presenters.

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Australasian College for Emergency Medicine Annual Scientific Meeting award for best scientific presentation from a fellow of the college awarded to Dr Diana Egerton-Warburton for presentation entitled: A RCT of Antiemetic Agents in Adult Emergency Department Patients with Nausea or Vomiting. Translational research: Point of care troponin testing in the ED reduces length of stay and improves efficiency of assessment of chest pain in the emergency department. In a study led by Dr Robert Meek, it was found that point of care testing of troponin was an efficient way to assist in the risk stratification of patients presenting to the ED with chest pain resulting in significant reduction in hospital length of stay of low-risk of cardiac disease chest pain patients as well as identification of high risk patients requiring on-going hospital management of their condition.

Research activities Completed and current projects include the following: Egerton-Warburton D, Mee M, Meek R. An RCT of Antiemetic Agents in Adult Emergency Department (ED) Patients with Nausea or Vomiting. This study showed that there was no significant benefit from the use of antiemetics (ondansetron or metoclopramide) compared to placebo in patients presenting to the emergency department with nausea and vomiting from all causes and is the first placebo controlled RCT addressing this common clinical problem in the ED.

Braitberg G, Mosley I, Nicolas C, Phan T, Srikanth V, Bray J. Inter-rater reliability of stroke recognition and stroke onset time. This study investigates stroke recognition and symptom onset time identification across the process of pre-hospital and ED care. Assessments made by ambulance calltakers, paramedics, triage nurses, ED physicians and Neurology Physicians were investigated. The results of this study showed that there was poor recognition of stroke symptoms by members of the general public of all cultural backgrounds. Braitberg G, Hood K, Mosley I, Nicolas C. Community stroke knowledge. A public health project to investigate community stroke knowledge and the response of community members to stroke symptom onset. Further analysis has been undertaken to assess stroke knowledge prior to and following “Stroke Week�. This study will inform community awareness campaigns to improve stroke awareness. Kalam Y, Graudins A. An assessment of the efficacy of levosimendan in the treatment of severe propranolol poisoning in an in-vivo model of drug toxicity. Levosimendan is a novel inotropic agent used in the treatment of heart failure but was found to be ineffective in improving blood pressure or cardiac output in propranolol poisoning.

Research Group Reports Emergency Medicine

Kalam Y, Graudins A. An assessment of the efficacy of levosimendan in the treatment of severe metoprolol poisoning in an in-vivo model of drug toxicity. Levosimendan is a novel inotropic agent used in the treatment of heart failure. It was found that this agent improved cardiac output but not blood pressure in a model of severe metoprolol poisoning. Kalam Y, Graudins A. An assessment of the efficacy of fructose-1,6-diphosphate (FDP) in the treatment of severe propranolol poisoning in an in-vivo model of drug toxicity. FDP is a simple phosphate sugar that improves heart function in many stress conditions. The current research aims to assess its effectiveness in severe drug poisoning causing heart failure. Markham D, Graudins A. Retrospective review of the characteristics of adult frequent presenters to the emergency department. This study showed that there was a preponderance of patients with mental health and chronic respiratory conditions that were representing to the ED on a regular basis. The study has resulted in targeted care plans for patients in these groups that are currently being assessed. Markham D, Graudins A. Retrospective review of the characteristics of children as frequent presenters to the emergency department. Meek R, Tong R. The incidence of VTE in patients discharged from the Emergency Department with below knee immobilisation for an isolated lower leg injury. In progress. This study will help establish whether or not thromboprophylaxis is warranted for ED patients who are discharged from ED in a below knee cast for lower leg fracture or soft tissue injury.

Meek R, Principal Investigator for the PACT Study Group. The Paramedic Collaboration with Triage (PACT) Study. Aiming to Improve Patient Safety at the ambulance – ED interface. In progress. This study will assess the possibility of paramedics triaging patients pre-arrival using the ATS in order to avoid re-triage at hospital by a nurse. This may shorten ambulance patient transfer times and mean that only one verbal handover will be needed to treating staff. Meyer A, Graudins A, EgertonWarburton D, Meek R. An assessment of three oral analgesic regimens for moderate pain in adult patients in the emergency department. This ongoing RCT (Randomised Controlled Trial) study is assessing the comparative effectiveness of the addition of opioid analgesia to paracetamol and non-steroidal anti-inflammatory agents in moderate pain in the ED. Mosley I, Braitberg G, Meek R, Nicolas C. Language spoken at home and responses to cardiac symptom onset. An analysis of preferred language and correlation to time from chest pain symptom onset (delay), use of ambulance resources and admission rate to the emergency department. Mosley I, Braitberg G. Time of presentation for patients with chest pain - out of hours versus in hours (Mon – Fri 8am to 6pm). Are people less likely to present to emergency in the middle of the night? Compare and contrast populations presenting ‘in-hours’ and ‘out of hours’. An analysis of HeartWatch survey data assessing what people reported as their ‘intended action’ if experiencing chest pain or warning signs ‘in and out of hours’.

Mosley I, Braitberg G. HeartWatch campaign impact analysis: Analysis and comparison of hospital presentation data for patients with chest pain - pre campaign (6weeks), during campaign, post campaign (3months). Aim to assess if there is a subgroup that showed a particular response pattern/increase in chest pain presentations or admissions to hospital. This will be compared to data from the previous 2 to 3 years to compare seasonal variation. Mosley I, Braitberg G, Bray J. Pre-Hospital care of patients with severe headache. This study examines patients presenting to the ED with severe headache by ambulance, the assessment of pre-hospital analgesia administration by paramedics and the impact of analgesic administration on care in the ED setting. The results will assist in development of ambulance policy and pre-hospital clinical care guidelines for pain relief of patients experiencing headache or migraine. Mosley I, Braitberg G. Recognition, response and organization of acute stroke care in the community, prehospital and emergency department settings. A prospective observational study that aims to look at ways to enhance stroke awareness by exploring the recognition, response and organisation of acute stroke among doctors, nurses and members of the general public. Mosley I, Braitberg G, Bray J, Nicolas C. Acute stroke “Ramp Time” delays. A retrospective study of delay times of acute stroke patients who present by ambulance to Southern Health EDs. The focus of this study is the impact of delays from triage assessment to ED cubicle availability on the implementation of acute stroke rapid care protocols. This study will inform ED protocols to facilitate rapid stroke care in an environment of ED overcrowding and increasing patient presentations by ambulance.

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Research Group Reports Emergency Medicine

Mosley I, Innis K, Morphet J, Bray J, Braitberg G. The role of Triage Nurses in facilitating acute stroke care protocols in the ED. A retrospective study of triage assessments, problem identification and triage codes allocated to acute stroke patients who present to Southern Health EDs . This study will inform the development of education programs for triage nurses. Mosley I, Braitberg G, Bray J. Delay times to hospital inpatient admission for patients diagnosed as “Stroke” in the ED. This study seeks to identify factors associated with delay times to hospital admission (and Stroke Unit admission) following confirmation of a diagnosis of Stroke in the ED. Mosley I, Braitberg G, Bray J. Linking ambulance and ED databases: Documenting the process of care for acute stroke patients. For the first time in Victoria, investigators from Ambulance Victoria and Southern Health have effectively linked computer based pre-hospital data with ED data and formed a single database that describes the process of care for acute stroke patients from ambulance call to hospital admission. Mosley I, Braitberg G, Thrift A. Meredith I. Predictors of patient delay following the onset of a heart attack symptoms. This study seeks to identify factors associated with delayed presentation to the ED following the onset of cardiac symptoms. Mosley I, Braitberg G, Thrift A. Meredith I. Identifying barriers to seeking urgent hospital based medical care following the onset of heart attack symptoms. In collaboration with the National Heart Foundation this study seeks to investigate and compare patterns of care seeking behaviour following the onset of heart attack symptoms among two cohorts of participants. Members of the general public who have not experienced symptoms (What would they do if they experienced symptoms?)

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Patients who have recently experienced heart attack symptoms. (What did they do when they experienced symptoms?) Oakley E. An on-going multi-centre randomised controlled trial comparing nasogastric and intravenous hydration in children with bronchiolitis (The CRIB study) (three year trial with second year of recruitment finished). This trial aims to assess whether the provision of nasogastric fluids for rehydration of children with bronchiolitis is as effective as intravenous administration of rehydration fluids. Data analysis is currently underway for this study which has completed participant enrolment.

Publications, postgraduate students and funding summary Journal articles

11

Book chapters

2

Conference presentations

16

Postgraduate research students

1

Funding: Competitive NHMRC, Project Grant. Randomised controlled trial comparing nasogastric and intravenous hydration in children with bronchiolitis. Oakley E. 2011: $200,000. 2009-2012: $851,850 (Murdoch Research Institute).

Other Brockhoff Foundation, Assessment of intranasal ketamine in sub-dissociative doses for the treatment of moderate to severe pain in children with limb injuries in the emergency department – dose finding study (Part-1 of a two part study protocol). Graudins, A, Oakley, E, Egerton-Warburton, D. 2011: $65,000 (Monash University).

Research Group Reports Emergency Medicine

Endocrinology Director: Professor Peter Fuller

The Department of Endocrinology was originally established at Prince Henry’s Hospital in 1968. It was also closely aligned with the Medical Research Centre at Prince Henry’s Hospital. Both organisations were directed by Professor Henry Burger for some 30 years. During that time over 40 endocrinologists have been trained through the Unit, many of whom now Head Endocrinology Units around the country. Under Professor Burger’s leadership it became the preeminent Endocrinology Unit in Australia. Some 10 years ago the Endocrinology and Diabetes functions were separated in acknowledgement of the large expansion in the service demands associated with provision of diabetes services.

Research activities The Endocrinology Unit has over its 40 years of existence made a range of contributions to Australian and international endocrinology. The current focuses of research by members of the Unit are: Reproductive Endocrinology: Studies of male fertility and infertility, as well as the role of androgens in healthy aging males. More recently the Unit is developing programs around the problems of androgen deprivation in men with prostate cancer. Research in female reproductive endocrinology has focused on breast cancer, the menopause and polycystic ovarian syndrome.

Endocrine Oncology: The Unit has an active program of research on the molecular basis of thyroid cancer together with an engagement of local and national initiatives around the collection of tissue, databases and clinical trials capacity. The Unit played a prominent role in the development of the current guidelines for the treatment of thyroid cancer. The Unit has a long standing involvement in the endocrine aspects of breast cancer. In addition, there is active research on aspects of ovarian cancer, particularly granulosa cell tumours of the ovary. A number of the latter studies follow from the ground breaking work of Prof. Henry Burger and colleagues in discovering the hormone ‘inhibin’.

Osteoporosis and Metabolic Bone Disease:

Molecular Endocrinology: Other work has focussed on the action of the adrenal steroid hormones (aldosterone and cortisol), with particular emphasis on aldosterone. There is emerging evidence for an important role of aldosterone in cardiovascular disease and the benefits of therapeutic blockade. This is an active subject for investigation as well as the development of guidelines for the management of primary hyperaldosteronism.

Awards for 2011

Menopausal Medicine: The Unit has over the years made major contributions to the development of the management of menopause, particularly with respect to the endocrinology of the menopausal transition. The members of the Unit have projects examining management issues in women with breast cancer and in premature menopause.

In 2009, the Unit launched the Osteoporosis and Secondary Prevention Project which is being led by Dr Francis Milat. Associated with the development of service delivery will be research into osteoporosis both with respect to patterns of service delivery and management as well as into specific areas such as in males, in patients with thalassaemia and in women after breast cancer treatment. This research crosses from bench to bedside with parallel laboratory and clinical research activities.

Jun Yang ENDO 2011 Presidential Poster Competition Winner. Novartis Junior Scientist Award (ESA 2011) Phillip Wong Australian Postgraduate Award 2011. Royal Australian College of Physicians and Osteoporosis Australia Research Award 2011 Jimmy Shen Royal Australian College of Physicians and Osteoporosis Australia Research Award 2011 Peter Fuller 2011 Society for Endocrinology Hoffenberg International Medal of the British Endocrine Society. 2011 Excellence in Mentoring Award: Academic and Research, Royal Australasian College of Physicians

Southern Health Research Report 2011

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Research Group Reports Endocrinology

NHMRC, Project. Mineralocorticoid

Publications, awards, postgraduate students and funding summary Journal articles

receptor blockade: mechanisms of selectivity. Peter Fuller. 2011: $182,122. 2011 – 2013: $546,366 (Prince Henry’s Institute).

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Books

1

Book chapters

1

Conference presentations

19

Awards

7

Postgraduate research students

6

Funding: Competitive

National Heart Foundation Travel Grant, Grant. Jun Yang. 2011: $2,000 (Prince Henry’s Institute).

Australasian Women in Endocrinology Travel Award, Travel Award. Jun Yang.

NHMRC Postgraduate Scholarship, Scholarship. Jun Yang. 2008-2012

Quantum Award, Award. Jun Yang

2011: $500 (Prince Henrys Institute).

NHMRC, Postgraduate Scholarship.

Jun Yang 2011: $20,110. 2008-2012: $120,491 (Prince Henry’s Institute).

The Healthy Man Study-Development

of a Valid Diagnostic Criteria for Age-related Androgen Deficiency in Men, MBF Research Foundation / ANZAC Institute. Cost reimbursement. Robert McLachlan. 2008-2011: $85,935 (Prince Henry’s Institute).

Genetics of Male Infertility. Robert

McLachlan. 2002 – Present (Prince Henry’s Institute).

Sperm suppression and contraceptive

protection provided by Norethisterone (NET-EN) and Testosterone Undecanoate (TU) in Healthy Men, WHO-CONRAD. Clinical Agreement. Robert McLachlan. 2011: US$22,700. 2008 – 2010: Melbourne budget $US205, 000 (Prince Henry’s Institute).

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NHMRC, Fellowship. Senior Principal

Research Fellowship. Peter Fuller. 2011: $173,972. 2011–2015: $869,860 (Prince Henry’s Institute).

National Breast Cancer Foundation,

Program Grant. Collaborative Program Grant. Identification of nuclear receptor networks as new targets for breast cancer. (Christine Clarke, Wayne Tilley, Peter Leedman, George Muscat, John W Funder, Mark Ragan, Evan R Simpson and Nadia Rosenthal) $1 million per year for 5 years. Peter Fuller. $1,000,000 (Prince Henry’s Institute).

Cancer Council of Victoria, Project.

Molecular pathogenesis of granulosa cell tumours of the ovary. Peter Fuller. 2011: $100,000. 2010-2012: $300,000 (Prince Henry’s Institute).

National Heart Foundation, Grant in aid. Peter Fuller. Identification of ligand-discriminant interactions of the mineralocorticoid receptor. 2011: $64,500. 2010–2012: $193,500 (Prince Henry’s Institute).

Diabetes Australia Research Trust

(DART), Project. Grant Wong, J, Kothari, V. Improving the metabolic health of patients treated with Clozapine, an atypical antipsychotic. 2011-2012: $31,000 (Monash University).

Novo Nordisk Wong J, Bergin S,

Lemoh C. An open-label randomised pilot trial comparing outcomes of oral versus intravenous antibiotic therapy for the treatment of diabetic foot osteomyelitis. 2011-2012: $10,000 (Southern Health).

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Gastrointestinal and Hepatology Director: Professor William Sievert

Current research programs in the Gastroenterology and Hepatology Unit involve clinical trials of viral hepatitis therapy, basic mechanisms and treatment of liver fibrosis, the use of stem-like cells to treat hepatic fibrosis, the host immune response in HBV(Hepatitis B Virus) infection, endoscopic outcomes research and inflammatory bowel disease therapy. The Unit has been involved in over 90 clinical trials of novel agents for the treatment of chronic viral hepatitis and hepatocellular carcinoma, including the initiation and development of clinical trial protocols for national studies while also participating in multi-centre international trials. Basic hepatology research has focused on mechanisms of liver fibrosis with investigators from the Monash Institute of Medical Research, The University of Melbourne and the Monash University Centre for Inflammatory Diseases, with whom we also collaborate on studies of the host immune response in Hepatitis B infection. These studies, supported in part by the NHMRC and by funds from diagnostic breath testing, have led to three successful PhD completions. Endoscopic outcomes are a significant focus of Unit research pursuits because these activities directly affect patient outcomes. A scientific approach to the development and evaluation of therapeutic endoscopy is fostered by contributions to national scientific meetings in combination with a training program to assist young gastroenterologists to think critically about the outcome of endoscopic procedures.

The Unit is involved in clinical trials evaluating novel treatments for patients with inflammatory bowel disease and in the investigation of basic mechanisms of intestinal inflammation in patients with Crohn’s disease.

Publications, postgraduate students and funding summary Journal articles

18

Conference presentations

15

Postgraduate research students

4

Funding: Competitive NHMRC, Project. Role of Human Amnion Epithelial Cells in Resolving Hepatic Fibrosis. U Manuelpillai, W Sievert. 2010-2012: $596,500 (Monash University). GESA Ferring IBD Clinician Establishment Award, Post graduate scholarship. The role of adipocytokines in Crohn’s disease. Moore, GT. 2011-2012: $25,000 (Monash University).

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Infection Control and Epidemiology Unit Co-directors: Dr Rhonda Stuart and Ms Elizabeth Gillespie

The Infection Control and Epidemiology Unit are committed to increasing the evidence that supports reducing healthcare associated infections. In 2011, we contributed to the scientific literature on a number of topics and lead an innovative trial on environmental cleaning without using chemicals that was supported by Sustainability Victoria. The results of our work, in collaboration with Support Services Southern Health, will be communicated widely in 2012.

Research activities Innovative cleaning trial without using chemicals.

Publications and funding summary Journal articles

9

Conference presentations

4

Funding: Competitive Sustainability Victoria, Grant. Innovative cleaning trial without chemicals. E Gillespie. 2011: $25,000 (Southern Health).

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Infectious Disease and Microbology Director: Dr Tony Korman

We provide a broad range of clinical services including an inpatient unit, a busy consultation service, intensive care service, hospital in the home, intravenous antibiotic therapy, and outpatient clinics (including refugee health, mycobacterial infections and HIV/AIDS), in addition to infection control, clinical microbiology laboratory, antimicrobial management service, research and teaching activities. The establishment of the Innate Immunity Laboratory lead by Kumar Visvanathan in the Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University now provides our department with the opportunity to use basic science techniques to augment and support clinical research in Infectious Diseases. Recent highlights include a number of grants for the innate immune laboratory including a NHMRC grant in Hepatitis, a grant from the Australian Centre for Hepatitis and HIV as well as a grant shared with the renal department from the transplantation society of Australia and New Zealand, a number of major publications involving, mycobacterium ulcerans, innate immune responses in Hepatitis B infection and splenectomy.

Research activities

Funding:

Immunological Function post splenectomy: Ian Woolley, Denis Spellman.

Competitive

Innate Immunity of HBV infection: Narelle Skinner and Kumar Visvanathan. Liver Transplantation and Innate Immune response: Jess Howell and Kumar Visvnathan.

The foundation for AIDS research amFA, Australian HIV Observational Database. Woolley, IJ, Giles, M. 2011: $2000,00 (National Centre for HIV). NHMRC, Flu Grant. Flucan. Korman, T. 2011: $50,000 (ANU).

HBV and Pregnancy: Michelle Giles and Kumar Visvanathan.

Breast Cancer Research Foundation, Project. Mechanisms of cancer susceptibility among BRCA1/2 mutation carriers. Visvanathan K. 2011: $60,000. 2010-2012: $120,000 (Johns Hopkins).

Early Immune Responses to Mycobacterium ulcerans: Grant Jenkin Vesna Markovska, Tim Stinnear and Kumar Visvanathan.

Other

Measuring adequate treatment responses to TB: Sabine de Silva, Grant Jenkin, Vesna Markovska and Kumar Visvanathan. Longitudinal changes to the immune response in moderate to severe sepsis: Chris Wright (ICU), Jay Achar, Narelle Skinner and Kumar Visvanathan.

Southern Health/Monash University Academic Training Fellowship, Scholarship. Immunological Mechanisms in TB. Sabine de Silva, Kumar Visvanathan, Grant Jenkin. 2011: $30,000 (Southern Health).

Clinical and Molecular Aspects of Cl difficille: Grant Jenkin, Des Kotsanas, Tony Korman.

Research achievements for 2011

Publications, awards, postgraduate students and funding summary

Associate Professor Visvanathan gave a plenary at the Asian Pacific Association for the Study of Liver (APASL) in 2011 in Bangkok Thailand and also gave an oral abstract talk at the American Association for the Study of Liver (AASLD) in 2011 in San Francisco.

Journal articles

38

Conference presentations

18

Postgraduate research students

2

Southern Health Research Report 2011

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Intensive Care Unit Director: Dr Craig Walker

The Intensive Care Unit at Monash Medical Centre is a large twenty-two bed unit. A new five bed extension for paediatric patients was completed in 2011. It has a broad case mix including cardiothoracic, paediatric and neurosurgery and is one of the only units to look after obstetric patients. Monash Medical Centre is also the only tertiary unit to provide advanced life support to critically ill adults and children. It provides academic support to both medical and nursing staff, in addition the unit welcomes and fosters trainees from all backgrounds and has a strong emphasis on teaching and research. The unit also provides a Medical Emergency Team for the hospital.

Research activities

We have had some of the nursing staff and medical staff presenting their work at the annual ANZICS conference in Brisbane. A number of senior registrars have submitted projects to be undertaken in 2011/2012 to complete their Fellowships.

Publications and funding summary Journal articles

9

Conference presentations

2

Funding: Commercial

2011 has been a busy year for the Intensive Care research team. A number of ANZIC (Australian and New Zealand Intensive Care Society), CTG (Clinical trials group) studies have been completed, including The Early PN study: Early parenteral nutrition versus standard care in the critically ill patient: An ANZICS CTG endorsed level 1 randomised controlled trial.

AstraZeneca. Cyto-Fab study: A Multicentre, Randomised, Double-Blind, Placebocontrolled Phase IIb Study to Compare the Efficacy and Safety of Two Dosing Regimens of Intravenous Infusions of CytoFab& (AZD9773) in Adult Patients With Severe Sepsis and/or Septic Shock – VIC.

The commercially sponsored study, Prowess-Shock Study: A randomised, double-blind, placebo-controlled, multicentre, Phase 3 Study of Drotrecogin Alfa (activated) administered as a continuous 96-hour infusion to adult patients with septic shock, was also completed and analysed.

GlaxoSmithKline. ZORO Study: A Phase III international, randomized, double-blind, double-dummy study to evaluate the efficacy and safety of 300mg or 600mg of intravenous zanamivir twice daily compared to 75mg of oral oseltamivir twice daily in the treatment of hospitalized adults and adolescents with influenza.

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Merck Sharp & Dohme. Clos/Diff study: A Phase III Randomised, Double-Blind, Placebo-Controlled, Adaptive Design Study of the Efficacy, Safety, and Tolerability of a single Infusion of MK-3415 (Human Monoclonal Antibody to Clostridium difficile toxin A), MK-6072 (Human Monoclonal Antibody to Clostridium difficile toxin B), and MK-3415A (Human Monoclonal Antibodies Clostridium difficile toxin A and toxin B) in Patients Receiving Antibiotic Therapy for Clostridium difficile Infection.

Medical Oncology Director: Dr Peter Briggs

The Medical Oncology Unit is part of the MONASH CANCER CENTRE at MMC (Monash Medical Centre) Moorabbin which incorporates the Breast, Head and Neck, Urology and Gynae-oncology surgical units, the Peter MacCallum Radiotherapy Unit, Breast Screen Victoria and the Southern Melbourne Integrated Cancer Service. Medical Oncology now has a full-time presence at Dandenong Hospital where it operates a satellite Chemotherapy Day Ward and outpatient clinics. Medical Oncology runs a large clinical trials program including Phase I, II and III studies The clinical researchers are supported by a research team of trial co-ordinators and research nurses. The phase I unit was established mid-2009 and has close links with the Monash Institute of Medical Research. Medical Oncology is a member of Cancer Trials Australia which is a collaborative cancer clinical trials group sharing resources and expertise. In-house research projects occur in collaboration with other Southern Health units, in addition to Monash University. The Medical Oncology unit is part of the newly formed Monash Comprehensive Cancer Consortium.

Research activities Numerous collaborations have been established under the auspices of the Monash Comprehensive Cancer Consortium in the areas of breast and lung cancers. Our collaborators include: Associate Professor Tracey Brown, Alchemia Laboratory, Monash University, Clayton (Stem cell markers), Dr Alex Swarbrick, Garvan Institute, Sydney (Stem cell markers), Dr Erik Thompson, St Vincent’s Institute, Fitzroy (Matrix metalloproteinase activity), Dr Kara Britt, Monash University, Clayton (Gene Array analysis), Dr Neil Watkins, Monash Institute of Medical Research, Clayton (Stem cell markers), Dr Charles Swanton, University College Hospital, London (Next Generation Gene Sequencing), Dr Kristy Brown, Prince Henry’s Institute, Clayton (Aromatase/ MTOR pathways), Dr John Price, Monash University, Clayton (Heat Shock Proteins), Dr Gavin Wright, St Vincent’s Hospital, Fitzroy (Stem cell markers), Castrate resistant prostate tissue genetics study (11178B)-Dr David Pook.

Publications and funding summary Journal articles

3

Funding: Competitive Bethlehem Griffiths Research Foundation, Project Grant. Toward Better End Stage Cancer Prognosticating: The Monash Prognostic Indicator (MPI). Franco, M. 2011: 37,000 (Southern Health).

Commercial Boehringer Ingelheim. 1200.89; An open label, phase II trial of afatinib with or without vinorelbine for the treatment of HER2-overexpressing Inflammatory Breast Cancer. Ganju V (Southern Health). Quintiles. An Open-Label, Multicenter, Randomized Phase Ib/II Study of Irinotecan Plus E7820 Versus FOLFIRI in Second-Line Therapy in Patients with Locally Advanced or Metastatic Colon or Rectal Cancer. Strickland A (Cancer Trials Australia). Medpace. Anamorelin HCl in the Treatment of Non-Small Cell Lung Cancer – Cachexia (NSCLC-C): A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase III Study to Evaluate the Safety and Efficacy of Anamorelin HCl in Patients with NSCLC-C ROMANA 2 HT-ANAM-302. Briggs P (Southern Health).

Southern Health Research Report 2011

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Research Group Reports Medical Oncology

Amgen. A I Phase First-in-Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Orally Administered AMG 900 in Adult Subjects with Advanced Solid Tumors. Markman B (Cancer Trials Australia). PRA International. A Phase 2, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of IPI-926 in Patients with Metastatic or Locally Advanced (Unresectable ) Chondrosarcoma. Markman B (Southern Health). Roche. A randomized, multicenter, open-label phase II study of RO5083945 in combination with FOLFIRI versus FOLFIRI plus cetuximab or FOLFIRI alone as second line treatment in patients with KRAS wild-type or mutant metastatic colorectal cancer. Markman B (Southern Health). Amgen. A Phase III, Multicenter, Randomized, Double-Blind, Placebo Controlled, Trial of AMG 479 or Placebo in Combination with Gemcitabine as First-line Therapy for Metastatic Adenocarcinoma of the Pancreas (GAMMA, Protocol Number 20060540). Harris M (Cancer Trials Australia). CONGO. A randomised phase II Study of Carboplatin and Bevacizumab in Recurrent Glioblastoma Multiforme (CABARET study); COGNO0902/ ML255442. Lickliter J (Southern Health). Amgen. A Phase III Randomized, Double-blind Trial of Weekly Paclitaxel plus AMG 386 or Placebo in Women with Recurrent Partially Platinum Sensitive or Resistant Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancers. Goss G (Cancer Trials Australia).

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PPD. A Phase III study comparing Orteronel (TAK-700) Plus Prednisone with Placebo plus Prednisone in patients with metastatic castrationresistant Prostate Cancer that has progressed during or following Docetaxel-based therapy. Pook D (Southern Health). Peter Macallum Cancer Institute. A randomised controlled trial evaluating a nurse-led survivorship care package (SurvivorCare) for bowel cancer survivors. Strickland A (Southern Health). Novotech. Randomized double-blind Phase III trial of FOLF(HA)iri vs FOLFIRI for second or third line therapy in irinotecan-na誰ve patients with metastatic colorectal cancer (Protocol No: ACO-002). Ganju V (Cancer Trials Australia).

Mental Health: Centre for Developmental Psychology and Psychiatry Director: Professor Louise Newman

The Monash University Centre for Developmental Psychiatry and Psychology (CDPP) was established in December 1989 as a conjoint clinical research Centre of Monash University, Faculty of Medicine and Monash Medical Centre (now Southern Health) Child and Adolescent Mental Health Service. The CDPP has developed a substantial funding base to conduct research and associated teaching and clinical services in three major streams: The psychopathology, neuropsychology and treatment of developmental disabilities (Intellectual Disability and Autism); The phenomenology and treatment of Childhood Emotional Internalizing Disorders (Depression and Anxiety). The impact of trauma on neurological and psychological development. We work in close affiliation with the clinical services provided by the Southern Region Child and Adolescent Mental Health Service as well as CAMHS (Child and Adolescent Mental Health Services) in Bendigo, Mildura, Barwon, Wangaratta, LaTrobe Valley. Close working affiliations also exist with the Intellectual Disability Services in the Murray Murrumbidgee, Sutherland, Wollongong and Grafton areas of NSW and in South Australia. These links provide a substantial base of patients who form the focus of the range of clinical research projects.

Funding:

Research achievements for 2011

Competitive NHMRC, Comparison of psychotherapy with and without medication for school refusing youth with an anxiety disorder. Professor B Tonge, Associate Professor N King, Associate Professor E Gullone, Dr G Melvin. 2011: $171,875.

Children’s Recovery Project. School Refusal Project. Treating Trauma in Refugee Youth. Parenting with Feeling - infant-parent group intervention project.

NHMRC, Project Grant. A course of oxytocin nasal spray to improve social communication in young people with autism. Dr A. Guastella, Professor S. Einfeld, Dr K. Gray, Dr N. Rinehart. 2011: $89,500.

Award of a NHMRC Project Grant to commence in 2012 “Mental Health of Young People with Developmental Disabilities” $5.2million over 5 years

NHMRC, Project Grant. Sex hormones and social interaction. Dr W.C.Boon, Dr D. Stanic, Professor B. Tonge, Dr N. Rinehart. 2011: $189,500.

Publications, awards, postgraduate students and funding summary Journal articles

16

Books

2

Book chapters

2

Conference presentations

50

Postgraduate research students

40

NHMRC, Training Fellowship. “An investigation of cortical function in autism spectrum disorders using TMS, fMRI and EEG”. Dr P Enticott. 2011:$71,250. Dara Foundation, Time for a Future: Youth Psychotherapy and follow-up project. Professor B Tonge, Ms J Pullen, Dr S Gold, Ms J Beaufoy. 2011: $68,000 ARC, Enhancing mental health in Aboriginal children. Professor L.K. Newman, R.A. Bryant, D. Silove, R.Brooks, Z. Steel, K.Senior. 2011: $333,070 ARC. Effectiveness of social skills training for children with autism. Professor S Einfeld, Dr Katherine Sofronoff, Dr Kylie Gray, Dr Jacqueline Roberts, Dr Renae Beaumont. 2011: $67,000.

Southern Health Research Report 2011

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Research Group Reports Mental Health: Centre for Developmental Psychology and Psychiatry

ARC Linkage. The transition from

secondary school to adulthood: experiences and life outcomes for youth with an intellectual disability and their families. Dr HM Leonard, Dr C Bower, Professor N de Klerk, Professor GM Llewellyn, Professor SL Einfeld, Professor TR Parmenter, Professor BJ Tonge, Dr V Riches, Associate Professor NG Lennox. 2011: $83,000 Total: $137,500.

Department of Human Services,

Children First Policy: Autism Secondary Consultation and Training Strategy. Professor B Tonge, Dr A. Brereton. 2011: $149,500.

Beyond Blue, Treating trauma

in refugee youth: An Australian experience. Dr Glenn Melvin, Professor Louise Newman, Ann Locarnini, Meredith Levi. 2011: $5,062.

Beyond Blue, Building Children’s

Resilience in Fire Affected Communities. Professor Graham Burrows, Dr Glenn Melvin, Mr Alan Sutherland, Ms Megan McQueenie, Professor B Tonge. 2011: $33,773

Department of Human Services,

A parent education and skills training programme for adults with an ASD. Professor B Tonge, Dr A. Brereton. 2011: $87,541.

Apex Foundation for Research into

Intellectual Disability, Assessing symptoms of ADHD in children and adolescents with intellectual disability. Professor Kim Cornish, Dr Kylie Gray. 2011: $21,055.

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NHMRC, Project Grant. Motor

functioning in young people with ADHD? Comorbid type: A three dimensional motor analysis study. N. Rinehart, J. McGuinley, B. Tonge, R Iansek, A Murphy, K Cornish, J Bradshaw. 2011: $369,417.00.

ARC Linkage, Acquiring physical

skills: exploiting games technology to teach sign language. Dr. K.Ellis, Dr. L.Willoughby, Associate Professor. J.Fisher, Associate Professor N.Rinehart, Mr.N.B.Ray. 2011: $33,912.00.

Monash University Early Career

Development Grant. Can transcranial direct current stimulation (tDCS) improve mirror system activity in autism spectrum disorders? P.G.Enticott, P.Fitzgerald. 2011: $35,000.00.

ARC, Small Mercies, Big Futures:

Enhancing law, policy and practice in the selection, protection and settlement of refugee children and youth. Professor. L. Newman, Professor. Mary Crock, Professor. Sandra Gifford, Associate Professor Ben Saul. 2011: $137,500.

Mental Health: Early in Life (infant to youth) Mental Health Services Director: Ms Lisa Lynch (Early in Life) Unit Head: Dr Michael Gordon (Child and Adolescent Program)

The Early in Life (EIL) Mental Health Service has a number of areas of research related to early intervention, Southern Health Butterfly Eating Disorders Program, School Refusal and evaluation of clinician’s assessment of suicidal adolescents. The main areas of research are: The CAMHS (Child and Adolescent Mental Health Services) and Schools Early Action (CASEA) program is an early intervention program with children (Grades prep-3) with behavioural/ emotional problems. The CASEA program is utilising a comprehensive educational group program involving the parents and children within the Southern Health catchment. The project is half way through the research period. Understanding Kids is a pilot group for parents who have kids with challenging behaviours. Understanding Kids is an innovative eight week pilot program for parents with children who display challenging behaviours. Understanding Kids is developed from evidence pertaining to effective parenting group programs, behavioural analysis and sensory processing. The group focuses on promoting parents’ awareness of their own parenting practices, the way their child notices and responds to sensory information from the environment (visual, auditory, touch, taste, smell and movement) and challenging behaviours.

Understanding Kids will include ways for parents to better understand the messages communicated by their child’s behaviour in light of their child’s individual abilities and difficulties. The goal of Understanding Kids is to support parents to develop greater understanding and confidence in their ability to promote positive behaviour change in their child and decrease the stress associated with parenting. Questionnaires will be completed by parents prior to and following the completion of the group. Statistical analyses will evaluate changes in parenting stress and sense of parenting competence and changes in the child’s behaviour. Groups will consist of parents of similar aged children (for example 6-8 year olds) and will run sequentially over two years. The Southern Health Butterfly Eating Disorders Day Program provides intensive treatment for participants aged 12 to 24 years diagnosed with an eating disorder. An experienced multidisciplinary team provides individual, group and family therapy with a focus on nutritional rehabilitation; normalisation of eating behaviour; correcting dysfunctional attitudes towards eating and weight; body image issues and relapse prevention. An evaluation of the first 50 patients with a restrictive eating disorder has been completed. Ongoing assessment of the program with a larger cohort and patients with symptoms of bulimia is being undertaken.

School-refusal clinic is a collaborative research between EIL and the Centre for Developmental Psychiatry & Psychology treating youth 11 to 16 years who are suffering with anxiety and depression and are unable to attend school. School-refusal clinic is a randomised control trial which is investigating the treatment of school refusing young people who experience anxiety and/or depression using both psychological and pharmacological treatment approaches. The service is also undertaking an assessment of how staff assess suicidality in adolescent patients.

Research achievements for 2011 The Butterfly Eating Disorders Day Program is a joint, self-funded project between Monash CAMHS and the Centre for Developmental Psychiatry & Psychology (CDPP). The Butterfly Program has treated young people (12-24 years) with eating disorders using a multi-disciplinary approach in a day-program setting. Since 2007 the program has treated over 80 young people with a restrictive or bulimic eating disorder. A standardised assessment battery is administered pre-treatment, at 2 monthly reviews and at discharge enabling an evaluation of treatment outcome. The CDPP has brought to this collaborative project expertise in evaluation of clinical programs, data management, and analysis.

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Research Group Reports Mental Health: Early in Life (infant to youth) Mental Health Services

This project has also involved several psychology students who have worked under the supervision of Professor Newman and Dr. Melvin. An initial evaluation of the first 50 patients with a restrictive eating disorder was completed in 2011 and the results presented at the Presentation to the 9th Annual Conference of The Australia & New Zealand Academy for Eating Disorders. In the main the participants improved across the measures of weight, Body Mass Index and across all the psychological questionnaires. This research in a cohort of patients with eating disorders treated in a day program is unique in the method of data collection and analysis. The results are in the process of being submitted to a peer review journal.

Depression is a chronic relapsing and

remitting condition which commonly presents later in adolescence and in adult life. In 2011, ELMHS has with Professor Bruce Tonge and the Centre for Developmental Psychiatry & Psychology completed a 3 to 9 year follow-up of 130 adolescents treated for depression.

The follow-up study reported on several clinical variables which affect the course of the adolescent’s depression into their early adult years. Clinical factors in the individual and their family were identified at baseline assessment, which predicted the course of the adolescent’s depression, service utilisation and substance use. The results are in the process of being submitted for publication.

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The School Refusal Clinic has

assessed 60 young people who were diagnosed with an anxiety disorder. Young people who were not attending school as a result of their anxiety disorder were randomly assigned to treatment and treated with Cognitive Behavioural Therapy, fluoxetine, or placebo. All of the participants have been treated and completed 12 month follow-up. The data is currently being analysed.

Publications and postgraduate students Journal articles

4

Conference presentations

4

Postgraduate research students

1

Mental Health: Psychology and Behavioural Medicine Director: Professor David Clarke

PABM (Psychology and Behavioural Medicine) comprises psychiatrists and psychologists and other health professionals interested in the psychological and behavioural dimensions of health and the interactions between physical illness and mental illness.

Publications, awards, postgraduate students and funding summary Journal articles

6

Book chapters

2

Conference presentations

Research achievements for 2011 Development of an integrated self-management program for people with chronic heart failure and depression. Development and trial of a low level intervention for distress in cancer patients.

11

Postgraduate research students

6

Funding: Competitive

Research activities

Department of Veteran Affairs, Project. Sequelae of psychiatric conditions and multisymptom disorder after stressful events: Gulf War veteran cohort follow-up. Sim MR, McFarlane A, Forbes AB, Kelsall H, Clarke DM McKenzie DP. 2011: $150,000. 2010-2013: $595,539.

Application of tailored psychosocial therapies to reduce distress and depression in cancer patients: a randomised trial (in progress). Investigators: J Turner, B Kelly, DM Clarke, P Yates, S Aranda, D Jolley. Funded by beyondblue.

Beyondblue, Project. Application of tailored psychosocial therapies to reduce distress and depression in cancer patients: a randomised trial. Turner J, Kelly B, Clarke DM, Yates P, Aranda S, Jolley D. 2011: $198,000. 2010-2012: $594,275.

Application of integrated disease self-management in Type 2 diabetes mellitus (in progress) Investigators: DM Clarke, DE Baird, V Hagger, H Teede. Funded by Pupa Foundation.

Bupa Foundation, Project. Application of integrated disease self-management in type 2 diabetes mellitus. Clarke DM, Baird D, Hagger V, Teede H. 2011: $137,446. 2010-2012: $437,141.

A cross national muti-center study of depression, demoralisation and functional impairment in cancer patients (in progress). Investigators: JM de Figueiredo, G Fava, DM Clarke. Funded by World Psychiatric Association.

World Psychiatric Association, Project. A cross-national multi-center study of depression, demoralization and functional impairment in cancer patients. de Figueiredo JM, Fava G, Clarke DM. 2011: $5,000. 2011-2012: $10,000.

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Mental Health: Southern Synergy Director: Professor Graham Meadows

Southern Synergy, which is the shorter name for the Southern Health Adult Psychiatry Research, Training and Evaluation Centre is part of the School of Psychology and Psychiatry at Monash University and is a Faculty Research Centre within the Faculty of Medicine, Nursing and Health Sciences. It was jointly established in 2003 with Southern Health and continues to be closely linked with and supported by the Southern Health Mental Health Program. The Centre is presently based at the Notting Hill Campus. The centre exists: to champion research, knowledge and understanding in mental health care. The centre is dedicated to activities aimed at both teaching/education and research/evaluation and this work is grouped into a series of programs including: a directorate; Early Intervention; Headache and Migraine Health Services Research; Mindfulness; Rehabilitation and Nutrition; and Workforce below. Each is headed by a Senior Monash Academic who also has a Southern Health appointment.

Research achievements for 2011 Mindfulness Program: The DARE (Depression Awareness Recovery Effectiveness) project: Investigators: Professors Graham Meadows, Fiona Judd, Paul Martin, Zindel Segal, Leon Piterman: This study has been examining if Mindfulness-Based Cognitive Therapy when added to existing treatment as usual plus supported self-monitoring (DRAM: Depressive Relapse Active Monitoring) is more effective than DRAM in preventing depressive relapse in people who have had at least three prior episodes of depression. Data collection was finalised during 2011. People who completed a “dose” of MBCT (≥ 4 sessions) had an extra 52 depression-free days relative to control over 2 years and cost effectiveness is confirmed considered against other preventive interventions. Our first paper describing the design of the project was published in BMC Psychiatry. A student successfully completed his Post Graduate Diploma in Psychology with us examining moderating and mediating effects of anxiety in the context of MBCT. With confirmation that our implementation of the MBCT model has proved effectiveness, MBCT will during 2012 and after be made available to Southern Health Clients through a University clinic and free of charge.

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Simulation Modelling of Mental Health Services: The increasing availability of epidemiological and service use data for mental illness and sophisticated modelling technology has made feasible the modelling of mental health services for assisting mental health services (MHS) managers with decision-making. By trialling various scenarios of how new systems of treatment and care are likely to impact client outcomes, MHS managers can identify the optimal system of care available, within parameters such as fiscal constraints and the incidence and prevalence of mental illnesses. In essence, simulation modelling provides a system in which possible changes in the service system can be explored in virtual reality before large numbers of staff and resources are committed to the changes. The focus of our research projects is the development of modelling tools that will allow scenarios regarding the delivery of mental services to be simulated, enabling predictions to be made about the cost and quality of care and directly applicable to decision making in Southern Health. The Modelling Mental Health Services team includes representatives from the Faculties of Medicine, Nursing and Health Sciences; Information Technology; and Business and Economics, as well as the University of Calgary and Southern Health. In 2011, the innovative nature and potential contribution of the modelling work has been recognised through the awarding of a Faculty Strategic Project Grant from Monash University and ARC Linkage Project funding.

Research Group Reports Mental Health: Southern Synergy

Better Mental Health Treatment Plans Project: The Better Mental Health Treatment Plans Project was commissioned by the Commonwealth Government Department of Health and Aging to create standardised templates for the completion of General Practitioner Mental Health Treatment Plans, as used within the Better Access initiative. Four templates were developed, representing the integration of a literature review and findings from focus groups with a broad range of stakeholder groups, including general practitioners, consumers, carers, psychiatrists, psychologists, social workers, occupational therapists, medico-legal and e-health experts. The final suite of documentation included templates for use with adults and children, as well as a third template based on the SOAP (Subjective Objective Assessment Plan) framework and a fourth template for gathering the minimal dataset mandated by Medicare. The project was guided by Steering and Reference Groups convened to provide a sophisticated understanding of the factors involved in the assessment and treatment of mental health disorders in the Australian context. Pivotal in this was the incorporation of the ‘Recovery’ agenda that is so influential in specialist mental health care into work in the primary care sector. We are now working towards research work using these templates to promote effective collaboration between Primary Care Locally and Southern Health Mental Health Services through adoption of recovery focused templates in primary care that will assist alignment of practice and documentation across service sectors.

Research activities Workforce program research: Staff, Stress Management, Risk Management and Occupational Mindfulness Research: Investigators: Mr. John Julian, Ms. Joanne Brooker, Professor Graham Meadows. Stress impacts personal leave usage and staff retention in mental health services. Stress Management Education and Occupational Mindfulness (OM) training programs have been developed at South East Education and Training Cluster (SEETC) with Southern Synergy, initially for work in the Intellectual Disability sector but now extending into other settings. OM, a behaviour change course consisting of 8x2 hour sessions, involves mindfulness processes and principles. Each session is carefully adapted from the evidence-based Mindfulness-based Cognitive Therapy program. Work with this intervention has demonstrated that where staff involved in care delivery in residential settings take part in these programs there may be associated reductions in rates of seclusion and other restrictive practices as well as improved rates of sick leave. This work now is being taken forward with planned interventions in psychiatric in-patient units. While not a research activity a substantial amount of work in 2011 has gone into revision and update for the third edition of ‘Mental Health in Australia, Collaborative Community Practice’, a major textbook published by Oxford University Press. Two of the editors including the lead (Professor Graham Meadows and Associate Professor Fiona McDermott) work with Southern Health, as do many of the authors, with contributions from these staff in over half of the chapters of this very widely read and influential text, this third edition scheduled for publication in October 2012.

Mindfulness Program: The DARE (Depression Awareness Recovery Effectiveness) project: Investigators: Professors Graham Meadows, Fiona Judd, Paul Martin, Zindel Segal, Leon Piterman: Data collection on this study concluded in 2011. The work is examining if MBCT when added to existing treatment as usual plus supported self-monitoring (DRAM: Depressive Relapse Active Monitoring) is more effective than DRAM in preventing depressive relapse in people who have had at least three prior episodes of depression. A first paper describing the study is in print; and further work actively being prepared for publication examining outcomes, health economics and subgroup analyses.

Health Services Research program: Work continued on service and policy relevant analyses of the 1997 and 2007 Surveys of mental health and wellbeing with conclusion of reporting to the Victorian Mental Health Branch of commissioned research looking at Victoria specific estimates and exploring patterns of change (Investigators: Professor Graham Meadows; Dr. Irene Bobevski, Professor Scott Patten, Professor Brett Inder, Professor Paul Martin). A successful grant proposal to beyondblue supported work looking at labour market costs of mental illness. (Investigators Professor Brett Inder, Professor Graham Meadows) A new strand of work involves simulation modelling approaches to support planning in mental health services; this broad collaboration with health economics and Information technology and also with Southern Health management is gathering pace with receipt at the start of the year of a Faculty grant from Monash to support pilot work. During 2011, an application for a substantial ARC linkage grant was successful and this grant we anticipate will be coming on stream in 2012 supporting this work until 2015.

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Research Group Reports Mental Health: Southern Synergy

National Surveys of Mental Health and Wellbeing: The second and third parts of a contract with the Department of Health, Victoria to analyse data from the National Surveys of Mental Health and Wellbeing 1997 and 2007 and from the National Health survey 2008 was completed and two reports were submitted to the Department of Health. This work investigated the prevalence of mental disorders, their impact on disability and days lost, and the use of mental health services in Victoria and Australia. The findings of this work make an important contribution to a better understanding of mental health issues and services in Victoria and nationally and to informing future policy in Victoria. A recent paper in the British Journal of Psychiatry has demonstrated real evidence of improvement over a decade in the overall response to needs in the community. The chief investigators for this work are Professor Graham Meadows, Dr. Irene Bobevski, Professor Brett Inder, Professor Scott Patten, Professor Paul Martin. A paper comparing perceived need and barriers to mental health care in Australia and The Netherlands was published (Prins M, Meadows G, Bobevski I, Graham A, Verhaak P, van der Meer K, et al.) Perceived need for mental health care and barriers to care in the Netherlands and Australia. Social Psychiatry and Psychiatric Epidemiology. This study found that in both countries, the vast majority of mental health care needs are not fulfilled and illustrated the value of examining perceived need across nations and suggest substantial commonalities of experience across the two countries.

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Early Intervention: Associate Professor Brendan Murphy has led the development of a research program to investigate negative symptoms, medical comorbidity, genetic epidemiology, service models and delivery, and neurocognitive markers of violence in schizophrenia. Collaborators include Orygen Youth Health, Forensicare, the Australian Schizophrenia Research Bank and the Alfred Psychiatry Research Centre. Clinically, Associate Professor Murphy has developed an early psychosis clinical pathway to ensure best practice, including the early detection and management of medical comorbidities, and a risk factor questionnaire for prognosis in schizophrenia. He is spearheading the Youth Service component of Australia’s first Mental Health Service for people aged 0 to 25 years, currently in development at Southern Health. The following studies were active during 2011, either in data collection or preparation of work for publication.

Aggression and Facial Affect

Recognition Deficits in First-episode Psychosis.

Incidence and prevalence of insulin

resistance, metabolic syndrome and cardiovascular risk factors in young adults with psychosis.

The Negative Symptom Onset Scale

– a new tool to assist the research and clinical management of negative symptoms: reliability and validity.

Neuroprotective Properties of

Quetiapine versus Lithium in a First Episode Mania Cohort: 12-month Neuroanatomical, Neurochemical and Neuro-cognitive effects and preliminary data of prophylactic properties.

TMS study - Developing Prefrontal Assessment of Cortical Inhibition as a Novel Endophenotype for Schizophrenia.

BDNF (Brain Derived Neurotrophic

Factor) levels before and treatment with quetiapine in drug-naïve first episode psychosis

Autoimmunity and first episode

psychosis: a preliminary investigation

Psychosis Risk Onset and Outcome

Factor questionnaire (PROOF) study.

The Conquer Headache Program: The Conquer Headaches Program is based on a functional model of headaches published by Professor Paul Martin which seeks to explain the variance in headaches, by asking questions such as: Why does a headache occur at one time rather than another? Why are headaches occurring at this time in a person’s life rather than at other times? Why did the headaches begin when they did? Why is this person vulnerable to suffering from headaches? Active projects generally concluding data collection through 2011, have been the Headaches and Depression - Overcome Now (HeaD-On) project funded by beyondblue (Investigators Professor Paul Martin, Professor Graham Meadows, Professor David Reutens, Professor Leon Piterman. Mr. Martin Sharman, Dr Lilian Nejad.) and the Headache and Migraine Program Mastery of Triggers to Conquer Headaches (MaTCH) project funded by the NHMRC (Investigators Paul Martin, Peter Goadsby).

Research Group Reports Mental Health: Southern Synergy

Department of Health and Ageing,

Publications, postgraduate students and funding summary

through Royal Australian College of General Practitioners, Contract work. Meadows G, Brooker, J. 2011: $135,591 (Monash University).

