Hanigan and Devarajan: Molecular mechanisms of cisplatin nephrotoxicity epithelial cells is associated with the activation of the Fas/Fas ligand system. Histochem Cell Biol 111, 359-365.
Tedeschi M, De Cesare A, Oriana S, Perego P, Silva A, Venturino P, Zunino F (1991) The role of glutathione in combination with cisplatin in the treatment of ovarian cancer. Cancer Treat Rev 18,253-259.
Reed JC (1997) Cytochrome c: can't live with it - can't livewithout it. Cell 91, 559-562.
Thadani R, Pascual M, and Bonventre JV (1996) Acute renal failure. N Engl J Med 334, 1448-1460.
Richter C, Gogvadze V, Laffranchi R, Schlapbach R, Schweizer M, Suter M, Walter P, Yaffee M (1995) Oxidants in mitochondria: from physiology to disease. Biochim. Biophys. Acta 1271, 67-74.
Thornberry NA, and Lazebnik Y (1998) Caspases: enemies within. Science 281, 1312-1316.
Sadowitz PD, Hubbard BA, Dabrowiak JC, Goodisman J, Tacka KA, Aktas MK, Cunningham MJ, Dubowy RL, Souid AK (2002) Kinetics of cisplatin binding to cellular DNA and modulations by thiol- blocking agents and thiol drugs. Drug Metab Dispos. 30, 183-190.
Townsend AJ, Tu CP, Cowan KH (1992) Expression of human mu or alpha class glutathione S-transferases in stably transfected human MCF-7 breast cancer cells: effect on cellular sensitivity to cytotoxic agents. Mol Pharmacol 41, 230-236.
Sadzuka Y, Shoji T, Takino Y (1992) Effect of cisplatin on the activities of enzymes which protect against lipid peroxidation. Biochem Pharmacol 43, 1872-1875.
Townsend DM, Deng M, Zhang L, Lapus MG, Hanigan MH (2003) Metabolism of cisplatin to a nephrotoxin in proximal tubule cells. J Am Soc Nephrol 14, 1-10.
Sadzuka Y, Shimizu Y, Takino Y (1994) Role of glutathione Stransferase isoenzymes in cisplatin-induced nephrotoxicity in the rat. Toxicol Lett 70, 211-222.
Townsend DM, Hanigan MH (2002) Inhibition of gammaglutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice. J Pharmacol Exp Ther 300, 142-148.
Sadzuka Y, Shimizu Y, Takino Y, Hirota S (1994) Protection against cisplatin-induced nephrotoxicity in the rat by inducers and an inhibitor of glutathione S-transferase. Biochem Pharmacol 48, 453-459.
Townsend DM, Marto JA, Deng M, Macdonald TJ, Hanigan MH (2003) HPLC and mass spectrometry characterization of the nephrotoxic biotransformation products of cisplatin. Drug Metab Dispos, in press.
Saikumar P, Dong Z, Weinberg JM, Venkatachalam MA (1998) Mechanisms of cell death in hypoxia/reoxygenation injury. Oncogene 17, 3341-3349.
Tsuruya K, Ninomiya T, Tokumoto M, Hirakawa M, Masutani K, Taniguchi M, Fukuda K, Kanai H, Kishihara K, Hirakata H, and Iida M (2003) Direct involvement of the receptormediated apoptotic pathways in cisplatin-induced renal tubular cell death. Kidney Int 63, 72-82.
Sano K, Fujigaki Y, Miyaji T, Ikegaya N, Ohishi K, Yonemura H, and Hishida A (2000) Role of apoptosis in uranyl acetateinduced acute renal failure and acquired resistance to uranyl acetate. Kidney Int 57, 1560-1570.
Ueda K, Suzuki H, Akiyama S, Sugiyama Y (1999) Differences in substrate specificity among glutathione conjugates (GS-X) pump family members: comparison between multidrug resistance- associated protein and a novel transporter expressed on a cisplatin- resistant cell line (KCP-4). Jpn J Cancer Res 90, 439-447.
Shiraishi F, Curtis LM, Truong L, Poss K, Visner GA, Madsen K, Nick HS, and Agarwal A (2000) Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. Am J Physiol (Renal Physiol) 278, F726F736.
Ueda N, Kaushal GP, and Shah SV (2000) Apoptotic mechanisms in acute renal failure. Am J Med 108, 403-415.
Siddik ZH, Newell DR, Boxall FE, Harrap KR (1987) The comparative pharmacokinetics of carboplatin and cisplatin in mice and rats. Biochem Pharmacol 36, 1925-1932.
Uozumi J, Ishizawa M, Iwamoto Y, Baba T (1984) Sodium thiosulfate inhibits cis-diamminedichloroplatinum (II) activity. Cancer Chemother Pharmacol 13, 82-85.
Singh G (1989) A possible cellular mechanism of cisplatininduced nephrotoxicity. Toxicology 58, 71-80.
Van Der Water B, Tijdens IB, Verbrugge A, Huigsloot M, Dihal AA, Stevens JL, Jaken S, and Mulder GJ (2000) Cleavage of the actin-capping protein !-adducin at Asp-Asp-Ser-Asp633Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells. J Biol Chem 275, 25805-25813.
Smyth JF, Bowman A, Perren T, Wilkinson P, Prescott RJ, Quinn KJ, Tedeschi M (1997) Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin: results of a double-blind, randomised trial. Ann Oncol 8, 569-573. Takeda M, Kobayashi M, Shirato I, Osaki T, and Endou H (1997) Cisplatin-induced apoptosis of immortalized mouse proximal tubule cells is mediated by interleukin-1# converting enzyme (ICE) family of proteases but inhibited by overexpression of Bcl-2. Arch Toxicol 71, 612-621.
Van der Water B, Houtepen F, Huigsloot M, Tijdens IB (2001) Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury. J Biol Chem 276, 36183-36193.
Takeda M, Kobayashi M, Shirato I, and Endou H (1998) Involvement of macromolecule synthesis, endonuclease activation and c-fos expression in cisplatin-induced apoptosis of mouse proximal tubule cells. Toxicol Lett 94, 83-92.
Van der Zee AG, van Ommen B, Meijer C, Hollema H, Van Bladeren PJ, de Vries EG (1992) Glutathione S-transferase activity and isoenzyme composition in benign ovarian tumours, untreated malignant ovarian tumours, and
60