Vol.4, No.1 (2011), 29-35
RESULTS AND DISCUSSION Antimicrobial activity Most of the synthesized copounds exhibited mild to moderate anti-microbial activity against the tested microorganisms. Compounds 2b, 2c, 2e, 3b and 3c were found to possess significant antibacterial and antifungal activity when compared to standard drug (Gentamicin and Fluconazol for antibacterial and antifungal respectively). The entire synthesized compounds exhibited mild to moderate activity are shown in Table -2. Table-1: Physical characterization data of the synthesized compounds. Compd 2a 2b 2c 2d 2e 2f 2g 3a 3b 3c 3d 3e 3f 3g 4a 4b 4c 4d 4e
m.p. 0C 113 145 128 118 115 140 136 190-192 186-188 160 153-154 175 183-184 170-173 150 164 170 175-174 153-152
Yield % 75.25 71.69 60.65 71.25 50.68 68.95 70.12 89.30 70.71 65.53 80.36 74.60 62.30 69.70 50.18 49.21 65.17 62.22 73.20
[α]D30 [c, in CHCl3] +180.01°(c, 0.968) +75.04°(c, 0.993) +120.05°(c, 0.932) +212.19°(c, 0.986) +105.88° (c, 0.986) +90.42° (c, 0.993) +150.50° (c,0.994) +99.75° (c, 0.978) + 45.32° (c, 0.987) +54.40° (c, 0.990) +65.70° (c, 0.993) +123.20° (c, 0.991) +141.51° (c, 0.982) -296.43° (c, 0.933) +60.32° (c, 0.667) -40.50° (c, 0.667) -70.35° (c, 0.668) +104.13° (c, 0.674) +64.62° (c, 0.667)
Rf, EtOA:Hexane, 1:1 0.79 0.81 0.83 0.72 0.86 0.82 0.76 0.78 0.90 0.93 0.87 0.79 0.78 0.82 0.65 0.63 0.71 0.77 0.80
Table-2: Anti-microbial activities of the synthesized compounds. (Invitro activity - zone of inhibition measured in mma) Compd E.coli 2a 2b 2c 2d 2e 2f 2g 3a 3b 3c 3d 3e 3f 3g 4a 4b
20 20 24 22 24 20 20 19 20 23 22 17 24 21 20 17
Bacteria P. aeruginosa P.vulgaris 18 19 20 16 21 15 19 13 17 21 16 12 15 13 16 16
MALTOSYL CARBAMIDES AND CARBAMATES
20 20 21 21 21 24 20 18 16 22 12 ------14 18 ---34
S.aureus ---23 20 20 17 23 23 16 19 23 20 24 18 16 14 14
A.niger 12 18 19 18 18 16 18 19 20 18 17 12 12 10 ------
Fungi C. albicans 10 16 17 15 11 17 16 17 18 19 18 17 19 16 10 09 S.P. Mote and S. P. Deshmukh