Journal articles

9

Conference presentations

5

Postgraduate research students

3

Funding: Competitive

NHMRC, Project Grant. Should all

Faculty of Medicine, Nursing and

Health Sciences, Monash University, Strategic Project Grant. Modelling Mental Health Care Services: Providing Evidence to Support Management Decision-Making Regarding Service Configuration. Meadows G, Inder B, Patten S, Gordon-Brown L. 2011: $48,125 (Monash University).

triggers of headaches be avoided, or should headache sufferers learn to cope with some triggers? Martin, P.R., Goadsby, P.J. 2011: $64,000. 2009 – 2011: $486,000 (Monash University).

Victorian Office of Senior Practitioner,

Contract research. Office of Senior Practitioner Training – Occupational Mindfulness. Meadows G, Julian J, Brooker J. 2011: $52,880. 2009 – 2011: $102,880 (Monash University).

Department of Mental Health Branch,

Contract research. National Survey of Mental Health & Wellbeing research. Meadows G, Bobesvski I, Inder B, Martin P. 2011: $79,000. 2010 – 2011: $99,000 (Monash University).

Heart Foundation, Project Grant.

Genetic epidemiology and metabolism study. Foley D, Murphy B. 2011: $32,250. 2009-2011: 130,000 (Orygen Youth Health).

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Monash Children’s Director: Professor Nick Freezer

The Children’s Cancer Centre: The current research focus is based on enrolment in clinical trials. From a clinical treatment perspective this has meant the development of a clinical trials program that aims to ensure the best practice treatment protocols are available to families. The clinical trials program at the Children’s Cancer Centre is expanding with the increased patient numbers and complexity of treatment protocols over the last few years. The Melbourne Children’s Sleep Centre: Is the only sleep centre in Victoria and Tasmania. We see large numbers of children with sleep disorders in our clinics and carry out over 1000 overnight sleep studies per year. Our major research foci are: cardiovascular control and sudden infant death syndrome in infants, the cardiovascular and neurocognitive sequelae of obstructive sleep apnoea in childhood, the effects of treatment of obstructive sleep apnoea, alternative diagnostic methods in paediatric sleep medicine and obstructive sleep apnoea in special populations (particularly Down Syndrome, Prader-Willi Syndrome and obesity) The Paediatric Endocrinology and Diabetes Department: Has a major focus on collaborative diabetes research. We established a diabetes database within the National Diabetes Database under the auspices of the Australasian Paediatric Endocrine Group (APEG) over 15 years ago and this has enabled us to participate in larger national and international epidemiological diabetes studies. Our Department also has a specific clinical focus of psychological support and we aim to develop increasing research expertise in this area, by establishing research links with Monash University’s School of Psychology and Psychiatry.

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Monash Newborn: Monash Newborn provides Victoria’s largest tertiary neonatal service and has a long standing and close association with the Ritchie Centre for Baby Health Research. Bringing together the clinical expertise of neonatal specialists and the scientific expertise of the Ritchie Centre for Baby Health Research staff, unrivalled opportunities exist to undertake translational research on topics of key relevance to the care of infants born preterm or critically unwell.

Research achievements for 2011 Lauren Nisbet won the Young Investigator Award at the Australasian Sleep Association annual scientific meeting in October 2011 for her project carried out through the Melbourne Children’s Sleep Centre and The Ritchie Centre for Baby Health Research, entitled “Pulse transit time and the cardiovascular effects of sleep disordered breathing: Is it a question of exposure time?” A collaborative research project with Professor Anne-Louise Ponsonby at Murdoch Children’s Research Institute and the Diabetes Unit at Royal Children’s Hospital exploring the role of vitamin D status in the development of type 1 diabetes mellitus in newly diagnosed children aged less than 15 years of age (EET1DM Study) Increased participation in the multi-institutional Children’s Oncology Group and ANZCHOG clinical trials for childhood cancer, particularly the enrolment of patients onto open studies.

Research activities Melbourne Children’s Sleep Centre 2011-2013 - National Institutes of Health and Medical Research Council (NHMRC) project grant: “Alternatives to polysomnography for children with suspected obstructive sleep apnoea.” ($345,444). Nixon GM, Davey MJ, Horne RSC, Jolley DJ. Recruitment is well underway for this project that aims to develop a clinical tool to avoid the need for in-laboratory polysomnography in children with suspected OSA. 2011-2013 NHMRC project grant: “Does treatment reverse the neurocognitive and cardiovascular sequelae of sleep disordered breathing in children?” ($501,884). Horne RSC, Anderson V, Nixon GM, Davey MJ. Recruitment is well underway for this project which aims to determine the effect of treatment on the neurocognitive, behavioural and cardiovascular sequelae of sleep disordered breathing that we have previously demonstrated in pre-school children.

Research Group Reports Monash Children’s

2008-2010 NHMRC project grant “Impact of sleep disordered breathing on cardiovascular, behavioural and neurocognitive function in pre-school children” ($425,703). Horne RSC, Anderson V, Trinder J, Davey MJ, Nixon GM, Hope S. This study has now been completed. We have shown that snoring and obstructive sleep apnoea have significant cognitive, behavioural and cardiovascular impacts on pre-school children. This study will help clinicians determine the need for treatment at different levels of severity of sleep-disordered breathing in very young children. A BMedSci student (Lauren Nisbet) won the Young Investigator Award at the Australasian Sleep Association annual scientific meeting in October 2011 for her project carried out as part of this study. We are taking part in an international study of ex-premature infants, funded by the National Institutes of Health in the USA. This study aims to evaluate the long term effects of caffeine treatment in neonates on breathing control in school-age children. We are carrying out sleep studies in the homes of children, work that we expect will also extend our research experience with home testing for sleep disorders. Children with cystic fibrosis have many potential factors that can impact on their sleep quantity and quality. The MCSC in conjunction with Associate Professor Horne supervising paediatric respiratory fellow completing a PhD evaluating sleep patterns in this group. In 2008, we received financial assistance from the Windermere Foundation Special Grant for a research project entitled “The impact of obstructive sleep apnoea on cardiovascular function: are children with Down Syndrome at higher risk?” (A$14,879).

In 2009-10 Dr Denise O’Driscoll, a post-doctoral fellow in The Ritchie Centre for Baby Health Research, held the Allen and Hanbury’s Fellowship of the Thoracic Society of Australia and NZ for this work, which is now complete and submitted for publication. It demonstrates that children with Down Syndrome have a diminished cardiovascular response to obstructive events during sleep, a finding that has important implications for the clinical care of these children.

Children’s Cancer Centre Clinical trial Principal Investigator: Dr. Peter Downie for Children’s Oncology Group (COG) clinical trials at Monash Medical Centre Clayton. Participation where appropriate in clinical trials for the treatment of childhood cancer. The Children’s Cancer Centre (CCC) currently has sixteen clinical trials open (and two more in the process of submission and approval) for the treatment, data collection and study of a range of childhood cancers. Of these ten are open for accrual. At total of 15 patients in the CCC are currently enrolled in a clinical trial with a further 23 on trial surveillance. The CCC currently has clinical trials open from the COG, ANZCHOG and UK paediatric oncology group and is rapidly developing capacity for clinical trials. A submission for independent COG accreditation is targeted for 2012 that will further develop and expand the clinical trial service within the CCC.

Nutrition project In 2008, the Paediatric Integrated Cancer Service (PICS) commissioned a project to develop a best practice service model for nutritional services. ‘Optimising nutritional outcomes for children with cancer- A service model for the future’. This project will answer some important clinical research questions including:

Quantifying the number of children within different diagnostic groups who require different levels of nutritional care. Determining what percentage of all children present with evidence of malnutrition at diagnosis. Determining whether there a screening tool is needed for our patient population. If so, implementation of such a tool to improve the nutritional management of children with cancer. Identifying what kinds of feeding tubes are best used and what are the advantages and disadvantages of each.

Paediatric Endocrinology and Diabetes Australasian Paediatric Endocrine Group National Diabetes Register – PI Assoc Professor Christine Rodda Results: published by AIHW August 2010 “Incidence of Type 1 Diabetes in Australian Children 2000-2008” – ongoing project TrialNet Natural History study – Principal Investigator: Dr Phil Bergman – ongoing project Australian Childhood Diabetes DNA Repository (ACDDR) – Associate Professor Christine Rodda – ongoing project. Reproductive Health Survey – “Reproductive Health knowledge, attitudes and beliefs in Young Women with Type 1 Diabetes Mellitus (T1DM) aged 15 – 25 years attending a Multidisciplinary Transition Clinic” – 2011/12 FRACP Project Dr Jesuina Noronha Adolescent Diabetes Intervention Trial (AdDIT) including Microalbuminuria screening project – A/Prof Christine Rodda – commenced August 2011 Intra Nasal Insulin Trial II (INIT II) – A/Prof Christine Rodda - commenced October 2011 Easypod Connect Observational Study (ECOS) – Dr Phil Bergman – commenced late 2011

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Research Group Reports Monash Children’s

Monash Newborn Associate Professor Arvind Sehgal Research over the year 2011 has focussed on cardiovascular function in critically sick infants (birth asphyxia, pulmonary hypertension) using point of care clinician performed echocardiography. Associate Professor Sehgal’s sentinel publication on “Effects of indomethacin on coronary perfusion in preterm infants” was awarded the prestigious 2011 Henry Burger Award for Clinical Research and was published in Neonatology. This work demonstrated for the first time that indomethacin causes a temporary reduction in coronary perfusion, a finding of potentially high importance since ECG changes suggestive of myocardial ischemia have already been demonstrated in infants with PDA. Invited to conduct two state-ofthe-art workshops on functional echocardiography for neonatologists and post-doctoral fellows in India (Hyderabad and New Delhi). Co-leader of the Targeted Neonatal Echocardiography workshop at the 2011 Paediatric Academic Societies Annual Meeting, Denver, Colorado, USA Presented original research paper at the 2011 Paediatric Academic Societies Annual Meeting, Denver, Colorado, USA. Functional echocardiography in Canada and Australia and New Zealand: Survey of Practice. Thirteen publications in international peer reviewed journals.

Dr. Flora Wong Award of NHMRC Project Grant to commence 2012 on the impact of dopamine on the brain (2012-2014) Award of NHMRC Research Fellowship (2012-2016) Holder of an NHMRC Project Grant (2011-2013)

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Plenary Lecture presented to the Perinatal Society of Australia and New Zealand.

NHMRC, Project grant. Developmental changes in cerebral oxygenation after term and preterm birth. Horne RSC, Wong FY, Walker AM. 2011: $143,340. 2011-2013: $430,022 Monash Institute of Medical Research (MIMR).

Invited international speaker at the IpoKrates Seminars in Jarkarta (February) and Kuala Lumpur (September)

Phosphagenics Ltd, Research Grant. Use of dopamine to improve brain oxygenation in preterm babies. Wong FY. 2011: $25,000. 2010-2011: $55,000 Monash Institute of Medical Research (MIMR).

Fetal cardiac project with Paediatric Cardiology and Obstetrics

Dr. M. Nold Award of the Larkins Fellowship, Monash University

Cerebral Palsy Alliance. Career development award. Investigating Neuroprotective Strategies in Hypoxia-ischaemia. Wong FY. 2011: $20,000. 2011-2012 $40,000 Monash Institute of Medical Research (MIMR).

Award of Monash Strategic Grant Award of Georges Koehler Prize of German Society of Immunology (This Prize is awarded yearly to one scientist for outstanding research and contribution to better understand the function of the Immune system)

Kathleen Tinsley Foundation, Clinical Research Fellowship. Novel approaches to bedside monitoring of cerebral oxygenation in infants with HIE undergoing therapeutic hypothermia. Wong FY. 2011: $60,000. 2009-2011: $180,000 (Department of Paediatrics, Monash University).

Holder of an NHMRC Project Grant for years 2011 - 13.

Publications, postgraduate students and funding summary Journal articles

46

Books Conference presentations

3 39

Postgraduate research students

Funding: Competitive Perpetual Trustees. Randomised controlled trial comparing nasogastric and intravenous hydration in children with bronchiolitis. Oakley, E. 2011: $38,100. Jack Brockhoff Foundation. An assessment of the effectiveness of sub-dissociative doses intranasal ketamine in the treatment of severe acute pain in the emergency dept in children: a dose finding study. Oakley, E. 2011: $67,000.

8

NHMRC, Project grant. Alternatives to polysomnography for children with suspected obstructive sleep apnoea. Nixon GM, Davey MJ, Horne RSC , Jolley DJ. 2011: $119,213.44. 2011-2013: $345,444.00 (Monash University). NHMRC, Project Grant. Does treatment reverse the neurocognitive and cardiovascular sequelae of sleep disordered breathing in children? Horne RSC, Davey MJ, Nixon GM, Anderson V, Trinder J. Hope S. 2011: $173,201.52. 2011-2013: $425,703.00 (Monash University).

Research Group Reports Monash Children’s

Nephrology Director: Professor Peter Kerr

The Nephrology Department operates a large clinical service. In conjunction with this, it conducts clinical research in several areas, especially with regard to diabetic nephropathy, bone and vascular disease in dialysis patients, vascular access for dialysis and transplantation. Research covers trialling of new therapeutic approaches and agents as well as extensive epidemiologic studies. The focus of laboratory-based research within the department is to understand inflammatory mechanisms of renal injury in different types of kidney disease, including glomerulonephritis, diabetic nephropathy, renal transplant rejection and acute renal failure. This involves analysis of animal models of kidney disease, cell culture studies, and examination of patient samples. There is an emphasis on developing new therapeutic strategies to prevent or halt renal injury using a range of different strategies, including pharmacologic drugs, protein-based molecules and cell-based treatments. Clinical nephrologists are closely involved in the laboratory-based research, including acting as co-supervisors for PhD students pursuing laboratory research.

Research achievements for 2011 The Department has a habit of picking up awards at the Australian and New Zealand Society of Nephrology Annual Scientific Meeting – this year we scooped the following: Young Investigator (Science) went to Dr Poh-Yi Gan who conducted her research in Steve Holdsworth’s lab but was co-supervised by Shaun Summers. Matthew Damasiewicz (supervisors P Kerr and K Polkinghorne) was a finalist in the Young Investigator (Clinical) section. Best Scientific presentation went to Dr Sharon Ricardo for a paper on stem cell development from renal tissue – this paper is co-authored by P Kerr. Best Clinical presentation went to Dr Susan Blair (supervised by K Polkinghorne).

Research activities The Department continues to be active in a broad range of research activities. The laboratory, under David Nikolic-Paterson, has active research projects in diabetic nephropathy, progression of renal damage (eg. in the ureteric obstruction model), and in glomerulonephritis. Immune and inflammatory mechanisms of disease in glomerulonephritis, with a particular focus on macrophage engagement, have been a long standing focus of the laboratory.

Two new NHMRC project grants in renal fibrosis mechanisms kicked off in 2011. The laboratory continues to be very successful with 10 peer reviewed publications in 2011. In addition, we are winding up our renal transplant experimental work with the re-establishment of rat renal transplants for studying mechanisms of transplant rejection. John Kanellis and Bill Mulley lead this research, both coming off strong research backgrounds. The focus here is the relatively newly described mechanisms of humoral rejection – for which there has not been a good animal model in the past. We have also welcomed Dr Shaun Summers into the Department and laboratory over the past 12 months. Shaun comes with a strong background in renal vasculitis – having completed work in the UK and a laboratory PhD with Steve Holdsworth in this area. We are looking forward to a very rewarding 2012 with the establishment of these new areas of research. On the clinical front, we are continuing to pursue elements of mineral and bone metabolism relevant to chronic kidney disease and Matt Damasiewicz is examining vitamin D in particular. Home dialysis, as a proven beneficial dialysis mode (compared to centre dialysis) is strongly promoted within the Department and we are involved with several ongoing projects aimed at both promoting this modality but also overcoming barriers to its uptake. Kevan Polkinghorne remains the lead on several epidemiological projects around dialysis and vascular access for dialysis.

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Research Group Reports Nephrology

NHMRC, Project Grant. Resolvin

Slowly, this is having a national impact in improving the early establishment of vascular access for dialysis, before patients actually need to commence dialysis. This simple concept results in much better long term survival for the patients (as shown by Kevan during his PhD).

E1 is a novel anti-inflammatory and anti-fibrotic lipid mediator for the treatment of chronic kidney disease. Li J, Nikolic-Paterson DJ. 2011: $66,417. 2010-2012: $499,251 (Monash University).

NHMRC, Project Grant New roles

The Department continues to foster a strong PhD contingent, with 2 new PhD students commencing in 2011. We are also working closely with Steve Holdsworth’s lab, with another Nephrology PhD student in that lab.

for the spleen tyrosine kinase in antibody-independent renal injury. Nikolic-Paterson DJ, Ma FY. 2011: $185,016. 2011-2013: $555,048 (Monash University).

NHMRC, Project Grant. Distinct

pathogenic roles for JNK signalling in glomerular and interstitial injury in kidney disease. Nikolic-Paterson DJ. 2011: $178,902. 2011-2013: $536,706 (Monash University).

Publications, awards, postgraduate students and funding summary Journal articles

58

Conference presentations

67

Awards

4

Postgraduate research students

5

Funding: Competitive

NHMRC, Project Grant. Identifying the mechanistic basis of microalbuminuria in diabetic nephropathy. Poronnik P and Tesch GH. 2011: $74,440. 2009-2011: $223,320 (RMIT).

NHMRC, Project Grant Selective

targeting of acute renal injury by inhibition of the receptor tyrosine kinase, c-fms.Nikolic-Paterson DJ, Tesch GH, Ma FY. 2011: $42,400. 2010-2012: $427,200 (Monash University).

NHMRC, Project Grant. ACTIVE

dialysis. Cass, A, Kerr,PG. 2011: $416,058. 2009-2011: $1,248,175 (George Institute).

NHMRC, Project Grant. Plasma

Exchange and Glucocorticoids in ANCA Associated Vasculitis: A Randomised Control Trial (PEXIVAS Australia). Peh, CA, Kerr,PG. 2011: $201,458. 2010-2012: $604,375 (Uni SA).

NHMRC, Project Grant. Mechanisms

of disease in humans with MPO-ANCA associated vasculitis. Holdsworth, SR, Kerr,PG. 2011: $171,500. 2010-12: $514,500 (Monash University).

NHMRC, Project Grant. Long-Term Implications of Becoming a Living Kidney Donor: An International Prospective Study. Boudville N, Kanellis J (CIC). 2011: $51,866. 2011-2015: $259,332 (University of WA).

NHMRC, PhD scholarship.

Signalling Pathways in AntibodyMediated Renal Injury Jessica Ryan. 2011: $27,298. 2009-2012: $102,625 (PHIMR).

74

Kidney Health Australia, PhD

scholarship. Macrophage activation in kidney disease and renal transplant rejection. Abu Abrahams. 2011: $33,000. 2009-2011: $99,000 (PHIMR).

NHMRC, PhD scholarship. Cell

specific mechanisms of mineralocorticoid mediated renal injury in glomerulonephritis and diabetic nephropathy. Louis Huang. 2011: $30,000 2010-2012: $90,000 (PHIMR).

NHMRC, PhD Scholarship. Vitamin D and Chronic Kidney Disease: effects on mineral metabolism, vascular calcification and transplant outcomes. Matthew Damasiewicz 2011: $30,000. 2011-2012: $60,000.

Neurosciences Director: Professor Dominic Thyagarajan

The essence of being human resides in the brain -- the most complex and poorly understood organ in the body and arguably the most sophisticated structure in the universe. It is the focus of the clinical neurosciences. Diseases of the nervous system cause much of the burden of ill-health but recent advances in imaging, therapeutics and molecular genetics are at last providing inroads into the treatment of some of the most intractable and devastating diseases in society. The Clinical Neurosciences Department at Southern Health is large and very active in research with numerous internal and external collaborators. Neurological diseases include: stroke; neurodegenerative disorders such as Alzheimer’s disease and other dementias, Parkinson’s disease and Huntington’s disease; neuromuscular disorders such as motor neuron disease, peripheral neuropathies, myopathies and muscular dystrophies; neuroimmunological disorders such as multiple sclerosis; the epilepsies; traumatic disorders of the nervous system; a vast array of neurogenetic and neurometabolic disorders; developmental disorders of the nervous system; brain tumours; the headaches etc. Subspecialty clinics with research interests exist in all these areas. The department is particularly active in stroke research, neurodegenerative disorders, especially movement disorders such as Huntington’s and Parkinson’s disease, and epilepsy.

Research achievements for 2011 Engagement of a Professor of Clinical Neurosciences and Director of Neurology. Professor Thyagarajan has now: established his own laboratory; the only adult Mitochondrial Genetics Clinic in Victoria (with a strong research focus); coordinated the Deep Brain Stimulation Program across the Kingston and Monash Medical Centre Clayton campus (with a focus on NHMRC supported cross-institutional research in the area), and has established several key basic and clinical research collaborative partnerships within Southern Health, at Monash University, the Monash Institute of Medical Research and CSIRO. Continuing strong research performance of the Stroke and Ageing Research Group. The group has been substantially strengthened by the recruitment of Professor Mandy Thrift, a stroke epidemiologist to the Monash Medical Centre Clayton campus, commencing 2011. Professor Thrift will lead her own independent research group but already has strong collaborations with the Stroke and Ageing Research Group, particularly Associate Professors Velandai Srikanth and Thanh Phan. Continuing strong performance of the Huntington’s disease research represented at Southern Health by Associate Professor Andrew Churchyard. To demonstrate his international standing in the area, Associate Professor Churchyard is the chief organiser of the World Congress of Huntington’s Disease which was held in Melbourne in 2011.

This is the main research meeting in Huntington’s disease research in the world. He has also been appointed to the seven-person Executive Organizing Committee of Enroll HD, a multi-centre international prospective study of the natural history of Huntington’s disease which is expected to enrol 15,000 subjects which commenced in 2011.

Research activities Stroke and Ageing Research Group: The group has been successful in major grant funding, publications and has now included two other large divisional groups joining in epidemiology and translational public health (Professor Mandy Thrift). The key figures from neurosciences are Associate Professors Velandai Srikanth and Thanh Phan. Movement Disorders: The research group is represented by Professor Dominic Thyagarajan, Associate Professor Peter Kempster, and Associate Professor Andrew Churchyard. Professor Thyagarajan and Associate Professor Churchyard’s activities are outlined above. Professor Thyagarajan has moved from Adelaide where he continues to supervise his two PhD students, one holding a prestigious Endeavour Scholarship through Flinders University and one the recipient of a Multiple Sclerosis Research Association Grant. Refurbishment of his laboratory finished in 2011, he is taking a PhD student in 2011 and has established a key research collaboration with Professor Justin St. John, the new Director of the Centre for Reproduction and Development.

Southern Health Research Report 2011

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Research Group Reports Neurosciences

Publications, awards, postgraduate students and funding summary

Commercial

IMS-III - A phase III, randomized,

Journal articles

32

Book chapters

1

Conference presentations

20

Postgraduate research students

4

Funding: Competitive

NHMRC/NHF, CDA. Cerebrovascular

disease and dementia. V Srikanth. 2011: $100,000. 2010-2014: $400,000 (Monash University).

NHMRC, Project Grant. Diabetes and

dementia. Srikanth V, Phan TG et al. 2011: $300,000. 2010-2015: $1.2 million (Monash University).

NHMRC, Project Grant. STANDFIRM

(STANDFIRM – a secondary stroke prevention RCT using shared CDM management between nurses, doctors and GPs). Thrift AG, Cadilhac D, Srikanth V, Phan TG et al. 2011: $300,000. 2010-2015: $1.6 million (Monash University).

NHMRC, Postgraduate scholarship

(PhD). Immune study of stroke. Sanders l. 2011: $25,000. 2010-2013: $80,000 (Monash University).

Endeavour Scholarship,

Postgraduate scholarship (PhD). A Novel Mitochondrial DNA (mtDNA) Mutation Significantly Attenuates Transcription Termination In A Patient With A Mitochondrial Myopathy. Raghupathi Ravinarayan. 2011: $30,000. 2007-2011: $120,000 (Flinders University).

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multi-centre, open label, 900 subject clinical trial that will examine whether a combined intravenous (IV) and intra-arterial (IA) approach to recanalisation is superior to standard IV rt-PA (Activase/Actilyse®) alone when initiated within 3 hours of acute ischemic stroke onset.

DIAS-3 - A randomised, double-blind, parallel-group, placebo-controlled phase III study to evaluate the safety and efficacy of desmoteplase in subjects with acute ischemic stroke.

Interact 2 - A randomised trial to

establish the effects of early intensive blood pressure lowering on death and disability in patients with stroke due to acute intracereral haemorrhage.

Interact 2 - A randomised trial to

establish the effects of early intensive blood pressure lowering on death and disability in patients with stroke due to acute intracereral haemorrhage.

PrePARE- Prediction and Prevention to Achieve Optimal Recovery Endpoints after stroke (Protocol NTA0902).

Start-EXTEND - Stroke imaging

prevention and Treatment (START); Extending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND) – (NTA0901) Garfield Prospective, multi centre, international registry of male and female patients newly diagnosed with atrial fibrillation.

BIAL 9-1067 indiopathic Parkinson’s

Disease patients with “wearing-off” phenomenon treated with levodopa plus a dopa decarboxlayse inhibitor (DDCC): a double blind, randomised, placebo controlled, parallep group multicentre clinical study 2010-2011.

Other

Immune study of stroke, Merck Serono. Sanders, Srikanth, Phan, Sobey. 2011: $50,000 (Monash University).

Data linkage study of TIA. Pfizer CVL. Choi, Srikanth, Phan. 2011: $50,000 (Monash University).

TMS in cervical dystonia. Ipsen.

Gangadharan Ganesvaran, Lee, Raghav, Thyagarajan. 2011: $50,000 (Southern Health).

Laryngeal function in early Parkinson’s disease in essential tremor. Project Grant. Dominic Thyagarajan. 2011: $50,000 (Southern Health).

Determining the imaging correlates

of parkinsonian gait disturbance in a cohort of patients aged 70 or older. Project Grant Dominic Thyagarajan. 2011: $50,000 (Southern Health).

Neurosurgery Director: Mr Andrew Danks

The neurosurgical department at Southern Health is one of the busiest in the state. It covers all aspects of neurosurgery from the newborn to the elderly. It is active in research and teaching and has an excellent reputation amongst trainees. Neurosurgery is constantly evolving with current focuses on extended endoscopic surgery, functional and stereotactic surgery as well as neuro-interventional vascular neurosurgery. The department has a high volume in these areas, which is attractive to patients and trainees. The department is active in both laboratory and clinical research. A major focus is in stem cell research which Monash neurosurgery has proudly led the way with first-in-man international clinical research.

Research achievements for 2011

Dr Oehme awarded NSA scholarship for PhD in the study of stem cells for disc disease. Dr Goldschlager’s PhD work led to cervical fusion stem cell trial which demonstrates rapid translation from the bench to clinic. Active collaborations with Monash Institute of Medical Research, Ritchie Centre for Baby Health Research, CSIRO, RMIT and The Alfred Hospital. Paediatric Neurosurgeons Mr Danks and Mr Xenos together with Paediatric Plastic Surgeons Mr Ying and the late Mr Dowling, pioneered surgical method for closure of myelomeningocele. Research projects and trials have generated over 1 million dollars in funding.

Publications and funding summary

Completed recruitment for Mesoblast – first-in-man cervical fusion stem cell trial.

Journal articles

15

Book chapters

3

Major centre for CONSCIOUS 3 international multicentre trial for vasospasm treatment in subarachnoid haemorrhage.

Conference presentations

5

Launching new stem cell trial to treat degenerative disc disease.

Research activities Highest recruitment for CONSCIOUS 3 trial. Highest recruitment for Cabaret trial studying Avastin in the treatment of Glioblastoma.

Funding: Commercial

Actelion, A Prospective, Multi-Centre, Double-Blind, Randomise, Placebo-Controlled, Parallel-Group Study to Assess The Efficacy and Safety of Clazosentan in ReducingVasospasm-Related Morbidity and All-Cause Mortality in Adult Patients with Aneurysmal Subarachnoid Haemorrhage Treated by Endovascular Coiling. Mr Andrew Danks (Principal Investigator)Tony Goldschlager (Co-Investigator) (Southern Health). Mesoblast, A Prospective Randomized, Double-Blinded, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse when Combined with MasterGraft Granules in Subjects Undergoing Multi-Level Anterior Cervical Discectomy. Tony Goldschlager (Principal Investigator), Andrew Danks, Michael Pullar, Chris Xenos, Craig Timms, Armin Drnda (Co-Investigators) (Southern Health). Mesoblast. Preclinical study evaluating the safety and efficacy of different formulations of STRO3+ immunoselected allogeneic mesenchymal precursor cells on the repair and reconstitution of the extracellular matrix of degenerative intevertebral discs using an ovine model. Dr David Oehme (Principle Investigator), Tony Goldschlager (Co-Investigator (Monash University).

Mesoblast, A Prospective, Multicenter, DoubleBlind, Controlled Study Evaluating Safety and Preliminary, Efficacy of a Single Injection of Adult, Allogeneic Mesenchymal Precursor Cells Combined with Hyaluronan in Subjects with Chronic Discogenic, Lumbar Back Pain (Co-Investigator). David Oehme, Mr Michael Pullar, Mr Chris Xenos (Principal Investigator), Tony Goldschlager (Co-Investigator) (Southern Health). Southern Health Research Report 2011

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Nursing: Deakin – Southern Health Nursing Research Centre Director: Professor Beverly O’Connell

The vision of the Deakin - Southern Health Nursing Research Centre is to be nationally and internationally recognised as a centre of excellence in nursing research in the areas of quality, safety and aged care. The centre is part of the School of Nursing and Midwifery at Deakin University which received an Excellence in Research for Australia (ERA) ranking of four, indicating that the research conducted is above world standards. The centre is staffed by clinical and academic staff from a number of disciplines, including nursing, psychology, and public health. This combination supports an eclectic approach to conducting high quality research that informs policy development, clinical practice, and education. In 2010, the centre relocated to new offices alongside Nursing and Midwifery Education and Strategy, a move that reinforces the strong links between our departments and provides increased opportunity for collaboration. Additionally, the Deakin – Southern Health Nursing Research Centre works closely with Southern Health clinicians who require guidance and support to translate their research ideas into achievable projects that will make a contribution to the evidence base. The centre has attracted over $1.8 million dollars in funding since its inception in 2006.

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Research achievements for 2011 Wendi Bradshaw (Casey renal dialysis nurse), Cherene Ockerby and Paul Bennett were awarded best haemodialysis nursing abstract at the 32nd Annual American Dialysis Conference held in San Antonio Texas in February 2012. Honours student and Deakin – Southern Health Nursing Research Centre team member Tasneem Islam achieved a high distinction for her thesis entitled ‘Risk of hospital readmission among elderly patients with congestive heart failure: A comparative study’. The centre received over $500,000 funding from the JO & JR Wicking Trust to further our work in the care of the older person and develop the Centre for Innovation and Education in Aged care.

Research activities Handover Evaluation Scale In 2008, the team first published the findings from a handover survey that was completed by nurses from 21 wards across Monash Medical Centre Clayton. To date, this tool is the most comprehensive survey of nursing handover practice reported in the literature and the team have received requests from numerous researchers internationally for permission to use this tool.

The team have recently conducted more rigorous psychometric testing of this Handover Evaluation Scale and have submitted a paper for publication. Monitoring and evaluating handover is an important quality assurance process to maximise patient safety and is now required to meet the new healthcare accreditation standards. Partnering with international researchers offers an opportunity to further test and refine the tool, comparing and contrasting results from different contexts.

Readmission among Elderly Patients with Congestive Heart Failure: A Comparative Study Tasneem Islam completed an honours thesis which examined the reasons for hospital readmission among older adults with congestive heart failure. The study addressed an important health care issue for a group of patients who are at high risk of adverse outcomes. A major finding was that patients admitted to hospital from non-acute healthcare facilities such as residential aged care, were at significantly greater risk of readmission than patients from the community. As part of the 2012 Southern Health emerging researcher fellowship, Tasneem will further investigate this disparity, with a particular focus on the reasons why older adults with congestive heart failure are transferred from residential aged care facilities into acute care. Research in this area will aid in the development of strategies to reduce in-hospital risks for patients with chronic illness and may help to minimise cost to the health care system.

Research Group Reports Nursing: Deakin – Southern Health Nursing Research Centre

Centre for Innovation and Education in Aged Care Professor O’Connell, together with Dr Helen Forbes from the School of Nursing and Midwifery at Deakin University, received funding to develop of a ‘Centre for Innovation and Education in Aged Care’. The aim of this Centre is to educate and support the residential aged care workforce to implement the Tri-focal Model of Care that improves the wellbeing of residents. It builds on the success of the ‘Teaching Nursing Home’ project that was funded by the JO & JR Wicking Trust for the period 2007 – 2010. It is envisaged that the implementation of the Tri-focal Model of Care will result in promoting a change of culture within the residential aged care sector. This culture and changes in care will improve the wellbeing of residents and staff as well as enhance the student learning experience and recruitment and retention of the workforce.

Chronic Condition Nursing Research Associate Professor Bennett has led a very active renal nursing research program including multi-centre research titled Improving Communication between nurses and patients (Dandenong, Moorabbin, Casey and Cranbourne). In addition, single centre research studies include the Effect of Arnica on Cannulation Related Haematoma (Dandenong), Reducing Intradialytic Hypotension (Casey), Dialysis ZUMBA Gold (Moorabbin), Improving Patient Phosphate Education (Moorabbin) and Care of the Bariatric Patient on Home Dialysis (Dandenong). Non-renal chronic condition research has included chronic heart failure readmission data study (Casey), Needs of People with Cancer from CALD (Culturally and Linguistically Diverse) backgrounds (Moorabbin), and Professional Governance (Dandenong, Casey, Cranbourne, Kingston, Moorabbin, Clayton).

Publications, awards, postgraduate students and funding summary Journal articles

Other

19

Books Conference presentations

2

Southern Health Nursing Research Scholarship, Project. Decreasing cannulation extravasation pain using Arnica cream. Goedemans, A, Liang, K, Cottell, B, Bennett, PN. 2011: $3,000 (Southern Health).

16

Awards

2

Postgraduate research students

3

Funding: Competitive JO & JR Wicking Trust, Project. Centre for Innovation and Education in Aged care. O’Connell, B, Forbes, H. 2011: $207,737. 2011-2013: $508,198 (Deakin University). Deakin University 2011, Project. The evidence-practice gap for management of ‘behaviours of concern ‘, Lakhan, P, O’Connell, B. 2011: $24,819 (Deakin University). Western Australian Country Health Service, Consultancy. Evaluation of WACHS Goldfields Kidney Disease Nurse Management Program. Bennett, PN, Ockerby, C, Cossich, T, O’Connell, B, 2011: $20,000. 2011-2013: $60,000 (Deakin University). Deakin University 2011, Project. A novel strategy to improve fluid adherence through improved self-management. Bennett, PN, Bonner, A. 2011: $19,000 (Deakin University). Wesley Research Institute, Project. Levels of fatigue and quality of life for people with end stage kidney disease on haemodialysis or haemodiafiltration. Moynahan, L Bonner, A Bennett, PN, Wyatt, J. 2011: $15,490 (Queensland University of Technology). Renal Society of Australasia, Project. Improving exercise in dialysis through Zumba Gold Bennett, PN Corridini, AM. 2011: $500 (Deakin University).

Southern Health Research Report 2011

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Occupational Therapy at Casey Hospital Directors: Donna Markham (General Manager) Susan Fone (Occupational Therapy Manager)

Occupational Therapy (OT) consists of 8 clinicians who work across acute and subacute and palliative care services. Although a small Department we still strive to be involved in research and utilise the resources of the universities. This year we have joined up again with Monash University Occupational Therapy Department and have an Honours Student working closely with the team. The Department encourages further education and clinicians are encouraged to complete further education, this year one of the team has recently completed her graduate certificate in Gerontology and another clinician is embarking on a Graduate certificate in Health Sciences in particular looking at stroke management which they will complete in 2012.

Research activities Research that we are completing this year – this is a cross site project involving the OT departments at Casey Hospital, DDH and Kingston Centre looking at: Are Cognitive Assessments able to predict the functional performance of patients in an acute and rehabilitation setting? In conjunction with Monash University Human Research Ethics Committee approved by Southern Health and Monash University Developed links with interpreting services (Southern Health) 12 week data collection cross site (February-May) Thesis to be completed after data collection Conference presentation in 2012 once written up. 80

Principal investigators: Debbie Roe - OT Casey Hospital Associate Researcher Dr. Ted Brown - Associate Professor from Monash University Student Researcher Laura Jolliffe – Monash University Research Co-ordinators Leesa Fielding - Dandenong Hospital Kate Rickard - Kingston Centre

Postgraduate students and funding summary Conference presentations

1

Postgraduate research students

2

Funding: Other Monash University, Are standardised cognitive assessments used in acute, sub-acute rehabilitation and geriatric evaluation and management setting predictive of clients’ functional performance. Cross site project for Casey Hospital, Dandenong Hospital and Kingston Centre, Occupational Therapy. Roe D, Brown T, Jolliffe L.(student), Fielding L, Rickard K (Southern Health and Monash University).

Obstetrics and Gynaecology Directors: Professor Euan Wallace (Obstetrics) Associate Professor Beverley Vollenhoven (Gynaecology)

The Department of Obstetrics and Gynaecology forms part of the Women’s and Children’s Program at Southern Health, Southern Health is the largest provider of women’s health services in Victoria. Gynaecological activity takes place at Monash Medical Centre Clayton, Monash Medical Centre Moorabbin Campus, Dandenong Hospital, Casey Hospital and the Cranbourne Integrated Care Centre. This state-wide service is a collaboration between Southern Health, Royal Women’s Hospital and Mercy Women’s Hospital, based at Monash Medical Centre. Obstetric (maternity) services are delivered at Monash Medical Centre, Clayton, Dandenong Hospital and Casey Hospital. The obstetric services include general obstetrics, midwifery, fetal diagnostic services, maternal-fetal medicine and the Victorian “Fetals Surgery Services”. Research activities are undertaken in all of these clinical services with research strengths in early pregnancy, fetal growth and development, pre-eclampsia and caesarean section. Gynaecology services include general gynaecology, urogynaecology, reproductive medicine, contraceptive counselling, menopause, gynaecology endoscopy and pelvic endometriosis pain. Research activities are undertaken in all of these clinical areas but with particular research strengths in reproductive medicine, endometrial biology, endometriosis, pelvic floor surgery and gynaecological cancer.

Funding:

Research achievements for 2011

Competitive NHMRC, Project Grant D 546005. Preventing Prenatal Brain Injury in Fetal Growth Restriction. Prof EM Wallace, Dr S L Miller, Prof G Jenkin, Dr G R Drummond, A/Prof D W Walker. 2011: $173,517. 2009-2011: $491,250 (Monash University).

RANZCOG ASM 2011 Best Scientific Paper – Dr Rebecca Lim NHMRC Project Grant to deliver new treatment for ectopic pregnancy Awarded $2M from Commonwealth Government to establish a Cell Therapy Centre

NHMRC, Project Grant ID 606479. Treatment of Cerebral Palsy – an experimental approach. Dr S Miller, Prof EM Wallace, Prof G Jenkin. 2011: $96,559. 2010-2012.: $568,500 (Monash University).

Research activities Research is undertaken in all branches of our specialty including fetal medicine, ultrasound, twins, clinical obstetric trials and clinical risk management, urogynaecology, gynaecological, reproductive medicine and gynaecological endoscopy, menopause and contraception. We collaborate with Prince Henry’s Institute of Medical Research, Monash IVF and many national and international colleagues.

Publications, awards, postgraduate students and funding summary Journal articles

21

Books

1

Book chapters

3

Conference presentations Awards Postgraduate research students

37 1 15

NHMRC. Project Grant ID 606483. Preventing preterm lung disease – a cell therapy approach. Prof EM Wallace, Prof G Jenkin, Dr T Moss, Dr S Miller, Dr A Veldman. 2011: $153,572. 2010-2012: $444,188 (Monash University). NHMRC, Development Grant RGMS ID APP1000615. Novel methods for promoting organ development and growth. A/Prof S Ricardo, Prof J Bertram, Prof EM Wallace, Prof G Jenkin 2011: $136,158. 2010-2012: $383,250 (Monash University). NHMRC, Project Grant RGMS ID APP1008276. Clinical trial of medication based treatment of ectopic pregnancies. Dr S Tong, Prof EM Wallace, A/Prof T Johns. 2011: $94,173. 2011-2013: $228,770 (Monash University). NHMRC, Project Grant 606613. Fibroblast function in uterine leiomyomas. Prof P Rogers A/Prof B Vollenhoven. 2011: $174,832. 2010-2012: $521,415 (University of Melbourne).

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Research Group Reports Obstetrics and Gynaecology

Therapeutic Innovation Australia Ltd, Education Investment Fund. To develop GMP facility for Cell Based Therapy. Prof EM Wallace. 2011: $1,981,818. 2011-2013: $2,000,000 (Monash University).

Syntocinon Bolus or Syntocinon Bolus plus Syntocinon infusion at elective caesarean section, a double-blind randomised controlled trial. Prof EM Wallace, Ms J Mockler (Southern Health and Monash University).

BUPA Foundation, Medical Research Grant. Damaged uterine receptivity as a cause of prematurity. Prof DL Healy. 2011: $48,448. 2009-2011: $146,004 (Monash University).

Progesterone after previous preterm birth for the prevention of neonatal respiratory distress syndrome. Prof EM Wallace, Ms J Mockler (Southern Health and Monash University).

Monash IVF, Research Education Foundation. Damaged uterine receptivity as a cause of prematurity. Prof DL Healy. 2011: $50,000 (Monash University).

Biomarkers of oxidative stress in pregnancy. Prof EM Wallace, Ms J Mockler (Southern Health and Monash University).

Factors influencing fibroid growth and development. A/Prof Vollenhoven (Southern Health, Monash University and Monash IVF). Birth weight after IVF in fresh versus frozen cycles. A/Prof Vollenhoven (Southern Health, Monash University and Monash IVF). Depo-Provera and bone density abnormalities. A/Prof Vollenhoven (Southern Health, Monash University and Monash IVF) XCEL bladeless trocar versus Veress needle: a randomized controlled trial comparing 2 entry techniques in gynaecological laparoscopic surgery. A/Prof Vollenhoven (Southern Health, Monash University and Monash IVF).

RANZCOG, BMedSci Medical Science Scholarship. Comparison of mother and baby outcomes in singleton ART pregnancies conceived at Monash IVF: 2004-2009 after day 3 and day 5&6 (blastocyst) in fresh and frozen embryo transfer cycles. Dr Dhanushi Fernando. 2011: $5,000 (Monash University).

Is vaginal birth after caesarean section (VBAC) being encouraged? A survey of the information given to women following a primary caesarean section. Prof EM Wallace, Ms J Mockler (Southern Health and Monash University).

RANZCOG, BMedSci Medical Science Scholarship Follistatin in the treatment of bronchopulmonary dysplasia. Eugenia Koulaeva. 2011: $5,000 (Monash University).

Improving the diagnosis and treatment of women who present with ovarian torsion. A Kroushev, L WarburtonEggerton, A Parera, B Vollenhoven (Southern Health, Monash University and Monash IVF).

Victorian Cancer Agency. Assessment of ovarian reserve in premenopausal women with breast cancer following chemotherapy. A/Prof Vollenhoven (Southern Health, Monash University and Monash IVF).

Randomised double blind placebo controlled trial on the effect of intraperitoneal ropivacaine on postoperative pain and recovery after diagnostic laparoscopy and hysteroscopy. N Frawley, R Jones, A Polyakov, A/Prof B Vollenhoven (Southern Health, Monash University and Monash IVF).

A protocol for induction of puberty in females diagnosed with premature ovarian failure. A/Prof Vollenhoven (Southern Health, Monash University and Monash IVF).

Commercial Melbourne Aquarium. Prof PD Temple-Smith. 2011: $10,300 (Monash University). Tek-Event, Prof PD Temple. 2011: $1,000 (Monash University). Monash IVF. Prof PD Temple. 2011: $100,000 (Monash University). Origio. Prof PD Temple. 2011: $55,000 (Monash University). Cook Medical, TPC and Gytech. Prof PD Temple. 2011: $2,500 (Monash University).

Other Preterm Prelabour Rupture Of Membranes close to Term trial Induction of labour versus expectant management in patients with preterm prelabour ruptured membranes (PPROM) between 34 and 37 weeks gestation. Prof EM Wallace, Prof J Morris (Southern Health and Monash University).

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Health differences between women with premature menopause and typical-age menopause. D Yap, E Farrell, A Vincent, B Vollenhoven (Southern Health, Monash University and Monash IVF). Establishment of primary cell cultures from human fetal tissues. S Hawes, A Elephanty G Weston, A/Prof B Vollenhoven (Southern Health, Monash University and Monash IVF). IVF pregnancy rates in women with polycystic ovaries versus normal looking ovaries. A/Prof Vollenhoven (Southern Health, Monash University and Monash IVF).

Analysis of unusual site ectopic pregnancies. A/Prof Vollenhoven (Southern Health, Monash University and Monash IVF).

Luke Proposch Grant, RANZCOG. Antenatal vitamin D study (AVID). Associate Professor Vollenhoven (Southern Health, Monash University and Monash IVF). Antral follicle number and IVF response. Associate Professor Vollenhoven (Southern Health, Monash University and Monash IVF). Health differences between women with premature menopause and typical-age menopause. Associate Professor Vollenhoven (Southern Health, Monash University and Monash IVF).

Ophthalmology Director: Dr Marcel Favilla

The Ophthalmology Department comprises 16 sessional consultant ophthalmologists, 5 registrars and an orthoptist providing ophthalmic clinical and surgical services. This department preforms around 2,000 cataract operations each year, making it the second largest provider of cataract surgery in the public system in Victoria. Therefore, the particular clinical focus is on the evaluation of cataract surgery outcomes to ensure a resource-efficient service providing the highest quality of patient care.

Publications and funding summary Journal articles

1

Conference presentations

3

Research activities Diabetic eye disease in patients presenting to the National Health Service Eye Clinic in Samoa, Timothy Langford, Marcel Favilla, Limbo Fiu. Diabetic retinopathy is a serious complication of diabetes mellitus and is a major cause of visual loss and blindness throughout the world. In Samoa the rates of diabetes have been steadily increasing, however no recent study has looked at the prevalence of diabetic retinopathy. The pilot study of a diabetic retinopathy screening program in Samoa found a very high prevalence (53%) of diabetic eye disease amongst diabetic patients presenting to the eye clinic in Apia. It was suggested that this may have occurred due to poor control of risk factors such as blood pressure, blood glucose levels and obesity. The study demonstrated that there is a great need for a diabetic retinopathy screening program in Samoa and provided a model that such a program could follow.

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Research Group Reports Orthopaedic Department

Orthopaedics Department Director: Mr Ton Tranh

The Department of Orthopaedic Surgery is a leader in its field for training and education. The Orthopaedic Unit currently has a high work load of elective and emergency patients. It is serviced by 26 consultants, one full time Fellow, 12 service registrars and 3 junior residents. It is proud to have funded a dedicated research and training room supported by a research officer. Further valuable working relationships include a team of highly regarded professionals including nursing, medical staff, allied health i.e. occupational therapy, physiotherapy, executive assistant and secretarial support. In addition the unit conducts numerous clinical trials. It has also provided a most valuable and informative Seminar on Clinical Research Training. In an ever growing and internationally recognised and respected unit Mr. Tran, as Director, fully encourages, supports, contributes and dedicates time specifically to his staff involved in research projects. As per the Southern Health Research Department his vision also “recognises that research is integral to Southern Health with the research purpose and objective to help achieve better health in our community and in particular to improve it’s care and the outcomes for patients and clients seeing the unique opportunities to advance care through clinical and scientific research across the full spectrum of health care”.

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Research achievements for 2011 The opening of the new Stan O’Loughlin Orthopaedic research/training room dedicated at Dandenong Hospital.

Research activities Stryker Australia Pty Ltd, A prospective non-randomized, longitudinal study of the clinical outcomes of participants that receive the Stryker Triathlon Total Knee System for Total Knee Arthroplasty implanted using ShapeMatch’” cutting guides. Investigators: Mr Ton Tran (Lead), Mr Robert Steele,Mr Adrian Trivett

Publications and funding summary Journal articles

1

Conference presentations

2

Pathology Anatomical Director: Dr Ian Simpson

The Department of Anatomical Pathology is involved with research projects in collaboration with various clinical units at Southern Health, the Monash Institute of Medical Research and the Cancer Council of Victoria. The research projects are based on morphological analysis which includes morphology on routine stains and identification of protein expression using monoclonal antibodies on tissue sections. The researchers in the department have been involved in interpreting / analysing both human and mouse pathology. The focus in the past year has been in involving anatomical pathology registrars and laboratory scientists in research projects, research publications and poster presentations.

Research activities Completed projects: Project titled “A retrospective cohort study to explore the influence of Biological Markers (CD44+/CD24cancer stem cells) on the risk of recurrence in Non Small Cell Lung Cancer. Muhammad Alamgeer, Beena Kumar, Tracey Brown, Neil Watkins, Vinod Ganju. Project completed. Results sent for publication. Project titled “Mucinous carcinomas of the breast: imaging features & potential for misdiagnosis”. Judith Tan, John Waugh, Beena Kumar, Jill Evans. Project completed. Results sent for publication.

Project titled “Detection of lymphatic invasion in breast core biopsies using D2-40 immunohistochemistry”.Yvette Beaber, Lucy Webster, Beena Kumar, Piero Nelva, Mila Volchek, Stewart Hart. Project completed, Thesis submitted towards Master’s degree. Project titled “Evaluation of immunohistochemical markers to predict tumour response to neoadjuvant chemotherapy in breast cancer”. Vinod Ganju, Beena Kumar, Peter Midolo, Jane Fox, Leonie Cann, Zdenka Prodanovic, Alexandra De Gusclin, John Stuckey, Peter Rogers, Stewart Hart. Project completed. Results being analysed.

Ongoing projects/projects in progress: Project titled “Correlative Studies in Lymphoid Cancer”. Stephen Opat, Beena Kumar, Ian Simpson, Hang Quach, Jake Shortt, Alex Laslowski, Piero Nelva. Project ongoing Project titled “Predictive role of cancer stem cell markers in locally advanced breast cancer, treated with neoadjuvant chemotherapy”.Vinod Ganju, Beena Kumar, Peter Midolo, Jane Fox, Muhammad Alamgeer, Alexandra De Gusclin, John Stuckey, Stewart Hart. Project ongoing. Project titled “Factors predicting lymph node response post neoadjuvant chemoradiotherapy as a step towards minimally invasive rectal surgery”. Naseem Mirbegheri, Beena Kumar, William Teoh. Project ongoing.

Project titled “Mortality prediction in high-grade prostate carcinoma”. Anthony Longano, G Giles. Project ongoing. Project titled “Tissue markers of prostate cancer mortality: discovery, validation, and translation”. Anthony Longano, G Severi. Project ongoing. Project titled “ErbB4 expression in glioblastoma multiforme”. Anthony Longano, T Johns. Project ongoing. Project titled “Emphysema in gp130 F/F mouse mode”. Anthony Longano, B Jenkins. Project ongoing. Project titled “Regulation of innate immunity and tumour progression by Activating Transcription Factor 3 (ATF3)”. Anthony Longano, Neil Watkins. Project ongoing. Project titled “The correlation between pre-operative evaluation of regional neck disease with Positive Emission Topography and histopathological specimens in head and neck squamous cell carcinoma”. Anthony Longano, E Sigston. Project ongoing. Project titled “EUS-FNA: A histological cytological correlation of a series of 100 consecutive procedures at Monash Medical Centre. Amanda Naismith, Cameron Skehan, Qui Nyugen, Christopher Desmond, Daniel Crough, Beena Kumar. Project ongoing. Project titled “Lobular carcinomas of the breast: imaging features with histological correlation”. John Waugh, Beena Kumar, Jill Evans. Project ongoing.

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Research Group Reports Pathology Anatomical

Project titled “Correlation of liver fibrosis – findings on fibroscan Versus histology”. Ian Simpson, Anook Dev. Project ongoing.

Project titled “Correlative studies in pediatric tumours”. Ian Simpson, Anthony Kelmann, Peter Downey. Project ongoing.

Project titled “Sequential evaluation

of tumours undergoing pre-operative therapy with aromatase inhibitors and metformin (Setup-AIM):A neoadjuvant study in operable hormone sensitive breast cancer”. Vinod Ganju, Beena Kumar, Peter Midolo, Jane Fox, Stewart Hart. Project ongoing.

Publications and funding summary Journal articles

4

Conference presentations

5

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Pharmacy Director: Mr Ian Larmour

The Pharmacy Department is involved in a wide variety of activities to promote medication safety and the quality use of medication. A primary goal of the Department is continuous quality improvement which requires the development of new systems and practices which need to be evaluated and refined which drives the Department’s Research focus.

Research achievements for 2011

Optimising clinical pharmacy service – implementation and evaluation of the General Level Framework, Advanced Level Frameworks and a restructured mentoring program. Marisa Hodgkinson, Kerryn Barned, Ian Larmour, Amanda Tey, Jacqueline Parkinson Targeting pharmacy services for an anaesthetic assessment clinic (AAC). Jeremy Austin, Marisa Hodgkinson, Ian Larmour, Jacqueline Parkinson Inappropriate continuation of stress ulcer prophylaxis agents beyond the intensive care unit. Kerryn Barned, Wendy Ewing

Larmour I, Pignataro S, Barned K, Mantas S, Korman MG. A therapeutic equivalence program: evidence based promotion of more efficient use of medicines. MJA, Vol 94, No 12, 631-631, 20 June 2011

Heparin infusion prescribing, monitoring and administration documentation on a single chart: post implementation audit. Wendy Ewing, Adriana Trang, Michal Lim

Larmour I, Marketing Pharmaceuticals: Are the Benefits Real? Journal of Pharmacy Practice and Research, Vol 41, No 3, 172-174, 3 Sept 2011

Review of paliperidone palmitate product familiarisation program. Patrick Lam, Adi Sesham, Annette Simpson, Mai Ta

George L, Senturk Raif R, Hodgkinson M, Emmerton M, Larmour I “Impact of a Surgical Pre-admission Clinical Pharmacist on the Quality of Medication Management from Pre-admission to Discharge: a Randomised Control Study” Journal of Pharmacy Practice and Research, Vol 41, No 3, 212-216, 3 Sept 2011

Treating refugees – a new clinical role for the pharmacist: Kathleen Cowie

Research activities Evaluation of a new pharmacy department service delivery model in an acute assessment unit; Pamela Fernando, Julie Drummond, Eugene Ong, Smriti Grover, Maggie Emmerton, Ian Larmour

Smoking cessation advice delivered by a hospital pharmacist. Pamela Fernando, Ian Larmour, Johnson George, Simone Taylor An evaluation of the effect of a surgical preadmission clinic pharmacist on the quality of medication management from preadmission clinic to discharge: Lewis George, Reyhan Senturk-Raif, Marisa Hodgkinson, Maggie Emmerton, Ian Larmour Are all agents equal? A review comparing the safety and efficacy of intravesical mitomycin C and epirubicin for the treatment of stage Ta T1 bladder carcinoma: Mary Hanna, Berenice Sheridan, Obaid Fazli

Pharmacy services in an acute assessment unit – meeting the needs of the profession. Eugene Ong, Smriti Grover, Pamela Fernando, Julie Drummond, Maggie Emmerton, Ian Larmour Lead poisoning in the modern age: Lisa Ciabotti, George Braitberg, Andis Graduins Demystifying continuous infusion devices for the chemotherapy patient: A pictorial approach. Debbie Parker, Theresa Norman, Claire Dizon, Obaid Fazli, Berenice Sheridan Remodelling of weekend pharmacy services – leading the Change: Lisa Ciabotti, Ian Larmour, Susanne Sturm, Connie Yin, Lee Kin Partridge, Chin Goh-Chew, Jane Frost How a pilot study in a new medial assessment unit led to recognition of the need for a clinical pharmacy service 7 days a week. Hayley Griffin Getting the basics right – implementing a dispensing competency accreditation procedure. Andrew Chong, Kathleen Cowie, Marisa Hodgkinson, Robin Lee, Shirley Ng, LeeKin Partridge, Reyhan Senturk-Raif Finding the bottle neck, A project inspired by the C2 (Connecting Constraints) project initiated by Department of Health – Redesigning Hospital Care Program. LeeKin Partridge, Susanne Sturm, Robin Lee

Publications Journal articles Conference presentations

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Respiratory and Sleep Medicine Director: Professor Philip Bardin Director of Sleep Research: Dr Garun Hamilton Director of Respiratory Disease Research: Dr Paul King

Respiratory and Sleep Medicine considers clinical research to be a cardinal component of our clinical activities. Staff are encouraged to be involved in some aspect of original investigation and the Departmental Research Directors in Sleep (Dr Garun Hamilton) and Respiratory Disease (Dr Paul King) have helped to champion research and to encourage younger members to become involved. Respiratory research programmes at Southern Health have concentrated on chronic obstructive Pulmonary/lung disease (asthma, COPD) and lung infection (bronchiectasis). There are both clinical and basic science components that form part of this programme. In addition, there is an active clinical trials unit conducting pharmaceutical research, mainly in asthma and COPD. Research in Sleep Medicine has focussed on various aspects of Sleep Disordered Breathing (‘Sleep Apnoea’). Current investigations are employing clinical studies in tandem with basic science studies. The latter studies are done in collaboration with the Ritchie Centre/ for Baby Health Research MIMR (Monash Institute of Medical Research). The Department is committed to delivery of high level clinical care to patients with respiratory and sleep diseases. This is best achieved through an active research programme that emphasises new treatment developments which encourage physicians and staff to keep abreast of the latest developments. Ultimately we believe that it is the key to evidence-based practice and high-level clinical care.

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Research achievements for 2011 Asthma research studies of vocal cord dysfunction in difficult-to-treat disease have continued in 2011. Using the new Southern Health/Monash Medical Centre 320-slice Toshiba Aquilion CT we were able to quantify this troublesome condition and to link it to difficult to treat asthma. A recent paper has been published in the American Journal of Respiratory and Critical Care Medicine, the most highly ranked journal in this field (see publications). Ongoing studies will examine the prevalence of ‘asthma of the voice-box’ in patients with severe asthma admitted to the Emergency Department. We are also about to embark on a randomised controlled trial of botulinum toxin (Botox) in the condition. Sleep research studies – We are involved in a study of central sleep apnoea with the Monash Institute of Medical Research. This study is investigating how a novel measurement of respiratory control can predict the treatment response to therapies such as CPAP and O2. A recent paper has been published in the American Journal of Respiratory and Critical Care Medicine, the most highly ranked journal in the field (see publication). Research studies in Lung infection. We are currently running several studies assessing the role of bacteria in COPD and the role of rhinovirus in COPD and viral influenza in pneumonia. We have submitted several papers on this.

Research activities Asthma research studies of vocal cord dysfunction in difficult-to-treat disease have continued in 2011. Using the new Southern Health/ Monash Medical Centre 320-slice Toshiba Aquilion CT we were able to quantify this troublesome condition. A recent paper has been published in the prestigious American Journal of Respiratory and Critical Care Medicine. Ongoing studies will examine the prevalence of ‘asthma of the voice-box’ in patients with severe asthma admitted to the Emergency Department. We are also about to embark on a randomised controlled trial of botulinum toxin (Botox) in the condition. The COPD research program in collaboration with Associate Professor Brendan Jenkins (MIMR) was expanded after receiving an NH&MRC Project Grant in 2009. These studies have used a new mouse model to study pathways to COPD disease and to examine new therapies. This has culminated in a recent publication in the American Journal of Respiratory Cell and Molecular Biology (see publications). Nutritional aspects of COPD have been investigated in collaboration with the Department of Human Nutrition headed by Associate Professor Boyd Strauss and a publication is being prepared. Studies of dynamic airway collapse in COPD have found this lethal condition to be highly prevalent in COPD and this was published in the prestigious journal, Thorax (see publications).

Research Group Reports Respiratory and Sleep Medicine

The bronchiectasis research programme under the leadership of Dr Paul King has continued to publish novel findings based on studies of our large cohort of >200 patients. Dr King was also invited to provide several lectures in this field at various scientific meetings and has continued to publish his findings (see publications). Ongoing studies in bronchiectasis currently have two papers in review and anticipate more studies to be finished this year. We are involved in setting up a national registry of bronchiectasis. The asthma virus exacerbation programme has continued a research programme that has linked with the Innate Immunity Group in MIMR (Monash Institute if Medical Research) headed by Professor Paul Hertzog. A senior post-doctoral scientist, Dr Michele Tate, has received an Asthma Victoria Research Grant for 2012. The Department has continued work on virus and asthma NH&MRC Project Grants in collaboration with Dr Reena Ghildyal and Prof. David Jans at Monash University. Professor Phil Bardin received a NHMRC project grant for further virus studies from 2012. The Sleep Research program is headed by Dr Garun Hamilton. A number of collaborative research projects are underway, including measurements of respiratory control in central sleep apnoea, in conjunction with the Ritchie Centre for Baby Health Research and Monash Institute of Health Services Research (MIMR). We are also involved in a clinical trial of erectile dysfunction and OSA (with the Woolcock Institute of Medical Research in Sydney) and have ongoing studies addressing the pathogenesis of different OSA phenotypes. Dr Garun Hamilton was also successful with two NHMRC project grants and one NHMRC development grant.

Publications, postgraduate students and funding summary

Commercial

Journal articles

14

Book chapters

1

Conference presentations

26

Postgraduate research students

1

Funding: Competitive NHMRC, Project RSV M-protein trafficking. Jans, D and Bardin P. 2011: $250,000. 2009-2012: $750,000 (Monash University). Asthma Victoria, Project. TGFb and Rhinovirus. Thomas B, Bardin P. 2011: $25,000 (Monash University). NHMRC, Project. Duty Ratio: A Simple Method for Quantifying Loop Gain During Breathing Instability. Berger P, Hamilton G, Naughton M. 2011: $106,250. 2010-2012 $331,841 (MIMR)

Compumedics APAP Study. Validation of Treatment Effectiveness of an Auto-titrating CPAP Device. Hamilton G. 2011: $30,000 (Southern Health). ARADIGM. ARD3150-0902 – Bronchiectasis. King P. 2011: $26,000 (Southern Health). NOVARTIS 2304, CNVA237A2304 – COPD. Bardin P. 2011: $50,000 (Southern Health). GLAXOSMITHKLINE, MEA112997 – Asthma. Bardin P. $170,000 (Southern Health). BOERINGER-INGELHEIM. BI 1222.37 – COPD. Bardin P. 2011: $24,000 (Southern Health). SYNAIRGEN. SG 005 – Asthma. Bardin P. 2011: $47,000 (Southern Health). MERCK SHARP & DOHME. MK4305-028 – Insomnia. Hamilton G. 2011: $13,000 (Southern Health). M-PEX. MPEX 207 – Cystic Fibrosis. Morton J. 2011: $4,000 (Southern Health).

NHMRC, Project. The SNORE-ASA Study: A Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnea. Storey E, Hamilton G, et al 2012-2014: $850,000 (Monash University). NHMRC, Project. What are the Lifetime Clinical Predictors and Risk Factors for Multiple Phenotypes of Adult Asthma, COPD and Sleep Disordered Breathing? Following up the TAHS Cohort from 1st to 6th Decade. Dharmage S, Hamilton G et al. 2012-2015: $1,865,881 (The University of Melbourne. NHMRC, Development Development of an Effective Therapy for Cheyne-Stokes Breathing in Heart Failure. Berger P, Hamilton G et al. 2012-2014: $584,700 (MIMR).

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Rheumatology Director: Associate Professor Geoffrey Littlejohn

The Department co-ordinates clinical care, teaching, training, and research into a wide range of disorders affecting the musculoskeletal system. These include inflammatory, degenerative and painful disorders affecting bone, joint, muscle, blood vessels and other organs of the body.

Research activities Lupus Clinic - Professor Eric Morand (Head of Clinic), Dr. Alberta Hoi, Ms. Sue Morton and Ms.Sarah Bode, examining cytokine profiles and disease activity and outcomes.

Research achievement for 2011

Scleroderma Clinic - Dr. Joanne Sahhar (Head of Clinic) , Dr. Gene-Siew Ngian and Ms. Kathleen Elford contributing data to the Australian Scleroderma Databank and studying vascular reactivity in scleroderma.

The Department conducts international collaborative clinical trial research focussing on novel treatments in Phase II/III development, principally in rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis and fibromyalgia. The outcomes of these trials have resulted in a large number of new and more effective treatments to become available for Australian patients.

Fibromyalgia Clinic - Dr. Emma Guymer (Head of Clinic), Ms. Kathleen Elford, Associate Professor Geoff Littlejohn, conducting prospective studies of treatment outcomes and triggering factors in fibromyalgia. Additional fibromyalgia studies examining psychological factors in fibromyalgia in conjunction with Katrina Malin, Ph.D. student.

Investigator driven studies derive from five specialty clinics combining clinical care with database driven and related research.

Rheumatoid arthritis Clinic - Associate Professor Michelle Leech (Head of Clinic), Professor Eric Morand, Ms. Sue Morton, conducting long-term observational outcome studies on a large cohort of patients. Additional rheumatoid arthritis studies include collaboration with the OPAL Australian wide database (Chairman Steering Committee Associate Professor Geoff Littlejohn) studying factors contributing to remission in 2,000 RA patients. Psoriatic arthritis clinic - Dr. Sally Ayoub (Head of Clinic) conducting database derived observational prospective research on a cohort of patients with psoriatic arthritis.

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Publications and funding summary Journal articles Conference presentations

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Funding: Commercial Abbott , A prospective multi centre, randomised, double-blind, active comparator-controlled, parallel groups study comparing the fully human anti-TNF antibody D2E7 given every second week with methotrexate given weekly and the combination of D2E7 and methotrexate administered over 2 years in patients with early rheumatoid arthritis.03048A. Littlejohn, G 2011: $12,800 (Southern Health). Roche, An open label study of the efficacy and safety of re–treatments with rituximab in patients with active rheumatoid arthritis. 04001A. Littlejohn G. 2011: $2658.00 (Southern Health). Roche, A Randomised, Double-Blind, International Study To Evaluate The Efficacy And Safety Of Various Retreatment Regimens Of Rituximab In Combination With Methotrexate In RA Patients With An Inadequate Response To Methotrexate. 05158A. Littlejohn G 2011: $5818.00 (Southern Health). Centecor, Multicenter, Randomised, Double-blind, Placebo-controlled Trial of golimumab, a Fully Human Anti-TNFι monoclonal Antibody, Administered Subcutaneously, in Subjects with Active Rheumatoid Arthritis Despite Methotrexate Therapy. 05177A. Littlejohn G 2011: $33,884 (Southern Health).

Research Group Reports Rheumatology

Pfizer, Randomized, Double Blind, Parallel-Group Study Of Cardiovascular Safety In Osteoarthritis or Rheumatoid Arthritis Patients With or at High Risk for Cardiovascular Disease Comparing Celecoxib With Naproxen and Ibuprofen. 06172A. Littlejohn G 2011: $3,379.05 (Southern Health).

Eli Lilly, A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Subcutaneous LY2127399 in Patients with Systemic Lupus Erythematosus (SLE). 10306A. Littlejohn G (Southern Health)

Merck Serono, A randomised, double-blind, placebo-controlled, multicentre prospective dose-finding Phase II/III study with atacicept given subcutaneously to subjects having recently experienced a flare of systemic lupus erythematosus (SLE). 08001A. Littlejohn G 2011: $3179.00 (Southern Health).

Orion Clinical Services, Phase IIa, 2:2:1 randomised, double-blind, placebocontrolled, parallel group, multi-centre clinical trial to investigate the safety, efficacy and pharmacokinetics of recombinant human soluble Fc-gamma receptor IIb (SM101) for intravenous application in the treatment of systemic lupus erythematosus (SLE) patients with or without a history of lupus nephritis. SM101-201-sle-10. 112074. Littlejohn G. 2011: $2,500.00 (Southern Health).

Sanofi-Aventis, A randomized, double-blind, placebo-controlled, multicenter, two-part, dose ranging and confirmatory study with an operationally seamless design, evaluating efficacy and safety of SAR153191 on top of methotrexate MTX in patients with active rheumatoid arthritis (Protocol EFC11072) (MOBILITY). 10019. Littlejohn G. 2011: $336 (Southern Health). Sanofi- Aventis, A multi-center, uncontrolled extension study evaluating efficacy and safety of SAR153191 on top of DMARDs in patients with active Rheumatoid Arthritis (RA) (LTS11210) (ABILITY). 10176X. Littlejohn G (Southern Health). UCB , A Phase 3, randomized, double blind, placebo-controlled, multicenter study of the efficacy and safety of four, 12 week cycles (48 weeks total) of epratuzumab in systemic Lupus Erythematosus with moderate to severe disease (EMBODY1) SL 0009. 11007A. Littlejohn G. 2011: $3317.00 (Southern Health). UCB, Research Project Application no. 11054A: A Phase 3, Multicenter, Open-Label, Extension Study to Assess the Safety and Tolerability of Epratuzumab Treatment in Systemic Lupus Erythematosus Subjects EMBODY 4 - Protocol SL0012. 11054A. Littlejohn G (Southern Health).

PPD Australia P/L, A randomized, double-blind, parallel group study of the safety and effect on clinical outcome of tocilizumab SC versus tacilizumab IV, in combination with traditional disease modifying anti-rheumatic drugs (DMARDs), in patients with moderate to severe active rheumatoid arthritis. 10164A. Littlejohn G. 2011: $17,770 (Southern Health). PPD Australia P/L, PALACE 1: Parallel-Group, Efficacy and Safety Study of Two Doses of Apremilast (CC-10004) in Subjects with Active Psoriatic Arthritis Who Have Not Been Previously Treated with Disease-modifying Antirheumatic Drugs. 10241A. Littlejohn G. 2011: $13,618 (Southern Health). PPD Australia P/L, PALACE 4: Project Title: Protocol No CC-10004PSA-005 : A Phase 3, Multicentre, Randomized, Double-Blind, Placebo-Controlled. 10343A. Littlejohn G. 2011: $5,500.00 (Southern Health). Novotech Australia P/L, ALLO-401: Long-term Allopurinol Safety Study Evaluating Outcomes in Gout Patients (LASSO). 11240A. Littlejohn G. 2011: $5,500.00 (Southern Health).

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Southern Health Simulation Centre Manager: Ms Jennifer Hogan

The Southern Health Simulation Centre provides a variety of simulation-based courses to a diverse healthcare population and has a strong international reputation for the quality of its innovative simulation-based training. One of our core strengths is to provide scenario-based learning in highly realistic clinical environments for clinicians to explore and reflect how they perform and communicate in clinical teams. The Centre's main aim is to reduce clinical risk and improve patient safety. Ongoing research, evaluation and improvement are fundamental to our mission. Research at the Southern Health Simulation Centre has focused on both the methods of education delivery and on practical techniques to improve patient safety in the clinical environment. Our educators and researchers maintain clinical roles and keep up-to-date with current evidence and issues in their areas of expertise. This expertise is used to develop education and research questions that are addressed by simulation techniques.

Research achievements for 2011 While only a small amount of research was conducted throughout 2011, the Centre established important collaborative links with internal and external stakeholders to facilitate the development of future research projects. An important achievement for the Simulation Centre in 2011 is that it is now a contributing partner to the Monash Injury Research Institute (MIRI); a collaboration of academic partners that conducts research into diverse areas such as road safety, sports injury and suicide prevention (www.monash.edu.au/miri). In partnership with Monash University and the Centre of Health Innovation, the Southern Health Simulation Centre have revised a simulation-based patient safety curriculum for final year medical students. This education initiative will facilitate an optimal research environment to conduct studies that aim to prepare our future junior medical staff. Centre staff have had a high overseas profile throughout 2011, presenting simulation-based research and education initiatives at various conferences and forums. Of particular note, Dr Stuart Marshall, Head of Research at the Southern Health Simulation Centre, was invited as keynote speaker for the 4th International Clinical Skills Conference in Prato, Italy.

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The Simulation Centre has continued to make strong research links within the local and national communities with representation on the Australian Society for Simulation in Healthcare Executive Board and with research presentations made to Worksafe Victoria and the Australian Human Factors and Ergonomics Society Victorian branch.

Research activities International Medical Graduates and intra-professional telephone communication: Authors: Elizabeth Pryor, Stuart Marshall, Robyn Woodward-Kron, Tim McNamara. This study explored the characteristics of the effects of telephone communication between clinicians. Data were analysed using linguistic tools from clinical telephone communications of International Medical Graduates. Education can now be targeted to be more effective in improving clinical communication which should lead to fewer errors in the clinical environment.

Research Group Reports Southern Health Simulation Centre

Capabilities and limitations of the METI Human Patient Simulator in demonstrating guedel’s stages of anaesthesia: Authors: Osman Osturk, Stuart Marshall When teaching practitioners about the depth of anaesthesia, it is clear that additional resources are required to the physical constraints of the mannequin. By using additional cognitive cues, anaesthetists can efficiently learn the features of inhalational anaesthesia in a safe environment without inherent patient risk.

Preparation (familiarisation) of learners into the simulation-based learning environment:

Initial educational evaluation of airway crisis management course (Team Response to Airway Crises): Authors: Stuart Marshall, Peter Fritz, Nicholas Chrimes An inter-disciplinary course on airway management outside of the operating theatre was initiated in 2011. In addition to overwhelmingly positive feedback from the participants, developers of the course uncovered several latent errors within the critical care areas with regard to the management of airway emergencies. Ongoing work is addressing the effects of this course, both from an educational and systems standpoint, with the provision of uniform airway equipment and with a standardised approach to emergencies.

Publications and postgraduate students

Author: Susan Ballinger-Doran Participation in a simulation-based course can be highly emotive for learners. This study explored the effect of preparation of learners in a structured, systematic manner on their engagement and learning in a simulation scenario. This work, for the first time, acknowledges the emotional preparation of participants in this potentially stressful educational modality.

Journal articles Conference presentations Postgraduate research students

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Southern Academic Primary Care Research Unit Director: Professor Grant Russell

The Southern Academic Primary Care Research Unit (SAPCRU) was established in 2009 as a joint venture between Southern Health, Monash University’s School of Primary Health Care and the Dandenong-Casey General Practice Association. SAPCRU’s mission is to conduct and facilitate high quality, regionally specific research to influence policy makers and health services in shaping a primary care system focused on improving the health and wellbeing of the South East metropolitan Melbourne community. SAPCRU’s interdisciplinary research program focuses on refugee health and the effects of primary care reform. Our research is conducted together with collaborators and strategic partners from other departments and facilities at Monash University, other universities in Australia, Canada and the United States, independent research institutes, General Practice Networks, public health services, consumers and consumer groups, industry, government and varied nongovernment organisations

Research achievements for 2011 In May 2011, the Refugee Health Research Consortium and SAPCRU successfully completed a twelve month study into refugee health needs assessment. The title of the report was; An Evaluation of the Primary Healthcare Needs of Refugees in South East metropolitan Melbourne.

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This project led by Principal Investigator (PI) Dr. I-Hao Cheng provided a comprehensive scope of the primary healthcare needs of local residents from refugee backgrounds and detailed important gaps to be addressed by existing primary care services We led and have completed the first stages of an international collaboration dedicated to investigating the ways in which primary care reforms influence the development of teamwork in primary care practices, and to examine the consequences of these teamwork related developments for the organisations, routines, relationships and participants within the primary care practice. Findings from our group (comprising research conducted in 3 Canadian provinces, 3 Australian states, and numerous jurisdictions within the (USA) have been disseminated to policy makers and the international primary care research community. Our group is continuing to disseminate our work on developing several major collaborative international grant proposals. SAPCRU has begun to attract significant funding for primary care health service research activities. In conjunction with partners at the University of New South Wales, University of Queensland SAPCRU was awarded an Australian Primary Health Care Research Institute (APHCRI) vulnerable population’s research grant of $150,000 to investigate a best practice framework for coordinated primary health care for refugees In Australia.

Our work will identify the components and effectiveness of existing models of delivering accessible, coordinated primary care to permanently resettled refugees in Australia and will generate an evidence based framework and implementation strategy for delivering refugee health care in Australia. A second APHRI grant, awarded as part of our collaborative activities with the Dandenong Casey General Practice Association (now renamed the South-East Melbourne Health Practitioner’s Association) has allowed us to develop a research based framework to support advanced nursing in general practice with particular relevance to the activities of the nation’s new Medicare Locals.

Research activities The Southern Academic Primary Care Research Unit (SAPCRU) has had a successful year in 2011 in which the unit successfully strengthened its partnerships, achieved numerous grant success and has work published. Please find below the list of SAPCRU’s achievements throughout the year:

Research Group Reports Southern Academic Primary Care Research Unit

2011 projects In May 2011 Principal Investigator (PI) Dr I-Hao Cheng successfully completed and published An Evaluation of the Primary Healthcare Needs of Refugees in South East Metropolitan Melbourne (SEMM), providing a comprehensive scope into the primary healthcare needs of local residents from refugee backgrounds. The needs assessment highlighted the increasing utilisation of local primary care services by refugees, particularly amongst certain nationalities in specific locations. Major gaps were found in General Practice utilisation data and there were surprisingly few studies of the refugee client experience of local primary care services. One key recommendation from this study was that health policy makers and health service providers should address the responsiveness of local primary care services to refugees, to ameliorate their higher use of public hospital services. Approaches should be especially mindful of the fast growing Afghani population. Not only has this report provided an extensive insight into the healthcare needs of refugees in SEMM, but the study has also acted as a springboard for range of studies and a Southern Health supported PhD. The Canadian Institutes of Health Research (CIHR) Catalyst Study: Shifting Ground, Common GroundUnderstanding the evolving primary care practice, led by PI Professor. Grant Russell is coming to its conclusion with its final meeting in Banff Alberta: including a writing retreat that followed the world’s premier primary care research conference. Plans for follow up grants are currently under consideration. This research project’s focus is to achieve common ground in forming a deeper understanding of the complexity of the primary care practice setting amongst different countries, states and provinces. SAPCRU’s work through the Catalyst program has generated significant work on primary care redesign and extensive potential for knowledge translation exchange.

SAPCRU is continuing to gather new information on the early implementation of GP Super Clinics through a Royal Australian College of General Practitioners (RACGP) funded project: A Week in the Life of Two General Practice Super Clinics: Piloting research to optimize chronic care delivery ((PI) Professor. Grant Russell). Through this research, SAPCRU aims to perform a synthesis of comparable studies to better understand the impact of primary healthcare reform on the organisation, routines and relationships within primary care practices in different health care settings. Findings of the synthesis will primarily be used to underpin a collaborative program of work designed to assess the common enabling factors that facilitate optimal performance of contemporary primary care practices within different healthcare settings.

2011 major grants $150,000 - Australian Primary Health Care Research Institute. Coordinated primary health care for refugees: A best practice framework for Australia. Russell G Harris M Alston M, Cheng I etal $139,850 - Australian Primary Care Research Institute/Australian General Practice Network. Russell G, Peek A, McKenna L, Naccarella L, Zwar N, Powell Davies G, Halcomb, E. Australian General Practice Network. Nursing in General Practice: A framework to support advanced nursing in general practice project. 2012 $53,551 - Parkinson’s Victoria. The Essence of managing Parkinson’s disease: The impact of a mindfulness based lifestyle program for patients with Parkinson’s disease. Russell G, Advocat J, Hassed C 2011. $9,970 - The Royal Australian College of General Practitioners Family Medical Care, Education and Research Grant application. Rights of Passage: Improving Refugee Access to Australian General Practice Services. Cheng I-H, Russell G. 2011

$20,000 - Royal Australian College of General Practitioners. Family Medical Care Education and Research Grant A Week in the life of two GP Super Clinics: Piloting Research to Optimise Chronic Care Delivery Russell G, Harris M, Zwar N.2010 $100,000 - Canadian Institutes of Health Research. Catalyst Grant: Primary and Community-Based Healthcare 2009-10-15 # 212271 Shifting ground, Common ground – understanding the evolving primary care practice. Hogg, WE, Russell GM (co-PI) Crabtree, BF, Scott C, Gunn J, Harris MF, Levesque JF, Geneau R, Miller W. 2010-2011 $16,000 - Refugee Health Research Consortium. An evaluation of refugee health needs in the Cities of Greater Dandenong and Casey. Russell G, Cheng I-H, Block A. 2010.

SAPCRU research grants (managed by others with our participation) $400,000 - 2011 beyondblue National Priority Driven Research Program. Mixed methods investigation of anxiety and depression, contributing factors, and health services provided to manage it amongst older adults discharged from hospital. Haines T, O’Connor D, Russell G, McDermott F, Stolwyk R, Brown T, Johnson J. 2012-2015 C$10,627.00 - Canadian Society of Hospital Pharmacists – Research and Education Foundation. Content analysis of a Primary Care Pharmacy Specialty Network Listserv Archive. Farrell B, Dolovich L, Kennie N, Schindel T, Waite N, Russell G. $115,378 - Victorian Government Department of Justice Office of Gaming and Racing Submission Based Grants System for Gambling Research 2010 (Round 3). A qualitative investigation of the impacts of socio-cultural factors, lived experiences and popular discourses in conceptualisations of risk amongst Victorian gamblers. Thomas SA, Russell G, Thomas S. 2010-2011

Southern Health Research Report 2011

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Research Group Reports Southern Academic Primary Care Research Unit

$40,000 - Canadian Health Services

Research Association. Economic Analysis of the Consequences of Achieving a High-Quality Primary Healthcare System in Canada. Dahrouge S, Devlin R, Hogg W, Coyle D, Russell G, Ferguson D. 2010

$500,000 - Quality Improvement &

Innovation Partnership (QIIP). Ministry of Health of Ontario. 2010-2012 Harris SB (executive lead), Evaluation of the Quality Improvement & Innovation Partnership Learning Collaboratives. Stewart M, Birtwhistle R, Green M (co-PIs) Russell G, Brown JB, Thind A Roberts S, Kotecha J, Webster-Bogaert S (co-Is).

$221,948 - Canadian Institutes of

Health Research. Operating Grant. Optimal range of patient to family physician ratios in primary care practices. Hogg W, Dahrouge S, Glazier R, Ramsay T, Russell G. 2010-2012.

$248,390 - Cancer Institute /

National Heart Foundation/Beyond Blue. 2010-2012 Testing the acceptability and feasibility of a system-oriented intervention, involving touch screen computers, for reducing health risk factors among general practice patients . Sanson-Fisher R, Paul C, Carey M, D’Este C, Inder K, Zwar N, Piterman L, Makeham M, Russell G

$744,498 - National Health and

Medical Research Partnerships for Better Health. Grant ID 568979 Implementing guidelines to routinely prevent chronic disease in general practice. Harris M, Zwar N, Litt J, Mazza D, van Driel M, Taylor R, Russell G, Raw J, Boyden A, Powell Davies A, Waters J. 2010-2012.

APHCRI, Project Grant. Coordinated

2011 highlights

Primary Health Care for Refugees: A best practice framework for Australia. Russell G. 2011: $40,000. 2011-2012 $150,000 (Monash University).

In February 2011 SAPCRU celebrated its launch with over 100 guests, including Steve Ballard, Director of Health and Aged Care Southern Metropolitan Region, Department of Health, who officially opened the unit. Following its launch SAPCRU conducted a half-day seminar, ‘Reforming Urban Primary Care’ which included presentations from a number of prominent Australian and international primary care researchers and policy makers.

Parkinson’s Victoria, Project Grant.

The Essence of Managing Parkinson’s Disease: The impact of a mindfulness based lifestyle program for patients with Parkinson’s disease. Russell G. Grant awarded 2011, fund transfer 2012. 20112012: $53,5511 (Monash University).

beyondblue, Project Grant. beyondblue

Mixed Methods Investigation of Anxiety and Depression, contributing factors and Health services Provided to Manage it Amongst older Adults Discharged from Hospital. Haines T. Funds held elsewhere in Southern Health. 20112013:$394,546 (Monash University).

SAPCRU Research Officer, Dr I-Hao

Cheng was one of five finalists nominated for a prestigious HESTA Primary Health Care award for his work delivering high quality, culturally appropriate primary care to refugees.

The Royal Australian College of General

SAPCRU Research Assistant,

Ms.Prashanti Manchikanti was awarded with a Bachelor of Medical Science for her investigation of Access to Primary Health Care in Afghani Refugees at Monash University.

SAPCRU’s Unit Director, Professor

Canadian Institutes of Health Research.

Publications, postgraduate students and funding summary 10

Books Conference presentations

Canadian institute of Health Research. Catalyst Grant. Shifting Ground, Common Ground-Understanding the Evolving Primary Care Practice. Russell G. 2011: $10,000. 2010-2011: $100,000 (Monash University).

Grant Russell, was appointed as the Head of the School of Primary Health Care at Monash University.

Journal articles

Practitioners Family Medical Care Education and Research Grant Rights of Passage: Improving Refugee Access to Australian General Practice Services. Cheng I-H. 2011: $9,970 (Monash University).

1 10

Postgraduate research students

Funding:

1

Operating Grant. Optimal Range of Patient to Family Physician Ratios in primary Care Practices. Hogg W. Funds held University of Ottawa. 2010-2012: $221,948 (University of Ottawa).

Cancer Institute/ National Heart

foundation/ Beyond Blue, Project Grant. Testing the Acceptability and Feasibility of a System-oriented Intervention, Involving Touch Screen Computers, for Reducing Health Risk Factors Among General Practice Patients. SansonFisher R. 2011: $20,000. 2010-2012: $248,390 (University of Newcastle).

National Health and Medical Research Competitive

APHCRI/AGPN, Project Grant. Nursing in General Practice; A framework to support advanced nursing in general practice. Russell G. Grant awarded 2011; fund transfer 2012. 2011-2012: $139,850 (Monash University).

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Partnerships for Better health, NHMRC Partnership Grant. Implementing Guidelines to Routinely Prevent Chronic Disease in General Practice. Harris M. 2011: $53,000 (held within Department of General Practice Monash). 20102012: $744,498 (Monash University).

Supportive and Palliative Care Director: Associate Professor Kate Jackson

The Supportive and Palliative Care Unit aims to improve symptom control, end of life care and provide support to patients/families and other health care professionals for patients with incurable disease. The Unit’s current major research focus is refractory cancer pain and auditing of the Pathway for Improving the Care of the Dying rollout across Southern Health.

Research achievements for 2011 Palliative Prognostic Index Melbourne Modification (PPIMM) – audit of over 300 patients – data collection completed analysis ongoing. Development of and successful application for external funding for collaborative project “Monash Prognostic Indicator (MPI)” between Southern Health Supportive and Palliative Care Unit, Gabrielle Jennings Werribee Mercy Hospital, and Clinical Research Program, Department of Public Health and Preventive Medicine Monash University. Human Research Ethics Committee approval, aim to start recruiting in March 2012. Principal investigator in the Victorian Cancer Agency (VCA) project by the multidisciplinary Palliative Care Research Network Victoria, “Why not at home, why in hospital: In depth case studies of hospital care in the last 3 months of life of patients with terminal cancer”, a subset of the overall VCA research “Exploring factors influencing the site of care and death trajectories in the last 12 months of life”.

Principal investigator in the collaborative research project “Multidisciplinary management of Glioblastoma Multiforme (GBM) patients and carer burden: A prospective, pilot study across the disease trajectory”, Southern Melbourne Integrated Cancer Service (SMICs) funded. 10 patients recruited to date. 6-monthly audit of Pathway for Improving the Care of the Dying (PICD) in Southern Health.

Research activities Principal investigators in three multidisciplinary externally funded projects: VCA - “Why not at home, why in hospital: In depth case studies of hospital care in the last 3 months of life of patients with terminal cancer”

Publications and presentations summary Book chapters

1

Conference presentations

6

Funding: Competitive Victorian Cancer Agency, Research project. 2011: $630,000 (shared across PCRNV) Bethlehem Griffiths Research Foundation, Research project. 2011: $37,000 SMICS, Research project. 2011: $29,960

Bethlehem Griffiths Research Foundation – “Toward better end stage cancer prognosticating: the Monash Prognostic Indicator (MPI)”. SMICS - “Multidisciplinary management of Glioblastoma Multiforme (GBM) patients and carer burden: A prospective, pilot study across the disease trajectory”

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Urology Director : Associate Professor Mark Frydenberg

The Urology Unit consists of a dedicated team who are committed to the multifaceted conduct of research. The research focus of the department is diverse with data analysis ranging from retrospective audits; assessment for prevalence of particular syndromes; laboratory work and meta-analysis of published studies. There is a strong commitment to focus on clinical trials which aim to increase the treatment options available to our patients.

Research achievements for 2011 Receiving the Victorian Cancer Agency grant for the project entitled ‘The cancer of prostate – translation research in Victoria’.

Funding:

Research activities The urology unit continues to participate in clinical trials for oncological cancer conditions in the urological patients with participation in ongoing trials. Associate Professor Mark Frydenberg has also been awarded a grant by the Victorian Cancer Agency for the project entitled ‘The cancer of prostate – translation research in Victoria’. Many clinical papers have been published throughout the 2011 year by urologists at Southern Health. Areas that the clinical papers have been written in are broad-ranging and have contributed to the urology field. Contributions to the clinical areas this year have included: Clinical management of urological conditions Oncological outcomes related to urology surgery Cancer screening processes Surgical approaches and techniques Therapies for the medical management of urology patients Genetic links to urological conditions

Publications and funding summary

98

Journal articles

36

Conference presentations

19

Competitive Victorian Cancer Agency. The Cancer of prostate Translational research in Victoria. Frydenberg M. 2012-2013: $2,000,000 (State Government).

Commercial Sinitinib; Treatment of Renal Adjuvant cancer (S-Trac): A randomised double-blind phase III study of Adjuvant Sunitinib versus placebo in subjects with high-risk Renal cell carcinoma. Pfizer. Frydenberg M. $24 566.88 (Southern Health). A randomised, Double-Blind, Phase III Trial to compare the efficacy of lpilimumab vs. Placebo in Asymptomatic or minimally Symptomatic Patients with Metastatic Chemotherapy-Naive castration Resistant Prostate Cancer. BMS. Pook D (Southern Health). A randomised, double-blind, placebo-controlled, multi centre phase III study of Denosumab on prolonging bone metastasis-free survival in men with hormone – refractory prostate cancer. Amgen. Frydenber M (Southern Health).

Monash Health Translation Precinct Partner Reports

Monash Institute of Medical Research Director: Professor Bryan Williams

The Monash Institute of Medical Research (MIMR) undertakes multi-disciplinary research into stem cells, inflammatory diseases, cancer, women’s and children’s health, and reproduction and development. MIMR was established in 1991 (as the Monash Institute of Reproduction and Development) by Emeritus Professor David de Kretser AC and Professor Alan Trounson. Research at MIMR is conducted in four research centres: Ritchie Centre for Baby Health Research Centre for Cancer Research Centre for Reproduction and Development Centre for Innate Immunity and Infectious Diseases

Our scientists have made discoveries in the key research areas of cancer, stem cells, infection and immunity, as well as men’s, women’s and newborn health. Important research findings include: the discovery of specific molecules that drive metastasis in invasive bladder cancer; the creation of induced pluripotent stem cells, derived from adult cells; the control of cytokine signalling pathways involved in inflammatory diseases and cancers; the identification of genes involved in male infertility; the isolation of adult stem cells in the endometrium; and mechanisms involved in Sudden Infant Death Syndrome. Collaboration plays a large part in MIMR’s innovative research. The Monash Health Translation Precinct is a partnership between MIMR, Monash University, Southern Health and Prince Henry’s Institute. The precinct partners’ emphasis on translational research encourages the development of improved treatments targeted to patients’ clinical needs.

Research achievements for 2011 Professor Neil Watkins and Dr Luciano Martelotto from MIMR’s Centre for Cancer Research teamed up with colleagues from the United States to discover how a deadly lung cancer manages to regenerate despite being blasted with chemotherapy, and this could have major implications for the future treatment of millions of cancer patients. The researchers focused on fastspreading small cell lung cancer, which has a five-year survival rate of just five per cent. The researchers discovered in a series of laboratory experiments that they could stop the cells regenerating by using a drug to block a type of protein, known as a hedgehog, which is responsible for growth in cells. By inhibiting hedgehogs, doctors may one day be able to increase the effectiveness of chemotherapy and reduce the risk of cancer returning.

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Monash Health Translation Precinct Partner Reports Monash Institute of Medical Research

MIMR PhD student Rajneesh Verma

has for the first time, produced embryonic stem-like cells from the tissue of an adult leopard. Never before have induced pluripotent stem (iPS) cells, which share many of the useful properties of embryonic stem cells, been generated from a member of the cat family. The breakthrough raises the possibility of cryopreservation of genetic material for future cloning and other assisted reproduction techniques.

Dr Graeme Polglase and his team have

undertaken the first study investigating how the combined role of blood flow to the brain, heart and lungs may influence the onset of brain injury. Up until now, these systems have only been studied in isolation. It will also be the first study to research the impact that respiratory care immediately following birth has on the incidence and severity of brain injury in preterm babies.

Key funding highlights for 2011 Cancer research at the Monash Health Translation Precinct has received a further boost, thanks to the recent $1.6 million grant from the Australian Cancer Research Foundation (ACRF) for the Precinct to establish the ACRF Centre for Cancer Genomic Medicine; a new facility that will house technologies to facilitate cancer research from a genomic perspective. This was supplemented by a $169,000 Equipment Grant from the National Health and Medical Research Council (NHMRC). The Gandel Charitable Trust has donated a further $75,000 to the Monash Health Translation Precinct’s DNA Sequencing Centre. This will provide researchers and clinicians with the highest possible level of microbial infection diagnosis and identification. The Rebecca L Cooper Medical Research Foundation has also provided a grant for the expansion of the Gene Expression service which is located within the Gandel Charitable Trust Sequencing Centre.

100

A number of MIMR researchers were successful in attaining funding for their research through the National Health and Medical Research Council (NHMRC) and the Australian Research Council (ARC). NHMRC grants were awarded to eight of MIMR’s researchers for nine research projects and NHMRC Fellowships were awarded to Associate Professor Mark Hedger, Dr Ryan Hodges, Professor Paul Hertzog, Dr Graeme Polglase, Dr Michelle Tate, Professor David Walker, Dr Flora Wong and Dr Di Wu. Four MIMR researchers received funding for collaborative research projects: Professor David de Kretser; Dr Carl Sprung; Professor Justin St John and Dr Stefan White, and Associate Professor Richard Ferrero received an ARC Discovery Grant. Four MIMR researchers received the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) Research Foundation Scholarships and Fellowships. Dr Sonya Hubbard received the Ella Macknight Memorial Scholarship for her project: Identification of endometrial cancer stem cell surface markers. Dr Rebeca Lim received the Luke Proposch Perinatal Research Scholarship, for her project: Pregnancy induced hypertension and endothelial dysfunction. Dr Kirsten Palmer was awarded the Arthur Wilson Memorial Scholarship for her work on Therapeutic antibody development: A potential treatment for pre-eclampsia. Dr Tamara Yawno received the Glyn White Research Fellowship for her work on Novel cell based therapy for the treatment of perinatal brain injury in premature babies, in particular, investigating the neuroprotective effects in hypoxiaischaemia.

Research overview for 2011 Dr Ashley Mansell, Professor Justin

St. John and Professor Paul Hertzog have been researching key pathways linking the body’s innate immune response, or the first line of defence with mitochondrial function in response to the threat of infection.

Dr Tony Goldschlager and Professor

Graham Jenkin have teamed up with Australian-based adult stem-cell company, Mesoblast, and clinicians at Southern Health, to use Mesoblast’s bone marrow derived adult mesenchymal precursor stem cells, with specially designed ceramic granules, to create a new ‘bony’ fabric for replacing damaged cervical discs, the part of the spine found in the neck.

This breakthrough potentially offers hope to sufferers of cervical spine degenerative disease, where the discs that lie between the vertebrae in the neck degenerate over years of wear and tear.

Professor Euan Wallace and

Professor Graham Jenkin have been conducting work which promises to be the first effective treatment for bronchopulmonary dysplasia (BPD), a lung disease affecting preterm babies. Their work, published in leading journal Cell Transplantation involves the delivery of placental cells (amnion cells) deep into the premature baby’s lung repairing damage and re-growing new lung.

Dr Michelle Tate received a 2011

Premier’s Award for her research which has provided a detailed understanding of the immune defences involved in the early recognition and destruction of influenza virus.

Monash Health Translation Precinct Partner Reports Monash Institute of Medical Research

Dr Scott Sands was awarded the 2010

Funding:

Monash University Mollie Hollman Doctoral Medal for the best PhD thesis in the Faculty of Medicine, Nursing and Health Sciences. His research involved the creation of a mathematical model of the respiratory system and the design of experiments to quantify the dynamics of oxygen transfer across the lung and into the blood and tissues. His work has led to a mathematical explanation for the rapidity and severity of the drop in blood oxygen levels that occur in preterm babies when they suffer repetitive apnoea’s or “stop breathing” episodes.

Professor Stuart Hooper and his

Graeme Polglase. 2011

FMN&HS, Faculty Fellowship. Melissa Siew. 2011

Cerebral Palsy Foundation, CP

Monash University, Larkins Fellowship.

Publications, awards, postgraduate students and funding summary

Postgraduate research students

FMN&HS, Faculty Fellowship.

Columbia University. High-Throughput Minimally-Invasive Radiation Biodosimetry Carl Sprung. 2011-2012: $151,544 (US150,000).

Professor Brendan Jenkins have honed in on a gene, which could contribute to the causes of stomach cancer. The team is looking at a gene called STAT3, which is over-active in the disease and how that affects molecules called miRNAs, which have been found to play a role in cancer.

Awards

Scholarship. Novel MSC and scaffolds for regenerating the pelvic floor. Caroline Gargett. 2011-13: $151,500.

NIH USA, NIH - Pilot project through

A team of scientists led by Associate

Book chapters

US Department of Defense, SMART

Foundation/CP Institute Grant Program. Investigating Neuroprotective Effects in Hypoxia-ischaemia. Flora Wong, Suzanne Miller. 2011-12: $40,000.

team have been producing videos showing exactly how air moves hrough the lungs. The team has been using a synchrotron – a particle accelerator – to observe how gases travel through each part of the lung. This method is the first of its kind internationally and allows researchers to know which specific areas of the lungs are affected by the disease.

Journal articles

Competitive

0.2 EFT of Salary. Marcel Nold. 2011

NHMRC CDA, (2009-12)

Assembly of Mitochondria Respiratory Chain Complexes and their Defects Associated with Disease Matthew McKenzie. 2011-12

Victorian Cancer Agency (VCA),

Clinical Research Fellowship. The role of the notch pathway ligand DLL4 in lung cancer. Ben Markman. 2011-12

Cerebral Palsy Foundation, CP 212 6 2 100

Foundation/CP Institute Grant Program. Novel cell based therapy for Cerebral Palsy. Tamara Yawno, Suzanne Miller, Euan Wallace. 2011: $50,000.

Cancer Australia, Priority-driven

Research Scheme. The prediction and treatment of radiation induced fibrosis following cancer radiotherapy. Carl Sprung, Peter Rogers, David de Kretser. 2012-2014: $549,000.

Cancer Council Victoria

Postdoctoral Cancer Research Fellowship, Defining the genetic basis of testis cancer. Denise Miles. 2011

NHMRC Centres for Research

Excellence Centre for Research Excellence in Asbestos Related Diseases. Bruce Robinson, Jenette Creaney, Anna Nowak, Richard Lake, Arthur Musk, Barbara Fazekas de St Groth, Lyle Palmer, Richard Simpson, Steve Skates, David Neil Watkins. 2011-2015: $450,000.

Victorian Cancer Agency (VCA),

Early Career Seed Grant. The anti tumor activity of AMG706 in glioma cell lines and xenografts alone or in combination with panitinumab and AMG102. Jacqueline Donoghue, Terry Johns. 2011: $49,912.

NHMRC, Project. “Does caffeine

affect the development of the very immature brain: dose response relationship? Richard Harding, Mary Tolcos, Rob De Matteo. 2012: $197,650.

Cerebral Palsy Foundation, Project.

Can erythropoietin treatment provide long-term protection against inflammation-induced brain injury?: Relevance to Cerebral Palsy. Mary Tolcos, Rob de Matteo, Jeannie Cheong, Richard Harding, Sandra Rees. 2010-2012: $284,882.

Victorian Cancer Agency (VCA),

Early Career Seed Grant Development of a new biomarker of Hedghog pathway activity in cancer. Jason Cain, Neil Watkins. 2011-2012: $88,400.

Tragara Pharmaceuticals Inc (USA),

Contract. Aquired chemo-resistance in small cell lung cancer: a multi-Kinase inhibitor approach. Neil Watkins, Luciano Martelotto. 2011: $80,925.

Harold Mitchell Foundation,

Post doctoral Travel Fellowship. Maria Liaskos. 2011: $5,000

Harold Mitchell Foundation, Senior PhD Student Travel Fellowship. Jing Jing Khoo. 2011: $5,000.

FMN&HS, Faculty Bridging Fellowship. Michelle Tate. 2011

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Monash Health Translation Precinct Partner Reports Monash Institute of Medical Research

Department of Innovation, Industry,

Science and Research, Australia-India Strategic Research Fund (AISRF). Engineering a novel bioreactor and cell sorter or pluripotent stem cell culture. Paul Verma, Jayesh Bellare, Wenlong Cheng, Kerry Hourigan, Sameer Jadhev, Mark Thompson. 2011-2014: $299,539.

The Evans Familty (Dr Dan & Mrs Linda Evans), Research Donation. Develop a novel therapy for pelvic organ repair. Caroline Gargett. 2011-2015: $50,000.

Therapeutic Innovation Australia

Limited - Federal Government Education Investment Fund Victorian Consortium for Cell Based Therapies (VCCT) - to develop a GMP facility for cell-based therapies. Euan Wallace, Graham Jenkin incl -19 CI’s from 16 public sector institutions and 12 CI’s from 8 Industry partners. 2011-2013: $2,000,000.

Marian & EH Flack Trust, Project grant. Purchase of a LightScanner High Resolution Melting Instrument. Stefan White. 2011: $30,000.

Rebecca L, Cooper Medical Research

Foundation. Al and Val Rosenstrauss Medical Research Fellowship. Graeme Polglase. 2012-2015: $400,000.

Monash IVF, Damaged uterine

receptivity as a cause of prematurity. David Healy, Jane Halliday, Sue Breheny. 2011-2012: $50,000.

NHMRC, Project. MicroRNA regulation

of antiviral responses. Michael Gantier . 2012-2014: $483,660.

NHMRC, Project. Tissue engineering

a cell-based therapy for pelvic organ prolapse repair. Caroline Gargett, Jerome Werkmeister, Anna Rosamilia. 2012-2014: $685,920.

NHMRC, Project. Neuro-protection

in the Preterm Brain - A New Role for Dopamine Therapy? Flora Wong, David Walker, Suzie Miller. 2012-2014: $521,755.

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NHMRC, Project. How does

NHMRC, Peter Doherty Biomedical

NHMRC,Project. Activin mediated

NHMRC, Senior Principal Research

endometrium regenerate? Role of epithelial stem/progenitor cells. Caroline Gargett, David Breault. 2012-2014: $640,920. endothelial dysfunction: novel therapies for preeclampsia. Euan Wallace, Grant Drummond, Milton Hearn, Rebecca Lim. 2012-2014: $581,198.

NHMRC, Project. Helicobacter pylori

acquisition of host cholesterol: its role in inflammation. Richard Ferrero, Ben Croker. 2012-2014: $403,238.

NHMRC, Project. An integrated systems biology approach for the development of new therapeutic strategies for the treatment of high grade glioma. Terrance Johns, Andrew Boyd, Kerrie MacDonald. 2012-2014: $673,520.

NHMRC, Project. Is mitochondrial

STAT3 necessary for K-RAS induced myeloid leukemia’s? Daniel Gough. 2012-2014: $411,175.

NHMRC, Project. Revealing molecular

mechanisms of the synchrotron radiation-induced bystander effect. Olga Martin, Carl Sprung, Lobachevsky. 2012-2014: $414,835.

NHMRC, Biomedical - Career

Development Fellowship (CDF). Unlocking the complexities of postnatal brain injury in preterm neonates. Graeme Polglase. 2012-2015.

NHMRC, NHMRC Health Professional Research Fellowship, Early Career F/ Ship. Neuro-protection in the preterm brain - A new role for dopamine therapy? Flora Wong. 2012-2015.

NHMRC, Neil Hamilton Fairley

Clinical Fellowship (Overseas) Early Career F/Ship. Cardiac function in the growth restricted fetus: the effects of betamethasone and melatonin. Ryan Hodges. 2012-2015.

Fellowship (Australia) - Early Career F/Ship. Recognition and interaction of virus by the innate immune system. Michelle Tate. 2012-2015. Fellowship (SPRF). Fellowship Renewal. Paul Hertzog. 2012-2016.

NHMRC, Research F/Ship Senior

Research Fellowship Level B Fellowship Renewal . Mark Hedger. 2012-2016.

NHMRC, CJ Martin Biomedical

Fellowship (Overseas) - Early Career F/Ship. Epistatic and cross-tissue analysis for human gene expression traits. Di Wu. 2012-2015.

Royal Australasian College of

Physicians (RACP), ResMed Foundation Research Scholarship. Moya Vandeleur. $30,000

Monash IVF, Do endometrial stem/

progenitor cells have a role in preparing a receptive endometrium. Caroline Gargett. 2012: $52,870.

Asthma Foundation of Victoria

Asthma Victoria - Helen Macpherson Smith Trust. The role of innate immune responses during influenzainduced asthma exacerbation. Michelle Tate. 2012: $8,333.

Victorian Cancer Agency (VCA),

Early Career Seed Grant. Novel therapeutic strategies for high grade flioma. Michelle Van Sinderen, Terry Johns. 2011-2012: $93,600.

ARC, Discovery Grant. Transport

and innate immune properties of DNA in bacterial nano-sized vesicles Richard Ferrero, Katryn Stacey. 2012-2014: $270,000.

NHMRC, Project. Understanding

the pathogenesis of mitochondrial disease using iPS cells. David Thorburn, Justin St John, Stefan White. 2012-2014: $618,675.

Monash Health Translation Precinct Partner Reports Monash Institute of Medical Research

FMN&HS, Strategic Grant Scheme.

Fetal cardiac intervention of congenital heart disease. Flora Wong. 2011: $54,677.

NHMRC, Project. Katanin p80 is a

key regulator of microtubule dynamics and male fertility. Moira O’Bryan, Liza O’Donnell, David de Kretser. 2012-2014: $582,350.

FMN&HS, Strategic Grant Scheme.

Investigation of the role of Toll like Receptor 8 in H. pylori-induced gastritis. Michael Gantier. 2011: $15,000.

FMN&HS, Strategic Grant Scheme.

Interleukin 37 - From promise to product. Claudia Nold. 2012: $35,000.

FMN&HS, Strategic Grant Scheme.

The last white spot on the map of the interleukin 1 family of cytokines: IL-1F10. Marcel Nold. 2012: $14,421.

FMN&HS, Strategic Grant Scheme.

Production of tools to study NLRC5 role and expression. Jonathan Ferrand. 2012: $14,200.

Prostate Cancer Foundation of

Australia New Directions Development Award (NDDA). How do castrate resistant prostate cancer cells escape dormancy. Elizabeth Williams, Izhak Haviv. 2012-2013: $300,000.

CASS Foundation Limited, Science

and Medicine Grant. Uterine mesenchymal stem cells and novel scaffolds for cell-based therapy of pelvic organ prolapse. Caroline Gargett. 2012: $53,000.

NHMRC, Development Grant.

Development of an effective therapy for Cheyne-Stokes breathing in heart failure. Philip Berger, Garun Hamilton, Matthew Naughton, Bradley Edwards, Scott Sands, Ian Cooke. 2012-2014: $584,700.

Ron Evans Cancer Research

Fellowship, Fellowship. Afsar Ahmed. 2012

National Heart Foundation of

Australia, Grant-in-Aid “Endothelial progenitor cells in fetal blood and brain: Role in repair and recovery from developmental brain injury. Margie Zakhem, Caroline Gargett, David Walker. 2012-2013: $130,000.

CASS Foundation Limited, Science

and Medicine Grants. The use of follistatin to treat the reperfusion injury in organ transplants. David de Kretser, Robyn O’Hehir. 2012: $55,000.

Cure Cancer Australia Foundation,

Fellowship. The anti tumor activity of AMG706 in glioma cell lines and xenografts alone or in combination with Panitumumab and AMG102. Jacqui Donoghue. 2012.

Monash IVF, Research Grant.

To develop a diagnostic test for endometrial receptivity: exploit the potential of master switch molecule proprotein convertase 6. A/Prof Luk Rombauts. 2011: $23,000.

NHMRC, Development Grant.

Development of new antivirals. Paul Hertzog, Mark Sullivan. 2012-2013: $422,418.

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Prince Henry’s Institute Director: Professor Matthew Gillespie

Established in 1960, Prince Henry’s Institute (PHI) is Australia’s leading centre for hormones and reproductive medicine research. First established as the research centre at Prince Henry’s Hospital, the Institute is now an NHMRC accredited, not-for-profit medical research institute at Monash Medical Centre in Clayton. With over 160 employees and 17 laboratories, research at PHI focuses on the role of reproductive hormones in fertility and their involvement in genetics and the development of diseases such as cancer, cardiovascular disease, osteoporosis and Parkinson’s disease. Specialising in translational research, researchers at PHI combine fundamental laboratory research with clinical trials and studies to deliver positive clinical outcomes for patients at every stage of life, including early diagnosis, improved treatments and prevention of disease. Prince Henry’s Institute remains competitive both within the national and international research community, maintaining a strong funding mix, including competitive grants from key national and international and government funding bodies, charitable trusts and funds, corporate and private philanthropic support and public donations.

Research achievements for 2011 Defining the role of key mechanisms linked to bone loss and renewal. Detailing key protein differentiations in the uterine fluid of fertile and infertile women. Developing innovative methods to investigate uterine repair. Identification of links between gender specific genes and gender prevalence of neurological disorders in men. Modification of a key protein complex to develop a novel therapy to inhibit muscle wastage and Cachexia in vivo. Publishing of findings detailing role of key protein critical to release of mature sperm and male fertility. Identifying and validating three protein markers of ovarian cancer, which may be useful for early detection of cancerous and pre-cancerous ovarian disease. Establishing a critical link between tight control of levels of a key growth factor receptor and optimal kidney formation. Identifying signalling molecules responsible for mediating the role of a key growth factor receptor involved in blocking mobility of ovarian cancer cells. Publishing findings showing levels of a key protein marker may indicate preeclampsia risk in early pregnancy.

104

Identifying underlying genetic factors responsible for controlling the number and protection of eggs within the ovary that may be critical to protecting egg supply in women undergoing cancer treatment. Identifying underlying mechanisms linked to inhibition of inflammation of the heart muscle

Key funding highlights in 2011 Cancer Council Victoria Department of Education, Employment and Workplace Relations – Prime Minister’s Education Assistance Harold and Cora Brennen Benevolent Trust (Equity Trustees Limited) Heart Foundation Flack Trust L.E.W. CARTY Charitable Fund Monash IVF Pty Ltd National Breast Cancer Foundation National Institutes of Health (USA) National Health and Medical Research Council (NHMRC)– Program Grants, Project Grants, Fellowships, Scholarships, Equipment and Infrastructure Ovarian Cancer Research Foundation Perpetual Trustees – Ramaciotti Foundation Raybiotech

Monash Health Translation Precinct Partner Reports Prince Henry’s Institute

Funding:

The Royal Australian College of Physicians Victorian Cancer Agency (VCA)

Competitive

Victorian Breast Cancer Research Consortium (VBCRC)

National Health and Medical Research Council of Australia (NHMRC), Research Fellowships. Robert McLachlan Principal Research Fellowship (2012-2016), Vincent Harley Senior Research Fellowship (2012-2016), Evdokia Dimitriadis Senior Research Fellowship (2012-2016), Peter Tipping Retiring Fellowship (2012),Jock Findlay Retiring Fellowship (2012).

Victorian Government’s Operational Infrastructure Support Program

Research Overview In 2011, Prince Henry’s Institute was successful in securing highly competitive funding, including National Health and Medical Research Council Program (NHMRC) and Project Grants, as well as support from key competitive national and international funding bodies such as the Victorian Breast Cancer Research Consortium (VBCRC), National Breast Cancer Foundation, Cancer Council Victoria and the National Institutes of Health (USA). Continued funding success has enabled PHI researchers to undertake fundamental and translational research impacting on key priority areas including, cancer, cardiovascular disease, bone health, Parkinson’s disease and fertility. Continued funding from the Ovarian Cancer Research Foundation has also enabled researchers at PHI to make considerable progress towards an early detection test for Ovarian Cancer.

Website www.princehenrys.org

Publications, awards, postgraduate students, patents and funding summary Journal articles

87

Book chapters

2

Conference presentations

89

Patents

4

Awards

1

National Health and Medical Research Council of Australia (NHMRC), Project Grants. Craig Harrison, David Robertson, Kenneth McNatty, Robert Gilchrist. Activation of GDF9 regulates female fertility (2012-2014), Evdokia Dimitriadis, Ellen Menkhorst. Decidual-trophoblast interactions critical for the establishment of pregnancy (2012-2014), Colin Clyne, Ashwini Chand, Belinda Michell, Michael Gorman. LRH-1 antagonists for cancer drug discovery (2012-2014), Joohyung Lee. SRY in the brain (2012-2014), Matthew Gillespie. New factors that build bone (2012-2014). Ovarian Cancer Research Foundation (OCRF), Stacey Jamieson. Post Doctoral Fellowship.Tyrosine Kinase Inhibitors as Potential Therapeutic Agents in the Treatment of Granulosa Cell Tumours of the Ovary (2011), Andrew Stephens. Operation of the OCRF ovarian cancer tissue bank (2011/12), Andrew Stephens. Discovery and development of screening markers for the early detection of ovarian cancer (2011/12), Andrew Stephens. Tissue bank support (ultrafreezer and staff) (2011/12), Simon Chu. Molecular Pathogenesis of Granulosa Cell Tumours & Fallopian Fimbria as the Cellular Origin of High Grade Serous Ovarian Cancer Project (2011/12).

Perpetual Trustees - Ramaciotti Foundation, Michelle Myers. Establishment Gift. Using and losing your eggs; challenges for women in the 21st century. 2011: $74,776.57. The Royal Australian College of Physicians, Phillip Wong. Osteoporosis Australia/ RACP Research Entry Scholarship. Thalassaemic bone disease and the role of iron on bone biology 2012: $30,000. Jimmy Shen Vincent Fairfax Family Foundation Research Entry Scholarship (2012). Department of Education, Employment and Workplace Relations- Prime Minister’s Education Assistance, Nirukshi Samarageewa. Prime Minister’s Education Assistance Program for Japan. Heart Foundation: Jun Yang. Travel Grant Cancer Council Victoria, Evan Simpson - Victorian Breast Cancer Research Consortium (VBCRC). National Breast Cancer Foundation (NBCF), Kristy Brown. SIRT1 activators to inhibit aromatase in obesity and breast cancer. Monash IVF Pty Ltd, Lois Salamonsen. Proteomic analysis of receptive endometrium: identification of discriminative markers (2011), Evdokia Dimitriadis. The endometrium is a sense of a blastocyst destined for implantation success or failure (2011), Guiying Nie. Dystroglycan in uterine fluid is a potential marker for receptivity (2011). Raybiotech, Evdokia Dimitriadis. Biomarker Discovery Pilot Program. (2011). Victorian Cancer Agency (VCA)Early Career Seed Grant, Kristy Brown. SIRT1 activators to inhibit aromatase in obesity and breast cancer (2011).

Other Graduate Excellence Award Scholarship

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Southern Clinical School Director: Professor Eric Morand

Southern Clinical School (SCS) is the major teaching and research hub of the medical and nutrition degrees of Monash University at Southern Health. Its leadership comprises senior teaching and research academics who are also clinicians of Southern Health. In addition, SCS is the University organizational unit to which the vast majority of Southern Health clinicians who have university affiliation are appointed. It is a member of the Monash Health Translation Precinct.

Research achievements for 2011

The SCS comprises the University Departments of Medicine, Surgery, Obstetrics/Gynaecology, and Paediatrics, and University Research Centres including the Centre for Inflammatory Diseases (Head: Professor Stephen Holdsworth) and the Monash Cardiovascular Research Centre (Head: Professor James Cameron).

Numerous scientific publications in leading journals including British Medical Journal, Proceedings of the National Academy of Sciences (USA), Arthritis & Rheumatism, American Journal of Pathology, Journal of Immunology, Nature Reviews Rheumatology, Journal of the American Society of Nephrology, International Journal of Stroke, Eurointervention, Hepatology, European Heart Journal and many others.

The Ritchie Centre for Baby Health Research. (Head: Professor Euan Wallace), which operates its research activities in the MIMR (Monash Institute of Medical Research), is also part of SCS.

The SCS had significant research achievements in 2011, many of which are also reported in discipline areas within the SH Research Report, reflecting in a positive way the joint nature of the collaboration between Monash University/ SCS and Southern Health.

Competitive grant funding was successfully achieved from sources including the National Health & Medical Research Council, National Heart Foundation, Breast Cancer Foundation US and Australian Learning and Teaching Council.

Website www.med.monash.edu.au/scs/index.html

Publications, awards, postgraduate students and funding summary Journal articles

218

Books

1

Book chapters

3

Postgraduate research students

53

Funding: Competitive NHMRC, Project Role of B lymphocytes in atherosclerosis. Ban-Hock Toh. 2011: $201,130. 2011-2013: $603,390. NHMRC, Project. Mechanisms of infection triggered renal vasculitis. AR Kitching. 2011 - $133,205. 2011-2013: $399,615. NHMRC, Project. Regulation of arthritis and skin inflammation by annexin-1. Y Yang 2011: $197,244. 2011-2013: $591,732. NHMRC, Project. Mechanisms of TH17 induced injury in the kidney. AR Kitching 2011 -$153,028. 2011-2013: $459,084. NHMRC, Project Defining the role of GILZ in inflammatory arthritis. EF Morand. 2011: $217,244. 2011-2013: $651,732. NHMRC, Project The role of Mast cells in renal disease. SR Holdsworth. 2011: $173,902. 2011-2013: $521,706.

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Monash Health Translation Precinct Partner Reports Southern Clinical School

NHMRC Scholarship - J Ghali (Kitching).2011-2014: $109,358. Gastroenterological Society of Australia-Ferring IBD Estab Award. Interaction between mesenteric adipose tissue, adipocytokines, obesity, corticosteroid resistance. G Moore. 2011: $25,000. NHMRC, Scholarship - S De Silva (Holdsworth). 2011-2014:$ 109,358. Breast Cancer Foundation US - via John Hopkins University, Bloomberg School of Public Health Scheme Research Grant. Mechanisms of cancer susceptibility among BRCA 1/2 mutation carriers. K Visvanathan. 2011: $56,880. Arthritis Victoria. A novel patient centered instrument for assessment of SLE. EF Morand 2011: $20,000. GlaxoSmithKline, Analysis of Systemic Lupus Erythematosus (SLE) Database. EF Morand 2011-2012: $153,000 NHMRC Scholarship - A Hodge (Sievert) 2011-2013: $71,500 NHMRC, Project. A case control study of hypertension in the setting of poverty, overcrowding and infection. AG Thrift. 2011: $198,113. 2011-2013: $ 534,339. Australia India Institute Scheme, Building capacity for Public Health Research in rural disadvantaged India, using a cohort of mothers and babies. AG Thrift. 2011: $45,617. NHMRC/NHF/Pdoc Training Fellowship. Establishment of factors to explain variation in care quality, resource use and outcomes for stroke. D Cadilhac. 2011: $30,755. 2011-2013: $178,381. National Heart Foundation Scholarship J Kim (Thrift). 2011-2014: $75,330. NHMRC, Project. The role of micro-RNAs in human cardiomyocyte specification. A White. 2011: $134,736. 2011-2013: $334,208.

Cardiac Society of Australian and New Zealand Research Scholarship A Hutchison (Cameron). 2011: $35,579. NHMRC/NHFScholarship – A Nasis (Cameron). 2011- 2014: $ 109,358.

NHMRC (shared), Project Grant. Role of tetraspanins in integrin function and leukocyte migration. Hickey, M. 2011: $71,134. 2009-2011: $201,375 (Monash University).

NHMRC, Project. New roles for the spleen tyrosine kinase in antibody-independent renal injury. D Nikolic-Paterson. 2011: $185,016. 2011-2013: $555,048.

NHMRC (shared), Project Grant. The role of renal dendritic cells in infection and immunity under immunosuppression. Kitching, A. 2011: $80,620. 2009-2011: $228,126 (Adelaide University)

NHMRC, Project. Distinct pathogenic roles for JNK signalling in glomerular and interstitial injury in kidney disease. D Nikolic-Paterson. 2011: $178,902. 2011-2013: $536,706.

Arthritis Research Phd scholarship. Morand, E / Gui, R. 2011: $30,000. 2009-2011: $79,777 (Monash University).

NHMRC 2011 Scholarship – M Voevodin (Truby). 2011-2013: $71,857.

NHMRC, Research Fellowship B (SRFB). Nikolic Paterson, D. 2011: $128,371. 2009-2013: $618,750 (Monash University).

Australian Learning and Teaching Council. Professional competence standards, learning outcomes and assessment: designing a valid strategy for nutrition and dietetics. C Palermo. 2011: $91,000. 2011-2012: $177,000. NHMRC, Program Grant. Innovative stem cell-based strategies to establish immune tolerance & tissue repair. Toh, B-H. 2011: $305,033. 2007-2011: $1,427,168 (Monash University). NHMRC, Project Grant. MIF regulation of MKP-1 & glucocorticoid responses in RA. Morand, E. 2011: $116,182. 2008-2010: $398,157 (Monash University).Hickey, M. 2010: $114,128. 2008-2012: $565,880 (Monash University). NHMRC Principal Research Fellow. Hickey, M. 2011: $11,182. 2008-2012: $565,880 (Monash University). NHMRC, Project Grant. A population based cohort study of brain ageing – rates of brain structural change, functional effects and mechanisms. Srikanth, V. 2011: $199, 289. 2008-2012: $148,800 (Monash University). NHMRC, Project Grant. The role of the cytoplasmic domain of tissue factor in maintenance of the glomerular filtration barrier. Tipping, P. 2011: $165,290. 2009-2011: $460,000 (Monash University).

NHMRC, Project Grant. Mechanisms of glomerular leukocyte recruitment. Hickey, M. 2011: $195,520. 2010-2012: $565,500 (Monash University). NHMRC, Project Grant. Mechanisms of disease in humans with MPO ANCA associated glomerunephritis. Holdsworth, S. 2011: $177,887. 20102012: $514,500 (Monash University). NHMRC, Project Grant. Immunoregulation in the pathogenesis and therapy of autoimmune anti-myeloperoxidase glomerulonephritis. Holdsworth, S. 2011: $94,648. 2010- 2012: $273,750 (Monash University). NHMRC, Project Grant. The role of myeloperoxidase in adaptive immunity and the development of experimental glomerulonephritis and arthritis. Odobasic, D. 2011: $177,887. 2010-2012: $514,500 (Monash University). NHF, Project Grant. Sequential NKT and NK activation and regulatory T cell suppression in atherosclerosis. Toh, B-H. 2011: $64,500. 2010 -2011: $129,000 (Monash University).

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Monash Health Translation Precinct Partner Reports Southern Clinical School

NHF, Project Grant. Regulation of leukocyte chemokine responses by MIF. Hickey, M. 2011: $64,500. 2010 – 2011: $129,000 (Monash University). NHMRC (shared), Program Grant. Vascular Biology. Hickey, M. 2011: $295,611. 2010-2011: $598,866 (University NSW). NHMRC, Project Grant. Role of human amnion epithelial cells in resolving hepatic fibrosis. Sievert, W. 2011: $65,000. 2010-2012: $195,000 (Monash University/MIMR). NHMRC, CDA. Cerebrovascular diseases in ageing populations. Srikanth, V. 2011: $97,769. 2010-2013: $384,160 (Monash University). NHMRC, Project Grant. Type 2 iabetes mellitus and cognitive decline – a longitudinal study of effects and mechanisms. Srikanth, V. 2011: $98,641. 2010-2014: $463,875 (Monash University). US NIH, Contract Research. Collaborative GWAS of dementia, AD and related MRI and cognitive endophenotypes. Srikanth, V. 2011: $4,882. 2010-2012: $42,000 (Monash University). NHMRC biomedical PG research scholarship. Sanders, L. 2011: $36,286. 2010-2012: $107,750 (Monash University). NHMRC, JC Martin Fellowship. The cellular origin and nuclear signaling mechanisms of cardiac stem cells. White, A. 2011: $81,448. 2010- 2011: $120,012 (Monash University). NHMRC, Project Grant. Selective targeting of acute renal injury by inhibition of the receptor tyrosine kinase, c-fms. Nikolic Paterson, D. 2011: $147,703. 2010-2012: $427,200 (Monash University).

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NHMRC Project Shared. Resolvin E1 is a novel anti-inflammatory and anti-fibrotic lipid mediator for the treatment of chronic kidney disease. Nikolic Paterson, D. 2011: $40,349. 2010 2012: $99,850 (Monash University). Kathleen Tinsley Trust, Fellowship. Novel approaches to bedside monitoring of cerebral oxygenation in infants with HIE undergoing therapeutic hypothermia. Wong, F. 2011: $70,000. 2010-2011: $135,000 (Monash University). Butterfly Foundation, Research Project. Evaluating the efficacy of the school based program ‘Girls on the Go’ to improve self esteem, body satisfaction and physical activity in a multi-cultural environment (a randomized controlled trial).Truby, H. 2011: $100,000. 2010-2011: $200,000 (Monash University).

Collaborations

BioGrid Australia Director: Associate Professor Peter Gibbs Chief Executive Officer: Ms Maureen Turner, Melbourne Health

Our Vision: Integrating health and research data to facilitate improved health outcomes. Our Mission: Providing a technology platform for the ethical integration of data from individuals, health services, industry, research organisations and governments for research to reduce the burden of disease and improve human health. BioGrid Australia Limited is a leading data sharing technology company, providing a secure infrastructure that advances health research by linking privacy-protected and ethically approved data among a wide network of health collaborators. BioGrid links real-time de-identified health data across institutions, jurisdictions and diseases to assist researchers and clinicians improve their research and clinical outcomes.

The web-based infrastructure provides ethical access while protecting both privacy and intellectual property. In 2009 BioGrid became an independent not-for-profit company and is now owned by 26 collaborators representing 42 hospitals and research organisations across five states and territories.

Research achievements for 2011

Data currently linked to BioGrid is in excess of 205,400 (at 31 December 2011) privacy protected patients across 14 tumour streams and life sciences including endocrinology, neurology and respiratory with ongoing expansions of the network of data.

The ongoing collaborative study between BioGrid and Roche Products has continued to provide insight into how clinicians choose from the multiple potential treatment options available for patients with advanced bowel cancer. Pleasingly, along with increasing involvement of clinicians in both the public and private sector in Victoria, the first interstate site (Canberra) has been linked and data collection is either initiated or about to begin at additional sites in Tasmania,

Roche Project:

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Collaborations BioGrid Australia

New South Wales and Queensland, which will make this a truly national project. The first of many anticipated research papers related to this activity has been drafted and will shortly be submitted. Feedback from Roche has been very positive and with accrual of the initial 1,000 patients across Australia likely to be completed toward the end of 2012, discussions are underway regarding expanding this project to include additional questions across a significantly larger number of patients.

Centre of Analysis of Rare Tumours: CART-WHEEL.org Since its launch in April 2010 by Professor Sir Gustav Nossal, the CART-WHEEL.org rare tumour database has attracted more than 240 registrants and 100 individuals have returned their consent forms for the use of their clinical information for future research. CART-WHEEL.org facilitated projects at present includes nevoid basal cell carcinoma syndrome, high-grade mucinous and small cell ovarian cancer studies. As part of promotional activities, CART-WHEEL.org has embraced social media by creating Twitter and Facebook accounts with daily cancer news and information updates. Cancer forums have also been utilised to spread the word of CART-WHEEL.org to the wider cancer community. Proof of principle projects utilising the CART-WHEEL.org data and social networking approaches will continue to drive consumer usage of CART-WHEEL.org.

Data linked through BioGrid has enabled a comprehensive analysis of the cost of treating bowel cancer according to the stage at which the cancer was diagnosed. Compared to 1999 estimates the cost of treating early stage cancer in 2010 is largely unchanged whereas the cost of treating advanced cancer has escalated from $6,300 in 1999 to $97,300 in 2010. The analysis demonstrated that despite the limited scope of NBCSP, it is leading to earlier diagnosis of bowel cancers and this earlier diagnosis is directly leading to increased survival from this disease. This research project is currently in submission for publication.

Translational research projects BioGrid is actively involved in Victoria Cancer Agency (VCA) funded translational research projects that are generating new patient-based data. This has been particularly important for common cancers like lung and prostate where large datasets are being created through registries, health services, clinical trials, biobanking and primary care projects. Numerous VCA funded projects that require data linkage requiring resources provided by BioGrid are in the pipeline for 2012.

Research overview for 2011 Southern Health Breast Services have

been involved in the development of the Australian Comprehensive Cancer Outcomes and Research database, module for data collection, which uses standards set in the VCDS dataset. This module is web based and includes fields to capture data in Multidisciplinary Team Meetings. Prospective data will be collected at the three sites involved in the module development and testing (Austin Health, Box Hill Hospital and Monash Medical Centre) and the database will be available to any other BioGrid member sites keen to collect breast data.

National Bowel Cancer Screening Program (NBCSP) in Australia BioGrid is supporting clinicians to capture a comprehensive dataset on patients with bowel cancer. Through multi-site data linkage an adequate sample size has been analysed to compare the outcomes for those diagnosed by the NBCSP versus those diagnosed when symptoms are detected.

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The module is in the final stages of user testing and will be available for use in the coming months. The project is lead by Dr Jane Fox and Jo Morgan at Southern Health.

Colorectal data at Southern Health

is currently being collected on paper forms. The IT department has approved the application for installation and the next step will be the installation of the ACCORD database. The project is lead by Prof Bruce Waxman at Southern Health.

The Melbourne collaboration for the

study of HCC has developed with BioGrid a consensus HCC module for the ACCORD to enable data collection across seven patient treatment sites in Victoria. Out of the seven sites, ACCORD HCC database is active and running at Royal Melbourne Hospital and Western Hospital, however it is not yet operational at St Vincent’s Hospital, Austin Hospital, Alfred Hospital, Box Hill Hospital and Monash Medical Centre. The implementation process has been commenced at these three sites. The project is lead by Dr Anouk Dev at Southern Health.

The lung cancer project funded by

Victorian Cancer Agency aims to make it easy for researchers to access data and tissue for lung cancer research. The project involves collection of tissue biopsy and surgery, collection of clinical and treatment data and the establishment of a lung cancer registry. The data will be made available through BioGrid for researchers to utilise and an over-arching ethics approval for clinical, laboratory and population health projects will be submitted across participating sites. The project is lead by Professor David Armstrong at Southern Health.

There is interest in the chemotherapy

prescribing module of ACCORD which is to be completed in 2012. The project is lead by Dr Peter Briggs at Southern Health.

Victorian Cancer Biobank Manager: Mrs Zdenka Prodnovic

The Tissue Bank at Southern Health is one of the four Consortium members and an active resource of human biospecimens for prospective research projects. We recruit prospective donors and collect biospecimens- tissues and bloods. At Southern Health we actively support a number of research projects currently run at Monash Institute of Medical Research and Prince Henry’s Institute.

Research achievements for 2011 Excellent technical and scientific support has been provided by the Biobank staff in various areas such as selection of relevant material, cutting of paraffin sections, preparation of Tissue Micro Array and utility of the digital imaging system. Aperio, the digital imaging system is being offered to the research community as well as the Anatomical Pathology department to obtain quality digital imaging of their research/ educational sections. The staff have shown keen interest in academic and research activities which have resulted in poster presentations at various conferences. The staff have also contributed towards the project undertaken by the Tissue Bank registrar which will eventuate into a valuable research publication.

Active collaboration with the MCCC (Monash Medical Centre Clayton) where Tissue Micro Array of lung samples that supports current lung studies has been created by Southern Health Tissue Bank staff has been acknowledged by Professor Neil Watkins and we are hoping to be able to provide more service to this Consortium collaborator.

Research activities During 2011, the biobank at Southern Health has recruited almost 900 donors willing to donate their samples as a resource for future research endeavours. Fresh high quality samples for lung stem cell studies and breast cancer studies have been provided. Material from thyroid FNAs (Fine Needle Aspirates) for a project specific study was collected. This was done in conjunction with the cytology scientists in Anatomical Pathology and clinical staff in Radiology. All staff members have contributed equally towards this venture and this combined effort has resulted in improvement of patient care and has strengthened the relationship with the pathology / radiology departments and the researchers concerned. The Biobank has started working with the Royal College of Pathologists Australasia in their Quality Assurance Program (RCPA QAP). Tissue Micro Arrays for Quality Assurance purposes was created by the highly skilled and motivated staff. These services were offered for a fee. This collaboration has improved our relationship with the RCPA and this is expected to expand and strengthen in the future.

The Biobank at Southern Health has made significant progress with data entry into the Cresalys database. All demographical and associated clinical data of specimens collected during 2011 has been uploaded. This is an important achievement where all staff contributed with minimum training. With the new Victorian Cancer Biobank website and this data uploaded into the database, prospective researchers will have access to the details of samples in our inventory. This will speed up prospective researcher’s decision making and result in improved cost recovery of our operational funds.

Publications and funding summary Conference presentations

2

Funding: Competitive Victorian Cancer Biobank, Tissue Collection and Distribution. Victorian Cancer Research. Dr Beena Kumar. 2011: $423,434.00. 2011: 2,042,884.00 (Southern Health).

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Postgraduate Students

Doctor of Philosophy (PhD) students

Pinglu (Louie) Ye

Alana Westover

Generation and characterisation of a human embryonic stem cell-derived developmental model of the human female reproductive tract epithelium.

The role of prostaglandins in the fetal pulmonary response to intrauterine inflammation.

Monash University

Monash University

Hui Wu

Patricia Visdoganes

Anticipated completion: 2012

Latasha Abeynaike Mechanisms of lymphocyte recruitment in dermal inflammation. Anticipated completion: 2014 Monash University

Activin and its role in neutral microglial cells.

Human amniotic epithelial cells in the treatment of preterm lung disease.

Anticipated completion: 2012

Anticipated completion: 2014

Monash University

Monash University

Alexander Wilding

Rajneesh Verma

Liang (Babinski) Yu Role of integrin-linked Kinase in bladder cancer progression. Anticipated completion: 2013 Monash University

Signalling of the EGFRvIII Oncogene in Glioblastoma. Anticipated completion: 2012

Application of assisted reproductive technology for the conservation of endangered wild cats.

Monash University

Anticipated completion: 2013 Monash University

Ka Yu (Vanessa) Yeung The generation of vasopressin secreting cells from embryonic and pluripotent stem cells.

Kevin Wheeler

Warwick University, United Kingdom

Anticipated completion: 2013

Studies of neonatal volume targeted ventilation. Monash University

Moya Vandeleur The impact of sleep disturbance on daytime functioning, mood & quality of life in children with CF. Monash University

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Postgraduate Students

Daniela Ulrich

Bandar Ali Suliman

Elizabeth Sigston

Adult stem cells and novel biomaterials for tissue engineering a cell-based therapy for pelvic organ prolapse.

Modulation of interferon sensitivity by PLZF.

The role of laminin-5 in head and neck squamous cell cancer.

Anticipated completion: 2013

Anticipated completion: 2014

Anticipated completion: 2015

Monash University

Monash University

Sebastian Stifter

Melissa Li-Lian Siew

Signalling mechanisms of a novel interferon. Anticipated completion: 2013

Identifying the most effective techniques for facilitating lung liquid clearance at birth in preterm rabbit pups.

Monash University

Monash University

Dhanya Sooraj

Georg Schmoelzer

The role of outer membrane vesicles in H.Pylori pathogenesis.

Characterising and Targeting self-renewing, Pleuripotent Cancer Cells (cancer stem cells) in Bladder Cancer.

Monash University

Anticipated completion: 2014

Anticipated completion: 2017

Monash University

Monash University

Monash University Mei (Hazel) Tye Yuet Characterization of gastric disease in gp130 mutant mice. Anticipated completion: 2013 Monash University Lori Turner

Monitoring respiratory function during neonatal resuscitation.

Soroush Sarvestani Protein recognition of small RNAs in innate immunity aims.

Matthew Thompson

Kristina Sobotka

Characterizing the function of ATF3 in innate immunity and cancer progression.

Determining the effect of commonly used medical interventions, surfactant and glucocorticoids, on lung structure and function in the extremely immature fetal lung.

Anticipated completion: 2015

Anticipated completion: 2014 Monash University

The effects of prenatal and maternal stress on cardiovascular dysfunction in the newborn.

Monika Skubisz

Anticipated completion: 2013

Combination methotrexate and gefitinib to medically cure ectopic pregnancies: phase I and II trials.

Monash University

Anticipated completion: 2014

Anticipated completion: 2012 Monash University Cheryl Yin Chih Tay Investigating the roles of SoxB1 and FezF2 transcription factors in neural differentiation from human embryonic stem cells. Monash University

Monash University Ayabaddage Thilini Damsarani Samarasinghe

Nur Akmarina Mohd Said

Epithelial progenitor cells in the human endometrium and endometriosis.

Monash University

High content screening assay to screen for modulators of epithelial/mesenchymal transition in cancer metastasis.

Monash University

Suzanne Sinni

Anticipated completion: 2013

Evaluation of maternity services at Casey Hospital – Casey Maternity Services (“Cas-Mat”).

Monash University

Anticipated completion: 2014

The effects of exposure to maternal immune activation in the offspring.

Charmaine Tan

Amy Sutherland Effect of beth amethasone and/or melatonin on the growth restricted ovine fetus.

Monash University

Udani Ratnayake

Anticipated completion: 2013

Anticipated completion: 2013

Monash University

Monash University

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Postgraduate Students

Tracey Quinn

Lauren Nisbet

Jovana Maksimovic

Susceptibility of the fetal brain and adrenal gland to maternal stress in a precocial rodent.

Impact of sleep disordered breathing on cardiovascular function in preschool children.

Expression and regulation of sialic acid biosynthesis and sialytransferase genes in the mammary gland.

Anticipated completion: 2013

Anticipated completion: 2015

Monash University

Monash University

Monash University Istiak Mahfuz

Renaud Pierre Quantin

Hong Nguyen

Pax6 involvement in bladder cancer metastasis.

Identifying stem/progenitor cells in normal and malignant endometrium.

Anticipated completion: 2013

Anticipated completion: 2012

Monash University

Monash University

Genetic screening of patients with bladder extrophy. Anticipated completion: 2015 Monash University Kevin Tuan-An Luu

Agnieszka Pindel

Belinda Murray

Investigation of a role for PKR in obesity-related diseases.

Stem Cell Lines in sheep – Isolation, culture and characterisation.

Anticipated completion: 2013

Anticipated completion: 2012

Monash University

Monash University

Investigating the Interaction Between TRAF6, STAT1 and STAT3. Anticipated completion: 2013 Monash University Qian Li

Rebecca Piganis

Alistair Miller

Mechanism and regulation of Type 1 IFN signalling.

Aging and assessment of emphysema in GP130 mutant mice.

Anticipated completion: 2013

Anticipated completion: 2013

Monash University

Monash University

Luis Malaver Ortega

Jacqueline Melville

Are adult mesenchymal stem cells a more successful target to generate induced pleuripotency stem cells?

Prenatal inflammation & glucocorticoids influence immune function.

Anticipated completion: 2014

Monash University Lisa McKenzie

Volume of Tissue Activated and its Relationship to Clinical Outcomes in Deep Brain Stimulation. Anticipated completion: 2015 Monash University Bree O’Connell Placentation, and the maintenance of pregnancy in the Spiny Mouse (/Acomys cahirinus/). Anticipated completion: 2013 Monash University

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The University of Melbourne Dominic LaRosa Can maternal dietary supplements protect fetal heart from hypoxic damage. Anticipated completion: 2013 Monash University

Anticipated completion: 2014

Monash University David Oehme

Targeting IL-13Ralpha2 in Glioma with a monoclonal antibody.

Developmental and signalling pathways in brain tumours. Anticipated completion: 2015 Monash University Kieren Marini Generation of a tripartite chimeric single chain receptor for enhancing cancer therapy. Anticipated completion: 2015 Monash University

Tali Lang The human hepatitis B e antigen targets and suppresses Toll-like receptor signalling pathways. Monash University Tejal Kulkarni Understanding how mitochondrial DNA is propagated through stem cell models of mitochondrial DNA disease. Anticipated completion: 2015 Monash University

Postgraduate Students

Anna Kourbasis

Corey Heffernan

Samuel Forster

Effectiveness of treatment for the resolution of the sequelae of sleep disordered breathing in children.

Transmembrane delivery of specific recombinant proteins for reprogramming of somatic cells and disease therapy.

Systems biology of the Type 1 interferon response.

Anticipated completion: 2013

Monash University

Monash University

Seshini Gurusinghe

Stacey Ellery

Anticipated completion: 2014

Monash University Jing Jing Khoo The role of mitochondrial ubiquitin ligase 1 (Mul1) in the initiation of inflammation and apoptosis in response to viral invasion.

Treating preecalmpsia by tagetting activin A with follistatin and NOX inhibitors.

Birth asphyxia and acute renal failure: the protective capacity of maternal dietary supplements.

Anticipated completion: 2015

Anticipated completion: 2014

Monash University

Monash University

Monash University

Alexandra Grubman

Yu (Carol) Dou

Lauren Kerr Paediatric brain cancers.

The role of strain heterogeneity in Helicobacter pylori colonisation, virulence and host adaptation.

Anticipated completion: 2013

Anticipated completion: 2012

Anticipated completion: 2012

Monash University Kelly Kenna Ethanol-induced fetal brain injury and fatty acid ethyl esters in meconium: Studies in pregnant sheep. Monash University

Claire Greenhill IL-6 trans-signalling modulates TLR4-dependent inflammatory responses via STAT1 and STAT3. Monash University Cynthia Gonzalez

Role of the IFN-induced helicase-1 (IFIH1) in Type 1 Diabetes. Anticipated completion: 2013 Monash University Melinda Dolan The mechanisms underlying inflammation-induced lung maturation in the fetus. Anticipated completion: 2015 Monash University

Anticipated completion: 2012

Effects of growth promoters and inhibitors on fibroblast activity in normal, keloid and Dupuytren’s disease tissues: developing strategies for improving treatment options.

Monash University

Anticipated completion: 2013

Anticipated completion: 2013

Monash University

Warwick University, United Kingdom

Robert Galinsky

Rebecca Craythorne

Effect of intrauterine inflamation on renal development, cardiopulmonary and cerebral haemodynamics.

The role of the follistatin isoforms in the female reproductive tract.

Melanie Hutton The role of cholesterol in H. pylori interactions with the host.

Alexander Hodge Efficacy, safety and mechanism of action of the novel antifibrotic agent FT52 in rodent models of liver fibrosis and cell cultures. Anticipated completion: 2014 Monash University Amy Herlihy An exploration of the prevalence and psychosocial aspects of Klinefelter Syndrome in the context of population-based genetic screening. Anticipated completion: 2011

Adam Dickinson The role of mitochondrial DNA in human neural stem cells and Glioblastoma Multiforme.

Monash University

Anticipated completion: 2013 Monash University

Sanja Coso

Characterization of the novel type I IFN – Ifn-epsilon.

Molecular Mechanisms Controlling Lymphatic Endothelial Cell Motility in Prostate Cancer Lymph Node Metastasis.

Monash University

Anticipated completion: 2012

Ka Yee Fung

Monash University

Monash University

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Postgraduate Students

Yi Chen

Allison Cody

Priyanka Gupta

Activin A and cardiopulmonary bypass and ischaemia reperfusion injury of the heart.

Modelling, design and optimisation of novel stem cell bioreactors.

Anticipated completion: 2012

The role of the pathogen recognition molecule, NOD1, in the induction of gastric epithelial cell signalling during Helicobacter pylori infection.

Monash University

Monash University

Stuart Cantsilieris

Nicole Alers

Genetics of Macular Degeneration. The University of Melbourne Madleen Busse

Maternal treatment with melatonin as an in-utero therapy for brain injury in IUGR. Anticipated completion: 2015 Monash University

Developing and testing of novel bismuth contrast agent for diagnostic imaging.

Georgina Ryland

Anticipated completion: 2012

Next generation sequencing of candidate ovarian tumor suppressor genes.

Monash University Badia Barakat Investigating the role of activin, inhibin and bone morphogenetic proteins during the first wave of mouse spermatogenesis. Monash University

An investigation into the effect of in utero hypoxia on cerebral blood vessels and brain activity in late gestation fetal sheep.

Monash University Edmund Carvalho In-situ gelling nanoparticulate systems for tissue engineering using stem cells. Anticipated completion: 2013 Monash University K Rowe

Anticipated completion: 2015

People with problematic drug and alcohol and mental health issues: complex clients or complexity of the service system? Case study of SEADS.

Monash University

Anticipated completion: 2013 Monash University and Victoria University

Andrew Rodda Functionalised nanofibres for neural tissue engineering. Anticipated completion: 2012

Ana Baburamani

Anticipated completion: 2012

Monash University

Jun Dr Yang The mineralocorticoid receptor: identification of ligand and tissue selection coregulators. Anticipated completion: 2012

Savvas Kondouros Improvement of the current culture in human embryonic stem cells.

B Wright

Anticipated completion: 2012 Anzari Atik

Longitudinal investigation of psychological outcomes and correlates in Australian War veterans.

Monash University

The effects of daily caffeine administration on the development of the immature brain: Short and long-term effects at escalating doses.

Anticipated completion: 2014

Saroj Yadav

Paul Wood

Anticipated completion: 2014

Generation and characterization of cell cycle regulation of induced pleuripotent cells (iPSCs).

Molecular oncology/translational research.

Monash University

Anticipated completion: 2013

Melbourne University

Monash University

Abdulaziz Alsharif Regulation of inflammatory signaling transduction pathways in innate immunity.

Anticipated completion: 2012

Monash University Phillip Wong Jubina Venghateri (nee Balan)

Thalassemia and bone disease. Anticipated completion: 2015

Anticipated completion: 2015

Generation of induced pleuripotent stem cells using a nonintegrating viral vector.

Monash University

Anticipated completion: 2012

Avoiding the Tumble – evaluation of a falls prevention program in an acute hospital.

Monash University

Willeke Walsh

Anticipated completion: 2012 University of Melbourne

116

Postgraduate Students

Lixian Wang

Jake Shortt

Poh-Yi Gan

Role of p53 in regulating aromatase in the breast.

Targeting the PI3K/mTOR pathway in pre-clinical models of B-cell neoplasia.

Anticipated completion: 2015

University of Melbourne

Effector mechanisms of glomerular injury in models of autoimmune Anti-MPO induced glomerulonephritis. Anticipated completion: 2012

Ken Walker The development and function of high nephron endowment. Anticipated completion: 2011 Patricia Vosdoganes Intrauterine infection and lung injury in sheep: A model investigating the use of human amnion epithelial cells in the treatment of preterm lung injury. Anticipated completion: 2012 Monash University Lana Tutin

Jimmy Shen Macrophage MR signalling regulates systolic blood pressure and cardiovascular remodelling. Anticipated completion: 2015

Fidelity in interventions for mental health care. Anticipated completion: 2014 Monash University

Padaphet Sayakhot Menopause and breast cancer.

Paul Jansons

Monash University

Integration with community-based exercise providers for people with chronic disease.

Satyan Chari Extrinsic risk factors and falls.

Anticipated completion: 2016

Anticipated completion: 2014

Monash University

Exploring the area of clinical risk in the operating theatre.

Monash University

Anticipated completion: 2014

Nirukshi Samarajeewa

Deakin University

Elucidating of the role of CRTC2 co-activation of CREB in regulating promoter II-driven aromatase expression in human breast adipose stromal cells.

Sarah To

Phuong Prowse

Nicole Papadopoulos An investigation of the “neuromotor signature” of Attention Deficit Hyperactivity Disorder (CRCMD&G). Anticipated completion: 2013 Monash University

TNFa and its role in breast oestrogen biosynthesis.

Anticipated completion: 2013

Anticipated completion: 2013

Sam Sevenhuysen

Rajini Sreenivasan

Peer-assisted learning in clinical education.

Providing continence care in residential aged care settings: A grounded theory study.

Genetic Regulatory Mechnaisms in Mammalian Sex Determination.

Anticipated completion: 2014

Anticipated completion: 2013

Monash University

Deakin University

Monika Skubisz

Robert Meek

Peter Nicholls

Combination Gefitinib and Methotrexate for Treatment of Disorders of Trophoblastic Tissue.

The paramedic collaboration with triage (PACT) study. Aiming to improve patient safety at the ambulance – ED interface.

Endocrine regulation of sertoli sell function.

Anticipated completion: 2013

Anticipated completion: 2018

Monash University

Monash University

Courtney Simpson

Scharmila Ramessur

Structure and function of growth and differentiation factor-9.

Signalling pathways in antibody-mediated renal allograft rejection.

Anticipated completion: 2013

Anticipated completion: 2014

Anticipated completion: 2013

Joan Ostaszkiewicz

Anticipated completion: 2012 Kanvar Nayer The development and testing of personalised entertainment devices for persons with dementia (AMHRU). Anticipated completion: 2014 Monash University

Monash University

Southern Health Research Report 2011

117

Postgraduate Students

Sean Murphy

Seong Lin Khaw

Zane Kaplan

Placental Stem Cells as a treatment for lung disease.

Translational and mechanistic studies with BH3-mimetics in haematological malignancies.

The Impact of Glycoprotein-IB Binding to Thrombin on Platelet and Neutrophil Interaction.

Submitted 2011

Anticipated completion: 2014

Michael Mond

Walter and Eliza Hall Institute of Medical

Monash University

Defining the genetic pathology of epithelial thyroid tumours.

Jason Liew

Jun Yang

Anticipated completion: 2014

The role of estrogen in ovarian function.

Prince Henry’s Institute

Monash University

Anticipated completion: 2011

Michele Callisaya

Kyren Lazarus

Monash University

Anju Joham Aging and Gait.

Role of LRH-1 in Breast Cancer.

Obesity, insulin resistance and polycystic ovary syndrome.

University of Tasmania

Anticipated completion: 2013

Anticipated completion: 2013

Stuart Marshall The effects of cognitive aids on team performance in medical emergencies. Anticipated completion: 2012 University of Queensland Marlena Klaic Uptake of evidence-based practice among allied health professionals. Anticipated completion: 2012 Monash University Mark Slee

Lauren Sanders Clinical and biological aspects of stroke.

Monash University Jessica Ryan

Anticipated completion: 2013

Signalling pathways in antibody-mediated renal injury.

Monash University

Anticipated completion: 2013

Laura Tirlea Girls on the Go! Program for improving self-esteem in young girls.

Monash University Jan Taylor

Anticipated completion: 2015

Mobility and independence in nursing home residents.

Monash University

Anticipated completion: 2015

Kim O’Sullivan

Monash University

Mitochondrial dysfunction in multiple sclerosis.

Characterisation of Th17 immune responses in Anti-neutrophil cytoplasmic antibody glomerulonephritis.

Anticipated completion: 2015

Anticipated completion: 2018

Molecular mechanisms in the pathogenesis of granulosa cell tumours of the ovary.

Renee Kharsas

Anticipated completion: 2012

A randomised controlled trial to assess the effectiveness of a support group intervention in the reduction of symptoms of depression, anxiety and burden in spouses/partners of aged care residents (AMHRU).

Prince Henry’s Institute

Anticipated completion: 2012

Monash University

Flinders University Louise Corben An examination of the temporal and kinematic components of voluntary movement in people with Friedreich’s ataxia. Completed 2011 Monash University

118

Monash University

Stacey Jamieson

Istiak Mahfus Genetics of bladder development. Anticipated completion: 2014

Postgraduate Students

Samantha Hutchison

Graham A

Adam Hutchinson

Role of exercise in treatment of women with PCOS: Mechanisms of action.

Bibliotherapy: its current and potential usage by Australians with mental health problems.

Approaches to optimising putcome in ST-elevation and Non-ST elevation Myocardial Infarction.

Anticipated completion: 2014

Anticipated completion: 2013

Monash University Louis Huang Cell specific mechanisms of mineralocorticoid mediated renal injury in glomerulonephritis and diabetic nephropathy. Anticipated completion: 2013

Melanie Gibson Health related behaviour in women of reproductive age. Anticipated completion: 2013 Monash University

Monash University

Monash University Diana Tan Regulatory T-Cells in the therapy of autoimmune crescentic glomerulonephritis. Anticipated completion: 2012

Elizabeth Skinner Annette Davis

Self as parent: developing the supportive figure.

Health-related quality of life and physical function in Australian survivors of critical illness.

Anticipated completion: 2014

University of Melbourne

Anticipated completion: 2016

Ryan Hodges

Elizabeth Rowland

Human amnion cells as a therapy for preterm lung disease. Anticipated completion: 2012

Returning to occupational activities to prevent falls amongst older hospital patients.

Monash University

Anticipated completion: 2014

Vitamin D and Chronic Kidney Disease: effects on mineral metabolism, vascular calcification and transplant outcomes.

Monash University

Anticipated completion: 2014

F Hopkins

Keeping elderly ladies on their feet (CRCMD&G). Monash University

Hui Ting Ho PC6 as a potential target for developing dual-role female contraception by blocking embryo implantation and HIV infection.

Matthew Damasiewicz

Monash University Damien Eeles The role of IL-33 in bone.

Daniel Czech

Anticipated completion: 2012

The sexually dimorphic brain.

Monash University

Anticipated completion: 2012

Jenna Haverfield

Brian Ko

Cylie Williams

Regulation of sertoli cell differentiation in vivo.

CT myocardial perfusion assessment in stable coronary artery disease.

Anticipated completion: 2014

Anticipated completion: 2012

Anticipated completion: 2013

Cheryce Harrison Lifestyle intervention in insulin resistant reproductive aged women. Monash University Sabrina Gupta Ethnicity, cardiovascular disease and diabetes: A comparison between South Asians and Anglo Australians in Melbourne. Anticipated completion: 2012

Monash University Arthur Nasis Novel imaging techniques for the diagnosis of coronary artery disease and myocardial ischaemia: Implications for the assessment of patients with chest pain. Anticipated completion: 2014 Monash University

Idiopathic Toe Walking: A Diagnosis or Symptom of Sensory Processing Dysfunction. Charles Sturt University Davina Cossigny The role of TGF-beta superfamily members: TFG-beta and activin in early folliculogenesis. Anticipated completion: 2011 Chris Moran Diabetes and dementia. Anticipated completion: 2014 Monash University

Monash University

Southern Health Research Report 2011

119

Postgraduate Students

Vanessa Cheung

Alicia James

The role of PTHrP/TRAIL in breast cancer.

Treatment approaches for Sever’s disease.

Completed 2011

Anticipated completion: 2015 Justin Chen Targetting the tgf-b signalling pathway to improve muscle growth and development in muscular dystrophy.

Monash University

Doctorate of Medicine (MD) students

Dimuthu Alankarage

Emma Guymer

Anticipated completion: 2014

ETV5 and DHH are novel genes in mammalian sex development.

Predicting treatment outcomes in Fibromyalgia.

Samantha Cassar

Anticipated completion: 2013

Anticipated completion: 2013

Women’s health: The role of mitochondria and exercise.

Abu Abrahams

Monash University

Anticipated completion: 2012

Macrophage activation in kidney disease and renal transplant rejection.

Genia Burchall

Anticipated completion: 2012

Haemostatic abnormalities in PCOS.

Monash University

Royal Melbourne Institute of Technology

Katrina Malin

Laura Bienvenu

Personality in fibromyalgia.

The role of the mineralocorticoid receptor (MR) in mediating cardiac inflammation.

Anticipated completion: 2012

Anticipated completion: 2014 Pratiti Bandopadhayay The role of the EWS/WT1 fusion protein in the development of tumours. Anticipated completion: 2011

Doctorate of Psychology (DPsych) students

Monash University

Alex Wynd Treating Headache and Depression – optimising approaches. Anticipated completion: 2013 Monash University E Gerschman Life meaning, psychological health and wellbeing.

University of Melbourne

K Priess

Baird D

Exploring the relationship between weight loss and depression in obese adults.

The Whole Person approach: how do clients experience an integrated approach to disease management. Anticipated completion: 2014 Annette Graham Bibliotherapy and mental health. Anticipated completion: 2014 Monash University

120

Anticipated completion: 2014 Monash University

Postgraduate Students

Masters students

G Reid

Lin Lorraine

Master of Social Work (Course Work)

Tomasz Mackowiak

Anticipated completion: 2012

The role of Leukemia Inhibitory Factor in endometrial stromal cell decidualization.

Master of Engineering Science Research

Monash University

Anticipated completion: 2011

Anticipated completion: 2012 Monash University

Lynette Ozols

Yali Li

Master of Social Work (Course Work)

Master of Engineering Science Research

Anticipated completion: 2012

Anticipated completion: 2013

Monash University

Monash University J Smith Master of Health Sciences (Course Work)

J Little Master of Social Work (Course Work) Anticipated completion: 2012

Seungmin Ham The regulation of aromatase expression by the LKB1/AMPK pathway in the testis. Anticipated completion: 2012 Monash University Sambridhi Adhikari Role of activin A in the pathophysiology of preeclampsia. Monash University

Newcastle University

Monash University

Yvette Beaber

G Scroggie

G Kerridge

Master of Health Sciences (Course Work)

Master of Social Work (Course Work)

“Detection of lymphatic invasion in breast core biopsies using D2-40 immunohistochemistry”.

Newcastle University

Monash University

Charles Sturt University Leyla Zaker-Tabrizi

Katherine Kibby

G Bawden

Masters of Biomedical Science

Diabetes care in young adults.

Master of Social Work (Course Work)

Monash University

Monash University

Hemalatha Umapathy

Anticipated completion: 2012 Monash University J Ward Master of Social Work (Course Work) Monash University K Smith Master of Social Work (Course Work)

Stephanie Ch’ng The influence of unit and surgeon volume on patient outcome after cardiac surgery. Anticipated completion: 2012 Monash University

Masters of Biomedical Science Monash University Jean Tan Masters of Biomedical Science Anticipated completion: 2013 Monash University

Zhe (Kimmy) Zhao Identification of novel LRH-1 target genes in breast cancer.

Catherine Pilapil

Anticipated completion: 2013

Monash University

R Singh

Kate McLachlan

Master of Social Work (Course Work)

Rachael Pasco

Masters in Nurse Practitioner

Masters of Biomedical Science

Anticipated completion: 2013

Monash University

Anticipated completion: 2012 Monash University

Anticipated completion: 2012

Masters of Biomedical Science

Deakin University

Melbourne University

Southern Health Research Report 2011

121

Postgraduate Students

Hadeel Khalil Khayat Masters of Biomedical Science Monash University Lisa Davis Masters of Biomedical Science Monash University Brooke Wadsworth Abdominal binders for people with spinal cord injury. Anticipated completion: 2012 University of Queensland Nicholas Hall Masters of Surgery Anticipated completion: 2012 Monash University Heba Zahid Oocyte competence and viability following ovarian tissue cryopreservation in domestic species. Monash University Hadeel Khayam Induced pluripotent stem cells in species conservation. Monash University Susan Ballinger-Doran Preparation (familiarisation) of learners into the simulation-based learning environment. Monash University Kaylene Wadd Mothers on dialysis. Flinders University

122

Funding Sources

Corporate Sponsors (Pharmaceutical and Biotechnology)

GESA Ferring IBD Clinician Establishment Award GlaxoSmithKline Janssen-Cilag

Abbott Medpace Actelion Melbourne Aquarium Allergen Pty Ltd Merck Serono Amgen Merck Sharp & Dohme Astra Zeneca Mesoblast Boehringer Ingelheim Novartis BUPA Novo Nordisk Wong CathRX Novotech Centecor Orion Cook Medical, TPC and Gytech. Pfizer Cordis Phosphagenics Ltd

PRA International Quintiles Raybiotech Roche Sanofi Aventis Tek-Event Terumo Therapeutic Innovation Australia Ltd Tragara Pharmaceuticals Trident Trident for Incyte TriReme Medical UCB Vifor Pharma

Eli Lilly PPD Australia Pty Ltd

Southern Health Research Report 2011

123

Funding Sources

Government Organisations Australian Government, Department of Families

Australian Government, Department

Victorian Office of Senior Practitioner

Institutional Support Non-Government Organisations

of Health and Ageing

Australian Government, Department of Mental Health Branch

Australian Primary Health Care Research Institute (APHCRI)

Australian Research Council Linkage Grants

Department of Defence (United States)

Australian Government, Department

of Education, Employment and Workplace Relations – Prime Minister’s Education Assistance

Victorian Government, Department of Human Services, Children’s First Policy

Australian Government,

Department of Innovation, Industry, Science and Research

Therapeutic Innovation Australia Limited - Federal Government

Victorian Cancer Agency Victorian Government, Department of Health

124

The Austin Anaesthetics’ Department

The Royal Australian College of

Australian and New Zealand

Society of Nephrology (ANZSN)

Australian Association of Social Workers

Beyondblue Cancer Council of Victoria Cardiac Society of Australia and New Zealand (CSANZ)

Caulfield Hospital Cerebral Palsy Alliance Dementia Collaborative Research Centre

Monash IVF

Southern Metropolitan Integrated Cancer Service (SMICS)

Partnership

Asthma Victoria

Quality Dementia Care Initiative

National Health and Medical National Institutes of Health (USA)

South East Healthy Communities

The Royal Australian College of

Haematology Society of

Research Partnerships for Better health

College of Obstetricians & Gynaecologists (RANZCOG)

Alzheimer’s Australia National

National Health and Medical Research Council

Royal Australian and New Zealand

Australia & New Zealand

National Heart Foundation of Australia

Parkinson’s Victoria Peter McCallum Cancer Institute Royal Australasian College of Physicians (RACP)

General Practitioners Family Medical Care

Physicians

The Royal Australasian New Zealand

College of Obstetrics and Gynaecology,

Victorian Breast Cancer Research Consortium

Western Australian Country Health Service

World Health Organisation World Psychiatric Association

Funding Sources

Philanthropic and Charitable Organisations

Marian & EH Flack Trust MBF Research Foundation Monash University

Apex Foundation for Research

NABO-Ovarian Cancer

Asthma Foundation VIC

National Breast Cancer

Australia-India Strategic

National Heart Foundation

Bethlehem Griffiths Research

National Parkinson

Butterfly Foundation

Ovarian Cancer Research

CASS Foundation Limited

Perpetual Trustees Grant

Cerebral Palsy Alliance

Prostate Cancer Foundation

into Intellectual Disability

Research Fund

Foundation

Research Foundation

Clive and Vera Ramaciotti Foundation

Dara Foundation Deakin University Diabetes Australia Research Trust Harold Mitchell Foundation Jack Brockhoff Foundation JO & JR Wicking Trust

Research Foundation

Foundation

Foundation (NPF)

Foundation

of Australia

Rebecca L. Cooper Medical Research Foundation

Ron Evans Cancer Research Fellowship

The Evans Family

(Dr Dan & Mrs Linda Evans), Research Donation

University of Sydney Wesley Research Institute

Kathleen Tinsley Trust Leukaemia Foundation Lions John Cockayne Memorial Fellowship Trust Fund

Southern Health Research Report 2011

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Southern Health and MHTP Publications

Journal articles Akhlaghi H, Corben LA, GeorgiouKaristianis N, Bradshaw JL, Storey E, Delatycki MB, Egan GF. Superior Cerebellar Peduncle Atrophy in Friedreich’s Ataxia Correlates with Disease Symptoms. Cerebellum 2011;10:81-87. Achhra AC, Zhou J, Choi JY, Hoy J, Zhang F, Templeton DJ, Merati T, Woolley I, Petoumenos K, Amin J. The Clinical Significance of CD4 Counts in Asian and Caucasian HIV-Infected Populations: Results from TAHOD and AHOD. J Int Assoc Physicians AIDS Care (Chic) 2011;10(3):160-70. Agar JWM, Hawley CM, Kerr PG. Home Hemodialysis in Australia and New Zealand: How and why it has been successful. Semin Dialysis 2011;24(6):658-63. Ahmed AU. An overview of inflammation: mechanism and consequences. Front Biol 2011;6(4):274-81. Aitken RJ, Findlay JK, Hutt KJ, Kerr JB. Apoptosis in the germ line. Reproduction 2011;141:139-150.

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Alexiadis M, Eriksson N, Jamieson S, Davis M, Drummond AE, Chu S, Clyne CD, Muscat GE, Fuller PJ. Nuclear receptor profiling of ovarian granulosa cell tumors. Hormones & Cancer 2011;2:157-169. Alexidais A, Eriksson N, Jamieson S, Davis M, Drummond AE, Chu S, Clyne CD, Muscat GE, Fuller PJ. Nuclear receptor profiling of ovarian granulosa cell tumors. Hormones and Cancer 2011;2:157-69. Allan CA, Collins VR, Frydenberg M, McLachlan RI, Matthiesson KL. Monitoring cardiovascular health in men with prostate cancer treated with Androgen Deprivation Therapy. 2011 International Journal of Urological Nursing 2011;6(1):35-41. Allan CA, Peverill RE, Strauss BJG, Forbers EA, McLachlan RI. Waist-to-height ratio as a predictor of serum testosterone in ageing men with symptoms of androgen deficiency. Asian Journal of Andrology 2011;13(3):424-431. Allan CA, Peverill RE, Strauss BJG, Forbes EA, McLachlan RI. Waist-to-height ratio as a predictor of serum testosterone in ageing men with symptoms of androgen deficiency Asian Journal of Andrology 2011;133:424-431.

Allan CA, Strauss BJ, Forbes EA, Paul E, McLachlan RI. Variability in total testosterone levels in ageing men with symptoms of androgen deficiency. Int J Androl 2011;34(3):212-6. Allan CA, Strauss BJ, Forbes EA, Paul E, McLachlan RI. Variability in total testosterone levels in ageing men with symptoms of androgen deficiency. International Journal of Andrology 2011;34:212-216. Aminoff MJ, Christine CW, Friedman JH, Chou KL, Lyons KE, Pahwa R, Bloem BR, Parashos SA, Price CC, Malaty IA, Iansek R, Bodis-Wollner I, Suchowersky O, Oertel WH, Zamudio J, Oberdorf J, Schmidt P, Okun MS; National Parkinson Foundation Working Group on Hospitalization in Parkinson’s Disease. Management of the hospitalized patient with Parkinson’s disease: current state of the field and need for guidelines. Parkinsonism and Related Disorders 2011;17(3):139-145. Amir LH, Cullinane M, Garland SM, Tabrizi SN, Donath SM, Bennett CM, Cooklin AR, Fisher JR, Payne MS. The role of micro-organisms (Staphylococcus aureus and Candida albicans) in the pathogenesis of breast pain and infection in lactating women: study protocol. BMC Pregnancy Childbirth 2011;22;11:54.

Southern Health and MHTP Publications

Andersen CC, Pillow JJ, Gill AW, Allison BJ, Moss TJ, Hooper SB, et al. The cerebral critical oxygen threshold of ventilated preterm lambs and the influence of antenatal inflammation. J Appl Physiol 2011;111(3):775-81.

Badve S, Brown F, Hawley C, Johnson D, Kanellis J, Rangan G, Perkovic V. Challenges and feasibility of conducting a trial of uric acid lowering therapy in chronic kidney disease. Nature Reviews Nephrology 2011;7(5):295-300.

Andrews PC, Ferrero RL, Forsyth CM, Junk PC, Maclellan JG, Peiris RM. Bismuth(III) Saccharinate and Thiosaccharinate Complexes and the Effect of Ligand Substitution on Their Activity against Helicobacter pylori. Organometallics 2011;30(22):6283-91.

Badve SV, Hawley CM, McDonald SP, Brown FG, Boudville NC, Wiggins KJ, Bannister KM, Johnson DW. Use of aminoglycosides for peritoneal dialysis associated peritonitis does not affect residual renal function. Nephrol Dial Transplant 2011 Jun 1.(Epub ahead of print).

Andrianopoulos N, Dinh D, Duffy S, Clark DJ, Brennan A, Chan W, Shardey GC, Smith JA, Yap C-H, Buxton BF, Reid CM. Quality control activities associated with registries in interventional cardiology and surgery. Heart Lung Circulation 2011;20:180-6. Ariyaratne TV, Billah B, Yap C-H, Dinh D, Smith JA, Shardey GC, Reid CM. An Australian risk prediction model for determining early mortality following aortic valve replacement. Eur J Cardiothorac Surg 2011;39:815-821. Aw H, Spernat D, Eapen R, Donnellan S, Kourambas J. Undetected Calyceal Diverticulum with Perioperative CT IVP. The Internet Journal of Urology 2011;8(2). Aw, HC, Spernat, D, Eapen R, Donnellan S. Supratrigonal Cystectomy and Ileocystoplasty in the Management of a Solitary Non-Malignant Bladder Lesion. The Internet Journal of Urology 2011;8(2). Babi FE, Young S, Oakley E. Developing Academic Pediatric Emergency Medicine in Australia and New Zealand (editorial). Emergency Medicine Australasia 2011;23:1-3. Babl FE, Young S, Oakley E. Developing Academic Pediatric Emergency Medicine in Australia and New Zealand. Emergency Medicine Australasia 2011:23,1-3. Editorial.

Bagheri-Fam S, Argentaro A, Svingen T, Combes AN, Sinclair AH, Koopman P, Harley VR. Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome. Human Molecular Genetics 2011;20:2213-2224. Bailey HD, Armstrong BK, de Klerk NH, Fritschi L, Attia J, Scott RJ, Smibert E, Milne E; Aus-ALL Consortium Collaborators (24), Milne E, van Bockxmeer FM, Haber M, Scott RJ, Attia J, Norris MD, Bower C, de Klerk NH, Fritschi L, Kees UR, Miller M, Thompson JR, Bailey HD, Alvaro F, Cole C, Pozza LD, Daubenton J, Downie P, Lockwood L, Kirby M, Marshall G, Smibert E, Suppiah R. Exposure to professional pest control treatments and the risk of childhood acute lymphoblastic leukemia. Int J Cancer 2011;129(7):1678-88. Bailey HD, de Klerk NH, Fritschi L, Attia J, Daubenton JD, Armstrong BK, Milne E; Aus-ALL Consortium Collaborators (24);, Milne E, van Bockxmeer FM, Haber M, Scott RJ, Attia J, Norris MD, Bower C, de Klerk NH, Fritschi L, Kees UR, Miller M, Thompson JR, Bailey HD, Alvaro F, Cole C, Dalla Pozza L, Daubenton J, Downie P, Lockwood L, Kirby M, Marshall G, Smibert E, Suppiah R. Refuelling of vehicles, the use of wood burners and the risk of acute lymphoblastic leukaemia in childhood. Paediatr Perinat Epidemiol 2011;25(6):528-39.

Baird D, Clarke DM. The Whole Person Model: A collaborative approach to chronic disease management. Health Issues 2011;106:21-26. Baleriola C, Rawlinson W, Dore G, Chaverot S, Stelzer-Braid S, Yoshihara M, Rizkalla B, McCaughan G, Sievert W, Crawford D, Weltman M, Cheng W, Dubois D, Thommes J, Roberts S. Effect of low level HCV viremia at week 24 on HCV treatment response in genotype 1 patients. Antiviral Therapy 2011;16(2):173-180. Bandopadhayay P, Hassall TE, Rosenfeld JV, Wheeler GC, Downie PA, Kirby ML, Cohn RJ, Sullivan MJ, Ashley DM. ANZCCSG BabyBrain99; intensified systemic chemotherapy, second look surgery and involved field radiation in young children with central nervous system malignancy. Pediatr Blood Cancer 2011;56(7):1055-61. Barker, A, Brand C, Haines T, Hill K, Brauer S, Jolly D, Botti M, Cumming R, Livingston T, Sherrington C, Zavaresk S, Morello R, Kamar J. The 6-PACK Program to decrease falls and fall injuries in acute hospitals: A protocol for a cluster randomised controlled trial. Injury Prevention 2011;17:e5. Bawden, G and McDermott F. Research and practice: Project Discovery: Social Work Research @ Southern Health, Australian Social Work, doi:10.1080/0312407X.2011.605155. Bayne S, Li H, Jones ME, Pinto AR, van Sinderen M, Drummond A, et al. Estrogen deficiency reversibly induces telomere shortening in mouse granulosa cells and ovarian aging in vivo. Protein Cell 2011;2(4):333-46. Beare RJ, Das G, Ren M, Chong W, Sinnott MD, Hilton JE, Srikanth V, Phan TG. Does the principle of minimum work apply at the carotid bifurcation: a retrospective cohort study. BMC Medical Imaging 2011;11:17. Beauchamp MH, Ditchfield M, Babl FE, et al. Detecting Traumatic Brain Lesions in Children: CT vs MRI vs SWI. Journal of Neurotrauma 2011;28:915-927.

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Southern Health and MHTP Publications

Beauchamp MH, Ditchfield M, Catroppa C, Kean M, Godfrey C, Rosenfeld JV, Anderson V. Focal thinning of the posterior corpus callosum: normal variant or post-traumatic? Brain Injury 2011;25(10),950-957. Beauchamp MH, Ditchfield MR, Maller JJ, et al. Hippocampus, amygdale and global brain changes 10 years after childhood traumatic brain injury. Int J Dev Neurosci 2011;29(2):137-43. Bell L, Stargatt R, Bosanac P, Castle D, Braitberg G, Coventry N. Child and adolescent mental health problems and substance use presentations to an emergency department. Australas Psychiatry 2011;19(6):521-5. Beltran MA, Paganin DM, Siu KK, Fouras A, Hooper SB, Reser DH, et al. Interface-specific x-ray phase retrieval tomography of complex biological organs. Phys Med Biol 2011;56(23):7353-69. Bennett PN, Gum L, Lindeman I, Lawn S, McAllister S, Richards J, Kelton M, Ward H. Faculty perspectives of inter-professional education. Nurse Education Today 2011;31:571-576. Bennett PN, Parker S, Smigiel, H. Paired peer review of university classroom teaching in a school of nursing and midwifery. Nurse Education Today Epub 10th August 2011: doi:10.1016/j.nedt.2011.07.005. Bennett PN. Satellite dialysis nursing: technology, caring and power. Journal of Advanced Nursing 2011;67(1):149-157. Bennett PN. Technological intimacy in hemodialysis nursing. Nursing Inquiry 2011;18(3):247-252. Berry CA, Nitsos I, Hillman NH, Pillow JJ, Polglase GR, Kramer BW, et al. Interleukin 1 in lipopolysaccharide induced chorioamnionitis in the fetal sheep. Reprod Sci 2011;18(11):1092-102.

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Bertucci M, Loose J, Wallace EM, Jenkin G, Miller S. Anti-inflammatory therapy in an ovine model of fetal hypoxia induced by single umbilical artery ligation. Reprod Fertil Dev 2011;23(2):346-352. Bertucci MC, Loose JM, Wallace EM, Jenkin G, Miller SL. Anti-inflammatory therapy in an ovine model of fetal hypoxia induced by single umbilical artery ligation. Reprod Fertil Dev 2011;23(2):346-52. Berzsenyi MD, Roberts SK, Preiss S, Woollard DJ, Beard MR, Skinner NA, et al. Hepatic TLR2 & TLR4 expression correlates with hepatic inflammation and TNF-alpha in HCV & HCV/HIV infection. J Viral Hepat 2011;18(12):852-60.

Bilandzic M, Stenvers KL. Betaglycan: A multifunctional accessory. Molecular and Cellular Endocrinology 2011;339:180-189. Bird AD, Flecknoe SJ, Tan KH, Olsson PF, Antony N, Mantamadiotis T, et al. cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development. PLoS One 2011;6(3):e17843. Bjornsdottir US, Holgate ST, Reddy PS, Hill AA, McKee CM, Csimma CI, et al. Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood. PLoS One 2011;6(7):e21902.

Bhattacharjee S, Yap K, Longano A, Powell A. Is fluorine 18 fluorodeoxyglucose positron emission tomography scanning a suitable diagnostic test for histologically active large vessel vasculitis? J Clin Rheumatol 2011;17(1):31-4.

Bjornsdottir US, Holgate ST, Reddy PS, Hill AA, McKee CM, Csimma CI, Weaver AA, Legault HM, Small CG, Ramsey RC, Ellis DK, Burke CM, Thompson PJ, Howarth PH, Wardlaw AJ, Bardin PG et al. Pathways activated during asthma exacerbation as revealed by gene expression patterns in blood. PLoS One 2011;6(7):e21902.

Biadasiewicz K, Sonderegger S, Haslinger P, Haider S, Saleh L, Fiala C, Pollheimer J, Knofler M. Transcription factor AP-2 alpha promotes EGF-dependent invasion of human trophoblast. Endocrinology 2011;152:1458-1469.

Black A, Roodveldt R, Brauer S, Economedis A, Haines T. Insights into the climate of safety among hospital staff towards the prevention of falls. Journal of Clinical Nursing 2011;20:2924-30.

Biggs SN, Bourke R, Anderson V, Jackman AR, Killedar A, Nixon GM, et al. Working memory in children with sleep-disordered breathing: Objective versus subjective measures. Sleep Med 2011;12(9):887-91.

Blacklow B, Kornhauser R, Hains PG, Loiacono R, Escoubas P, Graudins A. α-Elapitoxin-Aa2a, a long-chain snake α-neurotoxin with potent actions on muscle (α1)(2)βγδ nicotinic receptors, lacks the classical high affinity for neuronal α7 nicotinic receptors. Biochemical pharmacology 2011;81(2):314-325.

Biggs SN, Bourke RS, Anderson V, Jackman A, Killedar A, Nixon GM, Davey MJ, Walker AM, Trinder J, Horne RSC. Working memory in children with sleep disordered breathing: objective versus subjective measures. Sleep Medicine 2011;12(9):887-91. Biggs SN, Lushington K, van den Heuvel CJ, Martin AJ, Kennedy JD. Inconsistent sleep schedules and daytime behavioral difficulties in school-aged children. Sleep Med 2011;12(8):780-6.

Blombery P, Prince HM, Levinson M, Pianko S, Maxwell E, Bhathal P. Rituximab-induced immunodysregulatory ileocolitis in a patient with follicular lymphoma. J Clin Oncol 2011 Feb 10;29(5):e110-2.

Southern Health and MHTP Publications

Blombery PA, Wong SQ, Hewitt CA, Dobrovic A, Maxwell EL, Juneja S, Grigoriadis G, David Westerman D. (2011). Detection of BRAF mutations in patients with hairy cell leukemia and related lymphoproliferative disorders. Haematologica 2011 Dec 1. [Epub ahead of print] PMID: 22133769. Bobbitt L, Merriman E, Raynes J, Henderson R, Blacklock H, Chunilal S. PROTHROMBINEX(®)-VF (PTX-VF) usage for reversal of coagulopathy: prospective evaluation of thrombogenic risk.Thromb Res 2011;128(6):577-82. Boon WC, Horne MK. Aromatase and its inhibition in behaviour, obsessive compulsive disorder and Parkinsonism. Steroids 2011;76:816-819. Borden EC, Williams BR. Interferonstimulated genes and their protein products: what and how? J Interferon Cytokine Res 2011;31(1):1-4. Bose B, McDonald SP, Hawley CM, Brown FG, Badve SV, Wiggins KJ, Bannister KM, Boudville N, Clayton P, Johnson DW. Effect of dialysis modality on survival of Hepatitis C – infected ESRF patients. Clin J Am Soc Nephrol 2011;6(11):2657-61. Bourke R, Anderson V, Yang JS, Jackman AR, Killedar A, Nixon GM, et al. Cognitive and academic functions are impaired in children with all severities of sleep-disordered breathing. Sleep Med 2011;12(5):489-96. Bourke RS, Anderson V, Yang JS, Jackman AR, Killedar A, Nixon GM, et al. Neurobehavioral function is impaired in children with all severities of sleep disordered breathing. Sleep Med 2011;12(3):222-9. Bourke RS, Anderson V, Yang JSC, Jackman AR, Killedar A, Nixon GM, Davey MJ, Walker AM, Trinder J, Horne RSC. Cognitive and academic functions are impaired in children with all severities of sleep-disordered breathing. Sleep Medicine 2011;12(5):489-496.

Bourke RS, Anderson V, Yang JSC, Jackman AR, Killedar A, Nixon GM, Davey MJ, Walker AM, Trinder J, Horne RSC. Neurobehavioral function is impaired in children with all severities of sleep disordered breathing. Sleep Med 2011;12(3):222-9. Boyle J, Santamaria L. Two case studies: eccentric fixation and amblyopia – a challenge to the treating clinician. Aust Orthopt J 2011;43(1):24-28. Bozinovski S, Vlahos R, Zhang Y, Lah LC, Seow HJ, Mansell A, et al. Carbonylation caused by cigarette smoke extract is associated with defective macrophage immunity. Am J Respir Cell Mol Biol 2011;45(2):229-36. Bradbury LA, Barlow S, Geoghegan F, Hannon RA, Stuckey SL, Wass JA, Russell RG, Brown MA, Duncan EL. Risedronate in adults with osteogenesis imperfect type I: increased bone mineral density and decreased bone turnover, but high fracture rate persists. Osteoporos Int 2011 Jul 8 [Epub ahead of print]. Bradshaw W, Ockerby C, Bennett P. Pre-emptively pausing ultrafiltration to minimise dialysis hypotension. Renal Society Australia Journal 2011;7(3):101-106. Braitberg G.Toxicology Handbook. Ed 2. J Pharm Pract Res 2011;41:164-165. Braun T, Li S, Moss TJ, Connor KL, Doherty DA, Nitsos I, et al. Differential appearance of placentomes and expression of prostaglandin H synthase type 2 in placentome subtypes after betamethasone treatment of sheep late in gestation. Placenta 2011;32(4):295-303. Bray J, O’Connell B, Gilligan A, Livingston P, Bladin C. Author response to social marketing and the FAST Campaign. International Journal of Stroke 2011;6:371. Brew N, Hooper SB, Allison BJ, Wallace MJ, Harding R. Injury and repair in the very immature lung following brief mechanical ventilation. Am J Physiol Lung Cell Mol Physiol 2011;301(6):917-26.

Bridgewater D, Di Giovanni V, Cain JE, Cox B, Jakobson M, Sainio K, et al. beta-catenin causes renal dysplasia via upregulation of Tgfbeta2 and Dkk1. J Am Soc Nephrol 2011;22(4):718-31. Brown KA, McInnes KJ, Takagi K, Ono K, Hunger NI, Wang L, Sasano H, Simpson ER. LKB1 expression is inhibited by estradiol-17beta in MCF-7 cells. The Journal of Steroid Biochemistry and Molecular Biology 2011;127:439-443. Browne W, Siu LW, Monagle J. The impact of anaesthetic trainees on elective caesarian section procedure time: A prospective observational study. Anaesthesia and Intensive Care 2011;39:936-940. Bull A, Wilson J, Worth LJ, Stuart RL, Gillespie E, Waxman B, Shearer W, Richards M. A bundle of care to reduce colorectal surgical infections: an Australian experience. J Hosp Infect 2011;78(4):297-301. Bull A, Wilson J, Worth LJ, Stuart RL, Gillespie EE, Waxman B, Shearer W, Richards M. Uptake of a bundle of care to reduce colorectal surgical site infection infections: an Australian experience. JHI 2011;79:297-301. Burger HG, Hale GE, Dennerstein L, Robertson, DM.The unpredictable endocrinology of the menopausal transition. In: Menopause: State of the Art. CIC Edizioni Internazionali 2011; Roma 30-33. Burger HG,Teede HJ. Endocrinology of the menopause and hormone replacement therapy. In Oxford University Press: Wass Jah & Stewart Pn Eds. Oxford Texbook of Endocrinology & Diabetes (2nd Edition) 2011;492-1503. Burger HG. Unpredictable endocrinology of the menopause transition: clinical, diagnostic and management implications. Menopause International 2011;17(4):153-4.

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Burke M, Hawley CM, Badve SV, McDonald SP, Brown FG, Boudville N, Wiggins KJ, Bannister KM, Johnson DW. Relapsing and recurrent peritoneal-dialysis associated peritonitis : a multicenter registry study. Am J Kidney Dis 2011;58(3);429-36. Epub 2011 May 20.

Cannata DJ, Crossley KJ, Barclay CJ, Walker DW, West JM. Contribution of stretch to the change of activation properties of muscle fibers in the diaphragm at the transition from fetal to neonatal life. Front Physiol 2011;2(109):1-13.

Burns CJ, Wilks AF. c-FMS inhibitors: a patent review. Expert Opin Ther Pat 2011;21(2):147-65.

Carter GP, Douce GR, Govind R, Howarth PM, Mackin KE, Spencer J, Buckley AM, Antunes A, Kotsanas D, Jenkin GA, Dupuy B, Rood JI, Lyras D. The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile. PLoS Pathog 2011;7(10):e1002317.

Busija L, Pausenberger E, Haines TP, Haymes S, Buchbinder R, Osborne RH. Adult measures of general health and health-related quality of life: Medical Outcomes Study Short Form 36-Item (SF-36) and Short Form 12-Item (SF-12) Health Surveys, Nottingham Health Profile (NHP), Sickness Impact Profile (SIP), Medical Outcomes Study Short Form 6D (SF-6D), Health Utilities Index Mark 3 (HUI3), Quality of Well-Being Scale (QWB), and Assessment of Quality of Life (AQOL). Arthritis Care & Research 2011;63(S11):S383-S412. Cain JE, Islam E, Haxho F, Blake J, Rosenblum ND. GLI3 repressor controls functional development of the mouse ureter. J Clin Invest 2011;121(3):1199-206.

Castanelli D, Kitto S. Perceptions, attitudes, and beliefs of staff anaesthetists related to multi-source feedback used for their performance appraisal. British Journal of Anaesthesia 2011;107:372-7. Cate K, Noonan C, Monagle J. Preparedness for internship: a survey of new interns in a large Victorian Health Service. Australian Health Review 2011;35:146-151.

Chan W, Clark DJ, Ajani AE, Yap C-H, Andrianopoulos N, Brennan AL, Dinh D, Shardey GC, Smith JA, Reid CM, Duffy SJ. Progress towards a national cardiac procedure database – development of the Australasian Society of Cardiac and Thoracic Surgeons (ASCTS) and Melbourne Interventional Group (MIG) registries. Heart Lung Circulation 2011;20:10-18. Chand A, Legge M. Stereological assessment of developing mouse ovarian follicles in an in vitro culture system. Anatomical Record 2011;294:379-383. Chand AL, Herridge KA, Howard TL, Simpson ER, Clyne CD. Tissue-specific regulation of aromatase promoter II by the orphan nuclear receptor LRH-1 in breast adipose stromal fibroblasts. Steroids 2011;76:741-744. Chand AL, Legge M. Amino acid transport system L activity in developing mouse ovarian follicles. Human Reproduction 2011;26:3102-3108.

Cain JE, Rosenblum ND. Control of mammalian kidney development by the Hedgehog signaling pathway. Pediatr Nephrol 2011;26(9):1365-71.

Cathart P, Murphy DG, Moon D, Castello AJ, Frydenberg M. Perioperative functional and oncological outcomes from open and minimally invasive prostate cancer surgery: experience form Australasia. British Journal of Urology International 2011:105:18.

Chavez C, Gogos A, Hill R, Van Sinderen M, Simpson E, Boon WC, van den Buuse M. Differential effect of amphetamine on c-fos expression in female aromatase knockout (ArKO) mice compared to wildtype controls. Psychoneuroendocrinology 2011;36:761-768.

Cameron JD. Assessment of central blood pressure waveforms let the buyer beware: Different approaches result in different results Hypertension Research 2011;34;994-995.

Cave G, Harvey M, Graudins A. Intravenous lipid emulsion as antidote: a summary of published human experience. Emerg Med Australas 2011;23(2):123-141.

Chean R, Stefanski DA, Woolley IJ, Francis MJ, Korman TM. Rat Bite Fever as the presenting illness in a patient with AIDS. Infection 2011 Aug 30. [Epub ahead of print].

Cameron JD. Office and ambulatory blood pressure and pulse wave velocity. Journal of Hypertension 2011;29;5;832-833.

Chakravarty T, Buch MH, Naik H, White AJ, Doctor N, Schapira J, Mirocha JM, Fontana, G, Forrester JS, Makkar R. Predictive accuracy of SYNTAX score for predicting long-term outcomes of unprotected left main coronary artery revascularization American Journal of Cardiology 2011;107(3):360-366.

Chen Y, Phillips DJ, McMillan J, Bedford P, Goldstein J, Wu H, et al. Pattern of activin A and follistatin release in a sheep model of cardiopulmonary bypass. Cytokine 2011;54(2):154-60.

Cameron PU, Jones P, Gorniak M, Dunster K, Paul E, Lewin S, Woolley I, Spelman D. Splenectomy Associated Changes in IgM Memory B Cells in an Adult Spleen Registry Cohort. PLoS One 2011;6(8):e23164.

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Chen Y, Phillips DJ, McMillan J, Bedford P, Goldstein J, Wu H, Hedger MP, Smith JA. Pattern of activin A and follistatin release in a sheep model of cardiopulmonary bypass. Cytokine 2011;54:154-160.

Southern Health and MHTP Publications

Chen Y, Wu H, Winnall WR, Loveland KL, Makanji Y, Phillips DJ, et al. Tumour necrosis factor-alpha stimulates human neutrophils to release preformed activin A. Immunol Cell Biol 2011;89(8):889-96. Chen Y, Wu H, Winnall WR, Loveland KL, Makanji Y, Phillips DJ, Smith JA, Hedger MP. Tumour necrosis factoralpha stimulates human neutrophils to release preformed activin A. Immunol Cell Biol 2011;89:889-96. Chen Y, Wu H, Winnall WR, Loveland KL, Makanji Y, Phillips DJ, Smith JA, Hedger MP. Tumour necrosis factoralpha stimulates human neutrophils to release preformed activin A. Immunology and Cell Biology 2011;89:889-896. Cheng AC, Ferguson JK, Richards MJ, Robson JM, Gilbert GL, McGregor A, Roberts S, Korman TM, Riley TV. Australasian Society for Infectious Diseases guidelines for the diagnosis and treatment of Clostridium difficile infection. Med J Aust 2011;194(7):353-8. Cheng AC, Kotsimbos T, Kelly HA, Irving LB, Bowler SD, Brown SG, Holmes M, Jenkins CR, Thompson P, Simpson G, Wood-Baker R, Senanayake SN, Brady SJ, Paterson DL, Wark PA, Upham JW, Korman TM, Dwyer DE, Waterer GW, Kelly PM. Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study. Vaccine 2011;29(43):7320-5. Cheng I-H, Russell GM, Bailes M, Block A. An evaluation of the primary healthcare needs of refugees in south east metropolitan Melbourne: A report by the Southern Academic Primary Care Research Unit to the Refugee Health Research Consortium. Southern Academic Primary Care Research Unit 2011. Cho Y, Badve SV, Hawley CM, McDonald SP, Brown FG, Boudville N, Wiggins KJ, Bannister KM, Clayton PA, Johnson DW. Seasonal variation in peritoneal dialysis-associated peritonitis: a multi-centre registry study. NDT 2011 Oct 6 Epub.

Choi JY, Zhou J, Giles M, Broom J, Templeton DJ, Law MG, Chaiwarith R, Tanuma J; Asia-Pacific HIV Observational Database. Predictors and outcomes of HIV-infected antiretroviral-naive patients with discordant responses to combination antiretroviral treatment in Asian and Australian populations: results from APHOD. J Acquir Immune Defic Syndr 2011;57(1):e13-5. Chong W, Patel H, Holt M. Developmental Venous Anomalies (DVA): What are they really? NJR Digital – The Neuroradiology Journal 2011;1:155-166. Chow JD, Jones ME, Prelle K, Simpson ER, Boon WC. A selective estrogen receptor alpha agonist ameliorates hepatic steatosis in the male aromatase knockout mouse. The Journal of Endocrinology 2011;210:323-334. Chua KYL, Seemann T, Harrison PF, Monagle S, Korman TM, Johnson PD, Coombs GW, Howden BO, Davies JK, Howden BP, Stinear TP. The Dominant Australian Community-Acquired Methicillin-Resistant Staphylococcus aureus Clone ST93-IV [2B] Is Highly Virulent and Genetically Distinct. PLoS One 2011;6(10):e25887. Ciayadi R, Potdar M, Walton KL, Harrison CA, Kelso GF, Harris SJ, Hearn MT. 2-Phenyl and 2-heterocyclic-4-(3(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-beta1 and activin A signalling. Bioorganic & Medicinal Chemistry Letters 2011;21:5642-5645. Coleman RE, Marshall H, Cameron D, Dodwell D, Burkinshaw R, Keane M, Gil M, Houston SJ, Grieve RJ, Barrett-Lee PJ, Ritchie D, Pugh J, Gaunt C, Rea U, Peterson J, Davies C, Hiley V, Gregory W, Bell R; AZURE Investigators. Breast – cancer adjuvant therapy with zoledronic acid. N Engl J Med 2011;13;365(15):1396-405. Collins VR, McLachlan RI, Holden CA. Tackling inequities in men’s health: a reflective lens on the National Male Health Policy. Med J Aust 2011;194(2):62-4.

Collins VR, McLachlan RI, Holden CA. Tackling the inequities in men’s health: a reflective lens on the National Male Health Policy. Medical Journal of Australia 2011:194(2):62-64. Coombs PR, Gilbertson T, Teoh M. Prenatal sonographic diagnosis of a congenital oral fibrovascular hamartoma. Ultrasound Obstst Gyneco 2011;37(6):736-8. Corben LA, Akhlaghi H, GeorgiouKaristianis N, Bradshaw JL, Egan GF, Storey E, Churchyard AJ, Delatycki MB. Impaired inhibition of prepotent motor tendencies in Friedreich ataxia demonstrated by the Simon interference task. Brain and Cognition 2011;76(1)140-145. Corben LA, Delatycki MB, Bradshaw JL, Churchyard AJ, Georgiou-Karistianis,  N. Utilization of Advance Motor Information is impaired in Friedreich ataxia. Cerebellum 2011;10(4):793-803. Corben LA, Georgiou-Karistianis N, Bradshaw JL, Hocking DR, Churchyard AJ, Delatycki MB. The Fitts task reveals impairments in planning and online control of movement in Friedreich ataxia: reduced cerebellar-cortico connectivity? Neuroscience 2011;192:382-90. Coso S, Zeng Y, Sooraj D, Williams ED. Conserved signalling through vascular endothelial growth (VEGF) receptor family members in murine lymphatic endothelial cells. Exp Cell Res 2011;317(17):2397-407. Coveney N, Polkinghorne KR, Linehan L, Corradini AM, Kerr PG. Water soluble vitamin levels in extended hours hemodialysis. Hemodialysis Int 2011;15(1):30-38. Crossett MP, Schneider-Kolsky M, Troupis J. Normal perfusion of the left ventricular myocardium using 320 MDCT. Journal of Cardiovascular Computed Tomography 2011;5,406-411. Crozier T, Wallace EM, Wright C. Seventeen months of obstetric intensive care admissions to a general ICU in a quaternary obstetrics hospital. ANZJOG 2011;51(3):233-238.

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Crozier TM, Wallace EM, Obstetric admissions to an integrated general intensive care unit in a quaternary maternity facility, Australian and New Zealand Journal of Obstetric and Gynacology 2011 doi:10.1111/j. 1479-828X.2011.01303.x. Crozier TM, Wallace EM. Obstetric admissions to an integrated general intensive care unit in a quaternary maternity facility. Aust N Z J Obstet Gynaecol 2011;51(3):233-8. Cuffe JS, Dickinson H, Simmons DG, Moritz KM. Sex specific changes in placental growth and MAPK following short term maternal dexamethasone exposure in the mouse. Placenta 2011;32(12):981-9. Cvejic L, Harding R, Churchward T, Turton A, Finlay P, Massey D, Bardin PG, Guy P. Laryngeal penetration and aspiration in individuals with stable COPD. Respirology 2011;16:269-75. Cvejic L, Harding R, Churchward T, Turton A, Finlay P, Massey D, et al. Laryngeal penetration and aspiration in individuals with stable COPD. Respirology 2011;16(2):269-75. Cvrljevic AN, Akhavan D, Wu M, Martinello P, Furnari FB, Johnston AJ, et al. Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism. J Cell Sci 2011;124(Pt 17):2938-50. Czernichow S, Kengne AP, Huxley RR, Batty GD, de Galan B, Grobbee D, Pillai A, Zoungas S, Marre M, Woodward M, Neal B, Chalmers J; ADVANCE Collaborative Group. Comparison of waist-to-hip ratio and other obesity indices as predictors of cardiovascular disease risk in people with type-2 diabetes: a prospective cohort study from ADVANCE. Eur J Cardiovasc Prev Rehabil 2011;18(2):312-9. Dahrouge S, Delvin R, Hogg W, Russell G, Coyle D, Ferguson D, et al. The economic impact of improvements in primary healthcare performance. Report to the Canadian Health Services Research Foundation, 2011.

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Dahrouge S, Hogg W, Tuna M, Russell G, Devlin RA, Tugwell P, et al. Age equity in different models of primary care practice in Ontario. Can Fam Physician 2011;57(11):1300-9. Dahrouge S, Hogg WE, Russell G, Tuna M, Geneau R, Muldoon LK, et al. Impact of remuneration and organizational factors on completing preventive manoeuvres in primary care practices. CMAJ 2011. Damasiewicz M, Polkinghorne KR. Intradialytic hypotension and blood-volume and blood temperature monitoring. Nephrology 2011;16(1):13-18. Damasiewicz M, Toussaint ND, Polkinghorne KR. Fibroblast growth factor 23 in chronic kidney disease: new insights and clinical implications. Nephrology 2011;16(3):261-8. Davies JM, Dang TD, Voskamp A, Drew AC, Biondo M, Phung M, et al. Functional immunoglobulin E cross-reactivity between Pas n 1 of Bahia grass pollen and other group 1 grass pollen allergens. Clin Exp Allergy 2011;41(2):281-91. Dawson JA, Schmolzer GM, Kamlin CO, Te Pas AB, O’Donnell CP, Donath SM, et al. Oxygenation with T-piece versus self-inflating bag for ventilation of extremely preterm infants at birth: a randomized controlled trial. J Pediatr 2011;158(6):912-8 e1-2. Day BW, Stringer BW, Spanevello MD, Charmsaz S, Jamieson PR, Ensbey KS, Carter JC, Cox JM, Ellis VJ, Brown CL, Walker DG, Inglis PL, Allan S, Reynolds BA, Lickliter JD, Boyd AW. ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1. Neuro-Oncology 2011. Day BW, Stringer BW, Spanevello MD, Charmsaz S, Jamieson PR, Ensbey KS, et al. ELK4 neutralization sensitizes glioblastoma to apoptosis through downregulation of the anti-apoptotic protein Mcl-1. Neuro Oncol 2011;13(11):1202-12.

Day L, Finch C, Hill K, Haines T, Clemson L, Thomas M, Thompson C. A protocol for evidence-based targeting and evaluation of statewide strategies for preventing falls among communitydwelling older people in Victoria, Australia. Injury Prevention 2011;17(2):1-8. De Sousa A, Manohar P, Frydenberg M, McCahy P. “Detection of prostate cancer in the rural Australia; are we keeping up?” BJU Int 2011;107 1:20. Deeks A, Gibson-Helm M, Teede H, Vincent A. Premature Menopause: A Comprehensive Understanding of Psychosocial Aspects. Climacteric 2011;14:565-572. Deeks AA, Gibson-Helm M, Teede H, Vincent A. Premature menopause: a comprehensive understanding of psychosocial aspects. Climateric 2011;14(5):565-572. Deeks AA, Gibson-Helm ME, Paul E, Teede HJ. Is having polycystic ovary syndrome a predictor of poor psychological function including anxiety and depression? Hum Reprod 2011 Mar 23. DeLeyn P, Muller MR, Oosterhuis JW, Schmid T, Choong CK, Weder W, Sokolow Y. Prospective European multicenter randomized trial of PleuraSeal for control of air leaks after elective pulmonary resection. J Thorac Cardiovasc Surg 2011;141(4):881-7. Dev A, Nguyen JH, Munafo L, Hardie E, Iacono L Chronic hepatitis B – a clinical audit of GP management. Aust Fam Physician 2011;40(7):533-8. Diao M, Li L, Cheng W. Congenital biliary dilatation may consist of 2 disease entities. J Pediatr Surg 2011;46(8):1503-9. Diao M, Li L, Cheng W. Is it necessary to ligate distal common bile duct stumps after excising choledochal cysts. Peditr Surg Int 2011;27:829-832.

Southern Health and MHTP Publications

Diao M, Li L, Cheng W. Laparoscopic versus Open Roux-en-Y hepatojejunostomy for children with choledochal cysts: intermediateterm follow-up results. Surg Endosc 2011;25(5):1567-1573.

Downie S, Corben LA, Fielding L. Development and trial of an Upper Limb Assessment Tool for the acute neurological patient. British Journal of Occupational Therapy 2011;74(2):95-105(11).

Evans J, Kaitu’u-Lino T, Salamonsen LA. Extracellular matrix dynamics in scar-free endometrial repair: perspectives from mouse in vivo and human in vitro studies. Biology of Reproduction 2011;85:511-523.

Diao M, Li L, Dong N, Li Q, Cheng W. Single-incision laparoscopic Rouxen-Y hepaticojejunostomy using conventional instruments for children with choledochal cysts. Surg Endosc 2011; Dec 30.

Drew AC, Davies JM, Dang TD, Rolland JM, O’Hehir RE. Purification of the major group 1 allergen from Bahia grass pollen, Pas n 1. Int Arch Allergy Immunol 2011;154(4):295-8.

Evans-Galea MV, Corben LA, Hasell J, Galea CA, Fahey MC, du Sart D & Delatycki MB. A novel deletion-insertion mutation identified in exon 3 of FXN in two siblings with a severe Friedreich ataxia phenotype. Neurogenetics 2011;12(4):307-313.

Dienstmann R, Rodon J, Markman B, Tabernero J. Recent developments in anti-cancer agents targeting PI3K, Akt and mTORC1/2. Recent Pat Anticancer Drug Discov 2011;6(2):210-36. Diletti R, Onuma Y, Farooq V, GomezLara J, Brugaletta S, Van Geuns RJ, Regar E, De Bruyne B, Dudek D, Thuesen L, Chevalier B, McClean D, Windecker S, Whitbourn R, Smits P, Koolen J, Meredith I, Li D, Veldhof S, Rapoza R, Garcia-Garcia HM, Ormiston JA, Serruys PW. 6-month clinical outcomes following implantation of the bioresorbable everolimus-eluting vascular scaffold in vessels smaller or larger than 2.5 mm Journal of the American College of Cardiology 2011;58(3):258-264. Dimitriadis E, Menkhorst E. New generation contraceptives: interleukin 11 family cytokines as non-steroidal contraceptive targets. Journal of Reproductive Immunology 2011;88:233-239. Donnellan F, Swan MP, May GR, Kandel G, Marcon NE, Kortan PP Fluticasone propionate for treatment of esophageal lichen planus. A case series. Dis Esophagus 2011;24(4):211-4. Donnellan F, Swan MP, May GR, Kortan PP. Biliary papillomatosis diagnosed with mother-daughter narrow-band imaging (NBI) cholangioscopy Endoscopy 2011;43 Suppl 2 UCTN:E86-7. Epub 2011 Mar 18. Donoghue JF, Bogler O, Johns TG. A simple guide screw method for intracranial xenograft studies in mice. J Vis Exp 2011;55(e3157):1-5.

Drummond AE, Fuller PJ. Activin and inhibin, estrogens and NFκB play roles in ovarian tumorigenesis. Is there crosstalk? Molecular and Cellular Endocrinology August 4 2011 Epub. Duprez DA, Neuhaus J, Tracy R, Kuller LH, Deeks SG, Orkin C, Stoehr A, Woolley IJ, Neaton JD; for the INSIGHT SMART Group. N-terminal-proB-type natriuretic peptide predicts cardiovascular disease events in HIV-infected patients. AIDS 2011;25(5):651-7. Eastwood GM, O’Connell B, Considine J. Low-flow oxygen therapy in intensive care: an observational study. Australian Critical Care 2011;24(4):269-278. Edwards J, Cocks J, Burnett P, Maud D, Wong L, Yuen HP, Harrigan SM, Hermann-Doig T, Murphy BP, Wade D, McGorry PD Randomized Controlled Trial of Clozapine and CBT for FirstEpisode Psychosis with Enduring Positive Symptoms: A Pilot Study. Schizophrenia Research and Treatment (2011) doi:10.1155/2011/394896. Egerton T, Danoudis M, Iansek R. Central gait control mechanisms and the stride length – cadence relationship. Gait and Posture 2011;34(2):178-182. Egi M, Bellomo R,Stachowski E, French CJ, Taori G, Hegarty C, Bailey M. The Interaction of Chronic and Acute Glycaemia with Mortality in Critically ill Patients with Diabetes. Crit Care Med 2011;39(1)105. Endt H, Sprung CN, Keller U, Gaipl U, Fietkau R, Distel LV. Detailed analysis of DNA repair and senescence marker kinetics over the life span of a human fibroblast cell line. J Gerontol A Biol Sci Med Sci 2011;66(4):367-75.

Fahey MC, Wallace EM. Stem cells: Research tools and clinical treatments. J Paediatr Child Health 2011;47(9):672-5. Fahey MC, Wallace EM. Stem cells: research tools and clinical treatments. Journal of Paediatrics and Child Health 2011;47(9):672-5. Fang JW, Li JC, Au KY, Yim HC, Lau AS. Interleukin-17A differentially modulates BCG induction of cytokine production in human blood macrophages. J Leukoc Biol 2011;90(2):333-41. Feldman S, Radermacher H, Lorains F, Haines T. A research-based community-theatre performance to promote ageing well: Is it more than just a show? Educational Gerontology 2011;37(10):885-898. Ferguson JK, Cheng AC, Gilbert GL, Gottlieb T, Korman T, McGregor A, Richards M, Roberts S, Robson J, Van Gessel H, Riley TV. Clostridium difficile laboratory testing in Australia and New Zealand: national survey results and Australasian Society for Infectious Diseases recommendations for best practice. Pathology 2011;43(5):482-7. Ferrand J, Lehours P, Schmid-Alliana A, Megraud F, Varon C. Helicobacter pylori infection of gastrointestinal epithelial cells in vitro induces mesenchymal stem cell migration through an NF-kappaB-dependent pathway. PLoS One 2011;6(12):e29007.

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Ferrand J, Noel D, Lehours P, ProchazkovaCarlotti M, Chambonnier L, Menard A, et al. Human bone marrow-derived stem cells acquire epithelial characteristics through fusion with gastrointestinal epithelial cells. PLoS One 2011;6(5):e19569. Ficheux A, Kerr PG, Brunet P, Argilés A. The ultrafiltration coefficient of a dialyser (KUF) is not a fixed value, and it follows a parabolic function: the new concept of KUF max. Nephrol Dial Transplant 2011;26(2):636-40. Fisher J, Tran T, Biggs B, Tran T, Dwyer T, Casey G, Tho DH, Hetzel B. Iodine status in late pregnancy and psychosocial determinants of iodized salt use in rural northern Vietnam. Bull World Health Organ 2011;89(11):813-20. Fisher JR, Cabral de Mello M. Using the World Health Organization’s 4S-Framework to Strengthen National Strategies, Policies and Services to Address Mental Health Problems in Adolescents in Resource-Constrained Settings. Int J Ment Health Syst 2011;5(1):23. Fleischer R, Vollenhoven BJ, Weston GC. The effects of chemotherapy and radiotherapy on fertility in premenopausal women. Obstetrical and Gynaecological Survey 2011;66:248-25. Fleiss B, Coleman HA, Castillo-Melendez M, Ireland Z, Walker DW, Parkington HC. Effects of birth asphyxia on neonatal hippocampal structure and function in the spiny mouse. Int J Dev Neurosci 2011;29(7):757-66. Folker JE, Murdoch BE, Cahill LM, Rosen KM, Delatycki MB, Corben LA, Vogel AP. Articulatory kinematics in the dysarthria associated with Friedreich’s ataxia. Motor Control 2011;15(3):376-389.

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Folker JE, Murdoch BE, Rosen KM, Cahill LM, Delatycki MB, Corben LA, Vogel AP. Kinematic analysis of lingual movements during consonant productions in dysarthric speakers with Friedreich’s ataxia: A case by case analysis. Clinical Linguistics & Phonetics 2011;25(1):66-79.

Frydenberg, M. Equity in cancer screening and management. British Journal of Urology International 2011;107:33.

Fossey E, Harvey C, Mokhtari MR, Meadows GN. Self-Rated Assessment of Needs for Mental Health Care: A Qualitative Analysis. Community Mental Health Journal, 2011.

Fuller PJ, Yao YZ, Komesaroff PA, Smith BJ, Zennaro MC. Pseudohypoaldosteronism type 1: the index case revisited. Clinical Endocrinology 2011;74:408-410.

Francis JV, Padmanabhan S, Jaques L, Courtot J, Sehgal A. Respiratory and cardiovascular morbidity in the first 48 hours post duct ligation surgery. J Neonatal Perinatal Med 2011;4(1):16-19.

Funder J. Diagnosis and Treatment of Primary Aldosteronism Foreword. Reviews in Endocrine & Metabolic Disorders 2011;12:1-1.

Francis MJ, Doherty RR, Patel M, Hamblin JF, Ojaimi S, Korman TM. Curtobacterium flaccumfaciens septic arthritis following puncture with a Coxspur Hawthorn thorn. J Clin Microbiol 2011;49(7):2759-60. Franklyn K, Guymer E, Littlejohn G. Targeting fibromyalgia pain: brain-spinal cord and peripheral contributions. Int J Clin Rheumatol 2011;6. Frazão JM, Messa P, Mellotte GJ, Geiger H, Hagen EC, Quarles D, Kerr PG, Baños A, Dehmel B, Urena P. Cinacalcet reduces plasma intact parathyroid hormone, serum phosphate and calcium levels in patients with secondary hyperparathyroidism irrespective of its severity. Clin Nephrol 2011;76(3):233-243. Frei MY, Clarke DM. Meeting the challenge in care of co-occurring disorders. Medical Journal of Australia 2011;195(3):S5-6. Friesen BR, Gibson RN, Speer T, Vincent JM, Stella D, Collier NA. Lobar and segmental liver atrophy associated with hilar cholangiocarcinoma and the impact of hilar biliary anatomical variants: a pictorial essay. Insights Into Imaging IO 10.1007/s13244-011-0100-9.

Frydenberg, M. A potentially curable disease: Optimising testis cancer treatment. Medicine Today, 12:33-39 (2011).

Funder J. Envoi. Reviews in Endocrine and Metabolic Disorders 2011;12:53-54. Funder J. Foreword. Reviews in Endocrine and Metabolic Disorders 2011;12:1. Funder J. Mineralocorticoid receptor antagonists for heart failure. Expert Opinion on Pharmacotherapy 2011;12:2767-2769. Funder JW. Eplerenone, amlodipine and experimental hypertension: one plus one equals three. Hypertension Research 2011;34:795-796. Funder JW. Genetic modifications of corticosteroid receptors in hypertension. Advances in Experimental Medicine and Biology 2011;707:111-113. Funder JW. GPR30, mineralocorticoid receptors, and the rapid vascular effects of aldosterone. Hypertension 2011;57:370-372. Funder JW. Medicine. The genetics of primary aldosteronism. Science 2011;331:685-686. Galinsky R, Moss TJ, Gubhaju L, Hooper SB, Black MJ, Polglase GR. Effect of intra-amniotic lipopolysaccharide on nephron number in preterm fetal sheep. Am J Physiol Renal Physiol 2011;301(2):F280-5.

Southern Health and MHTP Publications

Gansevoort RT, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, Jong PE, Coresh J; The Chronic Kidney Disease Prognosis Consortium, Gansevoort RT, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, El-Nahas M, Eckardt KU, Kasiske BL, Ninomiya T, Chalmers J, Macmahon S, Tonelli M, Hemmelgarn B, Wang Y, Atkins RC, Polkinghorne KR, Chadban SJ, Shankar A, Klein R, Klein BE, Sacks F, Curhan G, Shlipak M, Sarnak MJ, Katz R, Fried LP, Hallan S, Lydersen S, Holmen J, Lee BJ, Ishani A, Neaton J, Svendsen K, Iseki K, Mann JF, Yusuf S, Teo KK, Gao P, Nelson RG, Knowler WC, Auguste P, Veldhuis K, Camarata L, Thomas B, Manley T. Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes in both general and high-risk populations. A collaborative meta-analysis of general and high-risk population cohorts. Kidney Int 2011;80:93-104. Gantier MP, McCoy CE, Rusinova I, Saulep D, Wang D, Xu D, et al. Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res 2011;39(13):5692-703. Gantier MP, Williams BR. Making sense of viral RNA sensing. Mol Ther 2011;19(9):1578-81. Garad R, Burger H, Davison S. Clinical update, Exploring the Hormone Replacement Therapy debate. Australian Nursing Journal 2011;19:(5),30-33. Garad R, Burger H, Davison S. Clinical Update: Exploring the Hormone Replacement Therapy debate. Australian Nursing Journal 2011;19:30-33. Garad R, Teede H, Moran L. An evidencebased guideline for polycystic ovary syndrome. Aust Nurs J 2011;19(4):30-3. Gargett CE, Healy DL. Generating Receptive Endometrium in Asherman’s Syndrome. J Hum Reprod Sci 2011;4:49-52. Gargett CE, Healy DL. Generating receptive endometrium in Asherman’s syndrome. Journal of Human Reproductive Sciences 2011;4(1):49-52.

Garrett CC, Hocking J, Chen MY, Fairley CK, Kirkman M. Young people’s views on the potential use of telemedicine consultations for sexual health: results of a national survey. BMC Infect Dis 2011;11:285. George L, Senturk Raif R, Hodgkinson M, Emmerton M, Larmour I. “Impact of a Surgical Pre-admission Clinical Pharmacist on the Quality of Medication Management from Pre-admission to Discharge: a Randomised Control Study”. Journal of Pharmacy Practice and Research 2011;41(3):212-216. Ghali JR, Bannister KM, Brown FG, Rosman JB, Wiggins KJ, Johnson DW, McDonald SP. Microbiology and outcomes of peritonitis in Australian peritoneal dialysis patients. Perit Dial Int 2011;(6):651-62. Epub 2011 Jun 30. Gibbs P, Clingan PR, Ganju V, Strickland AH, Wong SS, Tebbutt NC, et al. Hyaluronan-Irinotecan improves progression-free survival in 5-fluorouracil refractory patients with metastatic colorectal cancer: a randomized phase II trial. Cancer Chemother Pharmacol 2011;67(1):153-63. Gibbs P, Clingan PR, Ganju V, Strickland AH, Wong SS, Tebbutt NC, Underhill CR, Fox RM, Clavant SP, Leung J, Pho M, Brown TJ. Hyaluronan-Irinotecan improves progression-free survival in 5-flurouracil refractory patients with metastatic colorectal cancer: a randomized phase II trial. Cancer Chemother Pharmacol 2011;67(1):153-63. Giles M, Visvanathan K, Sasadeusz J. Antiviral therapy for hepatitis B infection during pregnancy and breastfeeding. Antivir Ther 2011;16(5):621-8. Giles ML, Barak S, Baker G, Perna S, Tabrizi S, Greengrass V, Bourne H, Clarke GN, Peak SA, Hoy JF, Foster P, Knight RL, On Behalf Of The CVI Study Group. Outcomes from the first assisted reproduction program for HIV-serodiscordant couples in Australia. Med J Aust 2011;195(10):599-601.

Gillespie E. Standard for using a fluorescent marker. Am J Infect Control 2011 Sep 20 [Epub ahead of print]. Gillespie EE, Scott C, Wilson J, Stuart R. Pilot study to measure cleaning effectiveness in health care. Am J Infect Control 2011 Sep 20. [Epub ahead of print]. Gillespie EE, Scott C, Wilson J. Stuart RL. Pilot study to measure cleaning effectiveness in healthcare. AJIC online September 2011. Goh JM, Bensley JG, Kenna K, Sozo F, Bocking AD, Brien J, et al. Alcohol exposure during late gestation adversely affects myocardial development with implications for postnatal cardiac function. Am J Physiol Heart Circ Physiol 2011;300(2):H645-51. Goh Y, Lau K. A rare cause of large posterior fossa mass: Giant varix. Hong Kong Journal of Radiology 2011;14(1):39-43. Goldschlager T, Ghosh P, Zannettino A, Williamson M, Rosenfeld JV, Itescu S, et al. A comparison of mesenchymal precursor cells and amnion epithelial cells for enhancing cervical interbody fusion in an ovine model. Neurosurgery 2011;68(4):1025-34; discussion 34-5. Goldschlager T, Rosenfeld JV, Ghosh P, Itescu S, Blecher C, McLean C, et al. Cervical interbody fusion is enhanced by allogeneic mesenchymal precursor cells in an ovine model. Spine 2011;36(8):615-23. Gordon L, Joo JH, Andronikos R, Ollikainen M, Wallace EM, Umstad MP, et al. Expression discordance of monozygotic twins at birth: Effect of intrauterine environment and a possible mechanism for fetal programming. Epigenetics 2011;6(5):579-92. Gordon L, Joo JHE, Andronikos R, Ollikrainen M, Wallace EM, Umstad MP, Permezel M, Oshlack A, Morley R, Carlin JB, Saffrey R, Smyth GK, Craig JM. Expression discordance of monozygotic twins at birth: effect of intrauterine environment and a possible mechanism for fetal programming. Epigenetics 2011;6(5):579-592.

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Gordon, MS, Tonge, B.J., & Melvin. G.A. The outcome of adolescent depression: 6 months after treatment. Australian and New Zealand Journal of Psychiatry 2011;45;232-239. Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, et al. IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. J Immunol 2011;186(2):1199-208. Gregory GP, Opat S, Quach H, Shortt J, Tran H. Failure of eculizumab to correct paroxysmal cold hemoglobinuria. Ann Hematol 2011 Aug;90(8):989-90. Grigoriadis G, Chang CC, Walker P, Patil S, Avery S, Morrissey O, Spencer A. Failure of haematopoietic recovery overcome by stem cell transplant despite invasive mucormycosis infection. Bone Marrow Transplant 2011 Jun 13. doi:10.1038/bmt.2011.116. Grigoriadis G, Condon J, Green K, Anderson MA, Borosak M, Wood E. Persistent complement-dependent anti-AnWj in a lymphoproliferative disorder: a case study and review. Immunohematology 2011;23:83-87. Grigoriadis G, Vasanthakumar A, Banerjee A, Grumont R, Overall S, Gleeson P, Frances Shannon F, Gerondakis S. (2011). c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells. PLoS One 6(10):e26851. Epub 2011. Guarda G, Zenger M, Yazdi AS, Schroder K, Ferrero I, Menu P, et al. Differential expression of NLRP3 among hematopoietic cells. J Immunol 2011;186(4):2529-34. Gugasyan R, Horat E, Kinkel SA, Ross F, Grigoriadis G, Gray D, O’Keefe M, Berzins S, Belz G, Grumont R, Banerjee A, Strasser A, Godfrey D, Tsichlis P, Gerondakis S. The NF-B1 transcription factor prevents the intra-thymic development of CD8 T cells with effector/memory properties. EMBO J 31:692-706 doi:10.1038/ emboj.2011.435.

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Gunja N, Graudins A. Management of cardiac arrest following poisoning. Emerg Med Australas 2011;23(1):16-22. Gutman MJ, Goldschlager T, Fahardieh RD, Ying D, Xenos C, Danks RA. Keystone design perforator island flap for closure of myelomeningocele. Childs Nerv Syst 2011;27(9):1459-63. Haines T, Hill A, Hill K, McPhail S, Oliver D, Brauer S, Hoffmann T, Beer C. Patient education to prevent falls among older hospital inpatients: a randomized controlled trial. Archives of Internal Medicine 2011;171(6):516-524. Haines T, Hill A. Inconsistent results in meta-analyses for the prevention of falls are found between study-level data and patient-level data. Journal of Clinical Epidemiology 2011;64(2):154-162. Haines T, Kuys S, Morrison G, Clarke J, Bew P. Dose-response relationship between physiotherapy resource provision with function and balance improvements in patients following stroke: A multi-centre observational study. Journal of Evaluation in Clinical Practice 2011;17(1):136-142. Haines T, McPhail S. Patient preference for falls prevention in hospitals revealed through willingness-to-pay, contingent valuation survey. Journal of Evaluation in Clinical Practice 2011;17(2):304-310. Haines T, McPhail S. Threat appraisal for harm from falls: Insights for development of education-based intervention. Open Longevity Science 2011;5:9-15. Haines T, Waldron N. Translation of falls prevention knowledge into action in hospitals: What should be translated and how should it be done? Journal of Safety Research 2011;42(6):431-442. Han Y, Ma FY, Tesch GH, Manthey CL, Nikolic-Paterson DJ: c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat. Lab Invest 2011;91:978-991.

Hannan NJ, Evans J, Salamonsen LA. Alternate roles for immune regulators: establishing endometrial receptivity for implantation. Expert Review of Clinical Immunology 2011;7:789-802. Hannan NJ, Paiva P, Meehan KL, Rombauts LJ, Gardner DK, Salamonsen LA. Analysis of fertilityrelated soluble mediators in human uterine fluid identifies VEGF as a key regulator of embryo implantation. Endocrinology 2011;152:4948-4956. Hannigan GE, McDonald PC, Walsh MP, Dedhar S. Integrin-linked kinase: Not so ‘pseudo’ after all. Oncogene 2011;30(43):4375-85. Haque A, Best SE, Ammerdorffer A, Desbarrieres L, de Oca MM, Amante FH, et al. Type I interferons suppress CD4 T-cell-dependent parasite control during blood-stage Plasmodium infection. Eur J Immunol 2011;41(9):2688-98. Harley G, Yeo AL, Stuart RL, Dendal C. A real-life snapshot of the use and abuse of urinary catheters on medical wards. ICHE 2011;32(12). Harley G, Yeo AL, Stuart RL, Dendle C. A real-life snapshot of the use and abuse of urinary catheters on general medical wards. Infect Control Hosp Epidemiol 2011;32(12):1216-8. Harman AN, Lai J, Turville S, Samarajiwa S, Gray L, Marsden V, et al. HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production. Blood 2011;118(2):298-308. Harper RW, Ko BS. A new algorithm for the management of stable coronary artery disease incorporating CT coronary angiography and fractional flow reserve: How we can improve outcomes and reduce costs Medical Journal of Australia 2011;194(4):186-189. Harper RW, Ko BS. Re: A new algorithm for the management of stable coronary artery disease incorporating CT coronary angiography and fractional flow reserve: How we can improve outcomes and reduce costs. Medical Journal of Australia 2011;194(12):669.

Southern Health and MHTP Publications

Harrison CA, Al-Musawi SL, Walton KL. Prodomains regulate the synthesis, extracellular localisation and activity of TGF-beta superfamily ligands. Growth Factors 2011;29:174-186.

Hedger MP. Toll-like receptors and signalling in spermatogenesis and testicular responses to inflammation-a perspective. J Reprod Immunol 2011;88(2):130-41.

Herlihy AS, Halliday JL, Cock ML, McLachlan RI. The prevalence and diagnosis rates of Klinefelter syndrome: an Australian comparison. Medical Journal of Australia 2011;194:24-28.

Harrison CL, Lombard CB, Moran LJ, Teede HJ. Exercise therapy in polycystic ovary syndrome: a systematic review. Hum Reprod Update 2011;17(2):171-83.

Heng S, Cervero A, Simon C, Stephens AN, Li Y, Zhang J, Paule S, Rainczuk A, Singh H, Quinonero A, Tapia A, Velasquez L, Salamonsen L, Rombauts LJ, Nie G. Proprotein convertase 5/6 is critical for embryo implantation in women: regulating receptivity by cleaving EBP50, modulating ezrin binding, and membrane-cytoskeletal interactions. Endocrinology 2011;152:5041-5052.

Herlihy AS, Halliday JL, Gillam LH. Ethical issues in recruiting prenatally diagnosed adults for research: Klinefelter syndrome as an example. Public Health Genomics 2011;15(1):31-3.

Harrison CL, Thompson RG, Teede H. Lombard CB. Measuring physical activity during pregnancy. Int J Behav Nutr Phys Act 2011;21;8:19. Harrison S, Quach H, Link E et al. A high rate of durable responses with romidepsin, bortezomib, and dexamethasone in relapsed or refractory multiple myeloma Blood 2011;118:6274-6283. Harrison S, Quach H, Link E, Schwarer A, Bake B, Spencer A,Catalano J, Campell P,Auguston B, Prince M. Bortezomib Dexamethasone From Cycle 1 as Treatment and Maintenance for Multiple Myeoma Relapse (the BoMER Trial) significantly Improves Respose and Time to Trogression: A Matched analysis of BOMER vs. APEX. Haematologica 2011;96(s1):100. Harrison S, Quach H. Immune Function in Multiple Myeloma: Plenty Left To Work With. Haematologica 2011;96(s1)99. Hawkins MT, Letcher P, Sanson AV, O’Connor M, Toumbourou JW, Olsson CA. . Stability and change in positive development during the transition to adulthood. Journal of Youth and Adolescence 2011;40(11):1436-1452. Hedger MP, Winnall WR, Phillips DJ, de Kretser DM. The regulation and functions of activin and follistatin in inflammation and immunity. Vitam Horm 2011;85:255-97. Hedger MP. Immunophysiology and pathology of inflammation in the testis and epididymis. J Androl 2011;32(6):625-40.

Heng S, Hannan NJ, Rombauts LJ, Salamonsen LA, Nie G. PC6 levels in uterine lavage are closely associated with uterine receptivity and significantly lower in a subgroup of women with unexplained infertility. Human Reproduction 2011;26:840-846. Herlihy AS, Gillam L, Halliday JL, McLachlan RI. Postnatal screening for Klinefelter syndrome: is there a rationale? Acta Paediatr 2011;100(6):923-33. Herlihy AS, Gillam L, Halliday JL, McLachlan RI. Postnatal screening for Klinefelter syndrome: Is there a rationale? Acta Paediatr 2011;100(6):923-933. Herlihy AS, Gillam L. Thinking outside the square: considering gender in Klinefelter syndrome and 47, XXY. Int J Androl 2011;34(5 Pt 2):e348-9. Herlihy AS, Gillam L. Thinking outside the square: considering gender in Klinefelter syndrome and 47, XXY. International Journal of Andrology 2011;34:E348-E349. Herlihy AS, Halliday JL, Cock M, McLachlan RI. The prevalence and diagnosis rates of Klinefelter syndrome: an Australian comparison. Medical Journal of Australia 2011;194(1):24-28. Herlihy AS, Halliday JL, Cock ML, McLachlan RI. The prevalence and diagnosis rates of Klinefelter syndrome: an Australian comparison. Med J Aust 2011;194(1):24-8.

Herlihy AS, McLachlan RI, Gillam L, Cock ML, Collins V, Halliday JL. The psychosocial impact of Klinefelter syndrome and factors influencing quality of life. Genet Med 2011;13(7):632-42. Herlihy AS, McLachlan RI, Gillam L, Cock ML, Collins V, Halliday JL. The psychosocial impact of Klinefelter syndrome and factors influencing quality of life. Genetics in Medicine 2011;13:632-642. Hertzog P, Forster S, Samarajiwa S. Systems biology of interferon responses. J Interferon Cytokine Res 2011;31(1):5-11. Hertzog PJ, Mansell A, van Driel IR, Hartland EL. Sculpting the immune response to infection. Nat Immunol 2011;12(7):579-82. Hill A, Hoffmann T, Beer C, McPhail S, Hill K, Brauer S, Haines T. Falls after discharge from hospital: Is there a gap between older peoples’ knowledge about falls prevention strategies and the research evidence? The Gerontologist 2011;51(5):653-662. Hill A, Hoffmann T, Beer C, McPhail S, Hill K, Brauer S, Haines T. Factors associated with older patients’ engagement in exercise after hospital discharge. Archives of Physical Medicine and Rehabilitation 2011;92(9):1395-1403. Hillman NH, Polglase GR, Pillow JJ, Saito M, Kallapur SG, Jobe AH. Inflammation and lung maturation from stretch injury in preterm fetal sheep. Am J Physiol Lung Cell Mol Physiol 2011;300(2):L232-41.

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Hocking DR, Rinehart NJ, McGinley JL, Galna B, Moss SA, Bradshaw JL. Gait adaptation during obstacle crossing reveals impairments in the visual control of locomotion in Williams syndrome. Neuroscience 2011;197:320-329.

Horne RS, Yang JS, Walter LM, Richardson HL, O’Driscoll DM, Foster AM, et al. Elevated blood pressure during sleep and wake in children with sleep-disordered breathing. Pediatrics 2011;128(1):e85-92.

Holmes J, Sievert W, Thompson AJ. Genetic biomarkers of viral clearance in HCV infection. Biomarkers in Medicine 2011;5(4):461-478.

Horne RSC, Yang JSC, Walter LM, O’Driscoll DM, Foster AM, Wong S, Ng M, Bashir F, Patterson R, Nixon GM, Jolley D, Walker AM, Anderson V, Trinder J, Davey MJ. Elevated Blood Pressure During Sleep and Wake in Children With Sleep-Disordered Breathing. Pediatrics 128(1):e85-92, 2011.

Holmes NE, Opat S, Kelman A, Korman TM. Refractory Bartonella quintana bacillary angiomatosis following chemotherapy for chronic lymphocytic leukaemia. J Med Microbiol 2011;60(Pt 1):142-6. Holmes NE. Turnidge JD. Munchkof WJ. Robinson JO. Korman TM. O’Sullivan MVN. Anderson TL. Roberts SA. Gao W. Christiansen KJ. Coombs GW. Johnson PDR. Howden BP. Antibiotic choice may not explain poorer outcomes in patients with high vancomycin MIC Staphylococcus aureus bacteremia. J Infect Dis 2011;204(3):340-7. Holton S, Fisher J, Rowe H. To have or not to have? Australian women’s childbearing desires, expectations and outcomes. Journal of Population Research 2011;28(4):353-379. Holton S, Rowe H, Fisher J. Women’s Health and Their Childbearing Expectations and Outcomes: A Population-Based Survey from Victoria, Australia. Womens Health Issues 2011;21(5):366-73. Hopper SM, Babi FE, McCarthy M, Tancharoen C, Lee KJ, Oakley E. A double blind, randomised placebo controlled trial of topical 2% viscous lidocaine in improving oral intake in children with painful infectious mouth conditions. BMC Paediatrics 2011;11:106. Hopper SM, Babl FE, McCarthy M, Tancharoen C, Lee KJ and Oakley E. A double blind, randomised placebo controlled trial of topical 2% viscous lidocaine in improving oral intake in children with painful infectious mouth conditions BMC Pediatrics 2011;11:106.

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Huang L, Kanellis J, Mulley W. Slow and steady. Reducing thrombotic events in renal transplant recipients treated with IVIg for antibody-mediated rejection. Nephrology 2011;16(2):239-242. Hudson PL, Thomas K, Trauer T, Remedios C, Clarke DM. Psychological and social profile of family caregivers on commencement of palliative care. Journal of Pain and Symptom Management 2011;41(3):522-34. Hughes JD, Coles MA, Joyce A. Calcium channel blocker associated lower urinary tract symptoms in males: an Australian retrospective observational study. Qual Prim Care 2011;19(4):223-31. Hutchison SK, Stepto NK, Harrison CL, Moran LJ, Strauss BJ, Teede H. Effects of exercise on insulin resistance and body composition in overweight and obese women with and without polycystic ovary syndrome. J Clin Endocrinol Metab 2011;96(1):E48-56. Iansek R, Danoudis M. A single-blind cross over study investigating the efficacy of standard and controlled release levodopa in combination with entacapone in the treatment of end-of-dose effect in people with Parkinson’s disease. Parkinsonism and Related Disorders 2011;17(7):533-536. Ignjatovic V, Than J, Summerhayes R, Newall F, Horton S, Cochrane A and Monagle P. Haemostatic response in paediatric patients undergoing Cardiopulmonary Bypass Surgery. Pediatric Cardiology 2011;32:621-627.

Ikezumi Y, Suzuki T, Karasawa T, Hasegawa H, Imai N, Ueno M, Narita I, Kawachi H, Nikolic-Paterson DJ, Uchiyama M: Identification of alternatively activated macrophages in new onset pediatric and adult IgA nephropathy; correlation with mesangial matrix expansion. Histopathology 2011;58:198-210. Ilic D, Misso ML. Screening for testicular cancer. Cochrane Database Syst Rev 2011;16;(2). Ilic D, Tepper K, Misso M. Teaching evidence based medicine literature searching skills to medical students during the clinical years – a protocol for a randomised controlled trial. BMC Med Educ 2011;11:49. Ireland Z, Castillo-Melendez M, Dickinson H, Snow R, Walker DW. A maternal diet supplemented with creatine from mid-pregnancy protects the newborn spiny mouse brain from birth hypoxia. Neuroscience 2011;194:372-9. Jamsai D, Sarraj MA, Merriner DJ, Drummond AE, Jones KT, McLachlan RI, O’Bryan MK. GGN1 in the testis and ovary and its variance within the Australian fertile and infertile male population. International Journal of Andrology 2011;34:624-632. Jans L, Ditchfield M, Gomez A, Jaremko JL, Verstraete KL. MR imaging findings and MR criteria for instability in osteochondritis dissecans of the elbow in children. European Journal of Radiology 2011 do8i:10.10.1016/j. ejrad.2011.01.007(in press). Jans L, Jaremko J, Ditchfield M, et al. Evolution of femoral condylar ossification at MRI imaging: frequency and patient age distribution. Radiology 2011;258(3):880-888. Jans LBO, Jaremko JL, Ditchfield M, Huysse WC, Verstraete KL. MRI differentiates femoral condylar ossification evolution from osteochongritis dissecans. A new sign. European Radiology 2011; vol.21(6), pp.1170-1179.

Southern Health and MHTP Publications

Jaques AM, Amor DJ, Baker HWG, Healy DL, Ukoumunne OC, Breheny S, Garrett C, Halliday JL. Adverse Obstetric and Perinatal Outcomes in Subfertile Women Conceiving Without Assisted Reproductive Technologies. Obstet Gynecol Surv 2011; 66:4;203-204. Jaques Am, Amor DJ, Baker HWG, Healy DL, Ukoumunne OC, Breheny S, Garrett C, Halliday JL. Adverse obstetric and perinatal outcomes in subfertile women conceiving without assisted reproductive technologies. Obstetrical & Gynecological Survery 2011;66(4):203-204. Jayaram L, Chunilal S, Pickering S, Ruffin RE, Zalewski PD. Sputum zinc concentration and clinical outcome in older asthmatics. Respirology 2011;16(3):459-66. Jenkins A, Best J, Cameron F, Colman P, Hamblin P, O’Connell M, Rodda C, Teede H, O’Neal D. An Algorithm Guiding Patient Responses To Real Time-Continuous Glucose Monitoring Improves Quality Of Life. Diabetes Technology and Therapeutics 2011;13:105-9. Jenkins AJ, Krishnamurthy B, Best JD, Cameron FJ, Colman PG, Hamblin PS, O’Connell MA, Rodda C, Teede H, O’Neal DN. An algorithm guiding patient responses to real-timecontinuous glucose monitoring improves quality of life. Diabetes Technol Ther 2011;13(2):105-9. Jiang Y, Kelly R, Peters A, Fulka H, Dickinson A, Mitchell DA, et al. Interspecies somatic cell nuclear transfer is dependent on compatible mitochondrial DNA and reprogramming factors. PLoS One 2011;6(4):e14805. Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, et al. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J 2011;25(1):409-19.

Jones ME, Taggart DA, Temple-Smith PD, Eldridge MDB. The impact of isolation and bottlenecks on genetic diversity in the Pearson Island population of the black-footed rock-wallaby, Petrogale lateralis pearsonii (Marsupialia: Macropodidae). Australian Mammalogy 2011;33,152-161. Joshi MS, Wattanapitayakul S, Schanbacher BL, Bauer JA. Effects of human endothelial gene polymorphisms on cellular responses to hyperglycaemia: Role of NOS3 (Glu298Asp) and ACE (I/D) polymorphisms. Diab Vasc Dis Res 2011;8(4):276-83. Joyce A, Pauli-Myler T, Zazryn TR, Batras D, Mayers K. Promoting help-seeking among adolescents and young adults through consideration of the adaptive functions of low mood: A pilot study. International Journal of Mental Health Promotion 2011;13(4):30-5.

Katz D, Chin W, Appu S, Vukasin F, Tay YK, Pang C, Dowling C. A Novel Extraction Technique to Remove a penile Constriction Device. Accepted for publication International Journal of Sexual Health, October 2011. Kazutaka S, Winnall WR, Muir JA, Hedger MP. Regulation of sertoli cell activin A and inhibin B by tumour necrosis factor alpha and interleukin 1alpha: interaction with follicle-stimulating hormone/ adenosine 3’,5’-cyclic phosphate signalling. Mol Cell Endocrinol 2011;335(2):195-203. Keane MJ. Dexmedetomidine and Procedural Sedation. Anaesthesia and Intensive Care 2011;39(1):133-134. Keane MJ. Prespectives – Opposing Views, “I want to consume this product, should public health experts stop me?” – No; MJA 2011;195(7):379-379.

Kallapur SG, Kramer BW, Knox CL, Berry CA, Collins JJ, Kemp MW, et al. Chronic fetal exposure to Ureaplasma parvum suppresses innate immune responses in sheep. J Immunol 2011;187(5):2688-95.

Keenan DM, Clarke IJ, Veldhuis JD. Noninvasive analytical estimation of endogenous GnRH drive: analysis using graded competitive GnRH-receptor antagonism and a calibrating pulse of exogenous GnRH. Endocrinology 2011;152:4882-4893.

Kallapur SG, Kramer BW, Nitsos I, Pillow JJ, Collins JJ, Polglase GR, et al. Pulmonary and systemic inflammatory responses to intra-amniotic IL-1{alpha} in fetal sheep. Am J Physiol Lung Cell Mol Physiol 2011;301(3):L285-95.

Kelleher MA, Palliser HK, Walker DW, Hirst JJ. Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on foetal guinea pig brain development. J Endocrinol 2011;208(3):301-9.

Kashimada K, Svingen T, Feng CW, Pelosi E, Bagheri-Fam S, Harley VR, Schlessinger D, Bowles J, Koopman P. Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB Journal 2011;25:3561-3569.

Kelly M, Bagnall RD, Peverill RE, Donelan L, Corben L, Delatycki MB, Semsarian C. A polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. Journal of Molecular and Cellular Biology 2011;51(5):848-854.

Kassahn KS, Ragan MA, Funder JW. Mineralocorticoid receptors: evolutionary and pathophysiological considerations. Endocrinology 2011;152:1883-1890.

Kelly M, Bagnall RD, Peverill RE, Donelan L, Corben L, Delatycki MB, Semsarian CA polymorphic miR-155 binding site in AGTR1 is associated with cardiac hypertrophy in Friedreich ataxia. Journal of Molecular and Cellular Cardiology 2011;51(5):848-854.

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Kenna K, De Matteo R, Hanita T, Rees S, Sozo F, Stokes V, et al. Daily ethanol exposure during late ovine pregnancy: physiological effects in the mother and fetus in the apparent absence of overt fetal cerebral dysmorphology. Am J Physiol Regul Integr Comp Physiol 2011;301(4):R926-36. Kennedy C, Najdovska M, Jones G, McLeod L, Hughes N, Allison C, Ferrero R, Jones S, Dev A, Sievert W, Bhathal P, Jenkins B. The molecular pathogenesis of STAT3-driven gastric tumorigenesis in mice is independent of IL-17. Journal of Pathology 2011;225(2):255-64. Kennedy CL, Najdovska M, Jones GW, McLeod L, Hughes NR, Allison C, et al. The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17. J Pathol 2011;225(2):255-64. Kerr PG, Agar JWM, Hawley CM. Alternate night nocturnal hemodialysis: the Australian experience. Semin Dialysis 2011;24(6):664-7. Kerr PG. Dialysis: Nocturnal hemodialysis – should we still provide this therapy? Nature Reviews Nephrology 2011;7(11):611-2. Kerr PG. International differences in hemodialysis delivery and their influence on outcomes. Am J Kidney Dis 2011;58(3):461-70. Keys C, Makkar N, Clarnette T, Muthucumarie M, Cheng W. Double duodenal atresia with a perforation: a case report. J Pediatr Surg 2011;46(5):e25-7. Khaw SL, Huang DC, Roberts AW. Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies. Pathology 2011;43:525-35. Khoo JJ, Forster S, Mansell A. Toll-like receptors as interferon-regulated genes and their role in disease. J Interferon Cytokine Res 2011;31(1):13-25. Kibbey K, Vincent A. Premature surgical menopause and Factor V Leiden heterozygosity: case report and literature review. Climacteric 2011;14(1):185-8.

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Kibbey K, Vincent AJ. Premature surgical menopause and Factor V Leiden heterozygosity: Case report and literature review. Climacteric 2011;14:185-188. Kim HS, Wilce MC, Yoga YM, Pendini NR, Gunzburg MJ, Cowieson NP, et al. Different modes of interaction by TIAR and HuR with target RNA and DNA. Nucleic Acids Res 2011;39(3):1117-30. King PT, Holmes PW, Use of antibiotics in Bronchiectasis. Rev Recent Clin Trials 2011 Oct 21. King PT, The Pathogenesis of Bronchiectasis. Paed Resp 2011;12;104-11. Kitchen MJ, Paganin DM, Uesugi K, Allison BJ, Lewis RA, Hooper SB, et al. Phase contrast image segmentation using a Laue analyser crystal. Phys Med Biol 2011;56(3):515-34. Kitching AR, Holdsworth SR. The emergence of TH17 cells as effectors of renal injury. J Am Soc Nephrol 2011;22(2):235-8. Kitson M, Roberts S, Kemp W, Iser D, Street A, Tran H. The prevalence of significant liver fibrosis and cirrhosis in haemophilia patients infected with hepatitis C using Fibroscan. Haemophilia 2011;17(2):316-7. Kitto SC, PellerJC, Villanueva EL, Gruen RL, Smith JA. Rural surgeons’ attitudes towards and usage of evidence-based medicine in rural surgical practice. J Eval Clin Pract 2011;17:678-83. Kitto SC, Petrovic A, Gruen RL, Smith JA. Evidence based medicine training and implementation in surgical practice: the role of surgical cultures. J Eval Clin Pract 2011;17:819-26. Klopper FK, Delatycki MB, Corben LA, Bradshaw JL, Rance G, GeorgiouKaristianis N. The Test of Everyday Attention reveals significant sustained volitional attention and working memory deficits in Friedreich ataxia. Journal of the International Neuropsychological Society 2011;17:196-200.

Knight V, Tchongue J, Lourensz D, Tipping P, Sievert W. Protease-activated receptor 2 promotes experimental liver fibrosis and activates human hepatic stellate cells. Hepatology 2011 Nov 16. doi:10.1002/hep.24784. [Epub ahead of print]. Knower KC, Kelly S, Ludbrook LM, Bagheri-Fam S, Sim H, Bernard P, Sekido R, Lovell-Badge R, Harley VR. Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations. PLoS One 2011;6:e17751. Ko B, Cochrane A, Seneviratne S. Saphenous vein coronary bypass graft aneurysm with fistula to right atrium demonstrated on dynamic-volume 320-slice computed tomography Heart Asia 2011;3(1):1. Ko BS, Cameron JD, Meredith IT, Leung M, Antonis PR, Nasis A, Crossett M, Hope SA, Lehman SJ, Troupis J, Defrance T, Seneviratne SK. Computed tomography stress myocardial perfusion imaging in patients considered for revascularization: a comparison with fractional flow reserve. Eur Heart J 2011 Aug 2 [Epub ahead of print]. Koh KH, Dayanath B, Doery JC, Polkinghorne KR, Epi MC, Teede H, Kerr PG. The effect of exercise on urine albuminuria excretion in diabetic subjects. Nephrology (Carlton) 2011;16(8):704-9. Koh KH, Dayanath B, Doery JCG, Polkinghorne KR, Teede H, Kerr PG. The effect of exercise on urine albuminuria excretion in diabetic subjects. Nephrology 2011;16(8):704-9. Kola I, Bell J. A call to reform the taxonomy of human disease. Nat Rev Drug Discov 2011;10(9):641-2. Kolosov A, Aurini L, Williams ED, Cooke I, Goodchild CS. Intravenous injection of leconotide, an omega conotoxin: synergistic antihyperalgesic effects with morphine in a rat model of bone cancer pain. Pain Med 2011;12(6):923-41.

Southern Health and MHTP Publications

Kulkarni J, DE Castella A, Headey B, Marston N, Sinclair K, Lee S, Gurvich C, Fitzgerald PB, Burger H. Estrogens and men with schizophrenia: Is there a case for adjunctive therapy? Schizophr Res 2011;125:278-283. Kulkarni J, de Castella A, Headey B, Marston N, Sinclair K, Lee S, Gurvich C, Fitzgerald PB, Burger H. Estrogens and men with schizophrenia: Is there a case for adjunctive therapy? Schizophrenia Research 2011;125:278-283. Künzli BM, Berberat PO, Dwyer K, Deaglio S, Csizmadia E, Cowan P, d’Apice A, Moore G, Enjyoji K, Friess H, Robson SC. Variable Impact of CD39 on Experimental Murine Colitis. Dig Dis Sci 2011;56(5):1393-403. Kuys S, Bew P, Morrison G, Clarke J, Haines T. Further validation of the Balance Outcome Measure for Elder Rehabilitation. Archives of Physical Medicine and Rehabilitation 2011;92(1):101-105. Lakhan P, Jones M, Wilson A, Courtney M, Hirdes J, Gray L. A prospective cohort study of geriatric syndromes among older medical patients admitted to acute care hospitals. Journal of the American Geriatrics Society 2011;59:2001-2008. Lang T, Lo C, Skinner N, Locarnini S, Visvanathan K, Mansell A. The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway. J Hepatol 2011;55(4):762-9. Lang T, Lo C, Skinner N, Locarnini S, Visvanathan K, Mansell A. The Hepatitis B e antigen (HBeAg) targets and suppresses activation of the Toll-like receptor signaling pathway. J Hepatol 2011;55(4):762-9. Lapinskas EJ, Svobodova S, Davis ID, Cebon J, Hertzog PJ, Pritchard MA. The Ets transcription factor ELF5 Functions as a tumor suppressor in the kidney. Twin Res Hum Genet 2011;14(4):316-22.

Larmour I, Pignataro S, Barned K, Mantas S, Korman MG. A therapeutic equivalence program: evidence based promotion of more efficient use of medicines. MJA 2011;94(12):631-631. Larmour I. Marketing Pharmaceuticals: Are the Benefits Real? Journal of Pharmacy Practice and Research 2011;41(3):172-174. Latifi A, Abubaker K, Castrechini N, Ward AC, Liongue C, Dobill F, Kumar J, Thompson EW, Quinn MA, Findlay JK, Ahmed N. Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile. Journal of Cellular Biochemistry 2011;112:2850-2864. Law MG, Woolley I, Templeton DJ, Roth N, Chuah J, Mulhall B, Canavan P, McManus H, Cooper DA, Petoumenos K, Database TA. Trends in detectable viral load by calendar year in the Australian HIV Observational Database. J Int AIDS Soc 2011;14(1):10. Le Marshall K, Littlejohn G O. Management strategies for fibromyalgia. Open Access Rheumatology Research and Reviews 2011;3:47-51. Lee AB, Nandurkar D, Schneider-Kolsky ME, Crossett M, Seneviratne SK, Cameron JD, Troupis JM. Coronary image quality of 320-MDCT in patients with heart rates above 65 beats per minute: a preliminary experience. AJR 2011;196(6):W729-35. Lee AB, Nandurkar D, Schneider-Kolsky ME, Crossett M, Seneviratne SK, Cameron JD, Troupis JM. Coronary image quality of 320-MDCT in patients with heart rates above 65 beats per minute: Preliminary experience American Journal of Roentgenology 2011;196(6):W729-W735. Lee AJ, Lambermont VA, Pillow JJ, Polglase GR, Nitsos I, Newnham JP, et al. Fetal responses to lipopolysaccharideinduced chorioamnionitis alter immune and airway responses in 7-weekold sheep. Am J Obstet Gynecol 2011;204(4):364 e17-24.

Lee, S-T, White AJ, Matsushita S, Malliaras K, Steenbergen C, Zhang Y, Li T-S, Terrovitis J, Yee K, Simsir S, Makkar R, Marbain E. Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction. Journal of the American College of Cardiology 2011;57(4):455-465. Leng L, Chen L, Fan J, Greven D, Arjona A, Du X, Austin D, Kashgarian M, Yin Z, Huang XR, Lan HY, Lolis E, NikolicPaterson D, Bucala R. A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/ NZW F1 and MRL/lpr mice. J Immunol 2011;186:527-38. Leonard JM, Cozens A, Reid S, Fahey MC, Ditchfield MR, Reddihough DS. Should children with cerebral palsy and normal imaging undergo testing for inherited metabolic disorders? Developmental Medicine & Child Neurology 2011;53:226-232. Leong A, “100 patient stories” – Just one side of the story for improving incident disclosure. British Medical Journal, September 2011. Lethaby A, Vollenhoven B. Fibroids (Uterine myomatosis, leiomyomas). Clinical Evidence (online) 2011; Jan 11. Leung C, Tsoi E, Burns G, Sievert W. An argument for universal prophylaxis of hepatitis B infection in patients receiving rituximab: a seven year institutional experience of hepatitis screening. The Oncologist 2011;16(5):579-584. Lewis PM, Goldschlager T, Rosenfeld JV. Image guidance for rapid temporal acoustic window localisation prior to transcranial Doppler ultrasound in the neurosurgical patient. Br J Neurosurg 2011;24(3):303-5. Li JC, Au KY, Fang JW, Yim HC, Chow KH, Ho PL, et al. HIV-1 trans-activator protein dysregulates IFN-gamma signaling and contributes to the suppression of autophagy induction. AIDS 2011;25(1):15-25.

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Li PKT, Cheung WL, Lui SL, Blagg C, Cass A, Hooi LS, Lee HY, Locatelli F, Wang T, Yang CW, Canaud B, Cheng YL, Choong HL, De Francisco AL, Gura V, Kaizu K, Kerr PG, Kuok UI, Leung CB, Lo WK, Misra M, Szeto CC, Tong KL, Tungsanga K, Walker R, Wong AKM, Yu AWY. Increasing home based dialysis therapies to tackle dialysis burden around the world: A Position Statement on Dialysis Economics from the 2nd Congress of the International Society for Hemodialysis. Jointly published in Hemodial Int (ePub 14 Jan 2011) and Nephrology 2011;16(1):53-6. Li Y, Puryer M, Lin E, Hale K, Salamonsen L, Manuelpillai U, Tong S, Chan W, Wallace EM, Nie G. Placental HtrA3 is regulated by oxygen tension and serum levels are altered during early pregnancy in women destined to develop preeclampsia. J Clin Endocrinol Metab 2011;96(2):403-411. Li Y, Puryer M, Lin E, Hale K, Salamonsen LA, Manuelpillai U, et al. Placental HtrA3 is regulated by oxygen tension and serum levels are altered during early pregnancy in women destined to develop preeclampsia. J Clin Endocrinol Metab 2011;96(2):403-11. Li Y, Puryer M, Lin E, Hale K, Salamonsen LA, Manuelpillai U, Tong S, Chan W, Wallace EM, Nie G. Placental HtrA3 is regulated by oxygen tension and serum levels are altered during early pregnancy in women destined to develop preeclampsia. Journal of Clinical Endocrinology and Metabolism 2011;96:403-411. Liberio MS, Sooraj D, Williams ED, Feng Y, Davis RA. Kingamide A, a new indole alkaloid from the ascidian Leptoclinides kingi. Tetrahedron Lett 2011;52(50):6729-31. Liddy C, Hogg W, Russell G Wells G, Deri Armstrong C, Akbari A, Dahrouge S, Taljaard M, Mayo-Bruinsma L, Singh J, Cornett A. Improved Delivery of Cardiovascular Care (IDOCC) through Outreach Facilitation: study protocol and implementation details of a cluster randomized controlled trial in primary care. Implementation Science 2011;110(6).

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Liew SH, Sarraj MA, Drummond AE, Findlay JK. Estrogen-dependent gene expression in the mouse ovary. PLoS One 2011;6:e14672. Lim AKH, Ma FY, Nikolic-Paterson DJ, Ozols E, Young MJ, Bennett BL, Friedman GC, Tesch GH. Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats. Am J Nephrol 2011;34:337-346. Lim ML, Vassiliev I, Richings NM, Firsova AB, Zhang C, Verma PJ. A novel, efficient method to derive bovine and mouse embryonic stem cells with in vivo differentiation potential by treatment with 5-azacytidine. Theriogenology 2011;76(1):133-42. Lim R, Sobey CG. Maternal nicotine exposure and fetal programming of vascular oxidative stress in adult offspring. Br J Pharmacol 2011;164(5):1397-9. Lim WH, Dogra GK, McDonald SP, Brown FG, Johnson DW. Compared with younger peritoneal dialysis patients, elderly patients have similar peritonitis – free survival and lower risk of technique failure, but higher risk of peritonitisrelated mortality. Perit Dial Int 2011;(6)663-71. Epub 2011 May 31. Littlejohn G O. Regional Pain Syndrome. Mod Medicine 2011;12:72-80. Liu J, Ashton MP, Sumer H, O’Bryan MK, Brodnicki TC, Verma PJ. Generation of stable pluripotent stem cells from NOD mouse tail-tip fibroblasts. Diabetes 2011;60(5):1393-8. Liu J, Sumer H, Leung J, Upton K, Dottori M, Pebay A, et al. Late passage human fibroblasts induced to pluripotency are capable of directed neuronal differentiation. Cell Transplant 2011;20(2):193-203. Liu J, Verma PJ, Evans-Galea MV, Delatycki MB, Michalska A, Leung J, et al. Generation of induced pluripotent stem cell lines from friedreich ataxia patients. Stem Cell Rev Rep 2011;7(3):703-13.

Lobachevsky PN, Vasireddy RS, Broadhurst S, Sprung CN, Karagiannis TC, Smith AJ, et al. Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol 2011;87(3):274-83. Lockwood SM, Alison JF, Obeyesekere MN, Mottram PM. Imaging the left atrial appendage prior to, during, and after occlusion. JACC: Cardiovascular Imaging 2011;4(3):303-306. Londrigan SL, Turville SG, Tate MD, Deng YM, Brooks AG, Reading PC. N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN. J Virol 2011;85(6):2990-3000. Loop gain as a means to predict a positive airway pressure suppression of Cheyne-Stokes respiration in patients with heart failure. Sands SA, Edwards BA, Kee K, Turton A, Skuza EM, Roebuck T, O’Driscoll D, Hamilton GS, Naughton MT, Berger PJ. American Journal of Respiratory and Critical Care Medicine 2011;184(1):1067-1075. Lopez-Vargas PA, Craig JC, Gallagher MP, Walker RG, Snelling PL, Pedagogos E, Gray NA, Divi MD, Gillies AH, Suranyi MG, Thein H, McDonald SP, Russell C, Polkinghorne KR. Barriers to Timely Arteriovenous Fistula Creation: A Study of Providers and Patients. Am J Kidney Dis 2011;57:873-82. Lotan C, Meredith IT, Jain A, Feres F, Firszt A, Garc­a AF, Rothman MT. Clinical outcomes by geographic region for patients implanted with the zotarolimuseluting stent. Arquivos Brasileiros de Cardiologia 2011;96(5):353-362. Low K, Lau K, Holmes P, Crossett M, Vallance N, Phylland D, Hamza K, Hamilton G, Bardin P. Abnormal vocal cord function in difficult-to-treat asthma. American Journal of Respiratory and Critical Care Medicine 2011;184:50-56. Low K, Lau KK, Holmes P, Crossett M, Vallance N, Phyland D, et al. Abnormal vocal cord function in difficult-to-treat asthma. Am J Respir Crit Care Med 2011;184(1):50-6.

Southern Health and MHTP Publications

Low K, Lau KK, Holmes P, Crossett M, Vallance N, Phyland D, Hamza K, Hamilton G, Bardin PG. Abnormal Vocal Cord Function in Difficult-to-Treat Asthma. Am J Respir Crit Care Med 2011;184:50-6.

Malhotra A, Veldman A. Recombinant activated Factor VII for prevention and treatment of intraventricular haemorrhage in neonates. Cochrane Database of Systematic Reviews 2011, Issue 3. Art. No: CD009032.

Ludbrook L, Harley VR. Genetic mechanisms underlying 46,XY DSD with gonadal dysgenesis. Advances in Experimental Medicine and Biology 2011;707:87-88.

Maloney S, Haas R, Molloy L, Morgan P, Keating J, Jolly B, Haines T. Effectiveness of Web-Based Versus Face-To-Face Delivery of Education in Prescription of Falls-Prevention Exercise to Health Professionals: Randomized Trial. Journal of Medical Internet Research 2011;13(4):e116.

Ludlow M, George CR, Hawley CM, Mathew TH, Agar JW, Kerr PG, Lauder LA. How Australian Nephrologists View Home Dialysis: Results of a National Survey. Nephrology 2011;16(4):446-52. Ma FY, Tesch GH, Ozols E, Schneider MD, Qie M, Nikolic-Paterson DJ: TGF-β1 activated kinase-1 (TAK1) regulates inflammation and fibrosis in the obstructed kidney. Am J Physiol – Renal Physiol 2011;300:F1410-1421. MacDonald M, Beasley RW, Irving L, Bardin PG. A hypothesis to phenotype COPD exacerbations by aetiology. Respirology 2011;16:264-8. MacDonald M, Beasley RW, Irving L, Bardin PG. A hypothesis to phenotype COPD exacerbations by aetiology. Respirology 2011;16(2):264-8. Makanji Y, Harrison CA, Robertson DM. Feedback regulation by inhibins A and B of the pituitary secretion of folliclestimulating hormone. Vitamins and Hormones 2011;85:299-321. Makanji Y, Walton KL, Chan KL, Gregorevic P, Robertson DM, Harrison CA. Generation of a specific activin antagonist by modification of the activin A propeptide. Endocrinology 2011;152:3758-3768. Maksimovic J, Sharp JA, Nicholas KR, Cocks BG, Savin K. Conservation of the ST6Gal I gene and its expression in the mammary gland. Glycobiology 2011;21(4):467-81. Malhotra A, Bergman P, Brown J, McGillivray G. Congenital hypothyroidism in association with chromosome 3p25.3 - chapter deletion. J Pediatr Endocrinol Metabol 2011;24(9-10):787-788.

Manuelpillai U, Moodley Y, Borlongan CV, Parolini O. Amniotic membrane and amniotic cells: Potential therapeutic tools to combat tissue inflammation and fibrosis? Placenta 2011;32 (Supp 4):320-5. Maple-Brown LJ, Cunningham J, Hodge A, Weeramanthri T, Dunbar T, Lawton PD, Zimmet P, Chadban S, Polkinghorne KR, Shaw J, O’Dea K. High rates of albuminuria but not of low eGFR in Urban Indigenous Australians: the DRUID Study. BMC Public Health 2011;19;11(1):346. Marini KD, Payne BJ, Watkins DN, Martelotto LG. Mechanisms of Hedgehog signalling in cancer. Growth Factors 2011;29(6):221. Marmor GO, Braitberg G, Nicolas CM. Medication Prescribing, Surveillance and Safety in Australasian Emergency Departments. J Pharm Pract Res 2011;41:113-117.

Marshall SD, Kitto S, Shearer W, Wilson SJ, Finnigan MA, Sturgess T, Hore T, Buist MD: Why don’t hospital staff activate the rapid response system (RRS)? How frequently is it needed and can the process be improved? Implement Science 2011;16:6-39. Martin CA, Cameron JD, Chen SS, McGrath BP. Two hour glucose post loading: A biomarker of cardiovascular risk in isolated clinic hypertension Journal of Hypertension 2011;29(4):749-757. McCarthy FP, Giles ML, Rowlands S, Purcell KJ, Jones CA. Antenatal interventions for preventing the transmission of cytomegalovirus (CMV) from the mother to fetus during pregnancy and adverse outcomes in the congenitally infected infant. Cochrane Database Syst Rev 2011;3:CD008371. McCoy CE. The role of miRNAs in cytokine signaling. Front Biosci 2011;17:2161-71. McDougall AR, Hooper SB, Zahra VA, Sozo F, Lo CY, Cole TJ, et al. The oncogene Trop2 regulates fetal lung cell proliferation. Am J Physiol Lung Cell Mol Physiol 2011;301(4):L478-89. Mckay L, Frydenberg M, Lipton L, Norris F, Winship I. Case report: renal cell carcinoma segregating with a t(2;3) (q37.3;q13.2) chromosomal translocation in a Ashkenazi Jewish Family. Familiar cancer, 10(2) 349-353.

Marshall MR, Hawley CM, Kerr PG, Polkinghorne KR, Marshall RJ, Agar JWM, McDonald SP. Home hemodialysis and mortality risk in Australian and New Zealand populations. Am J Kidney Dis 2011;58(5):782-93.

McKay MJ, Withana N, Davey DS, Bishop D, Chao M, Sprung CN. Lymphoid and fibroblastic cell lineages from radiosensitive cancer patients: molecular analysis of DNA double strand break repair by major nonhomologous end-joining sub-pathways. Asia Pac J Clin Oncol 2011;7(1):17-26.

Marshall SD, Kitto S, Shearer W, Wilson SJ, Finnigan MA, Sturgess T, Hore T, Buist MD. Why don’t hospital staff activate the Rapid Response System (RRS)? How frequently is it needed and can the process be improved? Implementation Science 2011;6:39.

McKenzie M, Tucker EJ, Compton AG, Lazarou M, George C, Thorburn DR, et al. Mutations in the gene encoding C8orf38 block complex I assembly by inhibiting production of the mitochondria-encoded subunit ND1. J Mol Biol 2011;414(3):413-26.

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McLintock C, Brighton T, Chunilal S, Dekker G, McDonnell N, McRae S, Muller P, Tran H, Walters BN, Young L. Recommendations for the diagnosis and treatment of deep venous thrombosis and pulmonary embolism in pregnancy and the postpartum period. Aust N Z J Obstet Gynaecol Oct 6 2011. McLintock C, Brighton T, Chunilal S, Dekker G, McDonnell N, McRae S, Muller P, Tran H, Walters BN, Young L. Recommendations for the prevention of pregnancy-associated venous thromboembolism. Aust N Z J Obstet Gynaecol Sep 23 2011. McMahon CA, Boivin J, Gibson FL, Fisher JR, Hammarberg K, Wynter K, Saunders DM. Older first-time mothers and early postpartum depression: a prospective cohort study of women conceiving spontaneously or with assisted reproductive technologies. Fertil Steril 2011 Nov;96(5):1218-24. McNamee EN, Masterson JC, Jedlicka P, McManus M, Grenz A, Collins CB, et al. Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci USA 2011;108(40):16711-6. Meadows GN, Bobevski I. Changes in met perceived need for mental healthcare in Australia from 1997 to 2007. Br J Psychiatry 2011;199(6):479-84. Meehan B, Appu S, St Croix B, RakPoznanska K, Rak J. Age related properties of the tumour vascuature in renal cell carcinoma. BJU Int 2011 Feb;107(3):416-24. Meijers B, Toussaint ND, Meyer T, Bammens B, Verbeke K, Vanrenterghem Y, Kerr PG, Evenepoel P. Reduction in Protein-Bound Solutes Unacceptable as Marker of Dialysis Efficacy during Alternate-Night Nocturnal Hemodialysis. Am J Nephrol 2011;34(3):226-32. Meinhardt A, Hedger MP. Immunological, paracrine and endocrine aspects of testicular immune privilege. Mol Cell Endocrinol 2011;335(1):60-8.

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Mellor KM, Bell JR, Young MJ, Ritchie RH, Delbridge LMD. Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice. Journal of Molecular and Cellular Cardiology 2011;50:1035-1043. Mendis SH, Meachem SJ, Sarraj MA, Loveland KL. Activin a balances sertoli and germ cell proliferation in the fetal mouse testis. Biol Reprod 2011;84(2):379-91.

Merriman E, Kaplan Z, Butler J, Malan E, Gan TE, Tran H. Rivaroxaban and False Positive Lupus Anticoagulant Testing. Thromb Haemost 2011;105(2):385-6. Merriman E, Nandurkar D, Opat S, Tran H. A case of ITP with cauda equina syndrome. Ann Hematol 2011;90(6):729-30. Epub 2010 Sep 18. Merriman E, Tran H. Antiplatelet drugs, anticoagulants and elective surgery. Australian Prescriber 2011;34:139-44.

Mendis SH, Meachem SJ, Sarraj MA, Loveland KL. Activin A balances Sertoli and germ cell proliferation in the fetal mouse testis. Biology of Reproduction 2011;84:379-391.

Metz AJ, Bourke MJ, Moss A, Williams SJ, Swan MP, Byth K Factors that predict bleeding following endoscopic mucosal resection of large colonic lesions Endoscopy 2011 Jun;43(6):506-11.

Menkhorst E, Zhang JG, Sims NA, Morgan PO, Soo P, Poulton IJ, Metcalf D, Alexandrou E, Gresle M, Salamonsen LA, Butzkueven H, Nicola NA, Dimitriadis E. Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice. PLoS One 2011;6:e19665.

Milliken O, Devlin R, Barham V, Hogg W, Dahrouge S, Russell G. Comparative efficiency assessment of primary care service delivery models using data envelopment analysis. Canadian Public Policy – Analyse de politiques 2011;37(1).

Meredith I, Rothman M, Erglis A, Parikh K, Lotan C. Extended follow-up safety and effectiveness of the Endeavor zotarolimus-eluting stent in real-world clinical practice: Two-year follow-up from the E-Five Registry. Catheterization and Cardiovascular Interventions 2011;77(7):993-1000. Meredith IT, Whitbourn R, Scott D, El-Jack S, Zambahari R, Stone GW, Teirstein PS, Starzyk RM, Allocco DJ, Dawkins KD. PLATINUM QCA: a prospective, multicentre study assessing clinical, angiographic, and intravascular ultrasound outcomes with the novel platinum chromium thin-strut PROMUS Element everolimus-eluting stent in de novo coronary stenoses. EuroIntervention 2011;7(1):84-90. Meredith IT, Worthley S, Whitbourn R, Webster M, Fitzgerald PJ, Ormiston J. First-in-human experience with the Medtronic Bifurcation Stent System. EuroIntervention 2011;7(6):662-9.

Mitchell B, Ware C, McGregor A, Brown S, Wells A, Stuart RL, Wilson F, Mason M. ASID (HICSIG)/AICA Position Statement: Preventing catheter associated urinary tract infections in patients. Healthcare Infection 2011;16:45-52. Mitchell B, Ware C, McGregor A, Brown S, Wells A, Stuart RL, Wilson F, Mason M. ASID (HICSIG)/AICA Position Statement: Preventing catheter-associated urinary tract infections in patients. Healthcare Infect 2011;16:45-52. Mohammad HP, Zhang W, Prevas HS, Leadem BR, Zhang M, Herman JG, et al. Loss of a single Hic1 allele accelerates polyp formation in Apc(Delta716) mice. Oncogene 2011;30(23):2659-69. Monagle P, Cochrane A, Roberts R, Manlhiot C, Weintraub R, Szechtman B, Gent M, Andrew M, McCrindle B. A Multicentre Randomized Trial comparing Heparin/Warfarin and Aspirin as Primary Thromboprophylaxis for two years after the Fontan procedure in children. JACC 2011;58:645-651.

Southern Health and MHTP Publications

Montag K, Gingold M, Boers A, Littlejohn G O. DMARD usage, prescribing patterns and disease activity in community-based practice. Int Med J 2011;41:450-455.

Morefield KM, Keane M, Felgate P, White JM, Irvine RJ. Pill content, dose, and resulting plasma concentrations of MDMA in recreational “ecstasy” users; Addiction 2011;106(7):1293-1300.

Montoya L, Liddy C, Papadakis S, Dojeiji L, Russell G, Akbari A, Pipe A, Higginson L. Development of t he Champlain primary care cardiovascular disease prevention and management guideline: Tailoring evidence to community practice. Can Fam Physician 2011;(57) e202-e207 http://www.cfp.ca/cgi/ content/abstract/57/6/e20.

Morris ME, Menz HB, McGinley JL, Huxham FE, Murphy AT, Iansek R, Danoudis M, Soh SE, Kelly D, Watts JJ. Falls and mobility in Parkinson’s disease: protocol for a randomised controlled clinical trial. BMC Neurology 2011;11:93.

Moodley Y, Manuelpillai U, Weiss DJ. Cellular therapies for lung disease: a distant horizon. Respirology 2011;16(2):223-37. Moore K, Hill K, Robinson A, Haines T, Haralambous B, Nitz J. The state of physical environments in Australian residential aged care facilities. Australian Health Review 2011;35(4)412-417. Moran LJ, Cameron JD, Strauss BJ, Teede HJ. Vascular function in the diagnostic categories of polycystic ovary syndrome. Hum Reprod 2011 May 25. Moran LJ, Cameron JD, Strauss BJ, Teede HJ. Vascular function in the diagnostic categories of polycystic ovary syndrome. Human Reproduction 2011;26(8):2192-2199. Moran LJ, Harrison CL, Hutchison SK, Stepto NK, Strauss BJ, Teede HJ. Exercise Decreases Anti-Müllerian Hormone in Anovulatory Overweight Women with Polycystic Ovary Syndrome – A Pilot Study. Horm Metab Res 2011;43(13):977-979. Moran LJ, Hutchison SK, Norman RJ, Teede HJ. Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Syst Rev. Rev 2011. Moran LJ, Strauss BJ, Teede HJ. Diabetes risk score in the diagnostic categories of polycystic ovary syndrome. Fertil Steril 2011;95(5):1742-8.

Mottram PM, Donelan L, Gelman JS, Delatycki MB, Peverill RE. Early Changes in Left Ventricular Long-Axis Function in Friedreich Ataxia: Relation with the FXN Gene Mutation and Cardiac Structural Change. J Am Soc Echocardiogr 2011;24(7):782-9. Mulley W, Kanellis J. Understanding crossmatch testing in organ transplantation: A case-based guide for the general nephrologist. Nephrology 2011;16(2):125-133.

Morrison G, Lee H, Kuys S, Clarke J, Bew P, Haines T. Changes in falls risk factors for geriatric diagnostic groups across inpatient, outpatient & domiciliary rehabilitation settings. Disability and Rehabilitation 2011;33(11):900-7.

Murila F, Francis JV, Bland A, Kumbla S, Doherty R, Sehgal A. Factors influencing treatment decisions in endotracheal positive culture. J Pediatr Ch Health 2011, doi:10.1111/j.1440-1754.2011.02041.x.

Moseley DS, Tonge, BT, Brereton AV, Einfeld SL. Psychiatric comorbidity in adolescents and young adults with autism. Journal of Mental Health Research in Intellectual Disability 2011;4(4): 229-243.

Murphy BP & Brewer WJ. Strengths and Limitations of Early Intervention in Psychosis: Clinical aspects Advances in Psychiatric Treatment 2011;17:408-16.

Moss A, Parrish FJ, Naidoo R, Upton A, Prime H, Leaney B, Gibson PR. Selfadministered, inhaled methoxyflurane improves patient comfort during nasoduodenal intubation for computed tomography enteroclysis for suspected small bowel disease: a randomized, double blind, placebo-controlled trial. Clinical Radiology 2011;66:125-131. Mottram PM, Delatycki MB, Donelan L, Gelman JS, Corben L, Peverill RE. Early changes in left ventricular longaxis function in Friedreich ataxia: Relation with the FXN gene mutation and cardiac structural change Journal of the American Society of Echocardiography 2011;24(7):782-789. Mottram PM, Delatycki MB, Donelan L, Gelman JS, Corben LA, Peverill RE. Early changes in left ventricular long axis function in Friedreich ataxia – relation with the FXN gene mutation and cardiac structural change. Journal of the American Society of Echocardiography 2011;24(7):782-789.

Murphy BP & Brewer WJ. Strengths and Limitations of Early Intervention in Psychosis: Service elements Advances in Psychiatric Treatment 2011;17:401-7. Murphy S, Lim R, Dickinson H, Acharya R, Rosli S, Jenkin G, et al. Human amnion epithelial cells prevent bleomycin-induced lung injury and preserve lung function. Cell Transplant 2011;20(6):909-23. Musk GC, Polglase GR, Bunnell JB, McLean CJ, Nitsos I, Song Y, et al. High positive end-expiratory pressure during high-frequency jet ventilation improves oxygenation and ventilation in preterm lambs. Pediatr Res 2011;69(4):319-24. Muthucumaru M, Yahya Z, Ferguson P, Cheng W. Torsion of hydatids of Morgagni in premenarchal adolescent girls – a case report and review of literature. J Pediatr Surg 2011;46(9):e-13-15. Nasis A, Harper RW, Mottram PM. Real-time three-dimensional transoesophageal echocardiography for guidance of transcatheter closure of a complex multifenestrated atrial septal defect. Heart Lung and Circulation 2011;20(5):343-344.

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Nasis A, Meredith IT, Nerlekar N, Cameron JD, Antonis PR, Mottram PM, Leung MC, Troupis JM, Crossett M, Kambourakis AG, Braitberg G, Hoffman U, Seneviratne SK. Acute chest pain investigation: utility of cardiac CT angiography in guiding troponin measurement. Radiology 2011;260(2):381-9.

Newton J, Cross W, White KT, Ockerby C, Billett S. Outcomes of a clinical partnership model for undergraduate nursing students. Contemporary Nurse 2011;39(1):119-27.

Nasis A, Meredith IT, Nerlekar N, Cameron JD, Antonis PR, Mottram PM, Leung MC, Troupis JM, Crossett M, Kambourakis AG, Braitberg G, Hoffmann U, Seneviratne SK. Acute chest pain investigation: Utility of cardiac CT angiography in guiding troponin measurement. Radiology 2011;260(2):381-389.

Ngian GS, Naidoo P, Morand EF, Hoi AY. Smooth muscle myopathy as an underrecognized manifestation of active systemic lupus erythematosus. Internal Medicine Journal 2011 Royal Australasian College of Physicians 495-498.

Nasis A, Meredith IT, Nerlekar N, Cameron JD, Antonis PR, Mottram PM, Leung MC, Troupis, Crossett M,Kambourakis AG, Braitberg G, Hoffmann U, Seneviratne SK. Acute Chest Pain Investigation: Utility of Cardiac CT Angiography in Guiding Troponin Measurement. Radiology 2011;259(3). Nasis A, Moir S, Seneviratne SK, Cameron JD, Mottram PM. Assessment of left ventricular volumes, ejection fraction and regional wall motion with retrospective electrocardiogram triggered 320-detector computed tomography: a comparison with 2D-echocardiography. 2011 International Journal of Cardiovascular Imaging 2011;11:1-9. Nayate A, Tonge BJ, Bradshaw JL, McGinley JL, Iansek R, Rinehart NJ. Differentiation of high-functioning Autism and Asperger’s Disorder based on neuromotor behaviour. J Autism Dev Disord 2011 Jun 10 [Epub] (doi:10.1007/s10803-011-1299-5). Top of Form. Nel HJ, Hams E, Saunders SP, Mangan NE, Smith P, Atzberger A, et al. Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice. J Immunol 2011;186(8):4631-9.

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Ngian GS, Guymer EK, Littlejohn GO. The use of opioids in fibromyalgia. Int J Rheum Dis 2011;14(1):6-11.

Ngian GS, Naidoo P, Morand EF, Hoi AY. Smooth muscle myopathy as an underrecognized manifestation of systemic lupus erythematosus. Intern Med J 2011;41(6):495-8. Ngian GS, Sahhar J, Wicks IP, Van Doornum S. Cardiovascular disease in systemic sclerosis – an emerging association? Arthritis Res Ther 2011;13(4):237. Nicholls PK, Harrison CA, Walton KL, McLachlan RI, O’Donnell L, Stanton PG Hormonal Regulation of Sertoli Cell microRNAs at Spermiation. Endocrinology 2011;152(4):1670-1683. Nicholls PK, Harrison CA, Walton KL, McLachlan RI, O’Donnell L, Stanton PG. Hormonal regulation of sertoli cell micro-RNAs at spermiation. Endocrinology 2011;152:1670-1683. Nicholls PK, Sun Z, Heng S, Li Y, Wang J, Nie G. Embryo implantation is closely associated with dynamic expression of proprotein convertase 5/6 in the rabbit uterus. Reproductive Biology and Endocrinology 2011;9:43. Nicol JL, Hoy WE, Su Q, Atkins RC, Polkinghorne KR. Reproducibility of Urinary Albumin Assays by Immunonephelometry After Long-term Storage at −70°C. Am J Kidney Dis 2011;58(4):685-7. Nie G, Stephens AN. A proteomic protocol to identify physiological substrates of pro-protein convertases. Methods in Molecular Biology 2011;768:325-341.

Nienaber JJ, Sharma Kuinkel BK, ClarkePearson M, Lamlertthon S, Park L, Rude TH, Barriere S, Woods CW, Chu VH, Marín M, Bukovski S, Garcia P, Corey GR, Korman T, Doco-Lecompte T, Murdoch DR, Reller LB, Fowler VG Jr; for the International Collaboration on Endocarditis-Microbiology Investigators. Methicillin-Susceptible Staphylococcus aureus Endocarditis Isolates Are Associated With Clonal Complex 30 Genotype and a Distinct Repertoire of Enterotoxins and Adhesins. J Infect Dis 2011;204(5):704-713. Nikpour M, Hissaria P, Byron J, Sahhar J, Micallef M, Paspaliaris W, Roddy J, Nash P, Sturgess A, Proudman S, Stevens W. Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort. Arthritis Research & Therapy 2011;13:R211 (22 December 2011). Nixon GM , Rodda CP, Davey MJ. Longitudinal association between growth hormone therapy and obstructive sleep apnoea in a child with Prader-Willi Syndrome. Journal of Clinical Endocrinology and Metabolism 2011;96:29-33. Nixon GM, Mihai R, Verginis N, Davey MJ. Patterns of continuous positive airway pressure adherence during the first 3 months of treatment in children. J Pediatr 2011;159(5):802-7. Nixon GM, Rodda C, Davey MJ. Longitudinal association between growth hormone therapy and obstructive sleep apnoea in a child with Prader Willi Syndrome. Journal of Clinical Endocrinology and Metabolism 2011;96:29-33. Nixon GM, Rodda CP, Davey MJ. Longitudinal association between growth hormone therapy and obstructive sleep apnea in a child with Prader-Willi syndrome. J Clin Endocrinol Metab 2011;96(1):29-33. Nixon GM, Verginis N, Mihai R, Davey MJ. Patterns of Continuous Positive Airway Pressure (CPAP) Adherence During the First Three Months of Treatment in Children. J Pediatr 2011;159(5):802-7.

Southern Health and MHTP Publications

Noonan C, Monagle J, Castanelli D. Development of a multi-source feedback tool for assessment of consultant anaesthetic performance. Australian Health Review 2011;35:141-145. Noonan C, Monagle J, Castanelli D. Development of a Multi-source Feedback Tool for Consultant Anaesthetist Performance. Australian Health Review 2011:35;141-145. Norbury LJ, Beckham S, Pike RN, Grams R, Spithill TW, Fecondo JV, et al. Adult and juvenile Fasciola cathepsin L proteases: different enzymes for different roles. Biochimie 2011;93(3):604-11. Novakovic B, Gordon L, Wong NC, Moffett A, Manuelpillai U, Craig JM, et al. Wide-ranging DNA methylation differences of primary trophoblast cell populations and derived cell lines: implications and opportunities for understanding trophoblast function. Mol Hum Reprod 2011;17(6):344-53. Nozaki Y, Nikolic-Paterson DJ, Snelgrove SL, Akiba H, Yagita H, Holdsworth SR, Kitching AR: Endogenous Tim-1 promotes T cell responses and cell mediated injury in experimental crescentic glomerulonephritis. Kidney Int E-pub 28 Dec 2011. Nozaki Y, Nikolic-Paterson DJ, Yagita H, Akiba H, Holdsworth SR, Kitching AR. Tim-1 promotes cisplatin nephrotoxicity. Am J Physiol Renal Physiol 2011;301(5):F1098-104. Nozaki Y, Nikolic-Paterson DJ, Yagita H, Akiba H, Holdsworth SR, Kitching AR: Tim-1 promotes cisplatin nephrotoxicity. Am J Physiol Renal Physiol 2011;301:F1098-1104. O’Callaghan C, Hudson P, McDermott F, Zalcberg J. ‘Music among family carers of people with life-threatening cancer’, Music and Medicine 2011;3(1)47-55. O’Connell B, Hawkins MT, Baker L, Ostaszkiewicz J. Care needs and functional status of older acute care patients. Research in Gerontological Nursing 2011;4(4):271-279.

O’Connell B, Orr J, Ostaszkiewicz J, Gaskin C. Nursing care needs of patients with and without dementia admitted to hospital with fractured neck of femur. International Journal of Orthopaedic and Trauma Nursing 2011;15:136-144. O’Connell B, Ostaszkiewicz J, Hawkins M. A suite of evidence-based continence assessment tools for residential aged care. Australasian Journal on Ageing 2011:30(1):27-32. O’Donnell L, Nicholls PK, O’Bryan MK, McLachlan RI, and Stanton PG. “Spermiation: The Process of Sperm Release” Spermatogenesis 2011;1(1):14-35. Oakley E, Deasey C, Robinson J. Using 0.45% normal saline solution and a modified dosing regimen for infusing N-acetylcysteine in children with paracetamol poisoning. Emergency Medicine Australasia 2011;23,63-67. Oakley, E. Deasey, C. Robinson, J. Using 0.45% normal saline solution and a modified dosing regimen for infusing N-acetylcysteine in children with paracetamol poisoning. Emergency Medicine Australasia 2011:23,63-67. Oberender F,Tibballs J. Withdrawal of Life Support in Paediatric Intensive care – a study of time intervals between discussion, decision and death. BMC Pediatrics 2011;11:39. O’Connell B, Ockerby CM, Johnson S, Smenda H, Bucknall TK. Team clinical supervision in acute hospital wards: A feasibility study. Western Journal of Nursing Research Epub 29th April 2011; doi:10.1177/0193945911406908. O’Connell BA, Moritz KM, Roberts CT, Walker DW, Dickinson H. The placental response to excess maternal glucocorticoid exposure differs between the male and female conceptus in spiny mice. Biol Reprod 2011;85(5):1040-7. O’Connor M, Hawkins M, Toumbourou J, Sanson A, Letcher P, Olsson C. The relationship between social capital and depression over the transition to adulthood. Australian Journal of Psychology 2011;63:26-35.

O’Connor M, Sanson A, Hawkins M, Letcher P, Toumbourou J, Smart D, Vassallo S, Olsson C. Predictors of positive development in emerging adulthood. Journal of Youth and Adolescence 2011;40:860-874. O’Connor M, Sanson A, Hawkins M, Toumbourou J, Letcher P, Frydenberg E. Differentiating three conceptualisations of the relationship between positive development and psychopathology during the transition to adulthood. Journal of Adolescence 2011;34:475-484. Odobasic D, Gan PY, Summers SA, Semple TJ, Muljadi RC, Iwakura Y, Kitching AR, Holdsworth SR. Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice. Am J Pathol 2011;179(3):1188-98. Odobasic D, Gan PY, Summers SA, Semple TJ, Muljadi RC, Iwakura Y, Kitching AR, Holdsworth SR. Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice. Am J Pathol 2011;179(3):1188-98. O’Donnell L, Nicholls PK, O’Bryan MK, McLachlan RI, Stanton PG. Spermiation: The process of sperm release. Spermatogenesis 2011;1:14-35. O’Driscoll DM, Horne RS, Davey MJ, Hope SA, Anderson V, Trinder J, et al. Increased sympathetic activity in children with obstructive sleep apnea: Cardiovascular implications. Sleep Med 2011;12(5):483-8. O’Driscoll DM, Horne RSC, Davey MJ, Hope SA, Anderson V, Trinder J, Walker AM, Nixon GM. Increased sympathetic activity in children with obstructive sleep apnea: Cardiovascular implications. Sleep Medicine 2011;12(5):483-488. O’Driscoll DM, Horne RSC, Davey MJ, Hope SA, Anderson V, Trinder J, Walker AM, Nixon GM. Increased Sympathetic Activity in Children with Obstructive Sleep Apnea: Cardiovascular Implications. Sleep Medicine 2011;12(5):483-488.

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O’Neill LA, Sheedy FJ, McCoy CE. MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nat Rev Immunol 2011;11(3):163-75. Onuma Y, Serruys PW, Gomez J, De Bruyne B, Dudek D, Thuesen L, Smits P, Chevalier B, McClean D, Koolen J, Windecker S, Whitbourn R, Meredith I, Garcia-Garcia H, Ormiston JA. Comparison of in vivo acute stent recoil between the bioresorbable everolimus-eluting coronary scaffolds (revision 1.0 and 1.1) and the metallic everolimus-eluting stent. Catheterization and Cardiovascular Interventions 2011;78(1):3-12. Ooi JD, Snelgrove SL, Engel DR, Hochheiser K, Ludwig-Portugall I, Nozaki Y, O’Sullivan KM, Hickey MJ, Holdsworth SR, Kurts C, Kitching AR. Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis. Kidney Int 2011;79(9):977-86. Ostaszkiewicz J, O’Connell B, Dunning T. Residents’ perspectives on urinary incontinence: a review of literature. Scandinavian Journal of Caring Sciences Epub 12th December 2011: doi:10.1111/j.1471-6712.2011.00959.x. O’Toole SA, Machalek DA, Shearer RF, Millar EK, Nair R, Schofield P, et al. Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer. Cancer Res 2011;71(11):4002-14. Ownsworth T, Fleming J, Haines T, Cornwell P, Kendall M, Nalder E, Gordon C. Development of depressive symptoms during early community reintegration after traumatic brain injury. Journal of the International Neuropsychological Society 2011;17(1):112-119. Paiva P, Hannan NJ, Hincks C, Meehan KL, Pruysers E, Dimitriadis E, Salamonsen LA. Human chorionic gonadotrophin regulates FGF2 and other cytokines produced by human endometrial epithelial cells, providing a mechanism for enhancing endometrial receptivity. Human Reproduction 2011;26:1153-1162.

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Paiva P, Whitehead C, Saglam B, Palmer K, Tong S. Measurement of mRNA transcripts of very high placental expression in maternal blood as biomarkers of preeclampsia. J Clin Endocrinol Metab 2011;96(11):1807-15. Palmer K, Saglam B, Whitehead C, Stock O, Lappas M, Tong S. Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression. Am J Pathol 2011;178(6):2484-8. Pan D, Tay K, Appu S, Frydenberg M. Primary Myeloid Sarcoma of the Bladder. Internet Journal of Urology, July 2011. Papadopoulos N, McGinley J, Tonge B, Bradshaw J, Saunders K, Murphy A, Rinehart N. Motor proficiency and emotional/behavioural disturbance in Autism and Asperger’s Disorder: another piece of the neurological puzzle? Autism 2011 Sept 26 [Epub] (doi:10.1177/1362361311418692). Parikh S, Brookhart MA, Stedman M, Avorn J, Mogun H, Solomon DH. Correlations of nursing home characteristics with prescription of osteoporosis medications. Bone 2011;48(5):1164-1168. Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, et al. A crucial requirement for Hedgehog signaling in small cell lung cancer. Nat Med 2011;17(11):1504-8. Patterson S, George J, Strasser S, Lee A, Sievert W, Nicoll A, Desmond P, Roberts S, Locarnini S, Bowden P, Angus S.Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B. Gut 2011;60:247-254. Paule S, Li Y, Nie G. Cytoskeletal remodelling proteins identified in fetal-maternal interface in pregnant women and rhesus monkeys. Journal of Molecular Histology 2011;42:161-166.

Paule S, Meehan K, Rainczuk A, Stephens AN, Nie G. Combination of hydrogel nanoparticles and proteomics to reveal secreted proteins associated with decidualization of human uterine stromal cells. Proteome Science 2011;9:50. Paz-Ares LG, Gomez-Roca C, Delord JP, Cervantes A, Markman B, Corral J, et al. Phase I pharmacokinetic and pharmacodynamic dose-escalation study of RG7160 (GA201), the first glycoengineered monoclonal antibody against the epidermal growth factor receptor, in patients with advanced solid tumors. J Clin Oncol 2011;29(28):3783-90. Pellatt L, Rice S, Dilaver N, Heshri A, Galea R, Brincat M, Brown K, Simpson ER, Mason HD. Anti-Mullerian hormone reduces follicle sensitivity to folliclestimulating hormone in human granulosa cells. Fertility and Sterility 2011;96:1246-1251. Pellegrino VA, Mudaliar Y, Gopalakrishnan M, Horton MD, Killick CJ, Parkin WG, Playford R, Raper RF. Computer based haemodynamic guidance system is effective and safe in management of postoperative patients. Anaesth Intensive Care 2011;39:191-201. Pellicano R, Strauss BJ, Polkinghorne KR, Kerr PG. Longitudinal body composition changes due to dialysis. Clin J Am Soc Nephrol 2011;6(7):1668-75. Phillips DJ, Harding PE, Bach LA. The history of the Endocrine Society of Australia. The first fifty years. Health History 2011;13(1):90-106. Pierce AB, Yohannes K, Guy R, Watson KM, Armishaw J, Price B, Hoy JF, Wright EJ, Stoové MA. HIV seroconversions among male nonoccupational post-exposure prophylaxis service users: a data linkage study. Sex Health 2011;8(2):179-83. Piganis RA, de Weerd NA, Gould JA, Schindler CW, Mansell A, Nicholson SE, et al. Suppressor of cytokine signaling (SOCS)1 inhibits type I interferon (IFN) signaling via the IFNAR1 associated tyrosine kinase, Tyk2. J Biol Chem 2011;286(39):33811-8.

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Pillow JJ, Musk GC, McLean CM, Polglase GR, Dalton RG, Jobe AH, et al. Variable ventilation improves ventilation and lung compliance in preterm lambs. Intensive Care Med 2011;37(8):1352-9. Pindel A, Sadler A. The role of protein kinase R in the interferon response. J Interferon Cytokine Res 2011;31(1):59-70. Pippal JB, Cheung CM, Yao YZ, Brennan FE, Fuller PJ. Characterization of the zebrafish (Danio rerio) mineralocorticoid receptor. Molecular and Cellular Endocrinology 2011;332:58-66. Pippal JP, Cheung CMI, Yao YZ, Brennan FE, Fuller PJ. Characterization of the zebrafish (Danio rerio) mineralocorticoid receptor. Molecular and Cellular Endocrinology 2011;332:58-66. Polekhina G, Ascher DB, Kok SF, Waltham M. Crystallization and preliminary X-ray analysis of the N-terminal domain of human thioredoxin-interacting protein. Acta Crystallogr Sect F Struct Biol Cryst Commun 2011;67(Pt 5):613-7. Polglase GR, Kluckow M, Gill AW, Allison BJ, Moss TJ, Dalton RG, et al. Cardiopulmonary haemodynamics in lambs during induced capillary leakage immediately after preterm birth. Clin Exp Pharmacol Physiol 2011;38(4):222-8. Polkinghorne KR. ACP Journal Club. An antimicrobial, antithrombotic lock solution reduced catheter-related bloodstream infections in patients receiving dialysis. Ann Intern Med 2011;155(4):JC2-11. Polkinghorne KR. Controversies in chronic kidney disease staging. Clin Biochem Rev 2011;32(2):55-9. Poulton DA, Schmolzer GM, Morley CJ, Davis PG. Assessment of chest rise during mask ventilation of preterm infants in the delivery room. Resuscitation 2011;82(2):175-9.

Pour SM, Woolley I, Canavan P, Chuah J, Russell DB, Law M, Petoumenos, K. Triple class experience after initiation of combination antiretroviral treatment in Australia: survival and projections. Sex Health 2011:8(3):295-303. Prasad SB, David T, Malaiapan Y, Cameron JD, Meredith IT. Selective drug-eluting stent implantation for high-risk patients with acute ST-elevation myocardial infarction: Rationale and safety. Catheterization and Cardiovascular Interventions 2011;77(2):193-200. Pratama G, Vaghjiani V, Tee JY, Liu YH, Chan J, Tan C, et al. Changes in culture expanded human amniotic epithelial cells: implications for potential therapeutic applications. PLoS One 2011;6(11):e26136. Prins M, Meadows G, Bobevski I, Graham A, Verhaak P, van der Meer K, et al. Perceived need for mental health care and barriers to care in the Netherlands and Australia. Soc Psychiatry Psychiatr Epidemiol 2011;46(10):1033-44. Priyadarshika R Capuge, Joeff C Crosbie, Beena K, Rogers PAW. Biodosimetric quantification of short-term synchrotron microbeam versus broad-beam radiation damage to mouse skin using a dermatopathological scoring system. The British Journal of Radiology 2011;84:833-842. Prowle JR, Echeverri JE, Ligabo EV, Sherry N, Taori GC, Crozier TM, Hart GK, Korman TM, Mayall BC, Johnson P, Bellomo R.: Acquired bloodstream infection in the intensive care unit: incidence and attributable mortality 2011, Critical care 15:R100. Purcell A, Fleming J, Burmeister B, Bennett S, Haines T. Is education an effective management strategy for reducing cancer-related fatigue? Supportive Care in Cancer 2011;19(9):1429-39.

Quach H, Fernyhough LJ, Henderson R, Corbett GM, Blacklock H, Hussein A, Lynch K, Dimpopoulos MA, Prince M. A Comparison of the Efficacy and Safety of Low-Dose Lenalidomide Plus Low-Dose Dexamethsone (rd) With Full Dose Lenalidomide + Dexamethaone (RD)in Pateints With Relapsed/ Reractory Multiple Myeloma (RRMM). Haematologica 2011;96(s1):105. Quach H, Hsu A (shared first author) et al. The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy [original study] Blood 2011;117:1605-1613. Quach H, Prince M, Spencer A. Treatment Of Multiple Myeloma In The Elderly: Are We Making Progress? [review article] Expert Rev Hematol 2011;4(3):301-305. Quach JM, Walker EC, Allan E, Solano M, Yokoyama A, Kato S, Sims NA, Gillespie MT, Martin TJ. Zinc finger protein 467 is a novel regulator of osteoblast and adipocyte commitment. The Journal of Biological Chemistry 2011;286:4186-4198. Rae PC, Kelly RD, Egginton S, St John JC. Angiogenic potential of endothelial progenitor cells and embryonic stem cells. Vasc Cell 2011;3(1):11. Rahman P, Huysmans RD, Wiradjaja F, Gurung R, Ooms LM, Sheffield DA, Dyson JM, Layton MJ, Sriratana A, Takada H, Tiganis T, Mitchell CA. Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton. J Biol Chem 2011;286(34):29758-70. Ramsden CA. High frequency ventilation: constraints of a slowly ticking clock. Acta Paediatrica 2011;100:9-11.

Quach H, Hsu A (shared first author) et al. Response: Dexamethasone dose alters expression of NK activating receptors. Blood 2011;118:6466-6468.

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Ratnam D, Dev A, Nguyen T, Sundararajan V, Harley H, Cheng W, Lee A, Rusli F, Chen R, Desmond P, Pianko S, Sievert W. Pegylated interferon α2a for chronic hepatitis B: a multicentre clinical experience. Journal of Gastroenterology and Hepatology 2011 Dec 14. doi:10.1111/j.1440-1746.2011.07051.x. [Epub ahead of print]. Ratnam I, Black J, Leder K, Biggs BA, Matchett E, Padiglione A, Woolley I, Panagiotidis T, Gherardin T, Pollissard L, Demont C, Luxemburger C, Torresi J. Incidence and seroprevalence of dengue virus infections in Australian travellers to Asia. Eur J Clin Microbiol Infect Dis 2011 Oct 9. [Epub ahead of print]. Ratnam I, Torresi J, Matchett E, Pollissard L, Luxemburg C, Lemoh CN, Black JF. Development and validation of an instrument to assess the risk of developing viral infections in Australian travelers during international travel. J Travel Med 2011;18(4):262-70. Rees S, Harding R, Walker D. The biological basis of injury and neuroprotection in the fetal and neonatal brain. Int J Dev Neurosci 2011;29(6):551-63. Reid A, Glass DC, Bailey HD, Milne E, de Klerk NH, Downie P, Fritschi L; Aus-ALL Consortium. Risk of childhood acute lymphoblastic leukaemia following parental occupational exposure to extremely low frequency electromagnetic fields. Br J Cancer 2011;105(9):1409-13. Reid S, Cozens A, Ditchfield M, Reddihough D, Fahey M. Should children with cerebral palsy and normal imaging undergo testing for inherited metabolic disorders? Developmental Medicine & Child Neurology 2011;53:226-232. Reinstein O, Neves MA, Saad M, Boodram SN, Lombardo S, Beckham SA, et al. Engineering a structure switching mechanism into a steroid binding aptamer and hydrodynamic analysis of the ligand binding mechanism. Biochemistry (Mosc) 2011;50(43):9368-76.

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Ricciardelli C, Frewin KM, Tan Ide A, Williams ED, Opeskin K, Pritchard MA, et al. The ADAMTS1 protease gene is required for mammary tumor growth and metastasis. Am J Pathol 2011;179(6):3075-85. Rickard AJ, Fuller PJ. The mineralocorticoid and epidermal growth factor receptors: partners in vivo. Hypertension 57:144-145, 2011. Rickard AJ, Fuller PJ. Mineralocorticoid and epidermal growth factor receptors: partners in vivo. Hypertension 2011;57:144-145. Ritchie GE, Kengne AP, Joshi R, Chow C, Neal B, Patel A, Zoungas S. Comparison of near-patient capillary glucose measurement and a risk assessment questionnaire in screening for type 2 diabetes in a high-risk population in rural India. Diabetes Care 2011;34(1):44-9. Robb RJ, Kreijveld E, Kuns RD, Wilson YA, Olver SD, Don AL, et al. Type I-IFNs control GVHD and GVL responses after transplantation. Blood 2011;118(12):3399-409. Roberts MA, Polkinghorne KR, McDonald SP, Ierino FL. Secular trends in cardiovascular mortality rates of patients receiving dialysis compared to the general population. Am J Kidney Dis 2011;58:64-72. Robertson DM, Hale GE, Fraser IS, Huges CL, Burger HG. Changes in serum anti-Mullerian hormone levels across the ovulatory menstrual cycle in late reproductive age. Menopause 2011;18:521-524. Robertson DM, Hale GE, Fraser IS, Hughes CL, Burger HG. Changes in serum antimullerian hormone levels across the ovulatory menstrual cycle in late reproductive age. Menopause 2011;18:521-524. Robertson DM. Hemochromatosis and ovarian cancer. Women’s Health (Lond Engl) 2011;7:525-527.

Rodrigues-Pereira J, Kim JH, Magallanes M, Lee DH, Wang J, Ganju V, et al. A randomized phase 3 trial comparing pemetrexed/carboplatin and docetaxel/ carboplatin as first-line treatment for advanced, nonsquamous non-small cell lung cancer. J Thorac Oncol 2011;6(11):1907-14. Rodrigues-Pereira J, Kim JH, Magallanes M, Lee DH, Wang J, Ganju V, MartinezBarrera L, Barraclough H, Kooten van M, Orlando M. A randomized phase 3 trial comparing pemetrexed/carboplatin and docetaxel/carboplatin as first-line treatment for advanced, nonsquamous non-small cell lung cancer. J Thorac Oncol 2011;6(11):1907-14. Rombauts L, Onwude JL, Chew HW, Vollenhoven BJ. The predictive value of antral follicle count remains unchanged across the menstrual cycle. Fertility & Sterility 2011;96:1514-1518. Rosen KM, Folker JE, Murdoch BE, Vogel AP, Cahill LM, Delatycki MB, Corben LA. (2011). Measures of spectral change and their application to habitual, slow and clear speaking modes. International Journal of SpeechLanguage Pathology 13(2):165-173. Rosen KM, Folker JE, Murdoch BE, Vogel AP, Cahill LM, Delatycki MB, Corben LA. Spectral measures of the effects of Friedreich’s ataxia on speech. International Journal of Speech-Language Pathology 2011;13(4):329-334. Russell G, Advocat J, Geneau R, Farrell B, Thille P, Ward N, Evans S. Examining organizational change in primary care practises: experiences from using ethnographic methods. Fam Pract 2011;117(1). Russell G, Building Ontario’s reform. Ann Fam Med. 2011. http://www.annfammed.org/cgi/ eletters/9/2/165. Ruwanpura SM, McLeod L, Miller A, Jones J, Bozinovski S, Vlahos R, Ernst M, Armes J, Bardin PG, Anderson GP, Jenkins BJ. Interleukin-6 promotes Pulmonary Emphysema Associated with Apoptosis in Mice. Am J Respir Cell Mol Biol 2011;45:720-30.

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Ruwanpura SM, McLeod L, Miller A, Jones J, Bozinovski S, Vlahos R, et al. Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice. Am J Respir Cell Mol Biol 2011;45(4):720-30. Ryan A, Lynch M, Smith SM, Amu S, Nel HJ, McCoy CE, et al. A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins. PLoS Pathog 2011;7(6):e1002076. Ryan J, Ludbrook L, Wilhelm D, Sinclair A, Koopman P, Bernard P, Harley VR. Analysis of gene function in cultured embryonic mouse gonads using nucleofection. Sexual Development 2011;5:7-15. Ryan J, Ma FY, Kanellis J, Delgado M, Blease K, Nikolic-Paterson DJ. Spleen tyrosine kinase promotes acute neutrophil-mediated glomerular injury via activation of JNK and p38 MAPK in rat nephrotoxic serum nephritis. Lab Invest 2011;91:1727-1738. Sadler AJ, Williams BR. Dynamiting Viruses with MxA. Immunity 2011;35(4):491-3. Said NA, Williams ED. Growth factors in induction of epithelial-mesenchymal transition and metastasis. Cells Tissues Organs 2011;193(1-2):85-97. Saleh H, Eeles D, Hodge JM, Nicholson GC, Gu R, Pompolo S, Gillespie MT, Quinn JMW. Interleukin-33, a target of parathyroid hormone and oncostatin m, increases osteoblastic matrix mineral deposition and inhibits osteoclast formation in vitro. Endocrinology 2011;152:1911-1922. Samarajeewa NU, Ham S, Yang F, Simpson ER, Brown KA. Promoter-specific effects of metformin on aromatase transcript expression. Steroids 2011;76:768-771. Sanchez-Partida LG, Kelly RD, Sumer H, Lo CY, Aharon R, Holland MK, et al. The generation of live offspring from vitrified oocytes. PLoS One 2011;6(6):e21597.

Sands SA, Edwards BA, Kee K, Turton A, Skuza EM, Roebuck T, et al. Loop gain as a means to predict a positive airway pressure suppression of CheyneStokes respiration in patients with heart failure. Am J Respir Crit Care Med 2011;184(9):1067-75. Sawhney R, Visvanathan K. Polymorphisms of Toll-like receptors and their pathways in viral hepatitis. Antivir Ther 2011;16(4):443-58. Saxena A, Diem D, Poh C-L, Smith JA, Shardey GC, Newcomb A. Analysis of early and late outcomes after concomitant aortic valve replacement and coronary artery bypass graft surgery in octogenarians: a multi-institutional Australian study. J Am Geriatr Soc 2011;59:1759-61. Saxena A, Dinh D, Smith JA, Shardey GC, Newcomb AE. Does patient gender affect outcomes after concomitant coronary artery bypass graft and aortic valve replacement? An Australasian Society of Cardiac and Thoracic Surgeons database study? Cardiology 2011;119:116-23. Saxena A, Dinh D, Yap C-H, Smith JA, Shardey GC, Newcomb AE. Critical analysis of early and late outcomes after isolated coronary artery bypass surgery in elderly patients. Ann Thorac Surg 2011;92:1703-11. Sayakhot P, Vincent A, Deeks A, Teede H. Potential adverse impact of ovariectomy on physical and psychological function of younger women with breast cancer. Menopause 2011;18(7):786-793. Sayakhot P, Vincent A, Deeks A, Teede H. Potential adverse impact of ovariectomy on physical and psychological function of younger women with breast cancer. Menopause 2011;18(7):786-93. Scally K, Charlton JL, Iansek R, Bradshaw JL, Moss S, GeorgiouKaristianis N. Impact of external cue validity on driving performance in Parkinson’s disease. Parkinsons Dis 2011;2011(2011): Article ID 159621.

Schilleman K, Schmolzer GM, Kamlin OC, Morley CJ, te Pas AB, Davis PG. Changing gas flow during neonatal resuscitation: a manikin study. Resuscitation 2011;82(7):920-4. Schmolzer GM, Dawson JA, Kamlin CO, O’Donnell CP, Morley CJ, Davis PG. Airway obstruction and gas leak during mask ventilation of preterm infants in the delivery room. Arch Dis Child Fetal Neonatal Ed 2011;96(4):F254-7. Schmolzer GM, Kamlin CO, Dawson JA, Morley CJ, Davis PG. Tidal volume delivery during surfactant administration in the delivery room. Intensive Care Med 2011;37(11):1833-9. Schmolzer GM, Poulton DA, Dawson JA, Kamlin CO, Morley CJ, Davis PG. Assessment of flow waves and colorimetric CO2 detector for endotracheal tube placement during neonatal resuscitation. Resuscitation 2011;82(3):307-12. Schmolzer GM, Roehr CC. Use of respiratory function monitors during simulated neonatal resuscitation. Klin Padiatr 2011;223(5):261-6. Schoenberger M, Ponsford J, Reutens D, Beare R, Clarke DM, O’Sullivan R. The relationship between mood disorders and MRI findings following traumatic brain injury. Brain Injury 2011;25(6):543-50. Schofield DJ, Meachem S, West C, Kavallaris M, Callander EJ. A crisis in the making? Education, ageing populations and the future of the medical research workforce. Medical Education 2011;45:200-207. Sehgal A, Francis JV, Lewis A. Use of Milrinone in the Management of Haemodynamic Instability Following Duct Ligation. Eur J Pediatr 2011;170(1):115-9. Sehgal A, Francis JV. Haemodynamic consequences of polycythemia. J Perinatol 2011;31(2):143-145. Sehgal A, McNamara PJ. Staging the ductus arteriosus facilitates identification of neonates at increased risk of respiratory morbidity. J Neonatal Perinatal Med 2011;4(1):13-16.

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Sehgal A. Haemodynamically unstable preterm infant: an unresolved management conundrum. European Journal of Pediatrics 2011;170(10):1237-1245. Sehgal A. Suprasternal Optical Window to Doppler the Superior Vena Cava in Neonates. J Echocardiography 2011;9(3):121-122. Serra V, Scaltriti M, Prudkin L, Eichhorn PJ, Ibrahim YH, Chandarlapaty S, et al. PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer. Oncogene 2011;30(22):2547-57. Serruys PW, Onuma Y, Dudek D, Smits PC, Koolen J, Chevalier B, De Bruyne B, Thuesen L, McClean D, Van Geuns RJ, Windecker S, Whitbourn R, Meredith I, Dorange C, Veldhof S, Hebert KM, Sudhir K, Garcia-Garcia HM, Ormiston JA. Evaluation of the second generation of a bioresorbable everolimus-eluting vascular scaffold for the treatment of de Novo Coronary Artery stenosis: 12-month clinical and imaging outcomes. Journal of the American College of Cardiology 2011;58(15):1578-1588. Sevenhuysen S, Haines TP. The Slave Of Duty: Why Clinical Educators Across The Continuum Of Care Provide Clinical Education In Physiotherapy. Hong Kong Physiotherapy Journal 2011;29:64-70. Shi W, Hayward PA, Yap CH, Diem DT, Reid CM, Shardey GC, Smith JA. Training in mitral valve surgery need not affect early outcomes and mid-term survival: a multicenter analysis. Eur J Cardiothorac Surg 2011;40:826-833. Shi W, Yap C-H, Hayward PA, Dinh D, Reid CM, Shardey GC, Smith JA. Impact of prosthesis-patient mismatch after mitral valve replacement: a multicenter analysis of early outcomes and midterm survival. Heart 2011;97:1074-81. Shilton H, Goldschlager T, Kelman A, Xenos C. Delayed post-traumatic capillary haemangioma of the spine. J Clin Neurosci 2011;18(11):1546-7.

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Shoushtarian M, Murphy A, Iansek R. Examination of central gait control mechanisms in Parkinson’s disease using movement-related potentials. Movement Disorders 2011;26(13):2347-2353. Shuya LL, Menkhorst EM, Yap J, Li P, Lane N, Dimitriadis E. Leukemia inhibitory factor enhances endometrial stromal cell decidualization in humans and mice. PLoS One 2011;6:e25288. Sievert W, Altraif I, Razavi HA, Abdo A, Ahmed EA, AlOmair A, Amarapurkar D, Chen C-H, Dou X, Khayat El H, elShazly M, Esmat G, Guan R, Han K-H, Koike K, Largen A, McCaughan G, Mogawer S, Monis A, Nawaz A, Piratvisuth T, Sanai FM, Sharara AI, Sibbel S, Sood A, Suh DJ, Wallace C, Young K, Negro F. A systematic review of HCV epidemiology in Asia, Australia and Egypt. Liver International 2011;31 2:61-80. Sievert W, Dore GJ, McCaughan GW, Yoshihara M, Crawford DHG, Cheng W, Weltman M, Rawlinson W, Rizkalla B, DePamphilis JK, Roberts SK. Virological response is associated with decline in hemoglobin concentration during pegylated interferon and ribavirin therapy in HCV genotype 1. Hepatology 2011;53:1109-1117.

Singh H, Endo Y, Nie G. Decidual HtrA3 negatively regulates trophoblast invasion during human placentation. Human Reproduction 2011;26:748-757. Singh PP, Joshi S, Russell PJ, Nair S, Khatri A. Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: a tangible union against chemoresistant cancer. BMC Cancer 2011;11:368. Singh PP, Joshi S, Russell PJ, Verma ND, Wang XC, Khatri A. Molecular chemotherapy and chemotherapy: A new front against late-stage hormone-refractory prostate cancer. Clinical Cancer Research 2011;17:4006-4018. Sinni S, Cross W, Wallace EW. Patient safety: a literature review to inform an evaluation of a maternity services. Midwifery 2011;27(6):E274-8. Sinni SV, Cross WM, Wallace EM. Designing a clinical audit tool to measure processes of pregnancy care Nursing: Research and Reviews 2011;1(1):15-25. Sinni SV, Wallace EM, Cross WM. Patient safety: A literature review to inform an evaluation of a maternity service. Midwifery 2011;27(6):274-8.

Siew ML, Te Pas AB, Wallace MJ, Kitchen MJ, Islam MS, Lewis RA, et al. Surfactant increases the uniformity of lung aeration at birth in ventilated preterm rabbits. Pediatr Res 2011;70(1):50-5.

Siva B, McDonald SP, Hawley CM, Rosman JB, Brown FG, Wiggins KJ, Bannister KM, Campbell SB, Johnson DW. End stage kidney disease due to scleroderma – outcomes in 127 consecutive ANZDATA registry cases. Nephrol Dial Transplant 2011;26(10):3165-71.

Silas R, Sehgal A, Walker AM, Wong FY. Cerebral oxygenation during subclinical seizures in neonatal hypoxic-ischaemic encephalopathy. Eur J Paediatr Neurol.

Skinner EH, Warrillow S, Denehy L. Health-related quality of Life in Australian survivors of critical illness. Crit Care Medicine 2011;39(8).

Sim H, Argentaro A, Czech DP, BagheriFam S, Sinclair AH, Koopman P, Boizet-Bonhoure B, Poulat F, Harley VR. Inhibition of SRY-calmodulin complex formation induces ectopic expression of ovarian cell markers in developing XY gonads. Endocrinology 2011;152:2883-2893.

Skinner EH, Warrillow S, Denehy L. Health-related quality of life in Australian survivors of critical illness. Crit Care Med 2011;39(8):1896-1905. Skubisz M, Lee J, Wallace E, Tong S. Decline in betahCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study. BJOG 2011;118(13):1665-8.

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Skubisz M, Lee J, Wallace EM, Tong S. Decline in ss hCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success. BJOG 2011;118(13);1665-8. Skubisz MM, Tong S. Of leaves and butterflies: how methotrexate came to be the savior of women. Obstet Gynecol 2011;118(5):1169-73. Sobotka KS, Hooper SB, Allison BJ, Te Pas AB, Davis PG, Morley CJ, et al. An initial sustained inflation improves the respiratory and cardiovascular transition at birth in preterm lambs. Pediatr Res 2011;70(1):56-60. Sonderegger S, Yap J, Menkhorst E, Weston G, Stanton PG, Dimitriadis E. Interleukin (IL)11 mediates protein secretion and modification in human extravillous trophoblasts. Human Reproduction 2011;26:2841-2849. Song B, Niclis JC, Alikhan MA, Sakkal S, Sylvain A, Kerr PG, Laslett AL, Bernard CA, Ricardo SD. Generation of induced pluripotent stem cells from human kidney mesangial cells. J Am Soc Nephrol 2011;22(7):1213-20. Sozo F, Vela M, Stokes V, Kenna K, Meikle PJ, De Matteo R, et al. Effects of prenatal ethanol exposure on the lungs of postnatal lambs. Am J Physiol Lung Cell Mol Physiol 2011;300(1):L139-47. Spernat D, Aw H, Eapen R, Appu S. The Use of Hyperbaric Oxygen Therapy in Radiation-Induced Haemorrhagic Cystitis. The Internet Journal of Urology 2011 Volume 8 Number 2 2011;8(2). Spernat D, Tay Y, Donnellan S. Androgen Deprivation and Exercise Tolerance. The Internet Journal of Urology 2011 Volume 8 Number 2 2011;8(2). Sprung CN, Cholewa M, Usami N, Kobayashi K, Crosbie JC. DNA damage and repair kinetics after microbeam radiation therapy emulation in living cells using monoenergetic synchrotron X-ray microbeams. J Synchrotron Radiat 2011;18(Pt 4):630-6.

Sprung CN, Li J, Hovan D, McKay MJ, Forrester HB. Alternative transcript initiation and splicing as a response to DNA damage. PLoS One 2011;6(10):e25758. Steinmetz OM, Summers SA, Gan PY, Semple T, Holdsworth SR, Kitching AR. The Th17-defining transcription factor RORgammat promotes glomerulonephritis. J Am Soc Nephrol 2011;22(3):472-83. Stephan-Blanchard E, Chardon K, Telliez F, Arnould JP, Leke A, Ammari M, et al. Are Benzo[a]pyrene-DNA adducts an accurate biomarker of long-term in utero exposure to smoking? Ther Drug Monit 2011;33(3):329-35. Stone GW, Teirstein PS, Meredith IT, Farah B, Dubois CL, Feldman RL, Dens J, Hagiwara N, Allocco DJ, Dawkins KD. A prospective, randomized evaluation of a novel everolimus-eluting coronary stent: The PLATINUM (a prospective, randomized, multicenter trial to assess an everolimus-eluting coronary stent system [PROMUS element] for the treatment of up to two de novo coronary artery lesions) trial. Journal of the American College of Cardiology 2011;57(16):1700-1708. Strachan R, Jaffe A on behalf of the Australian Research Network in Empyema (ARNiE) (including GM Nixon). Pleural fluid nucleic acid testing enhances Pneumococcal surveillance in children. Respirology 2011 August 17 [Epub ahead of print]. Strachan R, Jaffe A on behalf of the Australian Research Network in Empyema (ARNiE) (including GM Nixon). Recommendations for managing paediatric empyema thoracis. Position statement from the Thoracic Society of Australia and New Zealand. MJA 2011;195:95. Strachan RE, Cornelius A, Gilbert G et al. on behalf of the Australian Research Network in Empyema (ARNiE) (including GM Nixon). Bacterial Causes of Emypema in Children, Australia, 2007-2009. Emerg Infect Dis 2011;17(10):1839-1845.

Strachan RE, Cornelius A, Gilbert GL, Gulliver T, Martin A, McDonald T, et al. A bedside assay to detect streptococcus pneumoniae in children with empyema. Pediatr Pulmonol 2011;46(2):179-83. Strachan RE, Cornelius A, Gilbert GL, Gulliver T, Martin A, McDonald T, et al. Bacterial causes of empyema in children, Australia, 2007-2009. Emerg Infect Dis 2011;17(10):1839-45. Strachan RE, Cornelius A, Gilbert GL, Gulliver T, Martin A, McDonald T, Nixon G, Roseby R, Ranganathan S, Selvadurai H, Smith G, SotoMartinez M, Suresh S, Teoh L, Thapa K, Wainwright C, Jaffé A on behalf of the Australian Research Network in Empyema (ARNiE). A bedside assay to detect streptococcus pneumoniae in children with empyema. Pediatr Pulmonol 2011;46(2):179-83. Stuart RL and Marshall C. Clostridium difficile Infection – A new threat on our doorstep. Med J Australia 2011;194:331-332. Stuart RL Marshall C, McLaws M, Boardman C, Russo PL, Harrington G, Ferguson JK. ASID/AICA position statement – Infection control guidelines for patients with Clostridium difficile infection in healthcare settings. Healthcare Infect 2011;16(1):33-39. Stuart RL, Kotsanas D, Gillespie EE et al. High prevalence of multiresistant E coli in residential aged care facilities. MJA 2011;195:530-533. Stuart RL, Kotsanas D, Webb B, Vandergraff S, Gillespie EE, Hogg GG, Korman TM. Prevalence of antimicrobial-resistant organisms in residential aged care facilities. Med J Aust 2011;195(9):530-3. Stuart RL, Marshall C, McLaws ML, Boardman C, Russo PL, Harrington G, Ferguson JK. ASID/AICA Position Statement: Infection Control Guidelines for Patients with Clostridium difficile Infection in Healthcare Settings. Healthcare Infection 2011;16:33-39.

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Stuart RL, Marshall C. Clostridium difficile infection: a new threat on our doorstep. Med J Aust 2011;194(7):331-2. Sumer H, Liu J, Malaver-Ortega LF, Lim ML, Khodadadi K, Verma PJ. NANOG is a key factor for induction of pluripotency in bovine adult fibroblasts. J Anim Sci 2011;89(9):2708-16. Sumer H, Liu J, Verma PJ. Cellular reprogramming of somatic cells. Indian J Exp Biol 2011;49(6):409-15. Summers SA, Chan J, Gan PY, Dewage L, Nozaki Y, Steinmetz OM, NikolicPaterson DJ, Kitching AR, Holdsworth SR. Mast Cells Mediate Acute Kidney Injury through the Production of TNF. J Am Soc Nephrol 2011;22(12):2226-36. Summers SA, Chan J, Gan P-Y, Dewage L, Nozaki Y, Steinmetz OM, NikolicPaterson DJ, Kitching AR, Holdsworth SR: Mast cells induce acute kidney injury through the production of TNF. J Am Soc Nephrol 2011;22:2226-2236. Summers SA, Phoon RK, Odobasic D, Dewage L, Kitching AR, Holdsworth SR. Signal transducer and activation of transcription 6 (STAT6) regulates T helper type 1 (Th1) and Th17 nephritogenic immunity in experimental crescentic glomerulonephritis. Clin Exp Immunol 2011;166(2):227-34. Summers SA, Phoon RK, Odobasic D, Dewage L, Kitching AR, Holdsworth SR. Signal transducer and activation of transcription 6 (STAT6) regulates T helper type 1 (Th1) and Th17 nephritogenic immunity in experimental crescentic glomerulonephritis. Clin Exp Immunol 2011;166(2):227-34. Summers SA, Phoon RK, Ooi JD, Holdsworth SR, Kitching AR. The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses. Am J Pathol 2011;178(2):580-90. Summers SA, Phoon RK, Ooi JD, Holdsworth SR, Kitching AR. The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses. Am J Pathol 2011;178(2):580-90.

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Summers SA, Steinmetz OM, Gan PY, Ooi JD, Odobasic D, Kitching AR, Holdsworth SR. Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis. Arthritis Rheum 2011;63(4):1124-35. Sutherland MR, Gubhaju L, Moore L, Kent AL, Dahlstrom JE, Horne RS, et al. Accelerated maturation and abnormal morphology in the preterm neonatal kidney. J Am Soc Nephrol 2011;22(7):1365-74. Sutton E, Hughes J, White S, Sekido R, Tan J, Arboleda V, et al. Identification of SOX3 as an XX male sex reversal gene in mice and humans. J Clin Invest 2011;121(1):328-41. Sutton E, Hughes J, White S, Sekido R, Tan J, Arboleda V, Rogers N, Knower K, Rowley L, Eyre H, Rizzoti K, McAninch D, Goncalves J, Slee J, Turbitt E, Bruno D, Bengtsson H, Harley V, Vilain E, Sinclair A, Lovell-Badge R, Thomas P. Identification of SOX3 as an XX male sex reversal gene in mice and humans. Journal of Clinical Investigation 2011;121:328-341. Swan MP, Bourke MJ, Moss A, Williams SJ, Hopper A, Metz A. The target sign: an endoscopic marker for the resection of the muscularis propria and potential perforation during colonic endoscopic mucosal resection. Gastrointest Endosc 2011 Jan;73(1):79-85.

Tan DM, McGinley JL, Danoudis M, Iansek R, Morris ME. Freezing of gait and activity limitations in people with Parkinson’s disease. Archives of Physical Medicine and Rehabilitation 2011;92(7):1159-1165. Tan J, Lau K. Multi-detector CT/CT angiogram assessment of Acute Pancreatic Graft Dysfunction. Journal of Medical Imaging and Radiation Oncology 2011;55(6):571-576. Tan Z-Y, Burnes J. Post-traumatic prepubertal high-flow priapism: Bilateral superselective embolisation. Journal of Medical Imaging and Radiation Oncology 2011;55(5):498-501. Tang P, Argentaro A, Pask AJ, O’Donnell L, Marshall-Graves J, Familari M, Harley VR. Localization of the chromatin remodelling protein, ATRX in the adult testis. The Journal of Reproduction and Development 2011;57:317-321. Tang P, Frankenberg S, Argentaro A, Graves JM, Familari M. Comparative analysis of the ATRX promoter and 5’ regulatory region reveals conserved regulatory elements which are linked to roles in neurodevelopment, alphaglobin regulation and testicular function. BMC Research Notes 2011;4:200. Tat PA, Sumer H, Pralong D, Verma PJ. The efficiency of cell fusion-based reprogramming is affected by the somatic cell type and the in vitro age of somatic cells. Cell Reprogram 2011;13(4):331-44.

Swan MP, Bourke MJ, Williams SJ, Alexander S, Moss A, Hope R, Ruppin D. Failed biliary cannulation: clinical and technical outcomes after tertiary referral endoscopic retrograde cholangiopancreatography. World J Gastroenterol 2011;7;17(45):4993-8.

Tate MD, Brooks AG, Reading PC. Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus. Microbes Infect 2011;13(2):202-7.

Swan MP, Donnellan F, Kandel G Safe and effective dilatation in eosinophilic esophagitis: the tale of two subgroups. Gastrointest Endosc 2011;73(2):408-9.

Tate MD, Brooks AG, Reading PC. Inhibition of lectin-mediated innate host defences in vivo modulates disease severity during influenza virus infection. Immunol Cell Biol 2011;89(3):482-91.

Southern Health and MHTP Publications

Tate MD, Brooks AG, Reading PC. Receptor specificity of the influenza virus hemagglutinin modulates sensitivity to soluble collectins of the innate immune system and virulence in mice. Virology 2011;413(1):128-38. Tate MD, Brooks AG, Reading PC. Specific sites of N-linked glycosylation on the hemagglutinin of H1N1 subtype influenza A virus determine sensitivity to inhibitors of the innate immune system and virulence in mice. J Immunol 2011;187(4):1884-94. Tate MD, Ioannidis LJ, Croker B, Brown LE, Brooks AG, Reading PC. The role of neutrophils during mild and severe influenza virus infections of mice. PLoS One 2011;6(3):e17618. Tate MD, Job ER, Brooks AG, Reading PC. Glycosylation of the hemagglutinin modulates the sensitivity of H3N2 influenza viruses to innate proteins in airway secretions and virulence in mice. Virology 2011;413(1):84-92. Tate MD, Schilter HC, Brooks AG, Reading PC. Responses of mouse airway epithelial cells and alveolar macrophages to virulent and avirulent strains of influenza A virus. Viral Immunol 2011;24(2):77-88. Taylor J, Sims J, Haines T. The impact of manual handling on nursing home resident mobility during transfers on and off furniture: a systematic review. Journal of Gerontological Nursing 2011;37(8):48-56. Tebbutt NC, Murphy F, Zannino D, Wilson K, Cummins MM, Abdi E, Strickland AH, Lowenthal RM, Marx G, Karapetis C, Shannon J, Goldstein D, Nayagam SS, Blum R, Chantrill L, Simes RJ, Price TJ. Risk of arterial thromboembolic events in patients with advanced colorectal cancer receiving bevacizumab. Ann Oncol 2011. Teede H and Vincent A. Hormone Therapy: Where are we now? Australian Family Physician 2011;40(5):280-285.

Teede H Misso ML, Deeks AA, Moran LJ, Stuckey BG, Wong JL, Norman RJ, Costello MF; The Guideline Development Groups. Assessment and management of polycystic ovary syndrome: summary of an evidencebased guideline. Medical Journal of Australia 2011;195:suppl 65-112. Teede H, Vincent A. Hormone Therapy: Where are we now? Australian Family Physician 2011;40(5):280-285. Teede HJ, Harrison CL, Teh WT, Paul E, Allan CA. Gestational diabetes: Development of an early risk prediction tool to facilitate opportunities for prevention. Aust N Z J Obstet Gynaecol 2011;51(6):499-504. Teede HJ, Harrison CL, Teh WT, Paul E, Allan CA. Gestational Diabetes: development of an early risk prediction tool to facilitate opportunities for prevention. Aust N Z J Obstet Gynaecol 2011;51(6):499-504. Teede HJ, Harrison CL, Teh WT, Paul E, Allan CA. Gestational diabetes: Development of an early risk prediction tool to facilitate opportunities for prevention. Aust N Z J Obstet Gynaecol 2011;51(6):499-504. Teede HJ, Misso ML, Deeks AA, Moran LJ, Stuckey BG, Wong JL, Norman RJ, Costello MF; The Guideline Development Groups. Assessment and management of polycystic ovary syndrome: summary of an evidence-based guideline. Med J Aust 2011;195(6):s65-s112. Teede HJ, Misso ML, Deeks AJ, Moran LJ, Stuckey BGA, Wong JLA, Norman RJ, Costello MF. Assessment and Management of Polycystic ovarian syndrome: Summary of Evidence Based Guidelines. MJA 2011;195(6)S65-112. Teh WT, Teede HJ, Paul E, Harrison C, Wallace EM, Allan CA. Risk Factors for Gestational Diabetes Mellitus: Implications for the Application of Screening Guidelines. Aust N Z J Obstet Gynaecol 2011;51(1):26-30.

Teh WT, Teede HJ, Paul E, Harrison CL, Wallace EM, Allan C. Risk factors for gestational diabetes mellitus: implications for the application of screening guidelines. Aust N Z J Obstet Gynaecol 2011;51(1):26-30. Teh WT, Teede HJ, Paul E, Harrison CL, Wallace EM, Allan CA. Re: Risk factors for gestational diabetes mellitus: Implications for the application of screening guidelines. Aust N Z J Obstet Gynaecol 2011;51(4):383-384. Teh WT, Teede, H, Harrison C, Paul E, Wallace EM, Allan C. Risk factors for gestational diabetes mellitus: implications for the Application of Screening Guidelines. Aust NZ J Obstet Gynaecol 2011;51(1):26-30. Tesch GH, Lim AK. Recent insights into diabetic renal injury from the db/ db mouse model of type 2 diabetic nephropathy. Am J Physiol Renal Physiol 2011;300(2):F301-10. Testro AG, Visvanathan K, Skinner N, Markovska V, Crowley P, Angus PW, Gow PJ. Acute allograft rejection in human liver transplant recipients is associated with signaling through toll-like receptor 4. J Gastroenterol Hepatol 2011;26(1):155-63. Thai W-E, Gelman J. Persistent left with absent right superior vena cava. Heart 2011;97(1):88. Thai WE, Gelman JS. Descending thoracic aortic atherothrombus, a forgotten source of mesenteric embolism: Role of three-dimensional transoesophageal echocardiography. Heart Asia 2011;3(1):31. Thirugnanasambathan T, Hawley CM, Badve SV, McDonald SP, Brown FG, Boudville N, Wiggins KJ, Bannister KM, Clayton P, Johnson DW. Repeated peritoneal dialysis related peritonitis: A multicentre registry study. Am J Kidney Dis 2011 Aug 15. [Epub ahead of print].

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Thomas SA, Merkouris SS, Radermacher HL, Dowling NA, Misso ML, Anderson CJ, Jackson AC. Australian guideline for treatment of problem gambling: an abridged outline. Med J Aust 2011;195(11-12):664-5. Toivanen R, Berman DM, Wang H, Pederson J. Frydenberg M, Meeker AK, Ellem, SJ, Risebridger GP, Taylor RA. Brief Report: a bioassay to identify primary human prostate cancer repopulating cells. Stem cells 2011;1310-4. Tolcos M, Bateman E, O’Dowd R, Markwick R, Vrijsen K, Rehn A, et al. Intrauterine growth restriction affects the maturation of myelin. Exp Neurol 2011;232(1):53-65. Tonge B, Kenny R, Stanic D, Simpson E, Rinehart N, Boon WC. Testing the ‘Extreme male brain theory’. Journal of Intellectual Disability Research 2011;55:954-954. Toussaint N, Lau K, Polkinghorne K, Kerr P. Attenuation of aortic calcification with lanthanum carbonate vs calcium-based phosphate binders in haemodialysis – a pilot randomized controlled trial. Nephrology 2011;16:290-298. Toussaint N, Pedagogos E, Lau K, Heinze S, Becker G, Beavis J, Polkinghorne K, Damasiewicz M. Lateral lumber x-ray assessment of abdominal aortic calcifications in Australian haemodialysis patients. Nephrology 2011;16:389-395. Toussaint ND, Pedagogos E, Beavis J, Becker GJ, Polkinghorne KR, Kerr PG. Improving CKD-MBD management in haemodialysis patients: barrier analysis for implementing better practice. Nephrol Dial Transplant 2011;26(4):1319-26. Toussaint ND, Pedagogos E, Lau KK, Heinze S, Becker GJ, Beavis J, Polkinghorne KR, Damasiewicz MJ, Kerr PG. Lateral lumber X-ray assessment of aortic calcification in Australian haemodialysis patients. Nephrology 2011;16(4):389-95.

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Tran H. Lower-dose Lenalidomide and Dexamethasone Reduces Toxicity Without Compromising Efficacy in Patients with Relapsed/Refractory Myeloma, Who are Aged >60 years or have Renal Impairment: Planned Interim Results of a Prospective Multicentre Phase II Trial. Blood 2011;116:1639. Tran TD, Tran T, La B, Lee D, Rosenthal D, Fisher J. Screening for perinatal common mental disorders in women in the north of Vietnam: a comparison of three psychometric instruments. J Affect Disord 2011;133(1-2):281-93. Troupis J, Crossett M, Scneider-Kolsky M, Nandurkar D. Presence of accessory left atrial appendage/diverticula in a population with atrial fibrillation compared with those in sinus rhythm: a retrospective review. Int J Cardiovasc Imaging 2011 Feb 18. Truong QA, Bamberg F, Mahabadi AA, Toepker M, Lee H, Rogers IS, Seneviratne SK, Schlett CL, Brady TJ, Nagurney JT, Hoffmann U. Left atrial volume and index by multi-detector computed tomography: Comprehensive analysis from predictors of enlargement to predictive value for acute coronary syndrome (ROMICAT study). International Journal of Cardiology 2011;46(2):171-176. Tucker EJ, Hershman SG, Kohrer C, Belcher-Timme CA, Patel J, Goldberger OA, et al. Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation. Cell Metab 2011;14(3):428-34. Turner J, Kelly B, Clarke DM, Yates P, Aranda S, Jolley D, Chambers S, Hargreaves M, McFadyen L. A randomised trial of a psychosocial intervention for cancer patients integrated into routine care: The PROMPT study (Promoting Optimal Outcomes in Mood through tailored Psychosocial Therapies). BMC Cancer 2011;11:48.

Valkov E, Stamp A, Dimaio F, Baker D, Verstak B, Roversi P, et al. Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci USA 2011;108(36):14879-84. Van Schil PE, Hendriks JM, Hertoghs M, Lauwers P, Choong CK. Current surgical treatment of non-small-cell lung cancer. Expert Rev Anticancer Ther 2011;11(10):1577-85. Van Zuylen WJ, Garceau V, Idris A, Schroder K, Irvine KM, Lattin JE, et al. Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for schlafen-4 as a modulator of myelopoiesis. PLoS One 2011;6(1):e15723. Veiga-Lopez A, Steckler TL, Abbott DH, Welch KB, MohanKumar PS, Phillips DJ, et al. Developmental programming: impact of excess prenatal testosterone on intrauterine fetal endocrine milieu and growth in sheep. Biol Reprod 2011;84(1):87-96. Veldman A, Hennermann JB, Schwarz G, van Spronsen F, Weis I, Wong FY, et al. Timing of cerebral developmental disruption in molybdenum cofactor deficiency. J Child Neurol 2011;26(8):1059-60; author reply 61. Veldman A, Hennermann JB, Schwarz G, van Spronsen F, Weis I, Wong FY, et al. Timing of cerebral developmental disruption in molybdenum cofactor deficiency. J Child Neurol 2011;26(8):1059-60. Ventieri D, Clarke DM, Hay M. The effects of a school-based educational intervention on pre-adolescents’ knowledge and attitudes towards mental illness. Advances in School Mental Health Promotion 2011;4(3):5-17.

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Verma R, Holland MK, Temple-Smith PD, Verma PJ. Inducing pluripotency in somatic cells from the snow leopard (Panthera uncia), an endangered felid. Theriogenology doi.org/10.1016/ j.theriogenology.2011.09.022. Vivanti A, Horgan N, Haines T. Nutritional status and associations with falls, balance, mobility and functionality during hospital admission. The  Journal of Nutrition, Health and Ageing 2011;15(5):388-391. Vosdoganes P, Hodges RJ, Lim R, Westover AJ, Acharya RY, Wallace EM, et al. Human amnion epithelial cells as a treatment for inflammation-induced fetal lung injury in sheep. Am J Obstet Gynecol 2011;205(2):26-33. Vosdoganes P, Hodges RJ, Lim R, Westover AJ, Acharya RY, Wallace EM, Moss TJM. Human amnion epithelial cells as a treatment for inflammation-induced fetal lung injury in sheep. Am J Obstet Gynecol 2011;205(2):156.e26-33. Vremec D, O’Keeffe M, Wilson A, Ferrero I, Koch U, Radtke F, et al. Factors determining the spontaneous activation of splenic dendritic cells in culture. Innate Immun 2011;17(3):338-52. Wadd K, King L, Bennett PN, Grant J. Being a parent on dialysis: A literature review. Journal of Renal Care 2011;37(4):208-215. Wainwright CE, Vidmar S, Armstrong DS, Byrnes CA, Carlin JB, Cheney J, Cooper PJ, Grimwood K, Moodie M, Robertson CF, Tiddens HA; ACFBAL Study Investigator. Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung inquiry in children with cystic fibrosis: a randomized trial. JAMA 2011 Jul 13;2-6. Walker KA, Sims-Lucas S, Caruana G, Cullen-McEwen L, Li J, Sarraj MA, Bertram JF, Stenvers KL. Betaglycan is required for the establishment of nephron endowment in the mouse. PLoS One 2011;6:e18723.

Walker RG, Kanellis J, Robertson AJ, Saunder AC. Living donor transplantation: is there inequality of access? ANZ J Surg 2011;81(1-2):2-3. Walsh W, Hill K, Bennell L, Vu M, Haines T. Local adaptation and evaluation of a falls risk prevention approach in acute hospitals. International Journal for Quality in Health Care 2011;23(2):134-141. Walter LM, Nixon GM, Davey MJ, O’Driscoll, DM, Trinder J Horne RSC Sleep disturbance in pre-school children with obstructive sleep apnea syndrome. Sleep Medicine 1 2011;2(9):880-6. Walter LM, Nixon GM, Davey MJ, O’Driscoll DM, Trinder J, Horne RS. Sleep disturbance in pre-school children with obstructive sleep apnoea syndrome. Sleep Med 2011;12(9):880-6. Walton KL, Makanji Y, Robertson DM, Harrison CA. The synthesis and secretion of inhibins. Vitamins and Hormones 2011;85:149-184. Wang C, Ilani N, Arver S, McLachlan RI, Soulis T, Watkinson A. Efficacy and safety of the 2% formulation of testosterone topical solution applied to the axillae in androgen-deficient men. Clinical Endocrinology 2011;75:836-843. Wang X, Catt S, Pangestu M, TempleSmith P. Successful in vitro culture of pre-antral follicles derived from vitrified murine ovarian tissue: oocyte maturation, fertilization, and live births. Reproduction 2011;141(2):183-91. Wang X, Catt S, Pangestu M, TempleSmith PD. Successful in vitro culture of pre-antral follicles derived from vitrified murine ovarian tissue: oocyte maturation, fertilization and live births. Reproduction 2011;141:183-191. Ward SA, Parikh S, Workman B. Health perspectives: international epidemiology of ageing. Best Practice and Research Clinical Anaesthesiology 2011;25:305-317.

Watson AR, Harden PN, Ferris ME, Kerr PG, Mahan JD, Ramzy MF. Transition from pediatric to adult renal services: a consensus statement by the International Society of Nephrology (ISN) and the International Pediatric Nephrology Association (IPNA). Jointly published Kidney Int 2011;80(7):704-7 and Pediatr Nephrol 2011;26(10):1753-7. Watzka SB, Posch F, Pass HI, Huflejt M, Bernhard D, Hannigan GE, et al. Detection of integrin-linked kinase in the serum of patients with malignant pleural mesothelioma. J Thorac Cardiovasc Surg 2011;142(2):384-9. Weisberg E, Croxatto HB, Findlay JK, Burger HG, Fraser IS. A randomised study of the effect of Mifepristone alone or in conjunction with Ethinyl Estradiol on ovarian function in women using the etonorgestrel-releasing subdermal implant, Implanon®. Contraception 2011;84:600-608. Weisberg E, Croxatto HB, Findlay JK, Burger HG, Fraser IS. A randomized study of the effect of mifepristone alone or in conjunction with ethinyl estradiol on ovarian function in women using the etonogestrel-releasing subdermal implant, Implanon(R). Contraception 2011;84:600-608. Western PS, Ralli RA, Wakeling SI, Lo C, van den Bergen JA, Miles DC, et al. Mitotic arrest in teratoma susceptible fetal male germ cells. PLoS One 2011;6(6):e20736. Wheeler KI, Schmolzer GM, Morley CJ, Davis PG. High-frequency ventilation with the Drager Babylog 8000plus: measuring the delivered frequency. Acta Paediatr 2011;100(1):67-70. White S, Ohnesorg T, Notini A, Roeszler K, Hewitt J, Daggag H, et al. Copy number variation in patients with disorders of sex development due to 46,XY gonadal dysgenesis. PLoS One 2011;6(3):e17793.

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White S, Ohnesorg T, Notini A, Roeszler K, Hewitt J, Daggag H, Smith C, Turbitt E, Gustin S, van den Bergen J, Miles D, Western P, Arboleda V, Schumacher V, Gordon L, Bell K, Bengtsson H, Speed T, Hutson J, Warne G, Harley V, Koopman P, Vilain E, Sinclair A. Copy number variation in patients with disorders of sex development due to 46,XY gonadal dysgenesis. PLoS One 2011;6:e17793. White SL, Polkinghorne KR, Chadban SJ. Population prevalance of proteinuria and diagnostic accuracy of urine dipsticks. Am J Kidney Dis 2011;58(6). White SL, Yu R, Craig JC, Polkinghorne KR, Atkins RC, Chadban SJ. Diagnostic Accuracy of Urine Dipsticks for Detection of Albuminuria in the General Community. Am J Kidney Dis 2011;58:19-28. Whitehead C, Palmer K, Nilsson U, Gao Y, Saglam B, Lappas M, et al. Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia. BJOG 2011;118(10):1268-71. Wickham SE, Hotze EM, Farrand AJ, Polekhina G, Nero TL, Tomlinson S, et al. Mapping the intermedilysinhuman CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9. J Biol Chem 2011;286(23):20952-62. Wijeratne NG, Doery JCG, Graudins A. Occult lead poisoning from Ayurvedic medicine produced, prescribed and purchased in India. Med J Aust 2011;194(4):205-206. Winnall WR, Muir JA, Hedger MP. Differential responses of epithelial Sertoli cells of the rat testis to Toll-like receptor 2 and 4 ligands: implications for studies of testicular inflammation using bacterial lipopolysaccharides. Innate Immun 2011;17(2):123-36.

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Winnall WR, Muir JA, Hedger MP. Rat resident testicular macrophages have an alternatively activated phenotype and constitutively produce interleukin-10 in vitro. J Leukoc Biol 2011;90(1):133-43.

Wong FY, Witcombe NB, Yiallourou SR, Yorkston S, Dymowski AR, Krishnan L, et al. Cerebral oxygenation is depressed during sleep in healthy term infants when they sleep prone. Pediatrics 2011;127(3):e558-65.

Winter M, Lynch, App, S, Kourambas J. Surgery illustrated – focus on detail: Access sheath aided percutaneous antegrade ureteroscopy; a noval approach to the ureter. British Journal of Urology International 2011 Aug:108(4):620-2.

Woodward M, Patel A, Zoungas S, Liu L, Pan C, Poulter N, Januszewicz A, Tandon N, Joshi P, Heller S, Neal B, Chalmers J. Does Glycemic Control Offer Similar Benefits Among Patients With Diabetes in Different Regions of the World?: Results from the ADVANCE trial. Diabetes Care 2011;34(12):2491-2495.

Winter M, Manohar P, Appu S, McCahy P. Self-reported competence of urethral cauterization in interns. ANZ j. Surg 2011;81:583-584. Wolfe R, Zoungas S, Polkinghorne KR. Missing data and multiple imputation when predicting mortality in incident dialysis patients. Am J Kidney Dis 2011;58(4):679. Wolfs TG, Kallapur SG, Polglase GR, Pillow JJ, Nitsos I, Newnham JP, et al. IL-1alpha mediated chorioamnionitis induces depletion of FoxP3+ cells and ileal inflammation in the ovine fetal gut. PLoS One 2011;6(3):e18355. Wong DT, Leung MC, Das R, Liew GY, Williams K, Dundon BK, Molaee P, Teo KS, Meredith IT, Worthley MI, Worthley SG. Diagnostic accuracy of adenosine stress cardiovascular magnetic resonance following acute ST-segment elevation myocardial infarction post primary angioplasty. J Cardiovasc Magn Reson 2011;22;13:62. Wong DTL, Leung MCH, Das R, Liew GYH, Teo KSL, Chew DP, Meredith IT, Worthley, MI, Worthley SG. Intracoronary ECG during primary percutaneous coronary intervention for ST-segment elevation myocardial infarction predicts microvascular obstruction and infarct size Int J Cardiol 2011 Aug 27. Wong FY, Witcombe NB, Yiallourou SR, Yorkston S, Dymowski AR, Krishnan L, et al. Cerebral oxygenation is depressed during sleep in healthy term infants when they sleep prone. Pediatrics 2011;127(3):e558-65.

Woolley I, Kanapathipillai R. Comment on: The DART Trial: ‘The Doctor’s Dilemma’ revisited. J Antimicrob Chemother 2011;66(5):964-7. Wright ST, Carr A, Woolley I, Giles M, Hoy J, Cooper DA, Lawma MG; on behalf of the Australian HIV Observational Database. CD4 Cell Responses to Combination Antiretroviral Therapy in Patients Starting Therapy at High CD4 Cell Counts. J Acquir Immune Defic Syndr 2011;58(1):72-9. Yan J, Wood J. Bevan C, Cheng W, Wilson G. Traumatic abdominal wall hernia – a case report and literature review. J Pediatr Surg 2011;46(8):1642-5. Yang J, Chang CY, Safi R, Morgan J, McDonnell DP, Fuller PJ, Clyne CD, Young MJ. Identification of ligandselective peptide antagonists of the mineralocorticoid receptor using phage display. Molecular Endocrinology 2011;25:32-43. Yang J, Clyne C, Chang C, Safi R, Mcdonnell DP, Fuller PJ, Young MJ. Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display. Molecular Endocrinology 2011;25:32-43. Yang JSC, Nicholas CL, Nixon GM, Davey MJ, Anderson V, Walker AM, Trinder J, Horne RSC. EEG spectral analysis of respiratory event termination arousals confirms conventional visual scoring in children with sleep disordered breathing. Sleep Breath 2011.

Southern Health and MHTP Publications

Yao YW, Shi Y, Jia ZF, Jiang YH, Gu Z, Wang J, Aljofan M, Sun ZG. PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development. Histochemistry and Cell Biology 2011;136:205-215. Yap J, Foo CF, Lee MY, Stanton PG, Dimitriadis E. Proteomic analysis identifies interleukin 11 regulated plasma membrane proteins in human endometrial epithelial cells in vitro. Reproductive Biology and Endocrinology 2011;9:73. Yawno T, Yan EB, Hirst JJ, Walker DW. Neuroactive steroids induce changes in fetal sheep behavior during normoxic and asphyxic states. Stress 2011;14(1):13-22. Ye L, Mayberry R, Lo CY, Britt KL, Stanley EG, Elefanty AG, et al. Generation of human female reproductive tract epithelium from human embryonic stem cells. PLoS One 2011;6(6):e21136. Yeung PHJ, Lau KKP, Lac A. Behcet’s disease with resolving pulmonary artery aneurysm and intracardiac thrombus. Hong Kong Journal of Radiology 2011;14:167-169. Yiallourou SR, Sands SA, Walker AM, Horne RS. Baroreflex sensitivity during sleep in infants: impact of sleeping position and sleep state. Sleep 2011;34(6):725-32. Yim HC, Li JC, Pong JC, Lau AS. A role for c-Myc in regulating anti-mycobacterial responses. Proc Natl Acad Sci USA 2011;108(43):17749-54. Ymer SI, Greenall SA, Cvrljevic A, Cao DX, Donoghue JF, Epa VC, et al. Glioma specific extracellular missense mutations in the first cysteine rich region of epidermal growth factor receptor (EGFR) initiate ligand independent activation. Cancers 2011;3(2):2032-49.

Yong MK, Elliott JH, Woolley IJ, Hoy JF. Low CD4 Count is Associated with an Increased Risk of Fragility Fracture in HIV-infected Patients. J Acquir Immune Defic Syndr 2011;57(3):205-10. Youngson NA, Vickaryous N, van der Horst A, Epp T, Harten S, Fleming JS, et al. A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice. Mamm Genome 2011;22(3-4):235-48. Zamudio NM, Scott HS, Wolski K, Lo CY, Law C, Leong D, et al. DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription. PLoS One 2011;6(3):e18276. Zarruk JG, Garcia-Yebenes I, Romera VG, Ballesteros I, Moraga A, Cuartero MI, et al. Neurological tests for functional outcome assessment in rodent models of ischaemic stroke. Rev Neurol 2011;53(10):607-18. Zepp JA, Nold-Petry CA, Dinarello CA, Nold MF. Protection from RNA and DNA viruses by IL-32. J Immunol 2011;186(7):4110-8. Zimbudzi A, Stuart RL, Korman TM, Kotsanas D. Contamination of renal patients’ hospital chart covers with vancomycin resistant enterococci: Handle with care. AMJ 2011;4(10):538-541. Zimbudzi E, Stuart RL, Korman TM, Kotsanas D, Contamination of renal patient hospital charts with vancomycin-resistant enterococci: Handle with care. Accepted Aust Med J 2011:4;538-541. Zoungas S, Lui M, Kerr PG, Teede HJ, McNeil JJ, McGrath BP, Polkinghorne KR. Advanced Chronic Kidney Disease, Cardiovascular events and the Effect of Diabetes: Data from the ASFAST study. Int Med J 2011;41:825-32. Zoungas S, Woodward M. Diabetes: Insights from the extended follow-up of the ACCORD trial. Nat Rev Cardiol 2011;8(6):308-10.

Book Chapters Allan CA, Bannerjee M, Wu FCW. Androgens and Coronary Artery Disease. In ENDOTEXT 2011 www.Endotext.org Burger HJ, Teede H. Endocrinology of the Menopause and Hormone Replacement Therapy. In: Oxford University Press: Wass JAH, Stewart PN (Eds), Oxford Textbook of Endocrinology and Metabolism (2nd Edition) 2011:1492-1503 Clarke DM. Psychological adaptation, demoralization and depression in people with cancer. In Maj M, Kissane DW, Sartorius N. Depression and Cancer. Wiley-Blackwell, 2011. Corben LA, Georgiou-Karistianis, N, Bradshaw, J.L., Evans-GaleaM.V, Churchyard, A.J, Delatycki, M.B. (2011). Characterising the Neuropathology and Neurobehavioural Phenotype in Friedreich Ataxia in A Hannan (Ed) Tandem Repeat Polymorphisms: Genetic Plasticity, Neural Diversity and Disease. Landes Bioscience and Springer Science+Business Media. Texas, USA. Danks, RA, Carcinoma of the Paranasal Sinuses in Brain Tumours, Kaye and Law, Third Ed, Elsevier. Fisher J, Feekery C, Rowe HJ. Psycho-educational early parenting interventions to promote infant mental health. In: Fitzgerald H, editor. International Perspectives on Child Psychology and Mental Health. Santa Barbara: ABC-CLIO Inc; 2011:205-236. Goldschlager T, Rosenfeld JV, Pathophysiology of Traumatic Brain Injury in Practical Head Injury, in Practical Management of Head and Neck Management (in press 2012) Rosenfeld J.V, Elsevier. Goldschlager T, Rosenfeld JV, Neuroanatomy and Physiology in Practical Head Injury, in Practical Management of Head and Neck Management (in press 2012) Rosenfeld J.V, Elsevier.

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Southern Health and MHTP Publications

Gorski M, Gaskin CJ. 2011. Case studies in exercise as a therapy for neurological conditions. In: Cameron M, Selig S, Hemphill D (eds) Clinical Exercise: A Case Based Approach. Churchill Livingstone. Graudins A. 2011. Sedative Hypnotic Poisoning. In: Irwin and Rippes Intensive Care Medicine 7th Edition. Lippincott Press. Healy DL, Weston G. Uterine Fibroids. Gynaecology (Fourth Edition) Chapter 32 (pgs 473-487) Ed. Shaw R, Soutter W, Stanton S. Jackson K, Mooney C, O’Connor G. 2012. “Palliative care in the acute hospital system”. Palliative Care Nursing: A Guide to Practice 3rd Edition, Ausmed, pp 331-354. King PT, Painful Disorders of the Respiratory System in Pain Management, editor Waldman, SD. 2nd Edition, Elsevier, Philadelphia; 2011, pp 649-659. Meyer ADMcR, Parkinson JEL. 2011. Emergency Contraception. In: Paediatric Emergency Medicine Cameron et al. Churchill Livingston publications. Murphy S, Wallace E, Jenkin G. Placental-derived stem cells: potential clinical applications. In: Appasani K, Appasani R (eds). Stem Cell Biology and Regenerative Medicine. Humana Press 2011, pp 243-263. Newton J, Billett S, Jolly B, Ockerby C. 2011. Preparing nurses and engaging preceptors, in Billett S, Henderson A, (eds), Developing learning professionals: Integrating experiences in university and practice settings: Vol. 7. Professional and practice-based learning pp 43-57, Springer, London.

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Pritzwald-Stegman P, Almeida A, Smith JA. Valvular heart disease. In: How to Treat Year Book 2011. Reed Business Information, Sydney 2011, pp 115-120. Selig S, Levinger I, Teede H, Deeks A. Chapter 16: Case studies in exercise as therapy for metabolic conditions. In Cameron M, Selig S, Hemphill D. Clinical Exercise: a case-based approach (pp 221-237). Elsevier: Sydney, Australia 2011. Sinclair PM & Bennett PN 2011 Nursing care of clients with kidney disorders, in Sheppard, Mandy; Millar, Katie; Stone, Michael; Pittard, Katie; Kesteven, Sybil and de Rome, Liz (eds), Medical-surgical nursing: critical thinking in client care: vol. 2, pp 900-948, Pearson Australia, Frenchs Forest, N.S.W.

Books Colen T, Stewart AE. 2011 (in press). Right ventricular outflow tract abnormalities. In: Davies MW, Inglis GDT, Jardine LA, Koorts PJ (eds). Antenatal consults: a guide for neonatologists and paediatricians. Elsevier, Sydney. Davies MW, Inglis GDT, Stewart AE, Jardine LA. 2011 (in press). The antenatal consult. In: Davies MW, Inglis GDT, Jardine LA, Koorts PJ (eds). Antenatal consults: a guide for neonatologists and paediatricians. Elsevier, Sydney. Endometriosis surgery in the new millennium. Endometriosis: Science and Practice. (in press) Ed. Guidice L, Evers JLH, Healy DL Kelly P, Advocat J, Harrison L, Hickey C. 2011, Smashed! The many meanings of intoxication and drunkenness. Monash University Publishing, Australia. McLachlan RI, Kovacs G ‘The Sub fertility Handbook: Clinicians’ guide’, Editor: G Kovacs Chapter 7, ‘Treatment options for male fertility’, 2011 p 76-87 Cambridge University Press 2nd Edition, USBN 978-0-52114784-2. Savva J. 2011, The Practical Handbook of Oncology Nutrition, Allenby Press Stewart AE. 2011 (in press). Congenital Diaphragmatic Hernia. In: Davies MW, Inglis GDT, Jardine LA, Koorts PJ (eds). Antenatal consults: a guide for neonatologists and paediatricians. Elsevier, Sydney.

Strength in collaboration and partnerships We actively work with other world-class researchers to deliver the best possible care to our community

A partnership between Southern Health, Prince Henry’s Institute, Monash Institute of Medical Research and Monash University translating scientific discoveries into world’s best healthcare.

Southern Health has established the Deakin- Southern Health Nursing Research Centre. Deakin University is nationally and internationally recognised as a centre of excellence in nursing research in the areas of quality, safety and risk management.

Southern Health is a member of the Victorian Cancer Biobank, which is a not-for-profit consortium of tissue banks supported by Cancer Council Victoria and the Victorian Government. The aim is to provide researchers with high quality tissue samples and data to facilitate cancer research discoveries.

Southern Health is a member of Biogrid Australia. The BioGrid Australia data linkage platform provides a world class product to Southern Health researchers and has enhanced their ability to conduct cutting edge research and attract associated research grants.

Cancer Trials Australia is a network of oncology trial centres and Southern Health is a member. Units at Monash Medical Centre Moorabbin and Clayton participate in multisite trials contracted by Cancer Trials Australia, with pharmaceutical and biotech companies, thereby providing access to new investigational agents.

Design: Dynamic Creations

Southern Health Research Directorate Monash Medical Centre 246 Clayton Road, Clayton Vic 3168 Australia t: 03 9594 4611 f: 03 9594 6306 e: research@southernhealth.org.au w:www.southernhealth.org.au/research


2011 Southern Health Research Report